Keisuke Hirai

12.4k total citations · 3 hit papers
110 papers, 7.7k citations indexed

About

Keisuke Hirai is a scholar working on Molecular Biology, Physiology and Endocrinology, Diabetes and Metabolism. According to data from OpenAlex, Keisuke Hirai has authored 110 papers receiving a total of 7.7k indexed citations (citations by other indexed papers that have themselves been cited), including 37 papers in Molecular Biology, 27 papers in Physiology and 18 papers in Endocrinology, Diabetes and Metabolism. Recurrent topics in Keisuke Hirai's work include Alzheimer's disease research and treatments (15 papers), Thyroid Cancer Diagnosis and Treatment (14 papers) and Circadian rhythm and melatonin (13 papers). Keisuke Hirai is often cited by papers focused on Alzheimer's disease research and treatments (15 papers), Thyroid Cancer Diagnosis and Treatment (14 papers) and Circadian rhythm and melatonin (13 papers). Keisuke Hirai collaborates with scholars based in Japan, United States and Spain. Keisuke Hirai's co-authors include George Perry, Mark A. Smith, Akihiko Nunomura, Gjumrakch Aliev, Shigeru Chiba, Craig Atwood, Atsushi Takeda, Miguel A. Pappolla, Shun Shimohama and Robert B. Petersen and has published in prestigious journals such as Journal of Neuroscience, The Journal of Immunology and PLoS ONE.

In The Last Decade

Keisuke Hirai

108 papers receiving 7.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 1.5k citations Akihiko Nunomura, George Perry et al. profile →
Mitochondrial Abnormalities in Alzheimer's Disease

2001 1.1k citations Keisuke Hirai, Gjumrakch Aliev et al. profile →
RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 614 citations George Perry, Miguel A. Pappolla et al. profile →

Peers

Keisuke Hirai

PHYSI

PHARM

EDM

CMN

Gemma Casadesús United States

Miguel A. Pappolla United States

Jin Fu China

Kumar Sambamurti United States

Simonetta Camandola United States

Ângela Terezinha de Souza Wyse Brazil

Gary E. Gibson United States

Mercè Pallàs Spain

Fabio Di Domenico Italy

William M. Pierce United States

Gemma Casadesús United States

Keisuke Hirai

4.7k ×1.3

PHYSI

3.8k ×1.2

1.2k ×1.2

PHARM

679 ×0.7

EDM

1.6k ×1.8

CMN

Citations per year, relative to Keisuke Hirai Keisuke Hirai (= 1×) peers Gemma Casadesús

Countries citing papers authored by Keisuke Hirai

Since Specialization

Citations

This map shows the geographic impact of Keisuke Hirai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Keisuke Hirai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Keisuke Hirai more than expected).

Fields of papers citing papers by Keisuke Hirai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Keisuke Hirai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Keisuke Hirai. The network helps show where Keisuke Hirai may publish in the future.

Co-authorship network of co-authors of Keisuke Hirai

This figure shows the co-authorship network connecting the top 25 collaborators of Keisuke Hirai. A scholar is included among the top collaborators of Keisuke Hirai based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Keisuke Hirai. Keisuke Hirai is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Kawasaki, Tomohiro, et al.. (2023). Novel Stentless Strategy With Perfusion and Drug-Coated Balloons for Treating Acute Coronary Syndrome. Journal of the Society for Cardiovascular Angiography & Interventions. 3(1). 101175–101175. 1 indexed citations

Hirai, Keisuke, et al.. (2020). Efficient production of 1,3-propanediol by psychrophile-based simple biocatalysts in Shewanella livingstonensis Ac10 and Shewanella frigidimarina DSM 12253. Journal of Biotechnology. 323. 293–301. 3 indexed citations

Hirai, Keisuke, Hiromu Habashita, Yoshikazu Takaoka, et al.. (2010). Discovery of orally available spirodiketopiperazine-based CCR5 antagonists. Bioorganic & Medicinal Chemistry. 18(14). 5208–5223. 11 indexed citations

Hirai, Keisuke, Masanobu Kumakiri, Kumiko Ueda, et al.. (2009). Clonal evolution and progression of 20-methylcholanthrene-induced squamous cell carcinoma of mouse epidermis as revealed by DNA instability and other malignancy markers. European Journal of Histochemistry. 45(4). 319–319. 7 indexed citations

Hirai, Keisuke, Hiromu Habashita, Yoshikazu Takaoka, et al.. (2009). Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles. Bioorganic & Medicinal Chemistry Letters. 20(2). 763–766. 14 indexed citations

Nunomura, Akihiko, Kazuhiro Honda, Atsushi Takeda, et al.. (2006). Oxidative Damage to RNA in Neurodegenerative Diseases. BioMed Research International. 2006(1). 82323–82323. 103 indexed citations

Kato, Koki, Keisuke Hirai, Keiji Nishiyama, et al.. (2004). Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 48(2). 301–310. 304 indexed citations

Ito, Yasuhiro, Fumio Matsuzuka, Hiroshi Yoshida, et al.. (2003). Encapsulated Anaplastic Thyroid Carcinoma Without Invasive Phenotype with Favorable Prognosis: Report of a Case. Surgery Today. 33(4). 277–281. 11 indexed citations

Kobayashi, Kaoru, Tadashi Tatsumi, Masayuki Murota, et al.. (2003). Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-Tetrahydro-2H-azepin-2-imines. Bioorganic & Medicinal Chemistry. 11(5). 689–702. 12 indexed citations

10.

Ito, Yasuhiro, Hiroshi Yoshida, Keiichi Nakano, et al.. (2002). Overexpression of Human Tumor-Associated Antigen, RCAS1, Is Significantly Linked to Dedifferentiation of Thyroid Carcinoma. Oncology. 64(1). 83–89. 23 indexed citations

11.

Perry, George, Akihiko Nunomura, Keisuke Hirai, et al.. (2002). Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases?. Free Radical Biology and Medicine. 33(11). 1475–1479. 246 indexed citations

12.

Sumi, Toshiyuki, et al.. (2001). Expression of cyclooxygenase-2 in ovarian mature cystic teratomas with malignant transformation. International Journal of Molecular Medicine. 8(5). 495–8. 18 indexed citations

13.

Perry, George, Akihiko Nunomura, Keisuke Hirai, et al.. (2000). Oxidative damage in Alzheimer's disease: the metabolic dimension. International Journal of Developmental Neuroscience. 18(4-5). 417–421. 96 indexed citations

14.

Smith, Mark A., Keisuke Hirai, Karen Hsiao, et al.. (1998). Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress. Journal of Neurochemistry. 70(5). 2212–2215. 469 indexed citations

15.

Kotani, Takuya, et al.. (1995). Apoptosis in Thyroid Tissue from Patients with Hashimoto's Thyroiditis. Autoimmunity. 20(4). 231–236. 82 indexed citations

16.

Sato, Kei, et al.. (1992). Incidence of the plerocercoids of Spirometra erinacei in snakes, Elaphe quadrivirgata and Rhabdophis tigrinus tigrinus captured in Ehime Prefecture, Japan. Kiseichūgaku zasshi. 41(4). 340–343. 4 indexed citations

17.

Kotani, Takuya, Yujiro Asada, Yatsuki Aratake, et al.. (1992). Diagnostic usefulness of dipeptidyl aminopeptidase IV monoclonal antibody in paraffin‐embedded thyroid follicular tumours. The Journal of Pathology. 168(1). 41–45. 35 indexed citations

18.

Hata, Jun-ichiro, Hideo Kato, Keisuke Hirai, et al.. (1989). Stable high level expression of human thyroid peroxidase in cultured Chinese hamster ovary cells. Biochemical and Biophysical Research Communications. 164(3). 1268–1273. 23 indexed citations

19.

Hara, Masayuki, Yoshihiro Matsuda, Keisuke Hirai, Nobuaki Okumura, & Hachiro Nakagawa. (1989). Characteristics of Glucose Transport in Neuronal Cells and Astrocytes from Rat Brain in Primary Culture. Journal of Neurochemistry. 52(3). 902–908. 49 indexed citations

20.

Ishijima, Sumio, M. Taguchi, Keisuke Hirai, et al.. (1987). Preparation and Characterization of Monoclonal Antibodies against Phosphoenolpyruvate Carboxylase of Escherichia coli1. The Journal of Biochemistry. 102(5). 1231–1240.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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