Karen Hsiao

14.7k citations

37 papers · 11.6k indexed · 8 hit papers · h-index 26

Physiology top 0.1%
Molecular Biology top 1%
Neurology top 0.05%
Cellular and Molecular Neuroscience top 0.5%
Pharmacology top 0.2%

Co-authors: Chris Eckman Steven G. Younkin Fusheng Yang Greg M. Cole Paul F. Chapman Steven P. Nilsen Yasuo Harigaya Stanley B. Prusiner
Topics: Prion Diseases and Protein Misfolding (22 papers)Alzheimer's disease research and treatments (17 papers)Neurological diseases and metabolism (11 papers)
Cited by: Neurology Physiology Biological Psychiatry
Journals: Nature Science New England Journal of Medicine
Partner nations: United States United Kingdom Italy

In The Last Decade

Karen Hsiao

36 papers receiving 11.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 3.5k citations Karen Hsiao, Paul F. Chapman et al. Science profile →
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 1.1k citations Leigh A. Holcomb, Marcia N. Gordon et al. profile →
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 773 citations Paul F. Chapman, Matthew W. Jones et al. Nature Neuroscience profile →
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

1989 625 citations Karen Hsiao, Stanley B. Prusiner et al. profile →
APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 526 citations Michael C. Irizarry, M. McNamara et al. Journal of Neuropathology & Experimental Neurology profile →
Microglial response to amyloid plaques in APPsw transgenic mice.

1998 510 citations Fusheng Yang, Karen Hsiao et al. PubMed profile →
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein

1990 414 citations Karen Hsiao, Michael Scott et al. Science profile →
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins

1988 315 citations Michael R. Scott, David Borchelt et al. profile →

Peers

Countries citing papers authored by Karen Hsiao

Since Specialization

Citations

This map shows the geographic impact of Karen Hsiao's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karen Hsiao with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karen Hsiao more than expected).

Fields of papers citing papers by Karen Hsiao

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karen Hsiao. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karen Hsiao. The network helps show where Karen Hsiao may publish in the future.

Co-authorship network of co-authors of Karen Hsiao

This figure shows the co-authorship network connecting the top 25 collaborators of Karen Hsiao. A scholar is included among the top collaborators of Karen Hsiao based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Karen Hsiao. Karen Hsiao is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Induction of NADPH cytochrome P450 reductase by the Alzheimer β‐protein. Amyloid as a ‘foreign body’ 2001 ·Journal of Neurochemistry ·Miguel A. Pappolla,Rawhi Omar,Yau‐Jan Chyan,Jorge Ghiso,Karen Hsiao,Peter Bozner,George Perry,Mark A. Smith,Felix Cruz-Sánchez	11
2	Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic micebreakdown → 1999 ·Nature Neuroscience ·Paul F. Chapman,(unknown),Matthew W. Jones,(unknown),Vanessa Marshall,Michael C. Irizarry,Linda H. Younkin,Mark Good,T.V.P. Bliss,Bradley T. Hyman,Steven G. Younkin,Karen Hsiao	773
3	SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein 1999 ·Nature Neuroscience ·Costantino Iadecola,Fangyi Zhang,Kiyoshi Niwa,Chris Eckman,Sherry Turner,Elizabeth R. Fischer,Steven G. Younkin,David Borchelt,Karen Hsiao,George A. Carlson	334
4	Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits 1999 ·Behavior Genetics ·Leigh A. Holcomb,Marcia N. Gordon,Paul Jantzen,Karen Hsiao,Karen Duff,Dave Morgan	288
5	Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress 1998 ·Journal of Neurochemistry ·Mark A. Smith,Keisuke Hirai,Karen Hsiao,Miguel A. Pappolla,Peggy L.R. Harris,Sandra L. Siedlak,Massimo Tabaton,George Perry	469
6	Transgenic mice expressing Alzheimer amyloid precursor proteins 1998 ·Experimental Gerontology ·Karen Hsiao	96
7	Chapter 25 Strain dependent and invariant features of transgenic mice expressing Alzheimer amyloid precursor proteins 1998 ·Progress in brain research ·Karen Hsiao	10
8	From prion diseases to Alzheimer’s disease 1997 ·PubMed ·Karen Hsiao	6
9	APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1breakdown → 1997 ·Journal of Neuropathology & Experimental Neurology ·Michael C. Irizarry,M. McNamara,(unknown),Karen Hsiao,Bradley T. Hyman	526
10	Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein 1997 ·Journal of Neuroscience ·Fangyi Zhang,Chris Eckman,Steven G. Younkin,Karen Hsiao,Costantino Iadecola	169
11	Genetic Modification of the Phenotypes Produced by Amyloid Precursor Protein Overexpression in Transgenic Mice 1997 ·Human Molecular Genetics ·George A. Carlson,David Borchelt,(unknown),Sherry Turner,(unknown),J. Douglas Coffin,Christopher B. Eckman,(unknown),Steven P. Nilsen,Steven G. Younkin,Karen Hsiao	131
12	Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Micebreakdown → 1996 ·Science ·Karen Hsiao,Paul F. Chapman,Steven P. Nilsen,Chris Eckman,Yasuo Harigaya,Steven G. Younkin,Fusheng Yang,Greg M. Cole	3504
13	Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins 1995 ·Neuron ·Karen Hsiao,David Borchelt,Kristine Olson,(unknown),Cheryl A. Kitt,Wael S. Yunis,Sherry L. Xu,(unknown),Steven G. Younkin,Donald A. Price,Costantino Iadecola,H. Brent Clark,George A. Carlson	442
14	The Genetics and Transgenetics of Human Prion Disease 1994 ·Annals of the New York Academy of Sciences ·Karen Hsiao	7
15	Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles 1992 ·Nature Genetics ·Karen Hsiao,Stephen R. Dlouhy,Martin R. Farlow,(unknown),Maria Da Costa,P. Michael Conneally,M. E. Hodes,Bernardino Ghetti,Stanley B. Prusiner	174
16	A prion protein variant in a family with the telencephalic form of Gerstmann‐Straussler‐Scheinker syndrome 1991 ·Neurology ·Karen Hsiao,(unknown),Gerald D. Schellenberg,Thomas D. Bird,(unknown),H Wiśniewski,S. B. Prusiner	120
17	Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease 1991 ·New England Journal of Medicine ·Karen Hsiao,Zeev Meiner,Esther Kahana,(unknown),Irit Kahana,Dana Avrahami,G. Scarlato,Oded Abramsky,Stanley B. Prusiner,Ruth Gabizon	207
18	Molecular Genetics and Transgenic Model of Gertsmann???Str??ussler???Scheinker Disease 1991 ·Alzheimer Disease & Associated Disorders ·Karen Hsiao,Stanley B. Prusiner	8
19	Spontaneous Neurodegeneration in Transgenic Mice with Prion Protein Codon 101 Proline → Leucine Substitutiona 1991 ·Annals of the New York Academy of Sciences ·Karen Hsiao,Michael Scott,Dallas Foster,Stephen J. DeArmond,Darlene Groth,Hana Serban,Stanley B. Prusiner	12
20	Prion protein gene expression in cultured cells 1988 ·Protein Engineering Design and Selection ·Michael R. Scott,(unknown),Dale E. Bredesen,(unknown),Karen Hsiao,Stanley B. Prusiner	42

About Karen Hsiao

Karen Hsiao is a scholar working on Neurology, Biological Psychiatry and Physiology, having authored 37 papers that have together received 11.6k indexed citations. Recurring topics across this work include Prion Diseases and Protein Misfolding (22 papers), Alzheimer's disease research and treatments (17 papers) and Neurological diseases and metabolism (11 papers). The work is most often cited by research in Neurology (3.9k citations), Physiology (7.3k citations) and Biological Psychiatry (578 citations). Karen Hsiao has collaborated with scholars based in United States, United Kingdom and Italy. Frequent co-authors include Chris Eckman, Steven G. Younkin, Fusheng Yang, Greg M. Cole, Paul F. Chapman, Steven P. Nilsen, Yasuo Harigaya, Stanley B. Prusiner, Michael C. Irizarry and David Borchelt. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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