Christopher B. Eckman

18.3k total citations · 6 hit papers
78 papers, 12.6k citations indexed

About

Christopher B. Eckman is a scholar working on Physiology, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Christopher B. Eckman has authored 78 papers receiving a total of 12.6k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Physiology, 37 papers in Molecular Biology and 20 papers in Cellular and Molecular Neuroscience. Recurrent topics in Christopher B. Eckman's work include Alzheimer's disease research and treatments (55 papers), Cholinesterase and Neurodegenerative Diseases (18 papers) and Prion Diseases and Protein Misfolding (12 papers). Christopher B. Eckman is often cited by papers focused on Alzheimer's disease research and treatments (55 papers), Cholinesterase and Neurodegenerative Diseases (18 papers) and Prion Diseases and Protein Misfolding (12 papers). Christopher B. Eckman collaborates with scholars based in United States, Japan and Switzerland. Christopher B. Eckman's co-authors include Elizabeth A. Eckman, Steven G. Younkin, Todd E. Golde, Nobuhiro Suzuki, László Ötvös, Rudolph E. Tanzi, Asano Odaka, Tobun T. Cheung, Dennis J. Selkoe and Wesley Farris and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Christopher B. Eckman

78 papers receiving 12.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 1.2k citations Christopher B. Eckman, Debra Yager et al. Neuron profile →
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 1.2k citations Nobuhiro Suzuki, Tobun T. Cheung et al. Science profile →
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

2003 1.2k citations Wesley Farris, Yang Chang et al. Proceedings of the National Academy of Sciences profile →
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

2001 943 citations Camilla Nilsberth, Anita Westlind‐Danielsson et al. Nature Neuroscience profile →
Amyloid β Protein (Aβ) in Alzheimeri's Disease Brain

1995 553 citations Christopher B. Eckman, László Ötvös et al. Journal of Biological Chemistry profile →
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

2007 507 citations Christopher B. Eckman, Dennis W. Dickson et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Christopher B. Eckman United States	50	9.3k	5.9k	2.4k	2.3k	1.6k	78	12.6k
Marc Mercken Belgium	44	7.9k 0.9×	4.3k 0.7×	1.9k 0.8×	2.3k 1.0×	1.3k 0.8×	102	10.8k
Martin Citron United States	48	10.5k 1.1×	5.7k 1.0×	3.7k 1.5×	2.8k 1.2×	2.4k 1.6×	86	13.8k
Linda H. Younkin United States	44	9.2k 1.0×	4.6k 0.8×	2.1k 0.9×	2.8k 1.2×	1.3k 0.9×	72	12.1k
Nobuhisa Iwata Japan	50	6.8k 0.7×	4.4k 0.7×	1.8k 0.7×	2.9k 1.2×	861 0.6×	142	11.6k
Greg M. Cole United States	58	10.7k 1.2×	5.7k 1.0×	2.8k 1.2×	3.4k 1.5×	1.3k 0.8×	100	16.9k
Akihiko Takashima Japan	61	7.5k 0.8×	5.8k 1.0×	2.1k 0.9×	3.1k 1.3×	867 0.6×	195	12.4k
Mary P. Lambert United States	29	8.6k 0.9×	4.2k 0.7×	2.3k 1.0×	2.8k 1.2×	1.4k 0.9×	50	10.6k
Eric Karran United Kingdom	32	5.7k 0.6×	4.5k 0.8×	2.0k 0.8×	1.4k 0.6×	1.1k 0.7×	74	11.1k
Peter Seubert United States	50	9.7k 1.0×	5.4k 0.9×	2.3k 0.9×	3.1k 1.3×	1.7k 1.1×	81	13.3k
Cheng‐Xin Gong United States	70	9.5k 1.0×	7.5k 1.3×	2.4k 1.0×	3.3k 1.4×	777 0.5×	170	16.0k

Countries citing papers authored by Christopher B. Eckman

Since Specialization

Citations

This map shows the geographic impact of Christopher B. Eckman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher B. Eckman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher B. Eckman more than expected).

Fields of papers citing papers by Christopher B. Eckman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher B. Eckman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher B. Eckman. The network helps show where Christopher B. Eckman may publish in the future.

Co-authorship network of co-authors of Christopher B. Eckman

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher B. Eckman. A scholar is included among the top collaborators of Christopher B. Eckman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher B. Eckman. Christopher B. Eckman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Pacheco‐Quinto, Javier, Christopher B. Eckman, & Elizabeth A. Eckman. (2016). Major amyloid-β–degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex. Neurobiology of Aging. 48. 83–92. 32 indexed citations

Pugazhenthi, Subbiah, et al.. (2011). Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons. Molecular Neurodegeneration. 6(1). 60–60. 205 indexed citations

Hutter‐Paier, Birgit, Henri J. Huttunen, Luigi Puglielli, et al.. (2010). The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Neuron. 68(5). 1014–1014. 7 indexed citations

Hanna, Amanda, Patrick Horne, Debra Yager, et al.. (2009). Amyloid β and impairment in multiple memory systems in older transgenic APP TgCRND8 mice. Genes Brain & Behavior. 8(7). 676–684. 19 indexed citations

Kampen, Jackalina M. Van & Christopher B. Eckman. (2009). Agonist-induced restoration of hippocampal neurogenesis and cognitive improvement in a model of cholinergic denervation. Neuropharmacology. 58(6). 921–929. 39 indexed citations

Shimojima, Naoki, Christopher B. Eckman, Michael McKinney, et al.. (2008). Altered Expression of Zonula Occludens-2 Precedes Increased Blood–Brain Barrier Permeability in a Murine Model of Fulminant Hepatic Failure. Journal of Investigative Surgery. 21(3). 101–108. 31 indexed citations

Kampen, Jackalina M. Van & Christopher B. Eckman. (2006). Dopamine D₃Receptor Agonist Delivery to a Model of Parkinson's Disease Restores the Nigrostriatal Pathway and Improves Locomotor Behavior. Journal of Neuroscience. 26(27). 7272–7280. 109 indexed citations

Eckman, Elizabeth A., Frederick J. Troendle, Abdul H. Fauq, et al.. (2006). Regulation of Steady-state β-Amyloid Levels in the Brain by Neprilysin and Endothelin-converting Enzyme but Not Angiotensin-converting Enzyme. Journal of Biological Chemistry. 281(41). 30471–30478. 165 indexed citations

Yamamoto, Satoshi, Jeffery L. Steers, Robert E. Wharen, Christopher B. Eckman, & Justin H. Nguyen. (2006). Cerebrospinal fluid drainage and cranial decompression prolong survival in rats with fulminant hepatic failure. Transplant International. 19(8). 675–682. 5 indexed citations

10.

Farris, Wesley, Malcolm A. Leissring, Elizabeth A. Eckman, et al.. (2004). Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein. American Journal Of Pathology. 164(4). 1425–1434. 202 indexed citations

11.

Hutter‐Paier, Birgit, Henri J. Huttunen, Luigi Puglielli, et al.. (2004). The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Neuron. 44(2). 227–238. 221 indexed citations

12.

Farris, Wesley, Yang Chang, Loren Lindsley, et al.. (2003). Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences. 100(7). 4162–4167. 1191 indexed citations breakdown →

13.

Golde, Todd E. & Christopher B. Eckman. (2001). Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease. Drug Discovery Today. 6(20). 1049–1055. 56 indexed citations

14.

Pinnix, Inga, Han W. Tun, Arati Sridharan, et al.. (2001). A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor. Journal of Biological Chemistry. 276(1). 481–487. 126 indexed citations

15.

Nilsberth, Camilla, Anita Westlind‐Danielsson, Christopher B. Eckman, et al.. (2001). The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation. Nature Neuroscience. 4(9). 887–893. 943 indexed citations breakdown →

16.

Haugabook, Sharie J., Debra Yager, Elizabeth A. Eckman, et al.. (2001). High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid β peptide (Aβ). Journal of Neuroscience Methods. 108(2). 171–179. 35 indexed citations

17.

Harigaya, Yasuo, et al.. (2000). Amyloid β Protein Starting Pyroglutamate at Position 3 Is a Major Component of the Amyloid Deposits in the Alzheimer's Disease Brain. Biochemical and Biophysical Research Communications. 276(2). 422–427. 170 indexed citations

18.

Scheuner, Donalyn, Christopher B. Eckman, Martin Citron, et al.. (1996). 149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43). Neurobiology of Aging. 17(4). S38–S38. 2 indexed citations

19.

Chrestensen, Carol A., Christopher B. Eckman, David W. Starke, & John J. Mieyal. (1995). Cloning, expression and characterization of human thioltransferase (glutaredoxin) in E. coli. FEBS Letters. 374(1). 25–28. 40 indexed citations

20.

Suzuki, Nobuhiro, Tobun T. Cheung, Asano Odaka, et al.. (1994). An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants. Science. 264(5163). 1336–1340. 1196 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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