Christopher J. Schofield

62.5k total citations · 8 hit papers
803 papers, 45.6k citations indexed

About

Christopher J. Schofield is a scholar working on Molecular Biology, Cancer Research and Molecular Medicine. According to data from OpenAlex, Christopher J. Schofield has authored 803 papers receiving a total of 45.6k indexed citations (citations by other indexed papers that have themselves been cited), including 511 papers in Molecular Biology, 185 papers in Cancer Research and 103 papers in Molecular Medicine. Recurrent topics in Christopher J. Schofield's work include Cancer, Hypoxia, and Metabolism (177 papers), Epigenetics and DNA Methylation (107 papers) and Antibiotic Resistance in Bacteria (103 papers). Christopher J. Schofield is often cited by papers focused on Cancer, Hypoxia, and Metabolism (177 papers), Epigenetics and DNA Methylation (107 papers) and Antibiotic Resistance in Bacteria (103 papers). Christopher J. Schofield collaborates with scholars based in United Kingdom, United States and Germany. Christopher J. Schofield's co-authors include Peter J. Ratcliffe, M.A. McDonough, Christopher W. Pugh, Jack E. Baldwin, Ya‐Min Tian, Kirsty S. Hewitson, Christoph Loenarz, I.J. Clifton, David R. Mole and Patrick H. Maxwell and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Christopher J. Schofield

795 papers receiving 44.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

2001 4.5k citations Panu Jaakkola, David R. Mole et al. Science profile →
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 2.7k citations Luke A. McNeill, Kirsty S. Hewitson et al. profile →
Oxygen sensing by HIF hydroxylases

2004 1.6k citations Christopher J. Schofield, Peter J. Ratcliffe profile →
The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases

2011 762 citations Rasheduzzaman Chowdhury, Ya‐Min Tian et al. profile →
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL

2002 611 citations Michael Wilson, Timothy D. W. Claridge et al. profile →
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

2002 602 citations Kirsty S. Hewitson, Luke A. McNeill et al. profile →
UNDP/World Bank/WHO special programme for research and training in tropical diseases (TDR)

1989 321 citations Christopher J. Schofield profile →
Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

2022 175 citations Christopher J. Schofield et al. profile →

Peers

Countries citing papers authored by Christopher J. Schofield

Since Specialization

Citations

This map shows the geographic impact of Christopher J. Schofield's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher J. Schofield with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher J. Schofield more than expected).

Fields of papers citing papers by Christopher J. Schofield

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher J. Schofield. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher J. Schofield. The network helps show where Christopher J. Schofield may publish in the future.

Co-authorship network of co-authors of Christopher J. Schofield

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher J. Schofield. A scholar is included among the top collaborators of Christopher J. Schofield based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher J. Schofield. Christopher J. Schofield is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Electrostatic interactions influence diazabicyclooctane inhibitor potency against OXA-48-like β-lactamases 2025 ·RSC Medicinal Chemistry ·(unknown), (unknown), Karina Calvopiña, (unknown), Philip Hinchliffe, (unknown), Catherine L. Tooke, Yuiko Takebayashi, (unknown), Nicholas J. Harmer, Adrian J. Mulholland, Christopher J. Schofield, (unknown)	1
2	Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate 2024 ·Journal of Medicinal Chemistry ·(unknown), (unknown), E. Salah, Bhaskar Bhushan, A. Szykowska, (unknown), Anthony Tumber, Skirmantas Kriaučionis, N. Burgess-Brown, Christopher J. Schofield, Tom Brown, Akane Kawamura	4
3	Fixing the Achilles Heel of Pfizer’s Paxlovid for COVID-19 Treatment 2024 ·Journal of Medicinal Chemistry ·Lennart Brewitz, Christopher J. Schofield	1
4	Structure, function, and evolution of metallo-β-lactamases from the B3 subgroup—emerging targets to combat antibiotic resistance 2023 ·Frontiers in Chemistry ·(unknown), (unknown), (unknown), (unknown), Marcelo Monteiro Pedroso, (unknown), Christopher J. Schofield, Philip Hugenholtz, Gerhard Schenk, (unknown)	8
5	Dioxygen Binding Is Controlled by the Protein Environment in Non‐heme Fe^II and 2‐Oxoglutarate Oxygenases: A Study on Histone Demethylase PHF8 and an Ethylene‐Forming Enzyme 2023 ·Chemistry - A European Journal ·Shobhit S. Chaturvedi, (unknown), (unknown), (unknown), (unknown), (unknown), Christopher J. Schofield, Jian Hu, Robert P. Hausinger, (unknown), Christo Christov	10
6	Activity‐based proteomics uncovers suppressed hydrolases and a neo‐functionalised antibacterial enzyme at the plant–pathogen interface 2023 ·New Phytologist ·Daniela J. Sueldo, (unknown), Farnusch Kaschani, Daniel Krahn, (unknown), Pierre Buscaill, Christopher J. Schofield, Markus Kaiser, Renier A. L. van der Hoorn	10
7	Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer‐drug Kinetics 2023 ·Angewandte Chemie International Edition ·(unknown), Christopher J. Schofield, Fräser A. Armstrong	7
8	Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease 2021 ·ChemMedChem ·(unknown), (unknown), Tika R. Malla, Anthony Tumber, Lennart Brewitz, Hani Choudhry, E. Salah, Christopher J. Schofield	23
9	Human Oxygenase Variants Employing a Single Protein Fe^II Ligand Are Catalytically Active 2021 ·Angewandte Chemie ·(unknown), Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, M.A. McDonough, Christopher J. Schofield	1
10	An essential role for dNTP homeostasis following CDK-induced replication stress 2019 ·Journal of Cell Science ·Chen‐Chun Pai, Kuo‐Feng Hsu, (unknown), Andrea Keszthelyi, Stephen Kearsey, Charalampos Rallis, Lisa K. Folkes, (unknown), Sarah E. Wilkins, Sophia X. Pfister, (unknown), Christopher J. Schofield, Jürg Bähler, Antony M. Carr, Timothy C. Humphrey	14
11	Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations 2015 ·Cancer Research ·Uzay Emir, Sarah J. Larkin, Nick de Pennington, Natalie Voets, Puneet Plaha, Richard Stacey, (unknown), James McCullagh, Christopher J. Schofield, Stuart Clare, Peter Jezzard, Tom Cadoux‐Hudson, Olaf Ansorge	94
12	Is JmjC Oxygenase Catalysis Limited to Demethylation? 2013 ·Angewandte Chemie ·Richard J. Hopkinson, Louise J. Walport, Martin Münzel, Nathan R. Rose, (unknown), Akane Kawamura, Timothy D. W. Claridge, Christopher J. Schofield	4
13	Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing 2009 ·Science ·Celia J. Webby, Alexander Wolf, Natalia Gromak, Mathias Dreger, Holger Kramer, Benedikt M. Kessler, Michael L. Nielsen, Corinna Schmitz, Danica Butler, John R. Yates, Claire Delahunty, (unknown), Andreas Lengeling, Matthias Mann, Nicholas Proudfoot, Christopher J. Schofield, Angelika Böttger	315
14	A miniaturized screen for inhibitors of Jumonji histonedemethylases 2009 ·Molecular BioSystems ·Masaaki Sakurai, Nathan R. Rose, Lena Schultz, Amy Quinn, Ajit Jadhav, Stanley S. Ng, Udo Oppermann, Christopher J. Schofield, Anton Simeonov	76
15	Asparagine β-hydroxylation stabilizes the ankyrin repeat domain fold 2008 ·Molecular BioSystems ·(unknown), M.A. McDonough, Mathew L. Coleman, Peter J. Ratcliffe, Christopher J. Schofield	52
16	Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) 2006 ·Proceedings of the National Academy of Sciences ·M.A. McDonough, Vivian Li, Emily Flashman, Rasheduzzaman Chowdhury, Christopher Mohr, Benoît M. R. Liénard, James Zondlo, Neil J. Oldham, I.J. Clifton, Jeffrey Lewis, Luke A. McNeill, Robert J. Kurzeja, Kirsty S. Hewitson, Evelyn Yang, Steven R. Jordan, Rashid Syed, Christopher J. Schofield	295
17	Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling 2005 ·Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences ·Kirsty S. Hewitson, (unknown), Richard W.D. Welford, M.A. McDonough, Christopher J. Schofield	48
18	Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate 2005 ·Molecular BioSystems ·Luke A. McNeill, Emily Flashman, Matthew R. Buck, Kirsty S. Hewitson, I.J. Clifton, Gunnar Jeschke, Timothy D. W. Claridge, (unknown), Neil J. Oldham, Christopher J. Schofield	100
19	Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation breakdown → 2001 ·Science ·Panu Jaakkola, David R. Mole, Ya‐Min Tian, Michael Wilson, Adriana Gielbert, Simon J. Gaskell, Alex von Kriegsheim, Holger Hebestreit, Mridul Mukherji, Christopher J. Schofield, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe	4523
20	High level expression inEscherichia coliof a fungal gene under the control of strong promoters 1990 ·FEMS Microbiology Letters ·Jack E. Baldwin, Jonathan M. Blackburn, Christopher J. Schofield, John D. Sutherland	7

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact