F. von Delft

11.7k citations

121 papers · 5.3k indexed · 1 hit paper · h-index 41

Impact in

Molecular Biology top 2%
- Protein Structure and Dynamics
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- RNA and protein synthesis mechanisms
- Fibroblast Growth Factor Research
Cell Biology top 2%
- Proteoglycans and glycosaminoglycans research

Papers in

Structural Biology 2
Molecular Biology 90
- Protein Structure and Dynamics 25
- Biochemical and Molecular Research 11
- Protein Degradation and Inhibitors 11
- Ubiquitin and proteasome pathways 8
- RNA modifications and cancer 8

Co-authors: T. Krojer Tom L. Blundell Luca Pellegrini Barbara Mulloy David F. Burke O. Gileadi Stefan Knapp Udo Oppermann
Journals: Journal of Biological Chemistry (8 papers)Journal of Medicinal Chemistry (7 papers)Acta Crystallographica Section D Structural Biology (6 papers)Journal of Molecular Biology (4 papers)Journal of Chemical Information and Modeling (4 papers)
Partner nations: United Kingdom South Africa United States

In The Last Decade

F. von Delft

114 papers receiving 5.2k citations

Hit Papers

align trajectories log scale

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin 2000 · 567 citations

Peers

Countries citing papers authored by F. von Delft

Since Specialization

Citations

This map shows the geographic impact of F. von Delft's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by F. von Delft with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites F. von Delft more than expected).

Fields of papers citing papers by F. von Delft

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by F. von Delft. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by F. von Delft. The network helps show where F. von Delft may publish in the future.

Co-authors

The 25 scholars most cited alongside F. von Delft, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with F. von Delft Line = papers co-authored together F. von Delft links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Water Networks as Hydrophobic Recognition Motifs in Proteins Angewandte Chemie International Edition ·彬栗原, Nick Owen, Salvatore Scaffidi, C. Shen, A. L. Conner, 智寛伊東, S. Picaud, T. Krojer, P. Filippakopoulos, F. von Delft, Carmen Escolano, Carles Galdeano, Xavier Barril	2025	1
2	Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain Communications Chemistry ·岩井直温, Antonio Mennillo, Ayoub Aarab, L. H. P. Gaio, Martin P. Schwalm, Krishna Saxena, Thomas Hanke, L. Greeven, 祥世梶川, D. Fearon, F. von Delft, Andreas Krämer, Stefan Knapp	2025	0
3	Covalently constrained ‘Di-Gembodies’ enable parallel structure solutions by cryo-EM Nature Chemical Biology ·Zen-icji Yamamoto, مهسا مرادمند, Fismarada Agvi Examaya, Loïc Carrique, M. Fairhead, Huanyu Li, C Vasquez Juan, Peijun Zhang, David B. Sauer, F. von Delft, Benjamin G. Davis, Robert J.C. Gilbert	2025	0
4	Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology Journal of Cheminformatics ·Matteo P. Ferla, Rubén Sánchez-García, R. Skyner, Stefan Gahbauer, Jenny C. Taylor, F. von Delft, Brian D. Marsden, Charlotte M. Deane	2025	3
5	Structure–activity relationships can be directly extracted from high-throughput crystallographic evaluation of fragment elaborations in crude reaction mixtures Chemical Science ·N. Schpak, Jeong Sook Ahn, A. A., Warren Thompson, Xiaokang He, F. von Delft, Roberto Carú	2025	0
6	Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B eLife ·Timbunan pada Tanah Lunak, J.T. Biel, Н. В. Кірхар, 千原美重子, Ya-wei Xu, Louise Dunnett, Neil G. Paterson, A. Douangamath, R. Talon, Danny Axford, Yona Rahmawati, F. von Delft, D.A. Keedy	2023	37
7	SAMPL7 protein-ligand challenge: A community-wide evaluation of computational methods against fragment screening and pose-prediction Journal of Computer-Aided Molecular Design ·N. Schpak, Mehtap Işık, A. Aimon, David L. Mobley, John D. Chodera, F. von Delft, Philip C. Biggin	2022	16
8	Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase Nature Communications ·J.A. Newman, A. Douangamath, Nemati Dopolani Fatemeh, Y. Yosaatmadja, A. Aimon, J. Brandão-Neto, Louise Dunnett, T.J. Gorrie-Stone, R. Skyner, D. Fearon, Matthieu Schapira, F. von Delft, O. Gileadi	2021	155
9	Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia ACS Chemical Biology ·Mauro Carozzo Todaro, T. Krojer, Ronke Seyi Babatunde, L. Diaz Saez, Manshu Tang, K. Huber, F. von Delft, Kent Lai, Paul E. Brennan, G.A. Bezerra, Wyatt W. Yue	2021	9
10	Structure and activation mechanism of the human liver-type glutaminase GLS2 Biochimie ·Igor Monteze Ferreira, 尚素祐川, Joanne Barnieu, Maria Teresa Giuliani, M. Vollmar, T. Krojer, Claire Strain‐Damerell, N. Burgess-Brown, F. von Delft, Wyatt W. Yue, Yunus Yoldaş, A.L.B. Ambrosio	2021	15
11	A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process Journal of Molecular Biology ·G.D. Noske, A.M. Nakamura, Victor O. Gawriljuk, R.S. Fernandes, G.M.A. Lima, А В Кутузов, H.M. Pereira, Ana Carolina de Mattos Zeri, Andrey Fabricio Ziem Nascimento, Marjorie C. L. C. Freire, D. Fearon, A. Douangamath, F. von Delft, Glaucius Oliva, André S. Godoy	2021	44
12	Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures Communications Chemistry ·Lisa Baker, A. Aimon, James B. Murray, A.E. Surgenor, Natalia Matassova, Stephen D. Roughley, P.M. Collins, T. Krojer, F. von Delft, Roderick E. Hubbard	2020	12
13	Deliberately Losing Control of C−H Activation Processes in the Design of Small‐Molecule‐Fragment Arrays Targeting Peroxisomal Metabolism ChemMedChem ·Martin L. Moore, Lei Liang-can, T. Krojer, A.R. Bradley, Srikannathasan Velupillai, R. Talon, M. Fairhead, Iain J. Day, Wang Min-qian, Robert Felix, Paul D. Kemmitt, Paul E. Brennan, F. von Delft, L. Diaz Saez, K. Huber, John Spencer	2020	4
14	Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency Pathology ·J.R.C. Muniz, George Russell MacKenzie-Grieve, Rebecca Frise, Wen‐Hwa Lee, Chyrel Lichaa, Beat Thöny, Nastassja Himmelreich, Nenad Blau, Kwang-Jen Hsiao, Tze-Tze Liu, O. Gileadi, Udo Oppermann, F. von Delft, Wyatt W. Yue, Nelson L.S. Tang	2019	7
15	An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering eLife ·D.A. Keedy, Z.B. Hill, J.T. Biel, Emily L. Kang, T.J. Rettenmaier, J. Brandão-Neto, Nicholas M. Pearce, F. von Delft, James A. Wells, James S. Fraser	2018	117
16	Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin Journal of Medicinal Chemistry ·Rachel Harding, Renato Ferreira de Freitas, P.M. Collins, Ivan Franzoni, Mani Ravichandran, Hui Ouyang, Homma Mk, Mark Lautens, Matthieu Schapira, F. von Delft, IK Kefala, C.H. Arrowsmith	2017	29
17	Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures Proceedings of the National Academy of Sciences ·A.C.W. Pike, حمید زارع, Paolo Swuec, Matteo Berti, Ying Zhang, 真二高橋, Francesca Marino, F. von Delft, Ludovic Renault, Alessandro Costa, O. Gileadi, Alessandro Vindigni	2015	47
18	The Structural Basis of ZMPSTE24-Dependent Laminopathies Science ·Andrew Quigley, Yin Yao Dong, A.C.W. Pike, Liang Dong, Leela Shrestha, G. Berridge, Phillip J. Stansfeld, Mark S.P. Sansom, A.M. Edwards, C. Bountra, F. von Delft, Alex N. Bullock, N. Burgess-Brown, Elisabeth P. Carpenter	2013	79
19	Structural Insights into Functional Overlapping and Differentiation among Myosin V Motors Journal of Biological Chemistry ·Andrey Fabricio Ziem Nascimento, Daniel Maragno Trindade, C.C.C. Tonoli, P.O. Giuseppe, Alessandra Teles, Rodrigo V. Honorato, Paulo Sérgio Lopes de Oliveira, P. Mahajan, N. Burgess-Brown, F. von Delft, Roy Edward Larson, M.T. Murakami	2013	27
20	The 160 selenium atom substructure of KPHMT Acta Crystallographica Section A Foundations of Crystallography ·F. von Delft, T.L. Blundell	2002	1

About F. von Delft

F. von Delft is a scholar working on Structural Biology, Molecular Biology, Computational Theory and Mathematics, Materials Chemistry and Cell Biology, having authored 121 papers that have together received 5.3k indexed citations. Recurring topics across this work include Enzyme Structure and Function (37 papers), Protein Structure and Dynamics (25 papers), Computational Drug Discovery Methods (20 papers), Biochemical and Molecular Research (11 papers), Protein Degradation and Inhibitors (11 papers), Ubiquitin and proteasome pathways (8 papers), RNA modifications and cancer (8 papers) and Click Chemistry and Applications (6 papers). The work is most often cited by research in Molecular Biology (3.9k citations), Cell Biology (646 citations), Computational Theory and Mathematics (601 citations), Structural Biology (47 citations) and Oncology (716 citations). F. von Delft has collaborated with scholars based in United Kingdom, South Africa and United States. Frequent co-authors include T. Krojer, Tom L. Blundell, Luca Pellegrini, Barbara Mulloy, David F. Burke, O. Gileadi, Stefan Knapp, Udo Oppermann, Alex N. Bullock and A.C.W. Pike. Their work appears in journals such as Journal of Biological Chemistry, Journal of Medicinal Chemistry, Acta Crystallographica Section D Structural Biology, Journal of Molecular Biology and Journal of Chemical Information and Modeling.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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