Leigh A. Holcomb

4.8k citations

20 papers · 3.7k indexed · 2 hit papers · h-index 16

Physiology top 0.5%
Molecular Biology top 5%
Cellular and Molecular Neuroscience top 2%
Pharmacology top 1%
Neurology top 1%

Co-authors: Marcia N. Gordon Karen Duff Dave Morgan Xin Yu Paul Jantzen John Hardy Chris Eckman Cindy Zehr
Topics: Alzheimer's disease research and treatments (12 papers)Cholinesterase and Neurodegenerative Diseases (6 papers)Neuroscience and Neuropharmacology Research (4 papers)
Cited by: Physiology Biological Psychiatry Neurology
Journals: Nature Nature Medicine Gastroenterology
Partner nations: United States Italy Japan

In The Last Decade

Leigh A. Holcomb

20 papers receiving 3.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 1.2k citations Karen Duff, Chris Eckman et al. Nature profile →
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 1.1k citations Leigh A. Holcomb, Marcia N. Gordon et al. Nature Medicine profile →

Peers

Countries citing papers authored by Leigh A. Holcomb

Since Specialization

Citations

This map shows the geographic impact of Leigh A. Holcomb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leigh A. Holcomb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leigh A. Holcomb more than expected).

Fields of papers citing papers by Leigh A. Holcomb

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leigh A. Holcomb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leigh A. Holcomb. The network helps show where Leigh A. Holcomb may publish in the future.

Co-authorship network of co-authors of Leigh A. Holcomb

This figure shows the co-authorship network connecting the top 25 collaborators of Leigh A. Holcomb. A scholar is included among the top collaborators of Leigh A. Holcomb based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leigh A. Holcomb. Leigh A. Holcomb is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The Ca2+ sensor S100A1 modulates neuroinflammation, histopathology and Akt activity in the PSAPP Alzheimer's disease mouse model 2014 ·Cell Calcium ·(unknown),(unknown),Leigh A. Holcomb,Kerry S. Campbell,(unknown),Yan Zhang,Danna B. Zimmer	27
2	PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation 2010 ·Journal of Neuroinflammation ·(unknown),Leigh A. Holcomb,Keith A. Young,Alexander Marks,Danna B. Zimmer	36
3	Lipid Oxidation and Modification of Amyloid-β (Aβ) in vitro and in vivo 2010 ·Journal of Alzheimer s Disease ·(unknown),(unknown),(unknown),(unknown),Leigh A. Holcomb,Danna B. Zimmer,Daniel Martínez,Ian Murray	19
4	Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume 2008 ·The British Journal of Psychiatry ·Keith A. Young,Willy L. Bonkale,Leigh A. Holcomb,Paul B. Hicks,Dwight C. German	43
5	Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model 2008 ·Phytotherapy Research ·Muralikrishnan Dhanasekaran,Leigh A. Holcomb,(unknown),Binu Tharakan,(unknown),Keith A. Young,Bala V. Manyam	126
6	Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera 2007 ·Phytotherapy Research ·Muralikrishnan Dhanasekaran,Binu Tharakan,Leigh A. Holcomb,(unknown),Keith A. Young,Bala V. Manyam	115
7	5HTTLPR Polymorphism and Enlargement of the Pulvinar: Unlocking the Backdoor to the Limbic System 2006 ·Biological Psychiatry ·Keith A. Young,Leigh A. Holcomb,Willy L. Bonkale,Paul B. Hicks,Umar Yazdani,Dwight C. German	53
8	Bacopa monniera extract reduces amyloid levels in PSAPP mice 2006 ·Journal of Alzheimer s Disease ·Leigh A. Holcomb,Muralikrishnan Dhanasekaran,(unknown),Keith A. Young,Mark W. Riggs,(unknown)	7
9	Clozapine and the mitogen-activated protein kinase signal transduction pathway: Implications for antipsychotic actions 2005 ·Biological Psychiatry ·Jeffrey L. Browning,Tushar Patel,Paul Brandt,Keith A. Young,Leigh A. Holcomb,Paul B. Hicks	64
10	Elevated Neuron Number in the Limbic Thalamus in Major Depression 2004 ·American Journal of Psychiatry ·Keith A. Young,Leigh A. Holcomb,Umar Yazdani,Paul B. Hicks,Dwight C. German	132
11	Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse 2002 ·Experimental Neurology ·Marcia N. Gordon,Leigh A. Holcomb,Paul Jantzen,Giovanni DiCarlo,Donna M. Wilcock,(unknown),Karen E. Connor,(unknown),James P. O’Callaghan,Dave Morgan	206
12	Aβ and perlecan in rat brain: glial activation, gradual clearance and limited neurotoxicity 2000 ·Mechanisms of Ageing and Development ·Leigh A. Holcomb,Marcia N. Gordon,Stanley A. Benkovic,David Morgan	12
13	Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver 1999 ·American Journal of Physiology-Gastrointestinal and Liver Physiology ·Gene LeSage,Shannon Glaser,Luca Marucci,A. Benedetti,Jo Lynne Phinizy,Rebecca Rodgers,Alessandra Caligiuri,(unknown),Ziga Tretjak,(unknown),Leigh A. Holcomb,Gianfranco Alpini	109
14	Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion 1999 ·Gastroenterology ·Gianfranco Alpini,Shannon Glaser,Yoshiyuki Ueno,Rebecca Rodgers,Jo Lynne Phinizy,Heather Francis,Leonardo Baiocchi,Leigh A. Holcomb,Alessandra Caligiuri,Gene LeSage	132
15	Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits 1999 ·Behavior Genetics ·Leigh A. Holcomb,Marcia N. Gordon,Paul Jantzen,Karen Hsiao,Karen Duff,Dave Morgan	288
16	Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1 1998 ·Brain Research ·Dave Morgan,Leigh A. Holcomb,(unknown),Marcia N. Gordon,Mahin D. Maines	13
17	Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesbreakdown → 1998 ·Nature Medicine ·Leigh A. Holcomb,Marcia N. Gordon,Eileen McGowan,Xin Yu,(unknown),Paul Jantzen,Kristal Wright,(unknown),(unknown),Dave Morgan,(unknown),Cindy Zehr,(unknown),John Hardy,(unknown),Chris Eckman,Steve Younkin,Karen Hsiao,Karen Duff	1088
18	Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat 1997 ·The Journal of Comparative Neurology ·Marcia N. Gordon,Wayne A. Schreier,(unknown),Leigh A. Holcomb,David Morgan	91
19	Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat 1997 ·The Journal of Comparative Neurology ·Marcia N. Gordon,Wayne A. Schreier,(unknown),Leigh A. Holcomb,David Morgan	2
20	Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1breakdown → 1996 ·Nature ·Karen Duff,Chris Eckman,Cindy Zehr,Xin Yu,(unknown),Jordi Pérez‐Tur,Mike Hutton,Luc Buée,Yasuo Harigaya,Debra Yager,David Morgan,Marcia N. Gordon,Leigh A. Holcomb,Lawrence M. Refolo,(unknown),John Hardy,Steven G. Younkin	1176

About Leigh A. Holcomb

Leigh A. Holcomb is a scholar working on Physiology, Complementary and alternative medicine and Neurology, having authored 20 papers that have together received 3.7k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (12 papers), Cholinesterase and Neurodegenerative Diseases (6 papers) and Neuroscience and Neuropharmacology Research (4 papers). The work is most often cited by research in Physiology (2.5k citations), Biological Psychiatry (197 citations) and Neurology (623 citations). Leigh A. Holcomb has collaborated with scholars based in United States, Italy and Japan. Frequent co-authors include Marcia N. Gordon, Karen Duff, Dave Morgan, Xin Yu, Paul Jantzen, John Hardy, Chris Eckman, Cindy Zehr, Karen Hsiao and Keith A. Young. Their work appears in journals such as Nature, Nature Medicine and Gastroenterology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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