Darlene Groth

16.7k citations

69 papers · 13.3k indexed · 12 hit papers · h-index 49

Molecular Biology top 0.2%
Neurology top 0.02%
Nutrition and Dietetics top 0.02%
Physiology top 1%
Neurology top 2%

Co-authors: Stanley B. Prusiner Fred E. Cohen Marilyn Torchia Michael P. McKinley Stephen J. DeArmond Michael Scott Ana Serban David C. Bolton
Topics: Prion Diseases and Protein Misfolding (63 papers)Trace Elements in Health (33 papers)Neurological diseases and metabolism (23 papers)
Cited by: Neurology Nutrition and Dietetics Molecular Biology
Journals: Nature Science Cell
Partner nations: United States Germany Sweden

In The Last Decade

Darlene Groth

69 papers receiving 12.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 1.8k citations K M Pan, M. A. Baldwin et al. profile →
Eight prion strains have PrPSc molecules with different conformations

1998 1.0k citations Jiri Safar, Holger Wille et al. Nature Medicine profile →
Scrapie prions aggregate to form amyloid-like birefringent rods

1983 848 citations Stanley B. Prusiner, Michael P. McKinley et al. Cell profile →
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 700 citations Stanley B. Prusiner, Michael Scott et al. Cell profile →
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 632 citations Michael Scott, David Westaway et al. Cell profile →
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 557 citations Michael Scott, Dallas Foster et al. Cell profile →
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein

1990 414 citations Karen Hsiao, Michael Scott et al. profile →
Purification and structural studies of a major scrapie prion protein

1984 387 citations Stanley B. Prusiner, Darlene Groth et al. Cell profile →
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

1997 382 citations Kiyotoshi Kaneko, Darlene Groth et al. profile →
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

1993 373 citations Stanley B. Prusiner, Darlene Groth et al. profile →
Further purification and characterization of scrapie prions

1982 368 citations Stanley B. Prusiner, Darlene Groth et al. profile →
Measurement of the scrapie agent using an incubation time interval assay

1982 292 citations Stanley B. Prusiner, Darlene Groth et al. Annals of Neurology profile →

Peers

Countries citing papers authored by Darlene Groth

Since Specialization

Citations

This map shows the geographic impact of Darlene Groth's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Darlene Groth with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Darlene Groth more than expected).

Fields of papers citing papers by Darlene Groth

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Darlene Groth. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Darlene Groth. The network helps show where Darlene Groth may publish in the future.

Co-authorship network of co-authors of Darlene Groth

This figure shows the co-authorship network connecting the top 25 collaborators of Darlene Groth. A scholar is included among the top collaborators of Darlene Groth based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Darlene Groth. Darlene Groth is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Human prion strain selection in transgenic mice 2010 ·Annals of Neurology ·Kurt Giles,David V. Glidden,Smita S. Patel,Carsten Korth,Darlene Groth,Azucena Lemus,Stephen J. DeArmond,Stanley B. Prusiner	36
2	Transgenic mouse brains for the evaluation and quality control of BSE tests 2007 ·Biological Chemistry ·W. Philipp,Darlene Groth,Kurt Giles,(unknown),(unknown),(unknown),(unknown),(unknown),Awad A. Osman,Ingolf Lachmann,(unknown),Jean-Noël Arsac,Stanley B. Prusiner	3
3	Changes in neuropeptide expression in mice infected with prions 2006 ·Neurobiology of Aging ·Margarita Diez,Darlene Groth,Stephen J. DeArmond,Stanley B. Prusiner,Tomas Hökfelt	9
4	Search for a Prion-Specific Nucleic Acid 2005 ·Journal of Virology ·Jiri Safar,(unknown),Ana Serban,Darlene Groth,James E. Cleaver,Stanley B. Prusiner,Detlev Riesner	100
5	Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice 2002 ·Nature Biotechnology ·Jiri Safar,Michael Scott,(unknown),Camille Deering,Svetlana Didorenko,Julie Vergara,Haydn L. Ball,Giuseppe Legname,Estelle Leclerc,Laura Solforosi,Hana Serban,Darlene Groth,Dennis R. Burton,Stanley B. Prusiner,R. Anthony Williamson	195
6	Decreased MK-801 Binding in Discrete Hippocampal Regions of Prion-Infected Mice 2001 ·Neurobiology of Disease ·Margarita Diez,S. J. DeArmond,Darlene Groth,Stanley B. Prusiner,Tomas Hökfelt	10
7	Strain‐specified relative conformational stability of the scrapie prion protein 2001 ·Protein Science ·David Peretz,Michael R. Scott,Darlene Groth,R. Anthony Williamson,Dennis R. Burton,Fred E. Cohen,Stanley B. Prusiner	204
8	A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice 2000 ·Journal of Molecular Biology ·Kiyotoshi Kaneko,Haydn L. Ball,Holger Wille,Hong Zhang,Darlene Groth,Marilyn Torchia,Patrick Tremblay,Jiri Safar,Stanley B. Prusiner,Stephen J. DeArmond,Michael A. Baldwin,Fred E. Cohen	114
9	Kinetics of Prion Protein Accumulation in the CNS of Mice with Experimental Scrapie 1999 ·Journal of Neuropathology & Experimental Neurology ·Jörg Tatzelt,Darlene Groth,Marilyn Torchia,Stanley B. Prusiner,Stephen J. DeArmond	30
10	Eight prion strains have PrPSc molecules with different conformationsbreakdown → 1998 ·Nature Medicine ·Jiri Safar,Holger Wille,Vincenza Itri,Darlene Groth,Hana Serban,Marilyn Torchia,Fred E. Cohen,Stanley B. Prusiner	1010
11	Propagation of prion strains through specific conformers of the prion protein 1997 ·Journal of Virology ·Michael R. Scott,Darlene Groth,Jörg Tatzelt,Marilyn Torchia,Patrick Tremblay,S. J. DeArmond,Stanley B. Prusiner	74
12	Aberrant induction of neuropeptide Y mRNA in hippocampal CA3 pyramidal neurones in scrapie-infected mice 1996 ·Neuroreport ·Margarita Diez,Jari Koıstınaho,Stephen J. DeArmond,(unknown),Darlene Groth,(unknown),Stanley B. Prusiner,Tomas Hökfelt	7
13	Spectroscopic characterization of conformational differences between PrPC and PrPSc: an α-helix to β-sheet transition 1994 ·Philosophical Transactions of the Royal Society B Biological Sciences ·M. A. Baldwin,K M Pan,Jack Nguyen,Ziwei Huang,Darlene Groth,Ana Serban,Marı́a Gasset,Ingrid Mehlhorn,R.J. Fletterick,Fred E. Cohen,(unknown)	34
14	Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins 1994 ·Cell ·David Westaway,Stephen J. DeArmond,(unknown),Darlene Groth,Dallas Foster,(unknown),Marilyn Torchia,George A. Carlson,Stanley B. Prusiner	276
15	Spontaneous Neurodegeneration in Transgenic Mice with Prion Protein Codon 101 Proline → Leucine Substitutiona 1991 ·Annals of the New York Academy of Sciences ·Karen Hsiao,Michael Scott,Dallas Foster,Stephen J. DeArmond,Darlene Groth,Hana Serban,Stanley B. Prusiner	12
16	Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replicationbreakdown → 1990 ·Cell ·Stanley B. Prusiner,Michael Scott,Dallas Foster,Keh‐Ming Pan,Darlene Groth,C. Mirenda,Marilyn Torchia,(unknown),Dan Serban,George A. Carlson,Peter C. Hoppe,David Westaway,Stephen J. DeArmond	700
17	TRANSGENIC MICE EXPRESSING HAMSTER PRION PROTEIN PRODUCE SPECIES -SPECIFIC SCRAPIE INFECTIVITY AND AMYLOID PLAQUES 1990 ·Journal of Neuropathology & Experimental Neurology ·Michael Scott,Dallas Foster,C. Mirenda,D. Serban,Frank Coufal,(unknown),Marilyn Torchia,Darlene Groth,George A. Carlson,S. J. DeArmond,David Westaway,Stanley B. Prusiner	11
18	Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaquesbreakdown → 1989 ·Cell ·Michael Scott,Dallas Foster,C. Mirenda,Dan Serban,Frank Coufal,(unknown),Marilyn Torchia,Darlene Groth,George A. Carlson,Stephen J. DeArmond,David Westaway,Stanley B. Prusiner	557
19	Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da 1988 ·Virology ·(unknown),Ellis S. Kempner,Darlene Groth,Ruth Gabizon,Stanley B. Prusiner	113
20	Properties of scrapie prion protein liposomes. 1988 ·Journal of Biological Chemistry ·Ruth Gabizon,Michael P. McKinley,Darlene Groth,(unknown),Stanley B. Prusiner	57

About Darlene Groth

Darlene Groth is a scholar working on Neurology, Nutrition and Dietetics and Molecular Biology, having authored 69 papers that have together received 13.3k indexed citations. Recurring topics across this work include Prion Diseases and Protein Misfolding (63 papers), Trace Elements in Health (33 papers) and Neurological diseases and metabolism (23 papers). The work is most often cited by research in Neurology (7.0k citations), Nutrition and Dietetics (5.8k citations) and Molecular Biology (12.9k citations). Darlene Groth has collaborated with scholars based in United States, Germany and Sweden. Frequent co-authors include Stanley B. Prusiner, Fred E. Cohen, Marilyn Torchia, Michael P. McKinley, Stephen J. DeArmond, Michael Scott, Ana Serban, David C. Bolton, Ingrid Mehlhorn and Dallas Foster. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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