Shizuo Akira

334.6k citations
1.2k papers · 261.0k indexed · 91 hit papers · h-index 239
Co-authors
Taro KawaiKiyoshi TakedaOsamu TakeuchiSatoshi UematsuTsuneyasu KaishoShintaro SatoKatsuaki HoshinoHiroaki Hemmi
Topics
Immune Response and Inflammation (604 papers)interferon and immune responses (222 papers)Immune Cell Function and Interaction (206 papers)
Cited by
ImmunologyMicrobiologyCancer Research
Journals
NatureScienceCell
Partner nations
JapanUnited StatesGermany

In The Last Decade

Shizuo Akira

1.2k papers receiving 256.8k citations

Hit Papers

Pathogen Recognition and Innate Immunity1990202620022014200620102010200420032.5k5.0k7.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Pathogen Recognition and Innate Immunity
    2006 9.3k citations Shizuo Akira, Satoshi Uematsu et al. profile →
  2. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    2010 7.0k citations Taro Kawai, Shizuo Akira profile →
  3. Pattern Recognition Receptors and Inflammation
    2010 6.7k citations Osamu Takeuchi, Shizuo Akira profile →
  4. Toll-like receptor signalling
    2004 6.7k citations Shizuo Akira, Kiyoshi Takeda profile →
  5. Toll-Like Receptors
    2003 5.0k citations Kiyoshi Takeda, Tsuneyasu Kaisho et al. profile →
  6. Toll-like receptors: critical proteins linking innate and acquired immunity
    2001 3.9k citations Shizuo Akira, Kiyoshi Takeda et al. profile →
  7. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    2004 3.2k citations Mitsutoshi Yoneyama, Shizuo Akira et al. profile →
  8. Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
    2004 3.0k citations Hiroaki Hemmi, Hubertus Hochrein et al. Science profile →
  9. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    2006 3.0k citations Hiroki Kato, Osamu Takeuchi et al. profile →
  10. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
    2011 2.8k citations Taro Kawai, Shizuo Akira profile →
  11. Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product
    1999 2.8k citations Katsuaki Hoshino, Osamu Takeuchi et al. profile →
  12. Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
    1999 2.8k citations Osamu Takeuchi, Katsuaki Hoshino et al. profile →
  13. Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
    2004 2.7k citations Sandra S. Diebold, Tsuneyasu Kaisho et al. Science profile →
  14. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
    2003 2.6k citations Masahiro Yamamoto, Shintaro Sato et al. Science profile →
  15. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    2005 2.1k citations Taro Kawai, Shintaro Sato et al. profile →
  16. TLR signaling pathways
    2004 2.0k citations Kiyoshi Takeda, Shizuo Akira profile →
  17. Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
    2002 2.0k citations Hiroaki Hemmi, Tsuneyasu Kaisho et al. profile →
  18. Signaling to NF-κB by Toll-like receptors
    2007 2.0k citations Taro Kawai, Shizuo Akira profile →
  19. 5'-Triphosphate RNA Is the Ligand for RIG-I
    2006 1.9k citations Hiroki Kato, Shizuo Akira et al. Science profile →
  20. Unresponsiveness of MyD88-Deficient Mice to Endotoxin
    1999 1.7k citations Taro Kawai, Kiyoshi Takeda et al. profile →
  21. Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
    1998 1.7k citations Taro Kawai, Kiyoshi Takeda et al. profile →
  22. Pathogen Recognition by the Innate Immune System
    2011 1.7k citations Himanshu Kumar, Taro Kawai et al. profile →
  23. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
    2008 1.7k citations Tatsuya Saitoh, Naonobu Fujita et al. profile →
  24. TLR signaling
    2006 1.5k citations Taro Kawai, Shizuo Akira profile →
  25. Autophagy in infection, inflammation and immunity
    2013 1.5k citations Tatsuya Saitoh, Shizuo Akira et al. profile →
  26. Innate immune recognition of viral infection
    2006 1.5k citations Taro Kawai, Shizuo Akira profile →
  27. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
    2004 1.4k citations Shintaro Sato, Shizuo Akira et al. profile →
  28. Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
    2005 1.4k citations Mitsutoshi Yoneyama, Yueh–Ming Loo et al. profile →
  29. Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
    2003 1.3k citations Shizuo Akira et al. The Journal of Experimental Medicine profile →
  30. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    2001 1.3k citations Stefan Bauer, Carsten J. Kirschning et al. Proceedings of the National Academy of Sciences profile →
  31. Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
    2008 1.3k citations Hiroki Kato, Shizuo Akira et al. profile →
  32. Toll-like Receptor Signaling
    2003 1.2k citations Shizuo Akira profile →
  33. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
    2008 1.2k citations Hiroki Kato, Osamu Takeuchi et al. The Journal of Experimental Medicine profile →
  34. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    2006 1.2k citations Shizuo Akira et al. The Journal of Experimental Medicine profile →
  35. TLR signaling
    2007 1.2k citations Taro Kawai, Shizuo Akira profile →
  36. Interleukin-6 in Biology and Medicine
    1993 1.2k citations Shizuo Akira et al. profile →
  37. ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
    2007 1.2k citations Shizuo Akira et al. profile →
  38. Structure and function of a new STAT-induced STAT inhibitor
    1997 1.1k citations Shizuo Akira et al. profile →
  39. Toll-like receptors control activation of adaptive immune responses
    2001 1.1k citations Kiyoshi Takeda, Shizuo Akira et al. profile →
  40. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
    1990 1.1k citations Shizuo Akira et al. profile →
  41. Cell Type-Specific Involvement of RIG-I in Antiviral Response
    2005 1.1k citations Hiroki Kato, Shintaro Sato et al. profile →
  42. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    1997 1.1k citations Kiyoshi Takeda, Makoto Matsumoto et al. Proceedings of the National Academy of Sciences profile →
  43. Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
    2002 1.1k citations Osamu Takeuchi, Shintaro Sato et al. profile →
  44. Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils
    1999 1.0k citations Kiyoshi Takeda, Tsuneyasu Kaisho et al. profile →
  45. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
    2008 1.0k citations Shizuo Akira et al. profile →
  46. Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling
    2002 998 citations Masahiro Yamamoto, Shintaro Sato et al. profile →
  47. Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
    2003 969 citations Shizuo Akira et al. The Journal of Experimental Medicine profile →
  48. Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
    2005 967 citations Satoshi Uematsu, Shizuo Akira et al. profile →
  49. Innate immunity to virus infection
    2008 959 citations Osamu Takeuchi, Shizuo Akira profile →
  50. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
    2009 945 citations Kohichi Matsunaga, Tatsuya Saitoh et al. profile →
  51. Toll-like receptors and innate immunity
    2009 939 citations Himanshu Kumar, Taro Kawai et al. profile →
  52. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    2006 935 citations Shizuo Akira et al. profile →
  53. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
    2012 928 citations Shizuo Akira et al. profile →
  54. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
    2010 926 citations Takashi Satoh, Osamu Takeuchi et al. profile →
  55. Recognition of pathogen-associated molecular patterns by TLR family
    2003 910 citations Shizuo Akira, Hiroaki Hemmi profile →
  56. Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes
    2001 892 citations Taro Kawai, Osamu Takeuchi et al. profile →
  57. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    2005 880 citations Satoshi Uematsu, Shizuo Akira et al. profile →
  58. Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection
    2000 879 citations Osamu Takeuchi, Katsuaki Hoshino et al. profile →
  59. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
    1993 875 citations Shizuo Akira et al. Proceedings of the National Academy of Sciences profile →
  60. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    1994 868 citations Shizuo Akira et al. profile →
  61. Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
    2007 843 citations Yueh–Ming Loo, Jamie L. Fornek et al. Journal of Virology profile →
  62. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    2004 837 citations Taro Kawai, Shintaro Sato et al. profile →
  63. Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    2002 836 citations Shizuo Akira et al. profile →
  64. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
    2004 829 citations Shizuo Akira et al. Proceedings of the National Academy of Sciences profile →
  65. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway
    2003 828 citations Masahiro Yamamoto, Shintaro Sato et al. profile →
  66. Essential function for the kinase TAK1 in innate and adaptive immune responses
    2005 808 citations Shintaro Sato, Hideki Sanjo et al. profile →
  67. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    2002 801 citations Masahiro Yamamoto, Shintaro Sato et al. profile →
  68. Toll‐like Receptor and RIG‐1‐like Receptor Signaling
    2008 787 citations Taro Kawai, Shizuo Akira profile →
  69. Interleukin-6 and Its Receptor: A Paradigm for Cytokines
    1992 765 citations Shizuo Akira et al. Science profile →
  70. Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
    2002 760 citations Shizuo Akira et al. profile →
  71. Involvement of linear polyubiquitylation of NEMO in NF-κB activation
    2009 742 citations Fuminori Tokunaga, Masahiro Yamamoto et al. profile →
  72. STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
    2008 738 citations Kiyoshi Takeda, Shizuo Akira et al. profile →
  73. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    2005 733 citations Satoshi Uematsu, Shizuo Akira et al. The Journal of Experimental Medicine profile →
  74. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
    2013 700 citations Takuma Misawa, Michihiro Takahama et al. profile →
  75. Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
    2002 682 citations Shizuo Akira et al. profile →
  76. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    2004 677 citations Shizuo Akira, Kiyoshi Takeda et al. profile →
  77. Toll-like receptor function and signaling
    2006 676 citations Tsuneyasu Kaisho, Shizuo Akira profile →
  78. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
    2009 675 citations Tatsuya Saitoh, Naonobu Fujita et al. Proceedings of the National Academy of Sciences profile →
  79. Toll-like Receptors on Hematopoietic Progenitor Cells Stimulate Innate Immune System Replenishment
    2006 673 citations Shizuo Akira et al. profile →
  80. Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
    2011 671 citations Shizuo Akira et al. profile →
  81. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    2007 661 citations Shizuo Akira et al. profile →
  82. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    2003 647 citations Kiyoshi Takeda, Shizuo Akira et al. profile →
  83. A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
    2005 642 citations Ken J. Ishii, Hiroki Kato et al. profile →
  84. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    2005 641 citations Shizuo Akira, Richard A. Flavell et al. The Journal of Experimental Medicine profile →
  85. Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors
    2001 576 citations Osamu Takeuchi, Shizuo Akira et al. Science profile →
  86. Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling
    2003 568 citations Shintaro Sato, Masanaka Sugiyama et al. profile →
  87. Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus
    2004 554 citations Shizuo Akira et al. profile →
  88. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
    2009 548 citations Shizuo Akira et al. profile →
  89. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    2003 544 citations Shizuo Akira et al. profile →
  90. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    2008 513 citations Ken J. Ishii, Himanshu Kumar et al. profile →
  91. The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I
    2005 504 citations Nadège Goutagny, Masahiro Yamamoto et al. profile →

Peers

Shizuo Akira
Comparison fields: 5 of 201
  • Immunology 164.0k
  • Molecular Biology 79.6k
  • Epidemiology 48.5k
  • Cancer Research 29.0k
  • Oncology 27.9k
Replace Richard A. Flavell with:
Richard A. Flavell United States
Kiyoshi Takeda Japan
Ruslan Medzhitov United States
Osamu Takeuchi Japan
Kenneth J. Livak United States
Ulrich K. Laemmli Switzerland
Guido Kroemer France
Tom Maniatis United States
Alberto Mantovani Italy
Thomas D. Schmittgen United States
Shizuo Akira relative to Richard A. Flavell United States Richard A. Flavell's profile →
Citations per field
00.5×1.5×2×2.5×
Richard A. Flavell · 1×
Citations per year

Countries citing papers authored by Shizuo Akira

Since Specialization
Citations

This map shows the geographic impact of Shizuo Akira's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shizuo Akira with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shizuo Akira more than expected).

Fields of papers citing papers by Shizuo Akira

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shizuo Akira. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shizuo Akira. The network helps show where Shizuo Akira may publish in the future.

Co-authorship network of co-authors of Shizuo Akira

This figure shows the co-authorship network connecting the top 25 collaborators of Shizuo Akira. A scholar is included among the top collaborators of Shizuo Akira based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shizuo Akira. Shizuo Akira is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
#WorkIndexed citations
1
Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response
2017 ·Proceedings of the National Academy of Sciences ·Tatsuya Kozaki,Jun Komano,(unknown),Michihiro Takahama,Takuma Misawa,Takashi Satoh,Osamu Takeuchi,Taro Kawai,Shigeomi Shimizu,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh
53
2
RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
2014 ·Cancer Research ·(unknown),Nina Le Bert,Samantha S.W. Ho,Yu J. Shen,(unknown),Gordon M. Xiong,J. Ludovic Croxford,Christine X. Koo,Ken J. Ishii,Shizuo Akira,David H. Raulet,Stephan Gasser
128
3
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
2013 ·The Journal of Cell Biology ·Naonobu Fujita,Eiji Morita,Takashi Itoh,Atsushi Tanaka,(unknown),(unknown),(unknown),Tatsuya Saitoh,Hitoshi Nakatogawa,Shouhei Kobayashi,Tokuko Haraguchi,Jun‐Lin Guan,Kazuhiro Iwaï,Fuminori Tokunaga,Kazunobu Saito,Koutaro Ishibashi,Shizuo Akira,Mitsunori Fukuda,Takeshi Noda,Tamotsu Yoshimori
226
4
TLR13 Recognizes Bacterial 23 S rRNA Devoid of Erythromycin Resistance–Forming Modification
2012 ·Science ·Marina Oldenburg,Anne Krüger,Ruth Ferstl,Andreas M. Kaufmann,(unknown),Anna M. Sigmund,Barbara Bathke,Henning Lauterbach,Mark Suter,Stefan Dreher,Uwe Koedel,Shizuo Akira,Taro Kawai,Jan Buer,Hermann Wagner,Stefan Bauer,Hubertus Hochrein,Carsten J. Kirschning
320
5
Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 ( Irf2 ) in trypsinogen5 gene transcription
2011 ·Proceedings of the National Academy of Sciences ·Hideki Hayashi,Tomoko Kohno,Kiyoshi Yasui,Hiroyuki Murota,Tohru Kimura,Gordon S. Duncan,Tomoki Nakashima,Kazuo Yamamoto,(unknown),Yuhua Ma,Koon Jiew Chua,Takashi Suematsu,Isao Shimokawa,Shizuo Akira,Yoshinao Kubo,Tak W. Mak,T. Matsuyama
14
6
Enhanced Efficacy of Therapeutic Cancer Vaccines Produced by Co-Treatment with Mycobacterium tuberculosis Heparin-Binding Hemagglutinin, a Novel TLR4 Agonist
2011 ·Cancer Research ·In Duk Jung,Soo Kyung Jeong,Chang-Min Lee,Kyung Tae Noh,(unknown),Yong Kyoo Shin,Cheol‐Heui Yun,Won‐Jung Koh,Shizuo Akira,Jake Whang,Hwa‐Jung Kim,Won Sun Park,Sung Jae Shin,Yeong‐Min Park
77
7
LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responsesbreakdown →
2010 ·Proceedings of the National Academy of Sciences ·Takashi Satoh,Hiroki Kato,Yutaro Kumagai,Mitsutoshi Yoneyama,Shintaro Sato,Kazufumi Matsushita,Tohru Tsujimura,Takashi Fujita,Shizuo Akira,Osamu Takeuchi
519
8
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Minclebreakdown →
2009 ·The Journal of Experimental Medicine ·Eri Ishikawa,(unknown),Yasu S. Morita,Kenji Toyonaga,Hisakata Yamada,Osamu Takeuchi,Taroh Kinoshita,Shizuo Akira,Yasunobu Yoshikai,Sho Yamasaki
579
9
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis
2009 ·Proceedings of the National Academy of Sciences ·Yasuyuki Kihara,Takuya Matsushita,Yoshihiro Kita,Satoshi Uematsu,Shizuo Akira,Jun‐ichi Kira,Satoshi Ishii,Takao Shimizu
115
10
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia
2009 ·Proceedings of the National Academy of Sciences ·Sho Yamasaki,Makoto Matsumoto,Osamu Takeuchi,Tetsuhiro Matsuzawa,Eri Ishikawa,Machie Sakuma,Hiroaki Tateno,Jun Uno,Jun Hirabayashi,Yuzuru Mikami,Kiyoshi Takeda,Shizuo Akira,Takashi Saito
339
11
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune responsebreakdown →
2009 ·Proceedings of the National Academy of Sciences ·Tatsuya Saitoh,Naonobu Fujita,Takuya Hayashi,(unknown),Takashi Satoh,Hanna Lee,Kohichi Matsunaga,Shun Kageyama,Hiroko Omori,Takeshi Noda,Naoki Yamamoto,Taro Kawai,Ken J. Ishii,Osamu Takeuchi,Tamotsu Yoshimori,Shizuo Akira
675
12
Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
2009 ·Journal of Virology ·Andreas Pichlmair,Oliver Schulz,(unknown),Jan Rehwinkel,Hiroki Kato,Osamu Takeuchi,Shizuo Akira,Michael Way,Giampietro Schiavo,Caetano Reis e Sousa
369
13
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
2008 ·Proceedings of the National Academy of Sciences ·Jeremy B. Swann,Matthew D. Vesely,Anabel Silva,Janelle Sharkey,Shizuo Akira,Robert D. Schreiber,Mark J. Smyth
244
14
The Atg5–Atg12 conjugate associates with innate antiviral immune responses
2007 ·Proceedings of the National Academy of Sciences ·Nao Jounai,Fumihiko Takeshita,Kouji Kobiyama,Asako Sakaue‐Sawano,Atsushi Miyawaki,Ke-Qin Xin,Ken J. Ishii,Taro Kawai,Shizuo Akira,Koichi Suzuki,Kenji Okuda
486
15
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis
2007 ·The Journal of Experimental Medicine ·Zachary Roberts,Nadège Goutagny,Pin‐Yu Perera,Hiroki Kato,Himanshu Kumar,Taro Kawai,Shizuo Akira,Ram Savan,David Van Echo,Katherine A. Fitzgerald,Howard A. Young,Lai‐Ming Ching,Stefanie N. Vogel
127
16
Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunitybreakdown →
2007 ·Journal of Virology ·Yueh–Ming Loo,Jamie L. Fornek,(unknown),Gagan Bajwa,Olivia Perwitasari,Luis Martínez‐Sobrido,Shizuo Akira,Michelle A. Gill,Adolfo Garcı́a-Sastre,Michael G. Katze,Michael Gale
843
17
Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2breakdown →
2006 ·Proceedings of the National Academy of Sciences ·Takeshi Saito,Reiko Hirai,Yueh–Ming Loo,David M. Owen,Cynthia Johnson,(unknown),Shizuo Akira,Takashi Fujita,Michael Gale
592
18
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
2006 ·The Journal of Experimental Medicine ·Troy D. Querec,Soumaya Bennouna,(unknown),Yasmina Laouar,(unknown),Richard A. Flavell,Shizuo Akira,Rafi Ahmed,Bali Pulendran
416
19
Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNAbreakdown →
2004 ·Science ·Sandra S. Diebold,Tsuneyasu Kaisho,Hiroaki Hemmi,Shizuo Akira,Caetano Reis e Sousa
2680
20
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathwaybreakdown →
2003 ·Science ·Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hideki Sanjo,Osamu Takeuchi,Masanaka Sugiyama,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira
2604

About Shizuo Akira

Shizuo Akira is a scholar working on Immunology, Cancer Research and Microbiology, having authored 1.2k papers that have together received 261.0k indexed citations. Recurring topics across this work include Immune Response and Inflammation (604 papers), interferon and immune responses (222 papers) and Immune Cell Function and Interaction (206 papers). The work is most often cited by research in Immunology (164.0k citations), Microbiology (12.6k citations) and Cancer Research (29.0k citations). Shizuo Akira has collaborated with scholars based in Japan, United States and Germany. Frequent co-authors include Taro Kawai, Kiyoshi Takeda, Osamu Takeuchi, Satoshi Uematsu, Tsuneyasu Kaisho, Shintaro Sato, Katsuaki Hoshino, Hiroaki Hemmi, Masahiro Yamamoto and Ken J. Ishii. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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