David Borchelt

34.1k total citations · 12 hit papers
223 papers, 27.2k citations indexed

About

David Borchelt is a scholar working on Molecular Biology, Physiology and Neurology. According to data from OpenAlex, David Borchelt has authored 223 papers receiving a total of 27.2k indexed citations (citations by other indexed papers that have themselves been cited), including 118 papers in Molecular Biology, 91 papers in Physiology and 90 papers in Neurology. Recurrent topics in David Borchelt's work include Alzheimer's disease research and treatments (91 papers), Amyotrophic Lateral Sclerosis Research (78 papers) and Prion Diseases and Protein Misfolding (61 papers). David Borchelt is often cited by papers focused on Alzheimer's disease research and treatments (91 papers), Amyotrophic Lateral Sclerosis Research (78 papers) and Prion Diseases and Protein Misfolding (61 papers). David Borchelt collaborates with scholars based in United States, Japan and Canada. David Borchelt's co-authors include Donald L. Price, Sangram S. Sisodia, Neal G. Copeland, Michael K. Lee, Nancy A. Jenkins, Hilda H. Slunt, Guilian Xu, Philip C. Wong, Don W. Cleveland and Joanna L. Jankowsky and has published in prestigious journals such as Science, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

David Borchelt

223 papers receiving 26.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

APP Processing and Synaptic Function

2003 1.3k citations Taisuke Tomita, Helen Hsieh et al. Neuron profile →
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

2003 1.3k citations Joanna L. Jankowsky, Jeffrey C. Anderson et al. Human Molecular Genetics profile →
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 1.2k citations David Borchelt, Michael K. Lee et al. Neuron profile →
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 1.2k citations Philip C. Wong, David Borchelt et al. Neuron profile →
ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

1997 1.1k citations Michael K. Lee, N.A. Jenkins et al. Neuron profile →
BACE1 is the major β-secretase for generation of Aβ peptides by neurons

2001 868 citations Huaibin Cai, Hongjin Wen et al. profile →
Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 863 citations Gopal Thinakaran, David Borchelt et al. Neuron profile →
Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 830 citations David Borchelt, Tamara Ratovitski et al. Neuron profile →
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide

2007 752 citations David Borchelt et al. profile →
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies

2001 680 citations Joanna L. Jankowsky, Hilda H. Slunt et al. profile →
Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

1992 419 citations David Borchelt, Stanley B. Prusiner et al. Journal of Biological Chemistry profile →
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins

1988 315 citations David Borchelt, Stanley B. Prusiner et al. profile →

Peers

Countries citing papers authored by David Borchelt

Since Specialization

Citations

This map shows the geographic impact of David Borchelt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Borchelt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Borchelt more than expected).

Fields of papers citing papers by David Borchelt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Borchelt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Borchelt. The network helps show where David Borchelt may publish in the future.

Co-authorship network of co-authors of David Borchelt

This figure shows the co-authorship network connecting the top 25 collaborators of David Borchelt. A scholar is included among the top collaborators of David Borchelt based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Borchelt. David Borchelt is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Acetylation Mimetic and Null Mutations Within the Filament Core of P301L Tau Have Varied Effects on Susceptibility to Seeding and Aggregation 2025 ·Journal of Neurochemistry ·(unknown), (unknown), Robert W. McKenna, (unknown), Mario Mietzsch, David Borchelt, Stefan Prokop, Paramita Chakrabarty	1
2	Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the APPswePS1dE9 mouse model 2021 ·Glia ·(unknown), (unknown), David Borchelt, Willem Kamphuis, Jinte Middeldorp, Elly M. Hol	49
3	Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models 2016 ·Journal of Neurochemistry ·Jacob I. Ayers, Benjamin H. McMahon, Sabrina Gill, (unknown), Susan Fromholt, Hilda Brown, Joan Selverstone Valentine, Julian P. Whitelegge, David Borchelt	17
4	RAN Translation in Huntington Disease 2015 ·Neuron ·Mónica Báñez-Coronel, Fatma Ayhan, Alex D. Tarabochia, Tao Zu, B. Pérez, Solaleh Khoramian Tusi, Olga Pletniková, David Borchelt, Christopher A. Ross, Russell L. Margolis, Anthony T. Yachnis, Juan C. Troncoso, Laura P.W. Ranum	238
5	Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice 2014 ·Human Molecular Genetics ·Guilian Xu, Jacob I. Ayers, (unknown), Hilda Brown, Susan Fromholt, Cameron Green, David Borchelt	14
6	Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain 2013 ·PLoS ONE ·Paramita Chakrabarty, Awilda M. Rosario, Pedro E. Cruz, Zoe Siemienski, Carolina Ceballos‐Diaz, Keith Crosby, Karen Jansen, David Borchelt, Ji‐Yoen Kim, Joanna L. Jankowsky, Todd E. Golde, Yona Levites	132
7	A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis‐associated and experimental mutations in metal‐binding residues and free cysteines lacks toxicity in vivo 2012 ·Journal of Neurochemistry ·Mercedes Prudencio, (unknown), Hilda Brown, Julian P. Whitelegge, Joan Selverstone Valentine, David Borchelt	21
8	Premature death and neurologic abnormalities in transgenic mice expressing a mutant huntingtin exon-2 fragment 2011 ·Human Molecular Genetics ·Andrew T.N. Tebbenkamp, Debbie Swing, Lino Tessarollo, David Borchelt	24
9	Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse model 2010 ·Human Molecular Genetics ·(unknown), Zhong Wu Liu, Ying Liang, Naoki Masuda, Deborah A. Swing, N.A. Jenkins, Neal G. Copeland, Juan C. Troncoso, Mikhail V. Pletnikov, Ted M. Dawson, Lee J. Martin, Timothy H. Moran, Michael K. Lee, David Borchelt, Christopher A. Ross	57
10	Partial Depletion of CREB-Binding Protein Reduces Life Expectancy in a Mouse Model of Huntington Disease 2010 ·Journal of Neuropathology & Experimental Neurology ·Alexandra M. Klevytska, Andrew T.N. Tebbenkamp, Alena Savonenko, David Borchelt	26
11	Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease 2008 ·Journal of Neuroscience ·Ying Liu, Mi‐Jeong Yoo, Alena Savonenko, Wanda L.H. Stirling, Donald L. Price, David Borchelt, Laura A. Mamounas, W. Ernest Lyons, Mary E. Blue, Michael K. Lee	165
12	BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions 2005 ·Journal of Neuroscience ·Fiona M. Laird, Huaibin Cai, Alena Savonenko, Mohamed H. Farah, Kaiwen He, Tatyana Melnikova, Hongjin Wen, Hsueh‐Cheng Chiang, Guilian Xu, Vassilis E. Koliatsos, David Borchelt, Donald L. Price, Hey‐Kyoung Lee, Philip C. Wong	431
13	Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice 2004 ·Experimental Neurology ·Gabriele Schilling, Alena Savonenko, Michael L. Coonfield, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Christopher A. Ross, David Borchelt	67
14	Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase breakdown → 2003 ·Human Molecular Genetics ·Joanna L. Jankowsky, (unknown), Jeffrey C. Anderson, Guilian Xu, Victoria Gonzales, Nancy A. Jenkins, Neal G. Copeland, Michael K. Lee, Linda H. Younkin, Steven L. Wagner, Steven G. Younkin, David Borchelt	1252
15	APP Processing and Synaptic Function breakdown → 2003 ·Neuron ·(unknown), Taisuke Tomita, Helen Hsieh, Guy R. Seabrook, David Borchelt, Takeshi Iwatsubo, Sangram S. Sisodia, Roberto Malinow	1292
16	Enhanced Synaptic Potentiation in Transgenic Mice Expressing presenilin 1 Familial Alzheimer's Disease Mutation Is Normalized with a Benzodiazepine 2000 ·Neurobiology of Disease ·Shahid Zaman, Angèle Parent, (unknown), Michael K. Lee, David Borchelt, Sangram S. Sisodia, Roberto Malinow	57
17	Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins breakdown → 1997 ·Neuron ·David Borchelt, Tamara Ratovitski, (unknown), Michael K. Lee, (unknown), Nancy A. Jenkins, Neal G. Copeland, Donald L. Price, Sangram S. Sisodia	830
18	Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors 1997 ·Journal of Biological Chemistry ·Gopal Thinakaran, (unknown), Tamara Ratovitski, (unknown), Hilda H. Slunt, Donald L. Price, David Borchelt, Sangram S. Sisodia	275
19	CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS 1995 ·Neuroimaging Clinics of North America ·Sangram S. Sisodia, Lee J. Martin, Lary C. Walker, David Borchelt, Donald L. Price	6
20	Release of the cellular prion protein from cultured cells after loss of its glycoinositol phospholipid anchor 1993 ·Glycobiology ·David Borchelt, Mark Rogers, Neil Stahl, Glenn C. Telling, Stanley B. Prusiner	107

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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