Shizuo Akira

334.6k total citations · 91 hit papers
1.2k papers, 261.0k citations indexed

About

Shizuo Akira is a scholar working on Immunology, Molecular Biology and Cancer Research. According to data from OpenAlex, Shizuo Akira has authored 1.2k papers receiving a total of 261.0k indexed citations (citations by other indexed papers that have themselves been cited), including 863 papers in Immunology, 299 papers in Molecular Biology and 206 papers in Cancer Research. Recurrent topics in Shizuo Akira's work include Immune Response and Inflammation (604 papers), interferon and immune responses (222 papers) and Immune Cell Function and Interaction (206 papers). Shizuo Akira is often cited by papers focused on Immune Response and Inflammation (604 papers), interferon and immune responses (222 papers) and Immune Cell Function and Interaction (206 papers). Shizuo Akira collaborates with scholars based in Japan, United States and Germany. Shizuo Akira's co-authors include Taro Kawai, Kiyoshi Takeda, Osamu Takeuchi, Satoshi Uematsu, Tsuneyasu Kaisho, Shintaro Sato, Katsuaki Hoshino, Hiroaki Hemmi, Masahiro Yamamoto and Ken J. Ishii and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Shizuo Akira

1.2k papers receiving 256.9k citations

Hit Papers

Pathogen Recognition and ... 1990 2026 2002 2014 2006 2010 2010 2004 2003 2.5k 5.0k 7.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Pathogen Recognition and Innate Immunity
    2006 9.3k citations Shizuo Akira, Satoshi Uematsu et al. profile →
  2. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    2010 7.0k citations Taro Kawai, Shizuo Akira Nature Immunology profile →
  3. Pattern Recognition Receptors and Inflammation
    2010 6.7k citations Osamu Takeuchi, Shizuo Akira profile →
  4. Toll-like receptor signalling
    2004 6.7k citations Shizuo Akira, Kiyoshi Takeda profile →
  5. Toll-Like Receptors
    2003 5.0k citations Kiyoshi Takeda, Tsuneyasu Kaisho et al. profile →
  6. Toll-like receptors: critical proteins linking innate and acquired immunity
    2001 3.9k citations Shizuo Akira, Kiyoshi Takeda et al. Nature Immunology profile →
  7. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    2004 3.2k citations Shizuo Akira et al. Nature Immunology profile →
  8. Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
    2004 3.0k citations Hiroaki Hemmi, Shizuo Akira et al. Science profile →
  9. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    2006 3.0k citations Hiroki Kato, Osamu Takeuchi et al. Nature profile →
  10. Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
    2011 2.8k citations Taro Kawai, Shizuo Akira profile →
  11. Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product
    1999 2.8k citations Katsuaki Hoshino, Osamu Takeuchi et al. profile →
  12. Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
    1999 2.8k citations Osamu Takeuchi, Katsuaki Hoshino et al. profile →
  13. Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
    2004 2.7k citations Tsuneyasu Kaisho, Hiroaki Hemmi et al. Science profile →
  14. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
    2003 2.6k citations Masahiro Yamamoto, Shintaro Sato et al. Science profile →
  15. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
    2005 2.1k citations Taro Kawai, Shintaro Sato et al. Nature Immunology profile →
  16. TLR signaling pathways
    2004 2.0k citations Kiyoshi Takeda, Shizuo Akira profile →
  17. Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
    2002 2.0k citations Hiroaki Hemmi, Tsuneyasu Kaisho et al. Nature Immunology profile →
  18. Signaling to NF-κB by Toll-like receptors
    2007 2.0k citations Taro Kawai, Shizuo Akira profile →
  19. 5'-Triphosphate RNA Is the Ligand for RIG-I
    2006 1.9k citations Hiroki Kato, Shizuo Akira et al. Science profile →
  20. Unresponsiveness of MyD88-Deficient Mice to Endotoxin
    1999 1.7k citations Taro Kawai, Kiyoshi Takeda et al. profile →
  21. Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
    1998 1.7k citations Taro Kawai, Kiyoshi Takeda et al. profile →
  22. Pathogen Recognition by the Innate Immune System
    2011 1.7k citations Himanshu Kumar, Taro Kawai et al. profile →
  23. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
    2008 1.7k citations Tatsuya Saitoh, Satoshi Uematsu et al. Nature profile →
  24. TLR signaling
    2006 1.5k citations Taro Kawai, Shizuo Akira Cell Death and Differentiation profile →
  25. Autophagy in infection, inflammation and immunity
    2013 1.5k citations Tatsuya Saitoh, Shizuo Akira et al. profile →
  26. Innate immune recognition of viral infection
    2006 1.5k citations Taro Kawai, Shizuo Akira Nature Immunology profile →
  27. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
    2004 1.4k citations Shintaro Sato, Shizuo Akira et al. Nature profile →
  28. Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity
    2005 1.4k citations Yueh–Ming Loo, Michael Gale et al. profile →
  29. Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
    2003 1.3k citations Shizuo Akira et al. The Journal of Experimental Medicine profile →
  30. Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
    2008 1.3k citations Hiroki Kato, Shizuo Akira et al. profile →
  31. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
    2001 1.3k citations Shizuo Akira et al. Proceedings of the National Academy of Sciences profile →
  32. Toll-like Receptor Signaling
    2003 1.2k citations Shizuo Akira profile →
  33. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
    2008 1.2k citations Hiroki Kato, Osamu Takeuchi et al. The Journal of Experimental Medicine profile →
  34. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    2006 1.2k citations Shizuo Akira et al. The Journal of Experimental Medicine profile →
  35. TLR signaling
    2007 1.2k citations Taro Kawai, Shizuo Akira profile →
  36. Interleukin-6 in Biology and Medicine
    1993 1.2k citations Shizuo Akira et al. profile →
  37. ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim
    2007 1.2k citations Shizuo Akira et al. profile →
  38. Structure and function of a new STAT-induced STAT inhibitor
    1997 1.1k citations Shizuo Akira et al. Nature profile →
  39. Toll-like receptors control activation of adaptive immune responses
    2001 1.1k citations Kiyoshi Takeda, Shizuo Akira et al. Nature Immunology profile →
  40. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)
    1990 1.1k citations Shizuo Akira et al. profile →
  41. Cell Type-Specific Involvement of RIG-I in Antiviral Response
    2005 1.1k citations Hiroki Kato, Shintaro Sato et al. profile →
  42. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
    1997 1.1k citations Kiyoshi Takeda, Shizuo Akira et al. Proceedings of the National Academy of Sciences profile →
  43. Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
    2002 1.1k citations Osamu Takeuchi, Shintaro Sato et al. profile →
  44. Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils
    1999 1.0k citations Kiyoshi Takeda, Tsuneyasu Kaisho et al. profile →
  45. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
    2008 1.0k citations Shizuo Akira et al. Nature Immunology profile →
  46. Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling
    2002 998 citations Masahiro Yamamoto, Shintaro Sato et al. profile →
  47. Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
    2003 969 citations Shizuo Akira et al. The Journal of Experimental Medicine profile →
  48. Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
    2005 967 citations Satoshi Uematsu, Shizuo Akira et al. profile →
  49. Innate immunity to virus infection
    2008 959 citations Osamu Takeuchi, Shizuo Akira profile →
  50. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
    2009 945 citations Tatsuya Saitoh, Takashi Satoh et al. profile →
  51. Toll-like receptors and innate immunity
    2009 939 citations Himanshu Kumar, Taro Kawai et al. profile →
  52. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
    2006 935 citations Shizuo Akira et al. Nature profile →
  53. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
    2012 928 citations Osamu Yamaguchi, Manabu Taneike et al. Nature profile →
  54. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
    2010 926 citations Takashi Satoh, Osamu Takeuchi et al. Nature Immunology profile →
  55. Recognition of pathogen-associated molecular patterns by TLR family
    2003 910 citations Shizuo Akira, Hiroaki Hemmi profile →
  56. Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes
    2001 892 citations Taro Kawai, Osamu Takeuchi et al. profile →
  57. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    2005 880 citations Satoshi Uematsu, Shizuo Akira et al. Nature Immunology profile →
  58. Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection
    2000 879 citations Osamu Takeuchi, Katsuaki Hoshino et al. profile →
  59. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
    1993 875 citations Shizuo Akira et al. Proceedings of the National Academy of Sciences profile →
  60. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
    1994 868 citations Shizuo Akira et al. profile →
  61. Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
    2007 843 citations Yueh–Ming Loo, Jamie L. Fornek et al. Journal of Virology profile →
  62. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    2004 837 citations Taro Kawai, Shintaro Sato et al. Nature Immunology profile →
  63. Essential role of MD-2 in LPS responsiveness and TLR4 distribution
    2002 836 citations Shizuo Akira et al. Nature Immunology profile →
  64. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
    2004 829 citations Shizuo Akira et al. Proceedings of the National Academy of Sciences profile →
  65. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway
    2003 828 citations Masahiro Yamamoto, Shintaro Sato et al. Nature Immunology profile →
  66. Essential function for the kinase TAK1 in innate and adaptive immune responses
    2005 808 citations Shintaro Sato, Hideki Sanjo et al. Nature Immunology profile →
  67. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
    2002 801 citations Masahiro Yamamoto, Shintaro Sato et al. Nature profile →
  68. Toll‐like Receptor and RIG‐1‐like Receptor Signaling
    2008 787 citations Taro Kawai, Shizuo Akira profile →
  69. Interleukin-6 and Its Receptor: A Paradigm for Cytokines
    1992 765 citations Shizuo Akira et al. Science profile →
  70. Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
    2002 760 citations Shizuo Akira et al. profile →
  71. Involvement of linear polyubiquitylation of NEMO in NF-κB activation
    2009 742 citations Masahiro Yamamoto, Shizuo Akira et al. profile →
  72. STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
    2008 738 citations Kiyoshi Takeda, Shizuo Akira et al. profile →
  73. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    2005 733 citations Satoshi Uematsu, Shizuo Akira et al. The Journal of Experimental Medicine profile →
  74. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
    2013 700 citations Tatsuya Saitoh, Shizuo Akira et al. Nature Immunology profile →
  75. Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
    2002 682 citations Shizuo Akira et al. profile →
  76. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    2004 677 citations Shizuo Akira, Kiyoshi Takeda et al. profile →
  77. Toll-like receptor function and signaling
    2006 676 citations Tsuneyasu Kaisho, Shizuo Akira profile →
  78. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
    2009 675 citations Tatsuya Saitoh, Takashi Satoh et al. Proceedings of the National Academy of Sciences profile →
  79. Toll-like Receptors on Hematopoietic Progenitor Cells Stimulate Innate Immune System Replenishment
    2006 673 citations Shizuo Akira et al. profile →
  80. Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
    2011 671 citations Shizuo Akira et al. profile →
  81. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    2007 661 citations Shizuo Akira et al. profile →
  82. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    2003 647 citations Masaaki Murakami, Kiyoshi Takeda et al. Nature Immunology profile →
  83. A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
    2005 642 citations Ken J. Ishii, Hiroki Kato et al. Nature Immunology profile →
  84. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    2005 641 citations Shizuo Akira et al. The Journal of Experimental Medicine profile →
  85. Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors
    2001 576 citations Osamu Takeuchi, Shizuo Akira et al. Science profile →
  86. Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling
    2003 568 citations Shintaro Sato, Masanaka Sugiyama et al. profile →
  87. Involvement of Toll-like Receptor 3 in the Immune Response of Lung Epithelial Cells to Double-stranded RNA and Influenza A Virus
    2004 554 citations Shizuo Akira et al. profile →
  88. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
    2009 548 citations Shizuo Akira et al. Nature profile →
  89. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    2003 544 citations Shizuo Akira et al. profile →
  90. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    2008 513 citations Ken J. Ishii, Himanshu Kumar et al. Nature profile →
  91. The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I
    2005 504 citations Nadège Goutagny, Masahiro Yamamoto et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Shizuo Akira Japan 239 164.0k 79.6k 48.5k 29.0k 27.9k 1.2k 261.0k
Richard A. Flavell United States 219 86.8k 0.5× 75.7k 1.0× 19.7k 0.4× 13.8k 0.5× 23.1k 0.8× 1.2k 179.2k
Guido Kroemer France 228 51.4k 0.3× 128.2k 1.6× 47.5k 1.0× 28.9k 1.0× 45.9k 1.6× 1.4k 235.5k
Alberto Mantovani Italy 173 91.5k 0.6× 42.5k 0.5× 13.7k 0.3× 16.5k 0.6× 45.1k 1.6× 1.1k 157.6k
Michael Karin United States 229 60.2k 0.4× 113.1k 1.4× 23.0k 0.5× 56.6k 2.0× 45.8k 1.6× 652 212.6k
Kiyoshi Takeda Japan 118 57.1k 0.3× 27.9k 0.4× 14.7k 0.3× 10.5k 0.4× 9.7k 0.3× 463 92.8k
Kenneth J. Livak United States 42 26.2k 0.2× 95.0k 1.2× 12.1k 0.2× 23.5k 0.8× 11.6k 0.4× 95 199.5k
Ruslan Medzhitov United States 114 61.3k 0.4× 27.9k 0.4× 13.4k 0.3× 8.9k 0.3× 7.3k 0.3× 227 97.2k
Charles A. Dinarello United States 174 47.0k 0.3× 36.8k 0.5× 15.9k 0.3× 5.5k 0.2× 11.9k 0.4× 873 108.0k
Ulrich K. Laemmli Switzerland 62 24.1k 0.1× 154.2k 1.9× 12.7k 0.3× 10.0k 0.3× 15.2k 0.5× 84 261.7k
David Baltimore United States 190 46.6k 0.3× 76.2k 1.0× 11.4k 0.2× 32.4k 1.1× 18.2k 0.6× 804 141.8k

Countries citing papers authored by Shizuo Akira

Since Specialization
Citations

This map shows the geographic impact of Shizuo Akira's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shizuo Akira with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shizuo Akira more than expected).

Fields of papers citing papers by Shizuo Akira

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shizuo Akira. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shizuo Akira. The network helps show where Shizuo Akira may publish in the future.

Co-authorship network of co-authors of Shizuo Akira

This figure shows the co-authorship network connecting the top 25 collaborators of Shizuo Akira. A scholar is included among the top collaborators of Shizuo Akira based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shizuo Akira. Shizuo Akira is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Niitsu, Takayuki, Kiyoharu Fukushima, Daisuke Motooka, et al.. (2025). Spatial transcriptomics identifies SPARC as a prognostic marker in interstitial lung diseases. The Journal of Pathology. 267(1). 79–91.
2.
Nayer, Bhavana, Jean L. Tan, Yen‐Zhen Lu, et al.. (2024). Local administration of regulatory T cells promotes tissue healing. Nature Communications. 15(1). 7863–7863. 28 indexed citations
3.
Lu, Yen‐Zhen, Bhavana Nayer, Shailendra Kumar Singh, et al.. (2024). CGRP sensory neurons promote tissue healing via neutrophils and macrophages. Nature. 628(8008). 604–611. 145 indexed citations breakdown →
4.
Saltykova, Irina V., Sergio Li Calzi, Takashi Satoh, et al.. (2021). Tribbles Homolog 3 Mediates the Development and Progression of Diabetic Retinopathy. Diabetes. 70(8). 1738–1753. 18 indexed citations
5.
Julier, Ziad, Bhavana Nayer, Yen‐Zhen Lu, et al.. (2020). Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling. Science Advances. 6(24). eaba7602–eaba7602. 28 indexed citations
6.
Omiya, Shigemiki, Yosuke Omori, Manabu Taneike, et al.. (2020). Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts. Circulation. 141(8). 667–677. 22 indexed citations
7.
Tanaka, Hiroki, Yasunobu Arima, Daisuke Kamimura, et al.. (2019). Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response. The Journal of Experimental Medicine. 216(6). 1431–1449. 50 indexed citations
8.
Komine, Okiru, Hirofumi Yamashita, Noriko Fujimori-Tonou, et al.. (2018). Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death and Differentiation. 25(12). 2130–2146. 48 indexed citations
9.
Kawasaki, Takumi, Kosuke Ito, Haruhiko Miyata, Shizuo Akira, & Taro Kawai. (2017). Deletion of PIK fyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice. The EMBO Journal. 36(12). 1707–1718. 23 indexed citations
10.
Iwasaki, Hidenori, Osamu Takeuchi, Shunsuke Teraguchi, et al.. (2011). The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1. Nature Immunology. 12(12). 1167–1175. 228 indexed citations
11.
Jung, In Duk, Soo Kyung Jeong, Chang-Min Lee, et al.. (2011). Enhanced Efficacy of Therapeutic Cancer Vaccines Produced by Co-Treatment with Mycobacterium tuberculosis Heparin-Binding Hemagglutinin, a Novel TLR4 Agonist. Cancer Research. 71(8). 2858–2870. 77 indexed citations
12.
Kawai, Taro & Shizuo Akira. (2010). The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nature Immunology. 11(5). 373–384. 7035 indexed citations breakdown →
13.
Matsumoto, Koichiro, Keiko Kan‐o, Satoru Fukuyama, et al.. (2010). Essential Role of B7-H1 in Double-Stranded RNA–Induced Augmentation of an Asthma Phenotype in Mice. American Journal of Respiratory Cell and Molecular Biology. 45(1). 31–39. 11 indexed citations
14.
Pichlmair, Andreas, Oliver Schulz, Jan Rehwinkel, et al.. (2009). Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection. Journal of Virology. 83(20). 10761–10769. 369 indexed citations
15.
Swann, Jeremy B., Matthew D. Vesely, Anabel Silva, et al.. (2008). Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proceedings of the National Academy of Sciences. 105(2). 652–656. 244 indexed citations
16.
Jounai, Nao, Fumihiko Takeshita, Kouji Kobiyama, et al.. (2007). The Atg5–Atg12 conjugate associates with innate antiviral immune responses. Proceedings of the National Academy of Sciences. 104(35). 14050–14055. 486 indexed citations
17.
Roberts, Zachary, Nadège Goutagny, Pin‐Yu Perera, et al.. (2007). The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis. The Journal of Experimental Medicine. 204(7). 1559–1569. 127 indexed citations
18.
Loo, Yueh–Ming, Jamie L. Fornek, Gagan Bajwa, et al.. (2007). Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity. Journal of Virology. 82(1). 335–345. 843 indexed citations breakdown →
19.
Yamamoto, Masahiro, Shintaro Sato, Hiroaki Hemmi, et al.. (2003). Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway. Science. 301(5633). 640–643. 2604 indexed citations breakdown →
20.
Sano, Shigetoshi, Satoshi Itami, Kentaro Takeda, et al.. (1999). Functional involvement of Stat3 in skin remodeling including hair cycle and wound healing. Journal of Investigative Dermatology. 112(4). 529. 2 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Richard A. Flavell Breakdown of academic impact, for papers by Guido Kroemer Breakdown of academic impact, for papers by Alberto Mantovani Breakdown of academic impact, for papers by Michael Karin Breakdown of academic impact, for papers by Kiyoshi Takeda Breakdown of academic impact, for papers by Kenneth J. Livak Breakdown of academic impact, for papers by Ruslan Medzhitov Breakdown of academic impact, for papers by Charles A. Dinarello Breakdown of academic impact, for papers by Ulrich K. Laemmli Breakdown of academic impact, for papers by David Baltimore
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