Leigh A. Holcomb

4.8k total citations · 2 hit papers
20 papers, 3.7k citations indexed

About

Leigh A. Holcomb is a scholar working on Physiology, Molecular Biology and Pharmacology. According to data from OpenAlex, Leigh A. Holcomb has authored 20 papers receiving a total of 3.7k indexed citations (citations by other indexed papers that have themselves been cited), including 13 papers in Physiology, 8 papers in Molecular Biology and 6 papers in Pharmacology. Recurrent topics in Leigh A. Holcomb's work include Alzheimer's disease research and treatments (12 papers), Cholinesterase and Neurodegenerative Diseases (6 papers) and Neuroscience and Neuropharmacology Research (4 papers). Leigh A. Holcomb is often cited by papers focused on Alzheimer's disease research and treatments (12 papers), Cholinesterase and Neurodegenerative Diseases (6 papers) and Neuroscience and Neuropharmacology Research (4 papers). Leigh A. Holcomb collaborates with scholars based in United States, Italy and Japan. Leigh A. Holcomb's co-authors include Marcia N. Gordon, Karen Duff, Dave Morgan, Xin Yu, Paul Jantzen, John Hardy, Chris Eckman, Cindy Zehr, Karen Hsiao and Keith A. Young and has published in prestigious journals such as Nature, Nature Medicine and Gastroenterology.

In The Last Decade

Leigh A. Holcomb

20 papers receiving 3.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 1.2k citations Karen Duff, Chris Eckman et al. Nature profile →
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 1.1k citations Leigh A. Holcomb, Marcia N. Gordon et al. Nature Medicine profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Leigh A. Holcomb United States	16	2.5k	1.3k	1.0k	836	623	20	3.7k
Sarah L. Cole United States	12	3.1k 1.2×	1.6k 1.2×	1.1k 1.1×	814 1.0×	1.1k 1.7×	14	4.5k
Holly D. Oakley United States	8	2.5k 1.0×	1.2k 0.9×	933 0.9×	673 0.8×	924 1.5×	10	3.6k
Howard T.J. Mount Canada	30	2.6k 1.0×	1.9k 1.4×	1.7k 1.7×	809 1.0×	963 1.5×	61	5.0k
Jordi Pérez‐Tur Spain	37	3.5k 1.4×	2.2k 1.7×	1.3k 1.3×	787 0.9×	994 1.6×	91	5.6k
Takeshi Kawarabayashi Japan	31	4.1k 1.6×	2.2k 1.7×	1.3k 1.3×	889 1.1×	1.0k 1.6×	129	5.7k
Nina E. Shepardson United States	7	4.3k 1.7×	1.9k 1.5×	1.9k 1.8×	1.1k 1.3×	980 1.6×	8	5.4k
Laurent Pradier France	39	2.9k 1.1×	2.6k 2.0×	1.8k 1.8×	815 1.0×	777 1.2×	98	5.2k
Angela Guillozet-Bongaarts United States	16	3.0k 1.2×	1.6k 1.2×	1.3k 1.3×	887 1.1×	1.1k 1.8×	17	4.4k
Marie‐Christine Chartier‐Harlin France	35	2.8k 1.1×	2.3k 1.8×	1.8k 1.8×	478 0.6×	938 1.5×	88	6.0k
Birgit Hutter‐Paier Austria	30	1.9k 0.7×	1.1k 0.9×	669 0.7×	628 0.8×	975 1.6×	106	3.4k

Countries citing papers authored by Leigh A. Holcomb

Since Specialization

Citations

This map shows the geographic impact of Leigh A. Holcomb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leigh A. Holcomb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leigh A. Holcomb more than expected).

Fields of papers citing papers by Leigh A. Holcomb

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leigh A. Holcomb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leigh A. Holcomb. The network helps show where Leigh A. Holcomb may publish in the future.

Co-authorship network of co-authors of Leigh A. Holcomb

This figure shows the co-authorship network connecting the top 25 collaborators of Leigh A. Holcomb. A scholar is included among the top collaborators of Leigh A. Holcomb based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leigh A. Holcomb. Leigh A. Holcomb is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Holcomb, Leigh A., et al.. (2014). The Ca2+ sensor S100A1 modulates neuroinflammation, histopathology and Akt activity in the PSAPP Alzheimer's disease mouse model. Cell Calcium. 56(2). 68–80. 27 indexed citations

Holcomb, Leigh A., et al.. (2010). PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation. Journal of Neuroinflammation. 7(1). 78–78. 36 indexed citations

Holcomb, Leigh A., et al.. (2010). Lipid Oxidation and Modification of Amyloid-β (Aβ) in vitro and in vivo. Journal of Alzheimer s Disease. 22(2). 593–607. 19 indexed citations

Young, Keith A., Willy L. Bonkale, Leigh A. Holcomb, Paul B. Hicks, & Dwight C. German. (2008). Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume. The British Journal of Psychiatry. 192(4). 285–289. 43 indexed citations

Dhanasekaran, Muralikrishnan, et al.. (2008). Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer's disease animal model. Phytotherapy Research. 23(1). 14–19. 126 indexed citations

Dhanasekaran, Muralikrishnan, et al.. (2007). Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytotherapy Research. 21(10). 965–969. 115 indexed citations

Young, Keith A., Leigh A. Holcomb, Willy L. Bonkale, et al.. (2006). 5HTTLPR Polymorphism and Enlargement of the Pulvinar: Unlocking the Backdoor to the Limbic System. Biological Psychiatry. 61(6). 813–818. 53 indexed citations

Holcomb, Leigh A., et al.. (2006). Bacopa monniera extract reduces amyloid levels in PSAPP mice. Journal of Alzheimer s Disease. 9(3). 243–251. 7 indexed citations

Browning, Jeffrey L., Tushar Patel, Paul Brandt, et al.. (2005). Clozapine and the mitogen-activated protein kinase signal transduction pathway: Implications for antipsychotic actions. Biological Psychiatry. 57(6). 617–623. 64 indexed citations

10.

Young, Keith A., Leigh A. Holcomb, Umar Yazdani, Paul B. Hicks, & Dwight C. German. (2004). Elevated Neuron Number in the Limbic Thalamus in Major Depression. American Journal of Psychiatry. 161(7). 1270–1277. 132 indexed citations

11.

Gordon, Marcia N., Leigh A. Holcomb, Paul Jantzen, et al.. (2002). Time Course of the Development of Alzheimer-like Pathology in the Doubly Transgenic PS1+APP Mouse. Experimental Neurology. 173(2). 183–195. 206 indexed citations

12.

Holcomb, Leigh A., Marcia N. Gordon, Stanley A. Benkovic, & David Morgan. (2000). Aβ and perlecan in rat brain: glial activation, gradual clearance and limited neurotoxicity. Mechanisms of Ageing and Development. 112(2). 135–152. 12 indexed citations

13.

LeSage, Gene, Shannon Glaser, Luca Marucci, et al.. (1999). Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver. American Journal of Physiology-Gastrointestinal and Liver Physiology. 276(5). G1289–G1301. 109 indexed citations

14.

Alpini, Gianfranco, Shannon Glaser, Yoshiyuki Ueno, et al.. (1999). Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion. Gastroenterology. 116(1). 179–186. 132 indexed citations

15.

Holcomb, Leigh A., Marcia N. Gordon, Paul Jantzen, et al.. (1999). Behavioral Changes in Transgenic Mice Expressing Both Amyloid Precursor Protein and Presenilin-1 Mutations: Lack of Association with Amyloid Deposits. Behavior Genetics. 29(3). 177–185. 288 indexed citations

16.

Morgan, Dave, et al.. (1998). Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1. Brain Research. 808(1). 110–112. 13 indexed citations

17.

Holcomb, Leigh A., Marcia N. Gordon, Eileen McGowan, et al.. (1998). Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Medicine. 4(1). 97–100. 1088 indexed citations breakdown →

18.

Gordon, Marcia N., et al.. (1997). Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat. The Journal of Comparative Neurology. 388(1). 106–119. 91 indexed citations

19.

Gordon, Marcia N., et al.. (1997). Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat. The Journal of Comparative Neurology. 388(1). 106–119. 2 indexed citations

20.

Duff, Karen, Chris Eckman, Cindy Zehr, et al.. (1996). Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature. 383(6602). 710–713. 1176 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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