Dean C. Singleton

2.2k citations

24 papers · 1.6k indexed · 1 hit paper · h-index 14

Impact in

Cancer Research top 5%
- Cancer, Hypoxia, and Metabolism
Hematology top 5%
- Multiple Myeloma Research and Treatments

Papers in ⓘ

Cancer Research 10
- Cancer, Hypoxia, and Metabolism 8
Biotechnology 5
- Cancer Research and Treatments 5

Co-authors: Adrian L. Harris (6 shared papers)William R. Wilson (6 shared papers)Andrew Macann (3 shared papers)Tomasz Rzymski (1 shared paper)Manuela Milani (1 shared paper)Octovia Monteiro (3 shared papers)C. Tallant (3 shared papers)Susanne Müller (3 shared papers)
Journals: Cancer Gene Therapy (2 papers)Cancer Research (2 papers)Chemistry - An Asian Journal (1 paper)Molecular Oncology (1 paper)Nature Reviews Clinical Oncology (1 paper)
Partner nations: New Zealand United States United Kingdom

In The Last Decade

Dean C. Singleton

22 papers receiving 1.6k citations

Hit Papers

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Therapeutic targeting of the hypoxic tumour microenvironment 2021 · 338 citations

Peers

Countries citing papers authored by Dean C. Singleton

Since Specialization

Citations

This map shows the geographic impact of Dean C. Singleton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dean C. Singleton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dean C. Singleton more than expected).

Fields of papers citing papers by Dean C. Singleton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dean C. Singleton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dean C. Singleton. The network helps show where Dean C. Singleton may publish in the future.

Co-authors

The 25 scholars most cited alongside Dean C. Singleton, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dean C. Singleton Line = papers co-authored together Dean C. Singleton links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

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#	Work
1	Therapeutic targeting of the hypoxic tumour microenvironment Nature Reviews Clinical Oncology ·Dean C. Singleton, Andrew Macann, William R. Wilson Hit paper breakdown →	2021	338
2	Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains Journal of the American Chemical Society ·Duncan A. Hay, Oleg Fedorov, Sarah Martin, Dean C. Singleton, C. Tallant, Christopher Wells, S. Picaud, Martin Philpott, Octovia Monteiro, Catherine Rogers, Stuart J. Conway, Timothy P. C. Rooney, Anthony Tumber, Clarence Yapp, P. Filippakopoulos, Mark E. Bunnage, Susanne Müller, Stefan Knapp, Christopher J. Schofield, Paul E. Brennan	2014	208
3	Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia Cell Cycle ·Tomasz Rzymski, Manuela Milani, Dean C. Singleton, Adrian L. Harris	2009	163
4	LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor Angewandte Chemie International Edition ·Peter G. K. Clark, Lucas Campos Curcino Vieira, C. Tallant, O. Fedorov, Dean C. Singleton, Catherine Rogers, Octovia Monteiro, James M. Bennett, Roberta Baronio, Susanne Müller, Danette L. Daniels, Jacqui Méndez, Stefan Knapp, Paul E. Brennan, Darren J. Dixon	2015	134
5	Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival Biochemical Journal ·Luke Pike, Dean C. Singleton, Francesca M. Buffa, Olga Abramczyk, Kanchan Phadwal, Jiliang Li, Anna Katharina Simon, James T. Murray, Adrian L. Harris	2012	126
6	LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor Angewandte Chemie ·Peter G. K. Clark, Lucas Campos Curcino Vieira, C. Tallant, O. Fedorov, Dean C. Singleton, Catherine Rogers, Octovia Monteiro, James M. Bennett, Roberta Baronio, Susanne Müller, Danette L. Daniels, Jacqui Méndez, Stefan Knapp, Paul E. Brennan, Darren J. Dixon	2015	111
7	Targeting the ATF4 pathway in cancer therapy Expert Opinion on Therapeutic Targets ·Dean C. Singleton, Adrian L. Harris	2012	109
8	Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy Molecules ·Gabi U. Dachs, Michelle A. Hunt, Sophie P. Syddall, Dean C. Singleton, Adam V. Patterson	2009	91
9	Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth Cancer Research ·Alan McIntyre, Alžbeta Hulı́ková, Ioanna Ledaki, Cameron Snell, Dean C. Singleton, Graham Steers, Peter Seden, Dylan T. Jones, Esther Bridges, Simon Wigfield, Jiliang Li, Angela J. Russell, Pawel Swietach, Adrian L. Harris	2016	77
10	Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts Journal of Molecular Medicine ·Krishan Kumar, Simon Wigfield, Harriet E. Gee, Cecilia Devlin, Dean C. Singleton, Jiliang Li, Francesca M. Buffa, Melanie Huffman, Anthony L. Sinn, Jayne M. Silver, Helen Turley, Russell Leek, Adrian L. Harris, Mircea Ivan	2013	63
11	Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis Oncogene ·Dean C. Singleton, Pegah Rouhi, Christos E. Zois, Syed Haider, JL Li, Benedikt M. Kessler, Yihai Cao, Adrian L. Harris	2014	36
12	The nitroreductase prodrug SN 28343 enhances the potency of systemically administered armed oncolytic adenovirus ONYX-411NTR Cancer Gene Therapy ·Dean C. Singleton, D. Li, Sally Yan Bai, Sophie P. Syddall, Jeff B. Smaill, Y Shen, William A. Denny, William R. Wilson, Adam V. Patterson	2007	36
13	Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer BMC Cancer ·Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley, Euphemia Leung	2020	29
14	Patient-Derived Xenograft and Organoid Models for Precision Medicine Targeting of the Tumour Microenvironment in Head and Neck Cancer Cancers ·Tet Woo Lee, Amy Lai, Julia Harms, Dean C. Singleton, Benjamin D. Dickson, Andrew Macann, Michael P. Hay, Stephen M. F. Jamieson	2020	23
15	Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations Frontiers in Oncology ·Euphemia Leung, Marjan Askarian-Amiri, Dean C. Singleton, Carole Ferraro‐Peyret, Wayne R. Joseph, Graeme J. Finlay, Reuben Broom, Purvi M. Kakadia, Stefan K. Bohlander, Elaine S. Marshall, Bruce C. Baguley	2018	13
16	N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation Thrombosis and Haemostasis ·James I. Hearn, Taryn N. Green, Martin Chopra, Yohanes Nursalim, Leandro Ladvanszky, Nicholas Knowlton, Cherie Blenkiron, Raewyn C. Poulsen, Dean C. Singleton, Stefan K. Bohlander, Maggie L. Kalev‐Zylinska	2020	11
17	Hypoxia‐Activated Prodrugs of PERK Inhibitors Chemistry - An Asian Journal ·Lydia P. Liew, Dean C. Singleton, Way W. Wong, Gary J. Cheng, Stephen M. F. Jamieson, Michael P. Hay	2019	11
18	In vitro breast cancer models for studying mechanisms of resistance to endocrine therapy SHILAP Revista de lepidopterología ·Gary J. Cheng, Euphemia Leung, Dean C. Singleton	2022	10
19	Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit Cancer Gene Therapy ·Dean C. Singleton, Alexandra M. Mowday, Christopher P. Guise, Sophie P. Syddall, Sally Yan Bai, Dan Li, Amir Ashoorzadeh, Jeff B. Smaill, William R. Wilson, Adam V. Patterson	2021	6
20	Megakaryocyte maturation involves activation of the adaptive unfolded protein response Genes to Cells ·Mifra Faiz, Maggie L. Kalev‐Zylinska, Caitlin Dunstan‐Harrison, Dean C. Singleton, Michael P. Hay, Elizabeth C. Ledgerwood	2024	1

About Dean C. Singleton

Dean C. Singleton is a scholar working on Cancer Research, Biotechnology, Cell Biology, Oncology and Hematology, having authored 24 papers that have together received 1.6k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (8 papers), Endoplasmic Reticulum Stress and Disease (5 papers), Cancer Research and Treatments (5 papers), Protein Degradation and Inhibitors (4 papers), Virus-based gene therapy research (4 papers), Autophagy in Disease and Therapy (4 papers), Cancer Cells and Metastasis (3 papers) and CAR-T cell therapy research (3 papers). The work is most often cited by research in Cancer Research (367 citations), Hematology (202 citations), Molecular Biology (1.0k citations), Cell Biology (202 citations) and Biotechnology (102 citations). Dean C. Singleton has collaborated with scholars based in New Zealand, United States and United Kingdom. Frequent co-authors include Adrian L. Harris, William R. Wilson, Andrew Macann, Tomasz Rzymski, Manuela Milani, Octovia Monteiro, C. Tallant, Susanne Müller, Paul E. Brennan and Catherine Rogers. Their work appears in journals such as Cancer Gene Therapy, Cancer Research, Chemistry - An Asian Journal, Molecular Oncology and Nature Reviews Clinical Oncology.

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