Makoto Higuchi

20.9k total citations · 2 hit papers
392 papers, 13.1k citations indexed

About

Makoto Higuchi is a scholar working on Physiology, Cellular and Molecular Neuroscience and Molecular Biology. According to data from OpenAlex, Makoto Higuchi has authored 392 papers receiving a total of 13.1k indexed citations (citations by other indexed papers that have themselves been cited), including 153 papers in Physiology, 99 papers in Cellular and Molecular Neuroscience and 79 papers in Molecular Biology. Recurrent topics in Makoto Higuchi's work include Alzheimer's disease research and treatments (136 papers), Neuroscience and Neuropharmacology Research (63 papers) and Dementia and Cognitive Impairment Research (42 papers). Makoto Higuchi is often cited by papers focused on Alzheimer's disease research and treatments (136 papers), Neuroscience and Neuropharmacology Research (63 papers) and Dementia and Cognitive Impairment Research (42 papers). Makoto Higuchi collaborates with scholars based in Japan, United States and Sweden. Makoto Higuchi's co-authors include Tetsuya Suhara, Takaomi C. Saido, John Q. Trojanowski, Virginia M.‐Y. Lee, Nobuhisa Iwata, Jun Maeda, Yasumasa Yoshiyama, Bin Zhang, Shu-Ming Huang and Bin Ji and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Makoto Higuchi

378 papers receiving 12.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

2007 1.6k citations Makoto Higuchi, Takaomi C. Saido et al. profile →
Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

2003 698 citations Makoto Higuchi et al. profile →

Peers

Countries citing papers authored by Makoto Higuchi

Since Specialization

Citations

This map shows the geographic impact of Makoto Higuchi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Makoto Higuchi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Makoto Higuchi more than expected).

Fields of papers citing papers by Makoto Higuchi

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Makoto Higuchi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Makoto Higuchi. The network helps show where Makoto Higuchi may publish in the future.

Co-authorship network of co-authors of Makoto Higuchi

This figure shows the co-authorship network connecting the top 25 collaborators of Makoto Higuchi. A scholar is included among the top collaborators of Makoto Higuchi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Makoto Higuchi. Makoto Higuchi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Advances in PET imaging of protein aggregates associated with neurodegenerative disease 2025 ·Nature Reviews Neurology ·Makoto Higuchi, Kenji Tagai, Keisuke Takahata, Hironobu Endo	2
2	SLC9A6 -Linked Parkinson Syndrome in Female Heterozygotes Is Associated With PET-Detectable Tau Pathology 2025 ·Neurology Genetics ·Yasuharu Yamamoto, Keisuke Takahata, Morinobu Seki, (unknown), Harutsugu Tatebe, Ryo Ueda, Hironobu Endo, Kenji Tagai, Sho Moriguchi, Shin Kurose, (unknown), (unknown), Kazunori Kawamura, Ming‐Rong Zhang, Yuji Ueno, Yoshihisa Takiyama, Takahiko Tokuda, Makoto Higuchi, Daisuke Ito	1
3	Concurrent Alzheimer's disease pathologies in Lewy body diseases affect cognition and glucose metabolism in the posterior cingulate gyrus: A multimodal PET study 2025 ·Journal of Alzheimer s Disease ·(unknown), Kenji Tagai, Hitoshi Shinotoh, Shigeki Hirano, (unknown), Hironobu Endo, Keisuke Takahata, Yuhei Takado, Ming‐Rong Zhang, Kazunori Kawamura, Osamu Onodera, Makoto Higuchi, Hitoshi Shimada	1
4	Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community 2025 ·Cell Reports Methods ·(unknown), (unknown), Naoko Kamano, Hiroki Sasaguri, (unknown), Martha Foiani, Karen Duff, Seico Benner, Toshihiro Endo, Hiroshi Hama, Hiroshi Kurokawa, (unknown), Hiroshi Mizuma, Naruhiko Sahara, Masafumi Shimojo, Makoto Higuchi, Takaomi C. Saido, Naoto Watamura	1
5	Reliability and Validity Examination of a New Gait Motion Analysis System 2025 ·Sensors ·Tadamitsu Matsuda, Yuji Fujino, Tomoyuki Morisawa, Tetsuya Takahashi, (unknown), (unknown), (unknown), Hiroshi Fukushima, Makoto Higuchi, (unknown), (unknown), Toshiyuki Fujiwara, Hiroyuki Daida	1
6	Unsupervised decomposition of natural monkey behavior into a sequence of motion motifs 2024 ·Communications Biology ·Koki Mimura, Jumpei Matsumoto, Daichi Mochihashi, Tomoaki Nakamura, Hisao Nishijo, Makoto Higuchi, Toshiyuki Hirabayashi, Takafumi Minamimoto	3
7	Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder 2024 ·Translational Psychiatry ·Yasunori Sano, Yasuharu Yamamoto, Manabu Kubota, Sho Moriguchi, Kiwamu Matsuoka, Shin Kurose, Kenji Tagai, Hironobu Endo, Bun Yamagata, Hisaomi Suzuki, Ryosuke Tarumi, K. Nomoto, Yuhei Takado, Kazunori Kawamura, Ming‐Rong Zhang, Hajime Tabuchi, Masaru Mimura, Hiroyuki Uchida, Makoto Higuchi, Keisuke Takahata	1
8	Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model 2023 ·iScience ·(unknown), Hiroyuki Takuwa, Manami Takahashi, Takuya Urushihata, Masafumi Shimojo, (unknown), Mitsugu Yamanaka, Yutaka Tomita, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi	9
9	Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease 2023 ·Annals of Neurology ·Kosei Hirata, Kiwamu Matsuoka, Kenji Tagai, (unknown), Harutsugu Tatebe, (unknown), Naomi Kokubo, (unknown), Hitoshi Shinotoh, Keisuke Takahata, Takayuki Obata, (unknown), Jamie Near, Kazunori Kawamura, Ming‐Rong Zhang, Hitoshi Shimada, (unknown), Takahiko Tokuda, Makoto Higuchi, Yuhei Takado	11
10	Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain 2023 ·EJNMMI Radiopharmacy and Chemistry ·(unknown), Aya Ogata, Hiroko Koyama, Bin Ji, Hideki Ishii, Takashi Yamada, (unknown), Chie Seki, Yuji Nagai, (unknown), Takafumi Minamimoto, Makoto Higuchi, Ming‐Rong Zhang, Takashi Kato, Kengo Ito, Masaaki Suzuki, Yasuyuki Kimura	5
11	Parallel synthesis of donor-acceptor π-conjugated polymers by post-element transformation of organotitanium polymer 2023 ·Designed Monomers & Polymers ·Yoshimasa Matsumura, (unknown), (unknown), Makoto Higuchi, (unknown), (unknown), Yasuyuki Irie, Hiroaki Imoto, Kensuke Naka, (unknown), Shinsuke Inagi, Ikuyoshi Tomita	0
12	Capillary responses to functional and pathological activations rely on the capillary states at rest 2023 ·Journal of Cerebral Blood Flow & Metabolism ·Hiroki Suzuki, (unknown), Hiroyuki Takuwa, Bin Ji, Makoto Higuchi, Iwao Kanno, Kazuto Masamoto	1
13	Chemogenetic attenuation of cortical seizures in nonhuman primates 2023 ·Nature Communications ·Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, (unknown), Kei Oyama, Takeshi Matsuo, Ken‐ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto	24
14	Therapeutic effect of α7 nicotinic receptor activation after ischemic stroke in rats 2023 ·Journal of Cerebral Blood Flow & Metabolism ·(unknown), (unknown), (unknown), Sandra Plaza‐García, (unknown), (unknown), (unknown), (unknown), Vanessa Gómez‐Vallejo, Unai Cossío, Makoto Higuchi, Alfredo Rodríguez-Antigüedad, (unknown), Marı́a Domercq, Carlos Matute, Pedro Ramos‐Cabrer, Jordi Llop, Abraham Martín	6
15	Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein 2023 ·RSC Medicinal Chemistry ·(unknown), Maiko Ono, Tomoteru Yamasaki, Katsushi Kumata, Makoto Higuchi, Ming‐Rong Zhang, Michael Fulham, Andrew Katsifis, Paul A. Keller	6
16	Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [¹⁸F]PM‐PBB3 for clinical applications 2020 ·Journal of Labelled Compounds and Radiopharmaceuticals ·Kazunori Kawamura, Hiroki Hashimoto, Kenji Furutsuka, (unknown), (unknown), (unknown), (unknown), Toshiyuki Sakai, (unknown), Masanao Ogawa, (unknown), Nobuki Nengaki, Makoto Takei, (unknown), Makoto Higuchi, Ming‐Rong Zhang	17
17	Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation 2020 ·International Journal of Molecular Sciences ·Hiroyuki Shimada, (unknown), Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Takami Tomiyama, Yoshiaki Itoh	9
18	Staging of tau distribution by positron emission tomography may be useful in clinical staging of Alzheimer disease 2019 ·Neurology and Clinical Neuroscience ·(unknown), (unknown), Hiroko Kimura, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Yoshiaki Itoh	4
19	Functional Analysis of the Brain at Rest Studied by PET and EEG 1997 ·Masatoshi Itoh, Hiroshi Miyazaki, Manabu Tashiro, (unknown), Makoto Higuchi, Ren Iwata, Tatsuo Ido	1
20	A STUDY ON WELD REPAIR THROUGH HALF BEAD METHOD 1980 ·Makoto Higuchi, Hirotaka Sakamoto, (unknown)	8

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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