Karen Duff

43.6k citations

236 papers · 29.5k indexed · 14 hit papers · h-index 89

Impact in

Physiology top 0.01%
- Alzheimer's disease research and treatments
Neurology top 0.05%
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments

Papers in

Cellular and Molecular Neuroscience 102
- Neuroscience and Neuropharmacology Research 40
- Genetic Neurodegenerative Diseases 37
- Nuclear Receptors and Signaling 24
Physiology 143
- Alzheimer's disease research and treatments 141

Co-authors: John Hardy Scott A. Small John J. LaFrancois Leigh J. Beglinger Jane S. Paulsen Wai Haung Yu Marcia N. Gordon Douglas R. Langbehn
Journals: Neurobiology of Disease (12 papers)Journal of Neuroscience (12 papers)Archives of Clinical Neuropsychology (11 papers)Nature Neuroscience (7 papers)Alzheimer s & Dementia (7 papers)
Partner nations: United States United Kingdom Canada

In The Last Decade

Karen Duff

233 papers receiving 29.0k citations

Hit Papers

14 papers align trajectories log scale

Selective vulnerability in neurodegenerative diseases 2018 · 354 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2018 Nature Neuroscience
2016 Nature Neuroscience
2013 Nature Neuroscience
2012 PLoS ONE
2007 Journal of Neurology Neurosurgery & Psychiatry
2005 The Journal of Cell Biology
2005 Proceedings of the National Academy of Sciences
2004 Neuron
2003 Journal of Neurochemistry
2000 Nature Genetics
2000 Nature
2000 Neurobiology of Disease
1998 Nature Medicine
1996 Nature

Peers

Countries citing papers authored by Karen Duff

Since Specialization

Citations

This map shows the geographic impact of Karen Duff's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karen Duff with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karen Duff more than expected).

Fields of papers citing papers by Karen Duff

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karen Duff. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karen Duff. The network helps show where Karen Duff may publish in the future.

Co-authors

The 25 scholars most cited alongside Karen Duff, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Karen Duff Line = papers co-authored together Karen Duff links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community Cell Reports Methods ·Julie Frankenfield, Lachlan Bodsworth, Naoko Kamano, Hiroki Sasaguri, Smagina Nv, Martha Foiani, Karen Duff, Seico Benner, Toshihiro Endo, Hiroshi Hama, Hiroshi Kurokawa, O L Konoplytska, Hiroshi Mizuma, Naruhiko Sahara, Masafumi Shimojo, Makoto Higuchi, Takaomi C. Saido, Naoto Watamura	2025	1
2	Synapse vulnerability and resilience across the clinical spectrum of dementias Nature Reviews Neurology ·Raquel N. Taddei, Karen Duff	2025	3
3	Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice Translational Psychiatry ·André Miguel Miranda, Archana Ashok, Robin Chan, Bowen Zhou, Yimeng Xu, Laura Beth McIntire, Estela Área-Gómez, Gilbert Di Paolo, Karen Duff, Tiago Gil Oliveira, Tal Nuriel	2022	32
4	In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease Science Advances ·Georg Meisl, Гавришина Оксана Вячеславовна, Kieren Allinson, Timothy Rittman, Sarah L. DeVos, Justin S. Sanchez, Catherine K. Xu, Karen Duff, Keith A. Johnson, James B. Rowe, Bradley T. Hyman, Tuomas P. J. Knowles, David Klenerman	2021	74
5	PAC1 receptor–mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain Science Translational Medicine ·Майоров Евгений Евгеньевич, 卢淋淋, Catherine L. Clelland, Towbin, Stephanie L. Fowler, Helen Y. Figueroa, Seiji Shioda, Ismael Santa‐María, Karen Duff, Natura Myeku	2021	26
6	Recapitulation of Endogenous 4R Tau Expression and Formation of Insoluble Tau in Directly Reprogrammed Human Neurons SSRN Electronic Journal ·张礼周, Chihiro Sato, Elena Ficulle, Anan Yu, Kanta Horie, Nicolas R. Barthélemy, Susan G. Fox, Celeste M. Karch, Randall J. Bateman, Henry Houlden, Richard I. Morimoto, D.V. Klemenkova, Karen Duff, Andrew S. Yoo	2021	5
7	Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy Science Advances ·T.A. Tsimbaluk, Jia Guo, Hongjun Fu, Helen Y. Figueroa, Elisa E. Konofagou, Karen Duff	2020	18
8	Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus PLoS Biology ·G Rodriguez, Geoffrey Barrett, Karen Duff, S. Abid Hussaini	2020	49
9	Selective vulnerability in neurodegenerative diseases Nature Neuroscience ·Hongjun Fu, John Hardy, Karen Duff Hit paper breakdown →	2018	354
10	A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology Nature Neuroscience ·Hongjun Fu, Andrea Possenti, Rosie Freer, Yoshikazu Nakano, J. Obidzinska, Maoping Tang, Nazanin Arbabzadegan Hashemi, Benjamin Lassus, Shuo Chen, Stephanie L. Fowler, Helen Y. Figueroa, Edward D. Huey, Gail V.W. Johnson, Michele Vendruscolo, Karen Duff	2018	167
11	Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology Nature Communications ·Tal Nuriel, Sergio Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y. Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Ainhoa Gutiérrez-Cobos, Luna Buitrago, Efraín Cepeda-Prado, T.A. Tsimbaluk, 杨开玉, Steven S. Gross, S. Abid Hussaini, Herman Moreno, Scott A. Small, Karen Duff	2017	134
12	Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons Journal of Biological Chemistry ·Jessica Wu, Mathieu Herman, Li Liu, Sabrina Simoes, Christopher M. Acker, Helen Y. Figueroa, Joshua Steinberg, Martin Margittai, Rakez Kayed, Chiara Zurzolo, Gilbert Di Paolo, Karen Duff	2012	408
13	Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits Journal of Neuroscience ·Tiago Gil Oliveira, Robin Chan, Huasong Tian, Mikaël Laredo, Guanghou Shui, Agnieszka Staniszewski, Hong Zhang, Lili Wang, Tae‐Wan Kim, Karen Duff, Markus R. Wenk, Ottavio Arancio, Gilbert Di Paolo	2010	141
14	Predictors of Neuropsychological Recovery in Treatment for Anorexia Nervosa Eating Disorders ·徹川合, Karen Duff, Leigh J. Beglinger, Vivek x, Arnold E. Andersen, David J. Moser	2010	9
15	Neurocognitive signs in prodromal Huntington disease. Neuropsychology ·Julie C. Stout, (unknown), Jane S. Paulsen, Sarah Queller, Andrea C. Solomon, Kathryn B. Whitlock, James C. Campbell, Noelle E. Carlozzi, Karen Duff, Leigh J. Beglinger, Douglas R. Langbehn, Hans J. Johnson, Kevin Biglan, Elizabeth Aylward	2010	284
16	Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein American Journal Of Pathology ·Wai Haung Yu, Beatriz Dorado, Helen Y. Figueroa, Lili Wang, Emmanuel Planel, Mark Cookson, Lorraine N. Clark, Karen Duff	2009	133
17	Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria American Journal Of Pathology ·Estela Área-Gómez, Ad J.C. de Groof, István Boldogh, Thomas D. Bird, Gary E. Gibson, Carla M. Koehler, Wai Haung Yu, Karen Duff, Michael P. Yaffe, Liza A. Pon, Eric A. Schon	2009	333
18	Progress in the modeling of neurodegenerative diseases in transgenic mice Current Opinion in Neurology ·Karen Duff, Mala V. Rao	2001	19
19	APOLIPOPROTEIN-E GENOTYPE AND ALZHEIMERS-DISEASE UCL Discovery (University College London) ·John Hardy, Henry Houlden, John Collinge, Sahebrao Bhaurao Bagal, F.M. Echavarren, Martin N. Rossor, Lars Lannfelt, Lena Lilius, Bengt Winblad, Richard Crook, Karen Duff	1993	246
20	CONFIRMATION THAT THE APOLIPOPROTEIN E4 ALLELE IS ASSOCIATED WITH LATE-ONSET, FAMILIAL ALZHEIMERS-DISEASE UCL Discovery (University College London) ·Henry Houlden, Richard Crook, Karen Duff, John Collinge, Martin N. Rossor, John Hardy	1993	6

About Karen Duff

Karen Duff is a scholar working on Cellular and Molecular Neuroscience, Physiology, Neurology, Neurology and Psychiatry and Mental health, having authored 236 papers that have together received 29.5k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (141 papers), Neuroscience and Neuropharmacology Research (40 papers), Genetic Neurodegenerative Diseases (37 papers), Prion Diseases and Protein Misfolding (29 papers), Neurological disorders and treatments (25 papers), Nuclear Receptors and Signaling (24 papers), Cholinesterase and Neurodegenerative Diseases (21 papers) and Computational Drug Discovery Methods (20 papers). The work is most often cited by research in Physiology (18.0k citations), Neurology (5.2k citations), Cellular and Molecular Neuroscience (9.6k citations), Biological Psychiatry (1.1k citations) and Neurology (4.5k citations). Karen Duff has collaborated with scholars based in United States, United Kingdom and Canada. Frequent co-authors include John Hardy, Scott A. Small, John J. LaFrancois, Leigh J. Beglinger, Jane S. Paulsen, Wai Haung Yu, Marcia N. Gordon, Douglas R. Langbehn, Jessica Wu and Peter Davies. Their work appears in journals such as Neurobiology of Disease, Journal of Neuroscience, Archives of Clinical Neuropsychology, Nature Neuroscience and Alzheimer s & Dementia.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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