David Borchelt

34.1k total citations · 12 hit papers
223 papers, 27.2k citations indexed

About

David Borchelt is a scholar working on Molecular Biology, Physiology and Neurology. According to data from OpenAlex, David Borchelt has authored 223 papers receiving a total of 27.2k indexed citations (citations by other indexed papers that have themselves been cited), including 118 papers in Molecular Biology, 91 papers in Physiology and 90 papers in Neurology. Recurrent topics in David Borchelt's work include Alzheimer's disease research and treatments (91 papers), Amyotrophic Lateral Sclerosis Research (78 papers) and Prion Diseases and Protein Misfolding (61 papers). David Borchelt is often cited by papers focused on Alzheimer's disease research and treatments (91 papers), Amyotrophic Lateral Sclerosis Research (78 papers) and Prion Diseases and Protein Misfolding (61 papers). David Borchelt collaborates with scholars based in United States, Japan and Canada. David Borchelt's co-authors include Donald L. Price, Sangram S. Sisodia, Neal G. Copeland, Michael K. Lee, Nancy A. Jenkins, Hilda H. Slunt, Guilian Xu, Philip C. Wong, Don W. Cleveland and Joanna L. Jankowsky and has published in prestigious journals such as Science, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

David Borchelt

223 papers receiving 26.7k citations

Hit Papers

APP Processing and Synapt... 1988 2026 2000 2013 2003 2003 1996 1995 1997 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. APP Processing and Synaptic Function
    2003 1.3k citations Taisuke Tomita, Helen Hsieh et al. Neuron profile →
  2. Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
    2003 1.3k citations Guilian Xu, Victoria Gonzales et al. Human Molecular Genetics profile →
  3. Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
    1996 1.2k citations David Borchelt, Michael K. Lee et al. Neuron profile →
  4. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    1995 1.2k citations Philip C. Wong, David Borchelt et al. Neuron profile →
  5. ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions
    1997 1.1k citations Lucie Bruijn, Mark W. Bêcher et al. Neuron profile →
  6. BACE1 is the major β-secretase for generation of Aβ peptides by neurons
    2001 868 citations Huaibin Cai, Diane B. McCarthy et al. profile →
  7. Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo
    1996 863 citations Gopal Thinakaran, David Borchelt et al. Neuron profile →
  8. Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins
    1997 830 citations David Borchelt, Michael K. Lee et al. Neuron profile →
  9. Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
    2007 752 citations David Borchelt et al. profile →
  10. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies
    2001 680 citations Hilda H. Slunt, Nancy A. Jenkins et al. profile →
  11. Evidence for synthesis of scrapie prion proteins in the endocytic pathway.
    1992 419 citations David Borchelt, Albert Taraboulos et al. profile →
  12. Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins
    1988 315 citations David Borchelt, Albert Taraboulos et al. profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
David Borchelt 12.8k 12.2k 7.6k 6.7k 5.9k 223 27.2k
Sangram S. Sisodia 20.9k 1.6× 15.8k 1.3× 4.3k 0.6× 8.4k 1.2× 4.6k 0.8× 240 33.5k
M. Flint Beal 10.2k 0.8× 19.5k 1.6× 9.5k 1.3× 9.0k 1.3× 4.2k 0.7× 221 36.5k
Donald L. Price 17.3k 1.4× 16.9k 1.4× 9.8k 1.3× 16.3k 2.4× 6.2k 1.1× 365 44.1k
Michael K. Lee 7.6k 0.6× 8.0k 0.7× 8.0k 1.1× 5.6k 0.8× 3.2k 0.5× 155 20.0k
Peter St George‐Hyslop 16.8k 1.3× 12.1k 1.0× 4.7k 0.6× 5.3k 0.8× 3.7k 0.6× 391 28.3k
Philip C. Wong 7.2k 0.6× 7.2k 0.6× 5.3k 0.7× 3.1k 0.5× 2.1k 0.4× 148 16.6k
Masato Hasegawa 14.0k 1.1× 10.7k 0.9× 16.3k 2.2× 6.6k 1.0× 5.4k 0.9× 315 27.9k
Christian Haass 29.7k 2.3× 24.0k 2.0× 10.0k 1.3× 9.7k 1.4× 7.0k 1.2× 384 49.9k
Jesús Ávila 13.9k 1.1× 16.1k 1.3× 2.5k 0.3× 10.1k 1.5× 4.4k 0.8× 650 33.7k
Guojun Bu 14.8k 1.2× 12.1k 1.0× 2.4k 0.3× 4.6k 0.7× 6.8k 1.2× 336 30.8k

Countries citing papers authored by David Borchelt

Since Specialization
Citations

This map shows the geographic impact of David Borchelt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Borchelt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Borchelt more than expected).

Fields of papers citing papers by David Borchelt

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Borchelt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Borchelt. The network helps show where David Borchelt may publish in the future.

Co-authorship network of co-authors of David Borchelt

This figure shows the co-authorship network connecting the top 25 collaborators of David Borchelt. A scholar is included among the top collaborators of David Borchelt based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Borchelt. David Borchelt is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
McKenna, Robert W., et al.. (2025). Acetylation Mimetic and Null Mutations Within the Filament Core of P301L Tau Have Varied Effects on Susceptibility to Seeding and Aggregation. Journal of Neurochemistry. 169(9). e70221–e70221. 1 indexed citations
2.
Ayers, Jacob I., et al.. (2023). Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice. Viruses. 15(9). 1819–1819. 1 indexed citations
3.
McFarland, Karen N., et al.. (2023). Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy. Acta Neuropathologica Communications. 11(1). 99–99. 5 indexed citations
4.
Moore, Brenda D., Yona Levites, Guilian Xu, et al.. (2022). Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts. PubMed. 3(9). 9–9. 2 indexed citations
5.
6.
Brown, Hilda, et al.. (2019). N-terminal sequences in matrin 3 mediate phase separation into droplet-like structures that recruit TDP43 variants lacking RNA binding elements. Laboratory Investigation. 99(7). 1030–1040. 28 indexed citations
7.
Ayers, Jacob I., Benjamin H. McMahon, Sabrina Gill, et al.. (2016). Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models. Journal of Neurochemistry. 140(1). 140–150. 17 indexed citations
8.
Báñez-Coronel, Mónica, Fatma Ayhan, Alex D. Tarabochia, et al.. (2015). RAN Translation in Huntington Disease. Neuron. 88(4). 667–677. 238 indexed citations
9.
Borchelt, David & Christopher A. Ross. (2014). Gabriele Schilling (September 5, 1968—July 4, 2014. Journal of Huntington s Disease. 3(3). 225–227. 1 indexed citations
10.
11.
Liu, Ying, Mi‐Jeong Yoo, Alena Savonenko, et al.. (2008). Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease. Journal of Neuroscience. 28(51). 13805–13814. 165 indexed citations
12.
Laird, Fiona M., Huaibin Cai, Alena Savonenko, et al.. (2005). BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions. Journal of Neuroscience. 25(50). 11693–11709. 431 indexed citations
13.
Wang, Jiou, Guilian Xu, Hong Li, et al.. (2005). Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation. Human Molecular Genetics. 14(16). 2335–2347. 103 indexed citations
14.
Wang, Jiou, Guilian Xu, Hilda H. Slunt, et al.. (2005). Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA. Neurobiology of Disease. 20(3). 943–952. 91 indexed citations
15.
Tomita, Taisuke, Helen Hsieh, Guy R. Seabrook, et al.. (2003). APP Processing and Synaptic Function. Neuron. 37(6). 925–937. 1292 indexed citations breakdown →
16.
Borchelt, David, Donald L. Price, Diane B. McCarthy, et al.. (2001). β -Amyloid Peptide Vaccination Results in Marked Changes in Serum and Brain A β Levels in APPswe/PS1ΔE9 Mice, as Detected by SELDI-TOF-Based ProteinChip ® Technology. DNA and Cell Biology. 20(11). 713–721. 41 indexed citations
17.
Naruse, Satoshi, Gopal Thinakaran, Jin Jun Luo, et al.. (1998). Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons. Neuron. 21(5). 1213–1221. 316 indexed citations
18.
Bruijn, Lucie, Mark W. Bêcher, Michael K. Lee, et al.. (1997). ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions. Neuron. 18(2). 327–338. 1084 indexed citations breakdown →
19.
Sisodia, Sangram S., Lee J. Martin, Lary C. Walker, David Borchelt, & Donald L. Price. (1995). CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS. Neuroimaging Clinics of North America. 5(1). 59–68. 6 indexed citations
20.
Taraboulos, Albert, Alex J. Raeber, David Borchelt, D. Serban, & Stanley B. Prusiner. (1992). Synthesis and trafficking of prion proteins in cultured cells.. Molecular Biology of the Cell. 3(8). 851–863. 223 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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