Leo A. B. Joosten

97.8k total citations · 28 hit papers
701 papers, 52.3k citations indexed

About

Leo A. B. Joosten is a scholar working on Immunology, Molecular Biology and Infectious Diseases. According to data from OpenAlex, Leo A. B. Joosten has authored 701 papers receiving a total of 52.3k indexed citations (citations by other indexed papers that have themselves been cited), including 357 papers in Immunology, 220 papers in Molecular Biology and 119 papers in Infectious Diseases. Recurrent topics in Leo A. B. Joosten's work include Immune responses and vaccinations (137 papers), Inflammasome and immune disorders (104 papers) and Immune Response and Inflammation (92 papers). Leo A. B. Joosten is often cited by papers focused on Immune responses and vaccinations (137 papers), Inflammasome and immune disorders (104 papers) and Immune Response and Inflammation (92 papers). Leo A. B. Joosten collaborates with scholars based in Netherlands, United States and Germany. Leo A. B. Joosten's co-authors include Mihai G. Netea, Wim B. van den Berg, J.W.M. van der Meer, Frank L. van de Veerdonk, Charles A. Dinarello, Bart Jan Kullberg, Ramnik J. Xavier, Fons A. J. van de Loo, Niels P. Riksen and Erik Lubberts and has published in prestigious journals such as Science, New England Journal of Medicine and Cell.

In The Last Decade

Leo A. B. Joosten

678 papers receiving 51.6k citations

Hit Papers

Trained immunity: A program of innate ... 2004 2026 2011 2018 2016 2020 2012 2019 2012 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Trained immunity: A program of innate immune memory in health and disease
    2016 1.8k citations Mihai G. Netea, Leo A. B. Joosten et al. Science profile →
  2. Defining trained immunity and its role in health and disease
    2020 1.6k citations Mihai G. Netea, Jorge Domínguez‐Andrés et al. profile →
  3. Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes
    2012 1.2k citations Leo A. B. Joosten, Hendrik G. Stunnenberg et al. Proceedings of the National Academy of Sciences profile →
  4. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
    2019 1.1k citations Serena Sanna, Natalie R. van Zuydam et al. Nature Genetics profile →
  5. Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes
    2012 918 citations Cisca Wijmenga, Leo A. B. Joosten et al. profile →
  6. Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
    2016 826 citations Marije Oosting, Alexander Kurilshikov et al. profile →
  7. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
    2018 800 citations Rob J.W. Arts, Simone J.C.F.M. Moorlag et al. profile →
  8. Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages
    2008 660 citations Mihai G. Netea, Leo A. B. Joosten et al. profile →
  9. Inflammasome is a central player in the induction of obesity and insulin resistance
    2011 605 citations Rinke Stienstra, Janna A. van Diepen et al. Proceedings of the National Academy of Sciences profile →
  10. Treatment with a neutralizing anti‐murine interleukin‐17 antibody after the onset of collagen‐induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    2004 598 citations Leo A. B. Joosten et al. profile →
  11. Inflammasome activation and IL-1β and IL-18 processing during infection
    2011 558 citations Frank L. van de Veerdonk, Mihai G. Netea et al. profile →
  12. The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
    2010 538 citations Rinke Stienstra, Leo A. B. Joosten et al. profile →
  13. Metabolic Induction of Trained Immunity through the Mevalonate Pathway
    2018 529 citations Siroon Bekkering, Rob J.W. Arts et al. profile →
  14. Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes
    2014 504 citations Siroon Bekkering, Leo A. B. Joosten et al. profile →
  15. Immunometabolic Pathways in BCG-Induced Trained Immunity
    2016 476 citations Rob J.W. Arts, Marije Oosting et al. profile →
  16. Gout
    2019 455 citations Nicola Dalbeth, Leo A. B. Joosten et al. profile →
  17. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans
    2016 454 citations Siroon Bekkering, Max Nieuwdorp et al. profile →
  18. Immune defence against Candida fungal infections
    2015 444 citations Mihai G. Netea, Leo A. B. Joosten et al. profile →
  19. Long-Lasting Effects of BCG Vaccination on Both Heterologous Th1/Th17 Responses and Innate Trained Immunity
    2013 438 citations Leo A. B. Joosten, Ramnik J. Xavier et al. profile →
  20. Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
    2016 438 citations Rob J.W. Arts, Mark S. Gresnigt et al. profile →
  21. STAT1 Mutations in Autosomal Dominant Chronic Mucocutaneous Candidiasis
    2011 436 citations Frank L. van de Veerdonk, Leo A. B. Joosten et al. profile →
  22. Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens
    2019 369 citations Katarzyna Placek, Leo A. B. Joosten et al. profile →
  23. BCG-induced trained immunity in NK cells: Role for non-specific protection to infection
    2014 368 citations Leo A. B. Joosten, Ramnik J. Xavier et al. profile →
  24. Therapeutic targeting of trained immunity
    2019 312 citations Leo A. B. Joosten, Mihai G. Netea et al. profile →
  25. Trained Immunity: Reprogramming Innate Immunity in Health and Disease
    2021 207 citations Siroon Bekkering, Jorge Domínguez‐Andrés et al. profile →
  26. Engineering cytokine therapeutics
    2023 132 citations Leo A. B. Joosten, Mihai G. Netea et al. profile →
  27. Trained immunity: adaptation within innate immune mechanisms
    2022 117 citations Jorge Domínguez‐Andrés, Siroon Bekkering et al. profile →
  28. Trained immunity: General and emerging concepts
    2024 58 citations Brenda Kischkel, Leo A. B. Joosten et al. Immunological Reviews profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Leo A. B. Joosten Netherlands 116 27.5k 17.0k 8.5k 8.2k 6.1k 701 52.3k
Yoichiro Iwakura Japan 126 32.8k 1.2× 18.2k 1.1× 8.7k 1.0× 4.6k 0.6× 4.3k 0.7× 694 61.6k
Bruce Beutler United States 112 38.1k 1.4× 17.2k 1.0× 10.8k 1.3× 3.8k 0.5× 2.5k 0.4× 406 64.5k
Jay K. Kolls United States 101 21.6k 0.8× 8.5k 0.5× 8.5k 1.0× 5.8k 0.7× 2.0k 0.3× 477 40.9k
Anne O’Garra United States 101 36.0k 1.3× 8.3k 0.5× 9.5k 1.1× 6.6k 0.8× 2.2k 0.4× 210 55.1k
Robert L. Coffman United States 104 39.5k 1.4× 8.8k 0.5× 9.0k 1.1× 4.4k 0.5× 3.7k 0.6× 256 60.9k
Volker Brinkmann Germany 91 23.2k 0.8× 19.4k 1.1× 5.2k 0.6× 3.8k 0.5× 1.7k 0.3× 250 45.3k
Eicke Latz Germany 101 31.6k 1.1× 32.3k 1.9× 8.9k 1.0× 4.3k 0.5× 2.0k 0.3× 283 61.2k
Katherine A. Fitzgerald United States 119 39.7k 1.4× 37.7k 2.2× 12.3k 1.4× 6.7k 0.8× 1.7k 0.3× 334 69.4k
Taro Kawai Japan 83 46.7k 1.7× 20.2k 1.2× 12.5k 1.5× 7.0k 0.8× 1.4k 0.2× 177 67.0k
Nico van Rooijen Netherlands 146 38.1k 1.4× 21.4k 1.3× 13.1k 1.5× 4.9k 0.6× 2.8k 0.5× 838 80.5k

Countries citing papers authored by Leo A. B. Joosten

Since Specialization
Citations

This map shows the geographic impact of Leo A. B. Joosten's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leo A. B. Joosten with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leo A. B. Joosten more than expected).

Fields of papers citing papers by Leo A. B. Joosten

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leo A. B. Joosten. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leo A. B. Joosten. The network helps show where Leo A. B. Joosten may publish in the future.

Co-authorship network of co-authors of Leo A. B. Joosten

This figure shows the co-authorship network connecting the top 25 collaborators of Leo A. B. Joosten. A scholar is included among the top collaborators of Leo A. B. Joosten based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leo A. B. Joosten. Leo A. B. Joosten is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Blaauw, Marc J. T., W Vos, Erni Juwita Nelwan, et al.. (2025). Distinct metabolic perturbations link liver steatosis and incident CVD in lean but not obese PWH. BMC Medicine. 23(1). 78–78. 1 indexed citations
2.
Ulas, Thomas, Nico Reusch, Harsh Bahrar, et al.. (2025). Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition. Immunology. 175(3). 300–322.
3.
Mackenzie, Isla S., Marcel Flendrie, Călin D. Popa, et al.. (2025). Ischaemic cardiovascular risk with allopurinol and protective effect of colchicine in gout: a Dutch nationwide pharmaco-epidemiological study. European Journal of Preventive Cardiology. 33(5). 682–690.
4.
Taks, Esther, Joshua Gillard, Dimitri A. Diavatopoulos, et al.. (2024). Interleukin 38 reduces antigen-presentation capacity and antibody production after vaccination. Vaccine. 42(26). 126396–126396. 1 indexed citations
5.
Kılıç, Gizem, Vasiliki Matzaraki, Özlem Bulut, et al.. (2024). RORα negatively regulates BCG-induced trained immunity. Cellular Immunology. 403-404. 104862–104862. 5 indexed citations
6.
7.
Engquist, Elise N., et al.. (2024). Transcriptomic gene signatures measure satellite cell activity in muscular dystrophies. iScience. 27(6). 109947–109947. 1 indexed citations
8.
Kischkel, Brenda, et al.. (2024). Trained immunity: General and emerging concepts. Immunological Reviews. 323(1). 164–185. 58 indexed citations breakdown →
9.
Netea, Mihai G. & Leo A. B. Joosten. (2023). Beyond adaptive immunity: induction of trained immunity by COVID-19 adenoviral vaccines. Journal of Clinical Investigation. 133(2). 5 indexed citations
10.
Gaćeša, Ranko, Rinke Stienstra, Jingyuan Fu, et al.. (2022). The Gut Microbiome Composition Is Altered in Long-standing Type 1 Diabetes and Associates With Glycemic Control and Disease-Related Complications. Diabetes Care. 45(9). 2084–2094. 39 indexed citations
11.
Heijden, Charlotte D.C.C. van der, Samuel T. Keating, Laszlo Groh, et al.. (2019). Aldosterone induces trained immunity: the role of fatty acid synthesis. Cardiovascular Research. 116(2). 317–328. 84 indexed citations
12.
Sanna, Serena, Natalie R. van Zuydam, Anubha Mahajan, et al.. (2019). Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nature Genetics. 51(4). 600–605. 1055 indexed citations breakdown →
13.
Smits, Loek P., Ruud S. Kootte, Evgeni Levin, et al.. (2018). Effect of Vegan Fecal Microbiota Transplantation on Carnitine‐ and Choline‐Derived Trimethylamine‐N‐Oxide Production and Vascular Inflammation in Patients With Metabolic Syndrome. Journal of the American Heart Association. 7(7). 196 indexed citations
14.
Heijden, Charlotte D.C.C. van der, Marlies P. Noz, Leo A. B. Joosten, et al.. (2017). Epigenetics and Trained Immunity. Antioxidants and Redox Signaling. 29(11). 1023–1040. 194 indexed citations
15.
Groh, Laszlo, Samuel T. Keating, Leo A. B. Joosten, Mihai G. Netea, & Niels P. Riksen. (2017). Monocyte and macrophage immunometabolism in atherosclerosis. Seminars in Immunopathology. 40(2). 203–214. 168 indexed citations
16.
Becker, Katharina L., Vishukumar Aimanianda, Mark S. Gresnigt, et al.. (2016). Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway. mBio. 7(3). 58 indexed citations
17.
Netea, Mihai G., Leo A. B. Joosten, Eicke Latz, et al.. (2016). Trained immunity: A program of innate immune memory in health and disease. Science. 352(6284). aaf1098–aaf1098. 1772 indexed citations breakdown →
18.
McKinney, Cushla, Lisa K. Stamp, Nicola Dalbeth, et al.. (2015). Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout. Arthritis Research & Therapy. 17(1). 288–288. 52 indexed citations
19.
Stienstra, Rinke, Janna A. van Diepen, Cees J. Tack, et al.. (2011). Inflammasome is a central player in the induction of obesity and insulin resistance. Proceedings of the National Academy of Sciences. 108(37). 15324–15329. 605 indexed citations breakdown →
20.
Zwerina, Jochen, Kurt Redlich, Karin Polzer, et al.. (2007). TNF-induced structural joint damage is mediated by IL-1. Proceedings of the National Academy of Sciences. 104(28). 11742–11747. 225 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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