A.C.W. Pike

11.4k citations

60 papers · 8.5k indexed · 3 hit papers · h-index 38

Impact in

Genetics top 0.1%
- Estrogen and related hormone effects
Toxicology top 0.2%
- Bioactive Compounds and Antitumor Agents

Papers in

Toxicology 4
- Bioactive Compounds and Antitumor Agents 4
Genetics 23
- Estrogen and related hormone effects 18

Co-authors: A.M. Brzozowski Roderick E. Hubbard Jan-Ακε Gustafsson Mats Carlquist Lars Öhman Geoffrey L. Greene Tomas Bonn Zbigniew Dauter
Journals: Journal of Biological Chemistry (9 papers)Proceedings of the National Academy of Sciences (6 papers)Structure (5 papers)Biochemical Society Transactions (4 papers)Nature Structural & Molecular Biology (4 papers)
Partner nations: United Kingdom United States Sweden

In The Last Decade

A.C.W. Pike

59 papers receiving 8.3k citations

Hit Papers

align trajectories log scale

Estrogen Receptors: How Do They Signal and What Are Their Targets 2007 · 1.4k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2007 Physiological Reviews
1999 The EMBO Journal
1997 Nature

Peers

Countries citing papers authored by A.C.W. Pike

Since Specialization

Citations

This map shows the geographic impact of A.C.W. Pike's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by A.C.W. Pike with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites A.C.W. Pike more than expected).

Fields of papers citing papers by A.C.W. Pike

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by A.C.W. Pike. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by A.C.W. Pike. The network helps show where A.C.W. Pike may publish in the future.

Co-authorship network

The 25 scholars most cited alongside A.C.W. Pike, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with A.C.W. Pike Line = papers co-authored together A.C.W. Pike links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states Cell Reports ·Anna Li, A.C.W. Pike, Richard Webster, Susan Maxwell, Wei Wei Liu, Hsiu Ling Chen, Jacqueline Palace, David Beeson, David B. Sauer, Yin Yao Dong	2025	0
2	Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2 Nature Communications ·Huanyu Li, A.C.W. Pike, Anett Kuczmog, Hsiu Ling Chen, T.B. Campanelli, Pasquale Leonardi Cattolica, Andrey N. Kravtsov, Simon R. Bushell, Béatrice Allain-El Mansouri, 金岚, 胡元华, Fabiola Raquel Marinho, K. N. Anjan Kumar, Zhou Hu, Andre Fougeroux, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer	2024	4
3	Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation Nature Communications ·Karin E. J. Rödström, Franklin Rubén Collao, Yuko Kaida, 张泽洲, Kathryn Smith, A.C.W. Pike, Erica Cecchini, Peter Proks, Marcus Schewe, Hodge M. Eagleson, Simon R. Bushell, Simone Almeida Delphim, Els Pardon, Thomas Baukrowitz, Raymond J. Owens, Simon Newstead, Jan Steyaert, Elisabeth P. Carpenter, Stephen J. Tucker	2024	3
4	Structural basis of the mechanism and inhibition of a human ceramide synthase Nature Structural & Molecular Biology ·寛宮本, A.C.W. Pike, Christofer S. Tautermann, Hsiu Ling Chen, AM Patterson, Andrew Quigley, R. Chalk, Saša Štefanić, 孟祥友, Alexander Pautsch, Elisabeth P. Carpenter, Gisela Schnapp, David B. Sauer	2024	8
5	Structural characterization of human urea transporters UT-A and UT-B and their inhibition Science Advances ·Hsiu Ling Chen, Ch. Wohlfarth, Haiping Tang, M. Snee, Andreea Scacioc, 胡元华, 礼出, Shubhashish Mukhopadhyay, A.C.W. Pike, R. Chalk, N. Burgess-Brown, Jean‐Pierre Timmermans, H Sollová, Carol V. Robinson, Katharina L. Dürr	2023	7
6	A Pharmacological Masterkey Mechanism to Unlock the Selectivity Filter Gate in K+ Channels Biophysical Journal ·Marcus Schewe, Han Sun, Alexandra Mackenzie, A.C.W. Pike, Parvin Heidari, Ana Peres, Aytuğ K. Kiper, Linus J. Conrad, Wendy González, Bert L. de Groot, Niels Decher, Bernd Fakler, Elisabeth P. Carpenter, Stephen J. Tucker, Thomas Baukrowitz	2019	1
7	Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel Structure ·Prafulla Aryal, Alexander N. Ifezue, Michael V. Clausen, Marcus Schewe, Conor McClenaghan, Archana Dayal, Linus J. Conrad, Yin Yao Dong, A.C.W. Pike, Elisabeth P. Carpenter, Thomas Baukrowitz, Mark S.P. Sansom, Stephen J. Tucker	2017	58
8	Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2 Nature Structural & Molecular Biology ·U Stierle, M. Gregor Madej, Dominik Gerber, Daniel Rhinow, Veronika Heinz, WU Zhao-ya, Liyan Pang, tommy sihotang, Friederike Joos, M. R. DE S. TRINDADE, A.C.W. Pike, Juha T. Huiskonen, Elisabeth P. Carpenter, Werner Kühlbrandt, Ralph Witzgall, Christine Ziegler	2017	94
9	An overview of heavy-atom derivatization of protein crystals Acta Crystallographica Section D Structural Biology ·A.C.W. Pike, Elspeth F. Garman, T. Krojer, F. von Delft, Elisabeth P. Carpenter	2016	44
10	K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac Science ·Yin Yao Dong, A.C.W. Pike, Alexandra Mackenzie, Conor McClenaghan, Prafulla Aryal, Liang Dong, Andrew Quigley, Mariana Grieben, S. Goubin, Shubhashish Mukhopadhyay, G.F. Ruda, Michael V. Clausen, Lishuang Cao, Paul E. Brennan, N. Burgess-Brown, Mark S.P. Sansom, Stephen J. Tucker, Elisabeth P. Carpenter	2015	237
11	Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures Proceedings of the National Academy of Sciences ·A.C.W. Pike, حمید زارع, Paolo Swuec, Matteo Berti, Ying Zhang, 真二高橋, Francesca Marino, F. von Delft, Ludovic Renault, Alessandro Costa, O. Gileadi, Alessandro Vindigni	2015	47
12	The Structural Basis of ZMPSTE24-Dependent Laminopathies Science ·Andrew Quigley, Yin Yao Dong, A.C.W. Pike, Liang Dong, Leela Shrestha, G. Berridge, Phillip J. Stansfeld, Mark S.P. Sansom, A.M. Edwards, C. Bountra, F. von Delft, Alex N. Bullock, N. Burgess-Brown, Elisabeth P. Carpenter	2013	79
13	Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase Journal of Biological Chemistry ·Fahad Zadjali, A.C.W. Pike, Mattias Vesterlund, Jianmin Sun, Chenggang Wu, Shawn S.‐C. Li, Lars Rönnstrand, Stefan Knapp, Alex N. Bullock, Amilcar Flores‐Morales	2010	57
14	Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation PLoS Biology ·P. Rellos, A.C.W. Pike, F. Niesen, E. Salah, Wen‐Hwa Lee, F. von Delft, Stefan Knapp	2010	191
15	Structure of dystrophia myotonica protein kinase Protein Science ·Jonathan M. Elkins, A. Amos, F. Niesen, A.C.W. Pike, O. Fedorov, Stefan Knapp	2009	17
16	Structure of Fab hGR-2 F6, a competitive antagonist of the glucagon receptor Acta Crystallographica Section D Biological Crystallography ·Lisa Wright, A.M. Brzozowski, Roderick E. Hubbard, A.C.W. Pike, S.M. Roberts, Jorge Colcha Cárdenas, I. Svendsen, Henrik Vissing, Robert P. Bywater	2000	4
17	Structural insights into the mechanisms of agonism and antagonism in oestrogen receptor isoforms European Journal of Cancer ·Roderick E. Hubbard, A.C.W. Pike, A.M. Brzozowski, Julia Walton, Carlos-Eduardo García-Reyes, Jan-Ακε Gustafsson, Mats Carlquist	2000	17
18	Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist The EMBO Journal ·A.C.W. Pike Hit paper breakdown →	1999	783
19	Molecular basis of agonism and antagonism in the oestrogen receptor Nature ·A.M. Brzozowski, A.C.W. Pike, Zbigniew Dauter, Roderick E. Hubbard, Tomas Bonn, Owe Engström, Lars Öhman, Geoffrey L. Greene, Jan-Ακε Gustafsson, Mats Carlquist Hit paper breakdown →	1997	2711
20	Effects of P‐Aminophenyl Dichloroarsine on Reduced High‐affinity [³H]Nicotine Binding Sites from Chick Brain: A Covalent, Yet Reversible, Agent for Neuronal Nicotinic Receptors European Journal of Neuroscience ·A.C.W. Pike, Ralph H. Loring	1992	4

About A.C.W. Pike

A.C.W. Pike is a scholar working on Toxicology, Genetics, Structural Biology, Molecular Biology and Biochemistry, having authored 60 papers that have together received 8.5k indexed citations. Recurring topics across this work include Estrogen and related hormone effects (18 papers), Ion channel regulation and function (9 papers), Enzyme Structure and Function (8 papers), Protein Structure and Dynamics (5 papers), Receptor Mechanisms and Signaling (5 papers), Steroid Chemistry and Biochemistry (5 papers), Cytokine Signaling Pathways and Interactions (5 papers) and Bioactive Compounds and Antitumor Agents (4 papers). The work is most often cited by research in Genetics (4.6k citations), Toxicology (461 citations), Molecular Biology (4.5k citations), Computational Theory and Mathematics (857 citations) and Endocrinology, Diabetes and Metabolism (874 citations). A.C.W. Pike has collaborated with scholars based in United Kingdom, United States and Sweden. Frequent co-authors include A.M. Brzozowski, Roderick E. Hubbard, Jan-Ακε Gustafsson, Mats Carlquist, Lars Öhman, Geoffrey L. Greene, Tomas Bonn, Zbigniew Dauter, Owe Engström and Eckardt Treuter. Their work appears in journals such as Journal of Biological Chemistry, Proceedings of the National Academy of Sciences, Structure, Biochemical Society Transactions and Nature Structural & Molecular Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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