Mark A. Smith

82.7k total citations · 13 hit papers
733 papers, 61.9k citations indexed

About

Mark A. Smith is a scholar working on Physiology, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Mark A. Smith has authored 733 papers receiving a total of 61.9k indexed citations (citations by other indexed papers that have themselves been cited), including 336 papers in Physiology, 282 papers in Molecular Biology and 116 papers in Cellular and Molecular Neuroscience. Recurrent topics in Mark A. Smith's work include Alzheimer's disease research and treatments (299 papers), Cholinesterase and Neurodegenerative Diseases (87 papers) and Mitochondrial Function and Pathology (79 papers). Mark A. Smith is often cited by papers focused on Alzheimer's disease research and treatments (299 papers), Cholinesterase and Neurodegenerative Diseases (87 papers) and Mitochondrial Function and Pathology (79 papers). Mark A. Smith collaborates with scholars based in United States, Japan and United Kingdom. Mark A. Smith's co-authors include George Perry, Xiongwei Zhu, Akihiko Nunomura, Lawrence M. Sayre, Hyoung‐gon Lee, Rudy J. Castellani, Peggy L.R. Harris, Arun K. Raina, Paula I. Moreira and Gemma Casadesús and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Mark A. Smith

724 papers receiving 60.3k citations

Hit Papers

Mitochondrial Abnormalities in Alzheimer's Disease 1990 2026 2002 2014 2001 1997 2009 1997 2000 250 500 750 1000
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mitochondrial Abnormalities in Alzheimer's Disease
    2001 1.1k citations Gjumrakch Aliev, Akihiko Nunomura et al. profile →
  2. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
    1997 1.1k citations Mark A. Smith, Peggy L.R. Harris et al. profile →
  3. Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
    2009 1.0k citations Xinglong Wang, Bo Su et al. profile →
  4. Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K+Channels
    1997 854 citations Mark A. Smith et al. profile →
  5. Oxidative stress in Alzheimer’s disease
    2000 724 citations Mark A. Smith, Catherine A. Rottkamp et al. profile →
  6. Oxidative Stress and Neurotoxicity
    2007 690 citations Lawrence M. Sayre, George Perry et al. profile →
  7. RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease
    1999 614 citations George Perry, Shigeru Chiba et al. profile →
  8. Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
    1994 608 citations Mark A. Smith, Lawrence M. Sayre et al. profile →
  9. Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
    2009 585 citations Paula I. Moreira, Xiongwei Zhu et al. profile →
  10. Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats
    1990 573 citations Mark A. Smith et al. profile →
  11. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
    1997 518 citations Mark A. Smith et al. profile →
  12. Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons
    1999 513 citations Jing Zhang, George Perry et al. American Journal Of Pathology profile →
  13. Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease
    2001 508 citations Lawrence M. Sayre, Mark A. Smith et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Mark A. Smith United States 134 28.5k 23.8k 9.8k 8.4k 7.6k 733 61.9k
George Perry United States 134 36.7k 1.3× 29.0k 1.2× 9.3k 0.9× 10.1k 1.2× 10.4k 1.4× 905 69.0k
Rudolph E. Tanzi United States 109 32.5k 1.1× 22.9k 1.0× 9.1k 0.9× 7.0k 0.8× 7.6k 1.0× 483 57.5k
David M. Holtzman United States 166 53.8k 1.9× 27.2k 1.1× 15.7k 1.6× 8.5k 1.0× 23.7k 3.1× 580 99.8k
William R. Markesbery United States 114 22.1k 0.8× 17.0k 0.7× 5.8k 0.6× 4.9k 0.6× 6.8k 0.9× 404 49.9k
Carl W. Cotman United States 145 26.0k 0.9× 28.1k 1.2× 33.8k 3.5× 6.4k 0.8× 11.3k 1.5× 671 77.5k
Colin L. Masters Australia 135 52.1k 1.8× 31.1k 1.3× 9.5k 1.0× 10.0k 1.2× 10.4k 1.4× 1.1k 82.7k
Mark P. Mattson United States 193 53.0k 1.9× 51.4k 2.2× 29.0k 3.0× 9.9k 1.2× 18.3k 2.4× 955 128.3k
Frank M. LaFerla United States 97 23.2k 0.8× 13.1k 0.5× 10.1k 1.0× 6.3k 0.8× 8.0k 1.0× 248 36.7k
Ashley I. Bush Australia 118 26.9k 0.9× 17.1k 0.7× 5.8k 0.6× 6.5k 0.8× 4.9k 0.6× 536 57.7k
Stuart A. Lipton United States 125 12.3k 0.4× 26.9k 1.1× 18.7k 1.9× 2.5k 0.3× 8.0k 1.0× 386 52.8k

Countries citing papers authored by Mark A. Smith

Since Specialization
Citations

This map shows the geographic impact of Mark A. Smith's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mark A. Smith with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mark A. Smith more than expected).

Fields of papers citing papers by Mark A. Smith

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mark A. Smith. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mark A. Smith. The network helps show where Mark A. Smith may publish in the future.

Co-authorship network of co-authors of Mark A. Smith

This figure shows the co-authorship network connecting the top 25 collaborators of Mark A. Smith. A scholar is included among the top collaborators of Mark A. Smith based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mark A. Smith. Mark A. Smith is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Downey, Darragh, Arpan Dutta, Shane McKie, et al.. (2016). Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate. European Neuropsychopharmacology. 26(6). 994–1003. 81 indexed citations
2.
Zarate, Carlos A., Daniel C. Mathews, Lobna Ibrahim, et al.. (2012). A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression. Biological Psychiatry. 74(4). 257–264. 203 indexed citations
3.
Santos, Renato X., Sónia C. Correia, Xiongwei Zhu, et al.. (2012). Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease. Antioxidants and Redox Signaling. 18(18). 2444–2457. 148 indexed citations
4.
Kudo, Wataru, et al.. (2011). Early induction of c-Myc is associated with neuronal cell death. Neuroscience Letters. 505(2). 124–127. 23 indexed citations
5.
Chang, Kuei‐Hua, et al.. (2010). Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease. Journal of Neurochemistry. 113(5). 1221–1229. 67 indexed citations
6.
Lakics, Viktor, Hyoung‐gon Lee, Lisa M. Broad, et al.. (2009). Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide. Brain Research. 1260. 65–75. 75 indexed citations
7.
Bryan, Kathryn J., Joseph C. Mudd, Jaewon Chang, et al.. (2009). Down‐regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause‐associated cognitive deficits. Journal of Neurochemistry. 112(4). 870–881. 50 indexed citations
8.
Su, Bo, Xinglong Wang, Hyoung‐gon Lee, et al.. (2009). Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells. Neuroscience Letters. 468(3). 267–271. 147 indexed citations
9.
Liu, Qihui, Won‐Kyu Ju, Jonathan G. Crowston, et al.. (2007). Oxidative Stress Is an Early Event in Hydrostatic Pressure Induced Retinal Ganglion Cell Damage in Glaucoma Models. Investigative Ophthalmology & Visual Science. 48(13). 4942–4942. 1 indexed citations
10.
Moreira, Paula I., Sandra L. Siedlak, Xinglong Wang, et al.. (2007). Autophagocytosis of Mitochondria Is Prominent in Alzheimer Disease. Journal of Neuropathology & Experimental Neurology. 66(6). 525–532. 122 indexed citations
11.
Strobel, Gabrielle, et al.. (2006). Alzheimer Research Forum Live Discussion: Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look1. Journal of Alzheimer s Disease. 10(4). 457–465. 1 indexed citations
12.
Webber, Kate M., Mark A. Smith, Hyoung‐gon Lee, et al.. (2005). Mitogen‐ and stress‐activated protein kinase 1: Convergence of the ERK and p38 pathways in Alzheimer's disease. Journal of Neuroscience Research. 79(4). 554–560. 29 indexed citations
13.
Liu, Quan, Mark A. Smith, Jesús Ávila, et al.. (2004). Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology and Medicine. 38(6). 746–754. 105 indexed citations
14.
Dozza, Barbara, Mark A. Smith, George Perry, Massimo Tabaton, & Paola Strocchi. (2004). Regulation of glycogen synthase kinase‐3β by products of lipid peroxidation in human neuroblastoma cells. Journal of Neurochemistry. 89(5). 1224–1232. 39 indexed citations
15.
Zhu, Xiongwei, Osamu Ogawa, Yang Wang, George Perry, & Mark A. Smith. (2003). JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease. Journal of Neurochemistry. 85(1). 87–93. 54 indexed citations
16.
Lee, Hyoung‐gon, Xiongwei Zhu, Hossein Ghanbari, et al.. (2002). Differential Regulation of Glutamate Receptors in Alzheimer’s Disease. Neurosignals. 11(5). 282–292. 25 indexed citations
17.
Sayre, Lawrence M., et al.. (2000). In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease. Journal of Neurochemistry. 74(1). 270–279. 449 indexed citations
18.
Smith, Mark A., Catherine A. Rottkamp, Akihiko Nunomura, Arun K. Raina, & George Perry. (2000). Oxidative stress in Alzheimers disease. Biochimica et Biophysica Acta. 66 indexed citations
19.
Zhang, Jing, George Perry, Mark A. Smith, et al.. (1999). Parkinson's Disease Is Associated with Oxidative Damage to Cytoplasmic DNA and RNA in Substantia Nigra Neurons. American Journal Of Pathology. 154(5). 1423–1429. 513 indexed citations breakdown →
20.
Nunomura, Akihiko, George Perry, Jing Zhang, et al.. (1999). RNA Oxidation in Alzheimer and Parkinson Diseases. 2(3). 227–230. 11 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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