Bradley T. Hyman

178.9k total citations · 42 hit papers
730 papers, 114.1k citations indexed

About

Bradley T. Hyman is a scholar working on Physiology, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Bradley T. Hyman has authored 730 papers receiving a total of 114.1k indexed citations (citations by other indexed papers that have themselves been cited), including 492 papers in Physiology, 265 papers in Molecular Biology and 209 papers in Cellular and Molecular Neuroscience. Recurrent topics in Bradley T. Hyman's work include Alzheimer's disease research and treatments (479 papers), Neuroscience and Neuropharmacology Research (122 papers) and Dementia and Cognitive Impairment Research (120 papers). Bradley T. Hyman is often cited by papers focused on Alzheimer's disease research and treatments (479 papers), Neuroscience and Neuropharmacology Research (122 papers) and Dementia and Cognitive Impairment Research (120 papers). Bradley T. Hyman collaborates with scholars based in United States, Germany and United Kingdom. Bradley T. Hyman's co-authors include Tara L. Spires‐Jones, Brian J. Bacskai, John H. Growdon, Gary W. Van Hoesen, Teresa Gómez‐Isla, Creighton H. Phelps, William E. Klunk, Matthew P. Frosch, John C. Morris and Marilyn Albert and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Bradley T. Hyman

721 papers receiving 112.2k citations

Hit Papers

The diagnosis of dementia... 1984 2026 1998 2012 2011 2006 2012 1992 2011 4.0k 8.0k 12.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    2011 13.8k citations Bradley T. Hyman et al. Alzheimer s & Dementia profile →
  2. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    2006 9.3k citations Deborah Blacker, Bradley T. Hyman et al. profile →
  3. National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
    2012 2.1k citations Bradley T. Hyman, Matthew P. Frosch et al. Alzheimer s & Dementia profile →
  4. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    1992 2.1k citations John H. Growdon, Bradley T. Hyman et al. profile →
  5. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
    2011 1.9k citations Matthew P. Frosch, Bradley T. Hyman et al. profile →
  6. Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation
    1984 1.8k citations Bradley T. Hyman et al. Science profile →
  7. Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
    2005 1.5k citations Tara L. Spires‐Jones, Martin Ingelsson et al. Science profile →
  8. Alzheimer disease
    2021 1.4k citations Bradley T. Hyman et al. profile →
  9. Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
    1996 1.4k citations John H. Growdon, Bradley T. Hyman et al. profile →
  10. Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation
    2003 1.3k citations Bradley T. Hyman et al. Proceedings of the National Academy of Sciences profile →
  11. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    1997 1.1k citations John H. Growdon, Bradley T. Hyman et al. profile →
  12. The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease
    1991 1.1k citations Steven E. Arnold, Bradley T. Hyman et al. profile →
  13. Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
    2012 1.1k citations Alix de Calignon, Manuela Polydoro et al. Neuron profile →
  14. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
    1993 914 citations Bradley T. Hyman et al. Neuron profile →
  15. Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
    2007 853 citations Tiago F. Outeiro, Stephen M. Altmann et al. Science profile →
  16. The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease
    2014 845 citations Tara L. Spires‐Jones, Bradley T. Hyman Neuron profile →
  17. Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
    2008 814 citations Tara L. Spires‐Jones, Mónica García‐Alloza et al. profile →
  18. The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
    2010 810 citations Martin Ingelsson, Bradley T. Hyman et al. profile →
  19. Synergy between amyloid-β and tau in Alzheimer’s disease
    2020 785 citations Bradley T. Hyman et al. profile →
  20. Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
    2001 782 citations Bradley T. Hyman et al. profile →
  21. Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia
    2009 777 citations Reisa A. Sperling, Dorene M. Rentz et al. Neuron profile →
  22. Tau protein liquid–liquid phase separation can initiate tau aggregation
    2018 769 citations Susanne Wegmann, Bahareh Eftekharzadeh et al. The EMBO Journal profile →
  23. Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
    2013 765 citations Alberto Serrano‐Pozo, Bradley T. Hyman et al. Neuron profile →
  24. Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
    2009 672 citations Robert M. Koffie, Mónica García‐Alloza et al. Proceedings of the National Academy of Sciences profile →
  25. Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome
    2000 669 citations Bradley T. Hyman et al. profile →
  26. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches
    2020 609 citations Alberto Serrano‐Pozo, Sudeshna Das et al. profile →
  27. Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice
    2009 567 citations Kishore V. Kuchibhotla, Bradley T. Hyman et al. Science profile →
  28. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup
    2011 554 citations Reisa A. Sperling, Matthew P. Frosch et al. Alzheimer s & Dementia profile →
  29. Perforant pathway changes and the memory impairment of Alzheimer's disease
    1986 549 citations Bradley T. Hyman et al. profile →
  30. The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
    2019 539 citations Sudeshna Das, Bradley T. Hyman et al. profile →
  31. Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
    2004 531 citations Martin Ingelsson, John H. Growdon et al. profile →
  32. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease
    2000 527 citations Rudolph E. Tanzi, Bradley T. Hyman et al. profile →
  33. APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1
    1997 526 citations Michael C. Irizarry, Bradley T. Hyman et al. profile →
  34. Curcumin labels amyloid pathology in vivo , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model
    2007 519 citations Mónica García‐Alloza, Laura A. Borrelli et al. Journal of Neurochemistry profile →
  35. Alpha-2 macroglobulin is genetically associated with Alzheimer disease
    1998 518 citations Deborah Blacker, Bradley T. Hyman et al. profile →
  36. Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks
    2008 514 citations Kishore V. Kuchibhotla, Bradley T. Hyman et al. Neuron profile →
  37. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
    2005 510 citations Christine A. F. Von Arnim, Bradley T. Hyman et al. Proceedings of the National Academy of Sciences profile →
  38. Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue
    2015 450 citations Charles Vanderburg, John H. Growdon et al. profile →
  39. LRP1 is a master regulator of tau uptake and spread
    2020 370 citations Susanne Wegmann, Bradley T. Hyman et al. profile →
  40. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
    2018 289 citations Susanne Wegmann, Simon Dujardin et al. profile →
  41. Machine learning identifies candidates for drug repurposing in Alzheimer’s disease
    2021 181 citations Bradley T. Hyman et al. profile →
  42. Multifaceted roles of APOE in Alzheimer disease
    2024 54 citations Bradley T. Hyman, Alberto Serrano‐Pozo et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Bradley T. Hyman United States 156 60.6k 32.6k 24.2k 23.1k 21.1k 730 114.1k
David M. Holtzman United States 166 53.8k 0.9× 27.2k 0.8× 20.7k 0.9× 15.7k 0.7× 23.7k 1.1× 580 99.8k
Kaj Blennow Sweden 158 65.7k 1.1× 33.4k 1.0× 41.3k 1.7× 13.3k 0.6× 22.0k 1.0× 2.0k 122.7k
Dennis W. Dickson United States 153 48.5k 0.8× 25.2k 0.8× 22.4k 0.9× 16.5k 0.7× 23.9k 1.1× 1.3k 103.6k
John Q. Trojanowski United States 193 69.9k 1.2× 46.3k 1.4× 26.6k 1.1× 31.9k 1.4× 29.4k 1.4× 1.1k 151.7k
Henrik Zetterberg Sweden 135 46.4k 0.8× 26.3k 0.8× 28.5k 1.2× 10.8k 0.5× 17.0k 0.8× 2.0k 96.1k
Colin L. Masters Australia 135 52.1k 0.9× 31.1k 1.0× 14.9k 0.6× 9.5k 0.4× 10.4k 0.5× 1.1k 82.7k
Heiko Braak Germany 107 32.3k 0.5× 14.3k 0.4× 14.4k 0.6× 16.5k 0.7× 13.8k 0.7× 362 68.5k
John Hardy United Kingdom 132 49.9k 0.8× 34.8k 1.1× 8.3k 0.3× 20.6k 0.9× 18.0k 0.9× 884 93.4k
Dennis J. Selkoe United States 153 84.4k 1.4× 49.4k 1.5× 7.8k 0.3× 24.2k 1.0× 17.8k 0.8× 484 115.8k
Eliezer Masliah United States 156 47.0k 0.8× 34.2k 1.0× 7.3k 0.3× 29.4k 1.3× 23.3k 1.1× 841 104.9k

Countries citing papers authored by Bradley T. Hyman

Since Specialization
Citations

This map shows the geographic impact of Bradley T. Hyman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bradley T. Hyman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bradley T. Hyman more than expected).

Fields of papers citing papers by Bradley T. Hyman

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bradley T. Hyman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bradley T. Hyman. The network helps show where Bradley T. Hyman may publish in the future.

Co-authorship network of co-authors of Bradley T. Hyman

This figure shows the co-authorship network connecting the top 25 collaborators of Bradley T. Hyman. A scholar is included among the top collaborators of Bradley T. Hyman based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bradley T. Hyman. Bradley T. Hyman is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Magdamo, Colin, Bradley T. Hyman, John R. Dickson, et al.. (2025). Unsupervised Deep Learning of Electronic Health Records to Characterize Heterogeneity Across Alzheimer Disease and Related Dementias: Cross-Sectional Study. JMIR Aging. 8. e65178–e65178. 1 indexed citations
2.
Arnold, Steven E., Bradley T. Hyman, Rebecca A. Betensky, & Hiroko H. Dodge. (2024). Pathways to personalized medicine—Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease. Alzheimer s & Dementia. 20(10). 7384–7394. 10 indexed citations
3.
Chojnowska, Katarzyna, Michał Bieńkowski, Anna Kostecka, et al.. (2023). Size matters: the impact of nucleus size on results from spatial transcriptomics. Journal of Translational Medicine. 21(1). 270–270. 6 indexed citations
4.
Kamath, Tarun, Naomi Klickstein, Caitlin Commins, et al.. (2021). Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer’s cases. Brain Communications. 3(2). fcab096–fcab096. 6 indexed citations
5.
Pérez-Rando, Marta, et al.. (2020). Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathologica Communications. 8(1). 168–168. 2 indexed citations
6.
Wegmann, Susanne, Bahareh Eftekharzadeh, Katharina Tepper, et al.. (2018). Tau protein liquid–liquid phase separation can initiate tau aggregation. The EMBO Journal. 37(7). 769 indexed citations breakdown →
7.
DeVos, Sarah L., Bianca T. Corjuc, Derek H. Oakley, et al.. (2018). Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain. Frontiers in Neuroscience. 12. 267–267. 200 indexed citations
8.
Culley, Deborah J., Devon Flaherty, Margaret C. Fahey, et al.. (2016). Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-Sectional Study. Anesthesia & Analgesia. 123(1). 186–192. 72 indexed citations
9.
Wegmann, Susanne, Eduardo A. Maury, Molly J. Kirk, et al.. (2015). Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. The EMBO Journal. 34(24). 3028–3041. 93 indexed citations
10.
Rentz, Dorene M., Maria Dekhtyar, Samantha C. Burnham, et al.. (2015). THE FEASIBILITY OF AT-HOME IPAD COGNITIVE TESTING FOR USE IN CLINICAL TRIALS. The Journal of Prevention of Alzheimer s Disease. 3(1). 1–5. 46 indexed citations
11.
Kuchibhotla, Kishore V., Susanne Wegmann, Katherine J. Kopeikina, et al.. (2013). Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences. 111(1). 510–514. 150 indexed citations
12.
Calignon, Alix de, Manuela Polydoro, Marc Suárez‐Calvet, et al.. (2012). Propagation of Tau Pathology in a Model of Early Alzheimer's Disease. Neuron. 73(4). 685–697. 1062 indexed citations breakdown →
13.
Koffie, Robert M., et al.. (2011). Nanoparticles enhance brain delivery of blood–brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proceedings of the National Academy of Sciences. 108(46). 18837–18842. 203 indexed citations
14.
Serrano‐Pozo, Alberto, Gloria Lena Vega, Dieter Lütjohann, et al.. (2010). Effects of Simvastatin on Cholesterol Metabolism and Alzheimer Disease Biomarkers. Alzheimer Disease & Associated Disorders. 24(3). 220–226. 60 indexed citations
15.
O’Callaghan, P.W., Jin‐Ping Li, Rivka Ravid, et al.. (2008). Heparan Sulfate Accumulation with Aβ Deposits in Alzheimer's Disease and Tg2576 Mice is Contributed by Glial Cells. Brain Pathology. 18(4). 548–561. 72 indexed citations
16.
Mandal, Asim K., P. Jones, Angela M. Bair, et al.. (2008). The nuclear membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences. 105(51). 20434–20439. 82 indexed citations
17.
Outeiro, Tiago F., Stephen M. Altmann, Irina Kufareva, et al.. (2007). Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease. Science. 317(5837). 516–519. 853 indexed citations breakdown →
18.
García‐Alloza, Mónica, Laura A. Borrelli, Anete Rozkalne, Bradley T. Hyman, & Brian J. Bacskai. (2007). Curcumin labels amyloid pathology in vivo , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102(4). 1095–1104. 519 indexed citations breakdown →
19.
Outeiro, Tiago F., Stephen M. Altmann, Michele M. Maxwell, et al.. (2006). Pharmacological promotion of inclusion formation: A therapeutic approach for Huntington’s and Parkinson’s diseases. Proceedings of the National Academy of Sciences. 103(11). 4246–4251. 203 indexed citations
20.
Koh, Young Ho, Christine A. F. Von Arnim, Bradley T. Hyman, Rudolph E. Tanzi, & Giuseppina Tesco. (2005). BACE Is Degraded via the Lysosomal Pathway. Journal of Biological Chemistry. 280(37). 32499–32504. 144 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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