Makoto Higuchi

20.9k total citations · 2 hit papers
392 papers, 13.1k citations indexed

About

Makoto Higuchi is a scholar working on Physiology, Cellular and Molecular Neuroscience and Molecular Biology. According to data from OpenAlex, Makoto Higuchi has authored 392 papers receiving a total of 13.1k indexed citations (citations by other indexed papers that have themselves been cited), including 153 papers in Physiology, 99 papers in Cellular and Molecular Neuroscience and 79 papers in Molecular Biology. Recurrent topics in Makoto Higuchi's work include Alzheimer's disease research and treatments (136 papers), Neuroscience and Neuropharmacology Research (63 papers) and Dementia and Cognitive Impairment Research (42 papers). Makoto Higuchi is often cited by papers focused on Alzheimer's disease research and treatments (136 papers), Neuroscience and Neuropharmacology Research (63 papers) and Dementia and Cognitive Impairment Research (42 papers). Makoto Higuchi collaborates with scholars based in Japan, United States and Sweden. Makoto Higuchi's co-authors include Tetsuya Suhara, Takaomi C. Saido, John Q. Trojanowski, Virginia M.‐Y. Lee, Nobuhisa Iwata, Jun Maeda, Yasumasa Yoshiyama, Bin Zhang, Shu-Ming Huang and Bin Ji and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Makoto Higuchi

378 papers receiving 12.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

2007 1.6k citations Makoto Higuchi, Takaomi C. Saido et al. profile →
Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

2003 698 citations Makoto Higuchi et al. profile →

Peers

Makoto Higuchi

PHYSI

CMN

NEURO

Annemieke J.M. Rozemüller Netherlands

Irina Alafuzoff Sweden

Teresa Gómez‐Isla United States

Seth Love United Kingdom

James B. Leverenz United States

Thomas Wısnıewskı United States

Abhay P. Sagare United States

Rivka Ravid Netherlands

Lars M. Ittner Australia

Constantin Bouras Switzerland

Annemieke J.M. Rozemüller Netherlands

Makoto Higuchi

5.9k ×0.9

PHYSI

4.6k ×1.3

2.1k ×0.6

CMN

3.8k ×1.3

NEURO

2.8k ×1.2

NEURO

Citations per year, relative to Makoto Higuchi Makoto Higuchi (= 1×) peers Annemieke J.M. Rozemüller

Countries citing papers authored by Makoto Higuchi

Since Specialization

Citations

This map shows the geographic impact of Makoto Higuchi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Makoto Higuchi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Makoto Higuchi more than expected).

Fields of papers citing papers by Makoto Higuchi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Makoto Higuchi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Makoto Higuchi. The network helps show where Makoto Higuchi may publish in the future.

Co-authorship network of co-authors of Makoto Higuchi

This figure shows the co-authorship network connecting the top 25 collaborators of Makoto Higuchi. A scholar is included among the top collaborators of Makoto Higuchi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Makoto Higuchi. Makoto Higuchi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Higuchi, Makoto, Kenji Tagai, Keisuke Takahata, & Hironobu Endo. (2025). Advances in PET imaging of protein aggregates associated with neurodegenerative disease. Nature Reviews Neurology. 21(9). 506–522. 2 indexed citations

Yamamoto, Yasuharu, Keisuke Takahata, Morinobu Seki, et al.. (2025). SLC9A6 -Linked Parkinson Syndrome in Female Heterozygotes Is Associated With PET-Detectable Tau Pathology. Neurology Genetics. 11(1). e200235–e200235. 1 indexed citations

Tagai, Kenji, Hitoshi Shinotoh, Shigeki Hirano, et al.. (2025). Concurrent Alzheimer's disease pathologies in Lewy body diseases affect cognition and glucose metabolism in the posterior cingulate gyrus: A multimodal PET study. Journal of Alzheimer s Disease. 106(3). 1074–1086. 1 indexed citations

Kamano, Naoko, Hiroki Sasaguri, Martha Foiani, et al.. (2025). Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community. Cell Reports Methods. 5(4). 101024–101024. 1 indexed citations

Matsuda, Tadamitsu, Yuji Fujino, Tomoyuki Morisawa, et al.. (2025). Reliability and Validity Examination of a New Gait Motion Analysis System. Sensors. 25(4). 1076–1076. 1 indexed citations

Mimura, Koki, Jumpei Matsumoto, Daichi Mochihashi, et al.. (2024). Unsupervised decomposition of natural monkey behavior into a sequence of motion motifs. Communications Biology. 7(1). 1080–1080. 3 indexed citations

Sano, Yasunori, Yasuharu Yamamoto, Manabu Kubota, et al.. (2024). Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder. Translational Psychiatry. 14(1). 403–403. 1 indexed citations

Takuwa, Hiroyuki, Manami Takahashi, Takuya Urushihata, et al.. (2023). Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model. iScience. 26(4). 106342–106342. 9 indexed citations

Hirata, Kosei, Kiwamu Matsuoka, Kenji Tagai, et al.. (2023). Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease. Annals of Neurology. 95(1). 104–115. 11 indexed citations

10.

Ogata, Aya, Hiroko Koyama, Bin Ji, et al.. (2023). Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain. EJNMMI Radiopharmacy and Chemistry. 8(1). 31–31. 5 indexed citations

11.

Matsumura, Yoshimasa, Makoto Higuchi, Yasuyuki Irie, et al.. (2023). Parallel synthesis of donor-acceptor π-conjugated polymers by post-element transformation of organotitanium polymer. Designed Monomers & Polymers. 26(1). 190–197.

12.

Suzuki, Hiroki, Hiroyuki Takuwa, Bin Ji, et al.. (2023). Capillary responses to functional and pathological activations rely on the capillary states at rest. Journal of Cerebral Blood Flow & Metabolism. 43(6). 1010–1024. 1 indexed citations

13.

Miyakawa, Naohisa, Yuji Nagai, Yukiko Hori, et al.. (2023). Chemogenetic attenuation of cortical seizures in nonhuman primates. Nature Communications. 14(1). 971–971. 24 indexed citations

14.

Plaza‐García, Sandra, Vanessa Gómez‐Vallejo, Unai Cossío, et al.. (2023). Therapeutic effect of α7 nicotinic receptor activation after ischemic stroke in rats. Journal of Cerebral Blood Flow & Metabolism. 43(8). 1301–1316. 6 indexed citations

15.

Ono, Maiko, Tomoteru Yamasaki, Katsushi Kumata, et al.. (2023). Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein. RSC Medicinal Chemistry. 14(5). 858–868. 6 indexed citations

16.

Kawamura, Kazunori, Hiroki Hashimoto, Kenji Furutsuka, et al.. (2020). Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [¹⁸F]PM‐PBB3 for clinical applications. Journal of Labelled Compounds and Radiopharmaceuticals. 64(3). 109–119. 17 indexed citations

17.

Shimada, Hiroyuki, Jun Takeuchi, Akitoshi Takeda, et al.. (2020). Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation. International Journal of Molecular Sciences. 21(12). 4443–4443. 9 indexed citations

18.

Kimura, Hiroko, Jun Takeuchi, Akitoshi Takeda, et al.. (2019). Staging of tau distribution by positron emission tomography may be useful in clinical staging of Alzheimer disease. Neurology and Clinical Neuroscience. 8(2). 61–67. 4 indexed citations

19.

Itoh, Masatoshi, Hiroshi Miyazaki, Manabu Tashiro, et al.. (1997). Functional Analysis of the Brain at Rest Studied by PET and EEG. 15(2). 282–292. 1 indexed citations

20.

Higuchi, Makoto, et al.. (1980). A STUDY ON WELD REPAIR THROUGH HALF BEAD METHOD. 13(2). 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact