Mike Tyers

46.2k total citations · 19 hit papers
187 papers, 27.4k citations indexed

About

Mike Tyers is a scholar working on Molecular Biology, Cell Biology and Oncology. According to data from OpenAlex, Mike Tyers has authored 187 papers receiving a total of 27.4k indexed citations (citations by other indexed papers that have themselves been cited), including 163 papers in Molecular Biology, 46 papers in Cell Biology and 28 papers in Oncology. Recurrent topics in Mike Tyers's work include Ubiquitin and proteasome pathways (53 papers), Fungal and yeast genetics research (51 papers) and Bioinformatics and Genomic Networks (37 papers). Mike Tyers is often cited by papers focused on Ubiquitin and proteasome pathways (53 papers), Fungal and yeast genetics research (51 papers) and Bioinformatics and Genomic Networks (37 papers). Mike Tyers collaborates with scholars based in Canada, United States and United Kingdom. Mike Tyers's co-authors include Paul Jorgensen, Bobby‐Joe Breitkreutz, Bruce Futcher, Karen Craig, Andrew Willems, Chris Stark, Lorrie Boucher, Gerard D. Wright, Matthias Mann and Frank Sicheri and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Mike Tyers

181 papers receiving 27.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants

2001 1.6k citations Amy H.Y. Tong, Marie Evangelista et al. Science profile →
F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

1997 1.0k citations Karen Craig, Mike Tyers et al. profile →
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions

2020 949 citations Rose Oughtred, Bobby‐Joe Breitkreutz et al. profile →
The BioGRID interaction database: 2019 update

2018 934 citations Rose Oughtred, Chris Stark et al. profile →
The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

2008 744 citations Mike Tyers et al. Science profile →
The BioGRID interaction database: 2013 update

2012 728 citations Andrew Chatr‐aryamontri, Bobby‐Joe Breitkreutz et al. profile →
From genomics to proteomics

2003 712 citations Mike Tyers et al. profile →
The BioGRID interaction database: 2017 update

2016 705 citations Andrew Chatr‐aryamontri, Rose Oughtred et al. profile →
Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

2000 691 citations Mike Tyers, Charles Boone et al. Science profile →
The BioGRID Interaction Database: 2011 update

2010 681 citations Bobby‐Joe Breitkreutz, Andrew Chatr‐aryamontri et al. profile →
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

2001 629 citations Xiaojing Tang, Stephen Orlicky et al. profile →
The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation

1998 608 citations Karen Craig, Mike Tyers et al. profile →
Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast

2002 602 citations Paul Jorgensen, Joy L. Nishikawa et al. Science profile →
Drug combinations: a strategy to extend the life of antibiotics in the 21st century

2019 577 citations Mike Tyers, Gerard D. Wright profile →
The BioGRID Interaction Database: 2008 update

2007 540 citations Bobby‐Joe Breitkreutz, Teresa Reguly et al. profile →
SAINT: probabilistic scoring of affinity purification–mass spectrometry data

2010 539 citations Hyungwon Choi, Brett Larsen et al. profile →
A Global Protein Kinase and Phosphatase Interaction Network in Yeast

2010 512 citations Ashton Breitkreutz, Hyungwon Choi et al. Science profile →
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size

2004 505 citations Paul Jorgensen, Jeffrey R. Sharom et al. profile →
The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

2001 414 citations Brett Larsen, Mike Tyers et al. profile →

Peers

Countries citing papers authored by Mike Tyers

Since Specialization

Citations

This map shows the geographic impact of Mike Tyers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mike Tyers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mike Tyers more than expected).

Fields of papers citing papers by Mike Tyers

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mike Tyers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mike Tyers. The network helps show where Mike Tyers may publish in the future.

Co-authorship network of co-authors of Mike Tyers

This figure shows the co-authorship network connecting the top 25 collaborators of Mike Tyers. A scholar is included among the top collaborators of Mike Tyers based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mike Tyers. Mike Tyers is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation 2026 ·Disease Models & Mechanisms ·(unknown), Almer M. van der Sloot, (unknown), (unknown), Naseer Sangwan, (unknown), Bushra Ilyas, Haley L. Zubyk, Michael A. Cook, Gerard D. Wright, Brian K. Coombes, Mike Tyers	0
2	De novo design of potent inhibitors of clostridial family toxins 2025 ·Proceedings of the National Academy of Sciences ·Robert J. Ragotte, (unknown), John Kit Chung Tam, (unknown), Jacob M. Berman, (unknown), Connor Weidle, (unknown), (unknown), Greg L. Beilhartz, (unknown), Andrew J. Borst, Brian Coventry, Xinru Wang, John L. Rubinstein, Mike Tyers, Daniel Schramek, Roman A. Melnyk, David Baker	1
3	Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality 2022 ·The Journal of Cell Biology ·(unknown), Fred D. Mast, Jean Paul Olivier, Thierry Bertomeu, Maxwell L. Neal, Lindsay N. Carpp, Alexis Kaushansky, Jasmin Coulombe‐Huntington, Mike Tyers, John D. Aitchison	4
4	The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast 2022 ·PLoS Biology ·Sylvain Tollis, (unknown), (unknown), (unknown), (unknown), Jasmin Coulombe‐Huntington, Xiaojing Tang, Susan A. Moore, Deborah Blake, Éric Bonneil, Catherine A. Royer, Pierre Thibault, Mike Tyers	11
5	Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme–ubiquitin complex 2021 ·Science Advances ·Daniel J. St‐Cyr, Derek F. Ceccarelli, Stephen Orlicky, Almer M. van der Sloot, Xiaojing Tang, (unknown), Susan A. Moore, Clint A. James, (unknown), Jasmin Coulombe‐Huntington, Thierry Bertomeu, Anne Marinier, Frank Sicheri, Mike Tyers	26
6	G1/S transcription factors assemble in increasing numbers of discrete clusters through G1 phase 2020 ·The Journal of Cell Biology ·(unknown), Sylvain Tollis, Guo Fu, Jean-Bernard Fiche, (unknown), Jing Cheng, (unknown), Sean R. Notley, (unknown), (unknown), Marcelo Nöllmann, Mike Tyers, Catherine A. Royer	9
7	Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development 2020 ·Genetics ·(unknown), Almer M. van der Sloot, Caroline Huard, Jasmin Coulombe‐Huntington, Sarah Tsao, Sylvain Tollis, Thierry Bertomeu, Elizabeth Culp, (unknown), Michael A. Cook, Éric Bonneil, Pierre Thibault, Gerard D. Wright, Mike Tyers	42
8	Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality 2020 ·The Journal of Cell Biology ·Fred D. Mast, (unknown), Almer M. van der Sloot, Jasmin Coulombe‐Huntington, Michael P. Rout, Nitin S. Baliga, Alexis Kaushansky, Brian T. Chait, Alan Aderem, Charles M. Rice, Andrej Săli, Mike Tyers, John D. Aitchison	16
9	Proteome-wide, Structure-Based Prediction of Protein-Protein Interactions/New Molecular Interactions Viewer 2019 ·PLANT PHYSIOLOGY ·Shaowei Dong, (unknown), Richard Song, Matthew Ierullo, Eddi Esteban, Yingzhou Wu, (unknown), Hardeep K. Nahal-Bose, Allison Gaudinier, Asher Pasha, Rose Oughtred, Kara Dolinski, Mike Tyers, Siobhán M. Brady, Ruth Grene, Björn Usadel, Nicholas J. Provart	35
10	A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome 2017 ·Molecular and Cellular Biology ·Thierry Bertomeu, Jasmin Coulombe‐Huntington, Andrew Chatr‐aryamontri, (unknown), Étienne Coyaud, Brian Raught, Yu Xia, Mike Tyers	53
11	Regulation of the Histone Deacetylase Hst3 by Cyclin-dependent Kinases and the Ubiquitin Ligase SCFCdc4 2014 ·Journal of Biological Chemistry ·(unknown), Xiaojing Tang, Evgeny Kanshin, (unknown), Adam D. Rudner, Pierre Thibault, Mike Tyers, Alain Verreault	12
12	A Global Protein Kinase and Phosphatase Interaction Network in Yeast breakdown → 2010 ·Science ·Ashton Breitkreutz, Hyungwon Choi, Jeffrey R. Sharom, Lorrie Boucher, Victor Neduva, Brett Larsen, Zhen-Yuan Lin, (unknown), Chris Stark, Guomin Liu, (unknown), Danielle Dewar‐Darch, Teresa Reguly, Xiaojing Tang, Ricardo Almeida, Zhaohui Qin, Tony Pawson, Anne‐Claude Gingras, Alexey I. Nesvizhskii, Mike Tyers	512
13	"Fuzzy" complexes: How much disorder can a biologically relevant complex tolerate, and can it even be beneficial? 2010 ·Biochemistry and Cell Biology ·(unknown), (unknown), (unknown), Mark G. Borg, (unknown), (unknown), (unknown), (unknown), Mike Tyers, Julie D. Forman‐Kay	2
14	SCF ^Cdc4 Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor 2010 ·Molecular and Cellular Biology ·Qingquan Liu, Brett Larsen, Markéta Řičicová, Stephen Orlicky, Hille Tekotte, Xiaojing Tang, Karen Craig, (unknown), Thierry Le Bihan, Carl L. Hansen, Frank Sicheri, Mike Tyers	13
15	Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor 2008 ·Proceedings of the National Academy of Sciences ·Tanja Mittag, Stephen Orlicky, Wing‐Yiu Choy, Xiaojing Tang, Hong Lin, Frank Sicheri, Lewis E. Kay, Mike Tyers, Julie D. Forman‐Kay	284
16	Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity 2007 ·Proceedings of the National Academy of Sciences ·Mikael Borg, Tanja Mittag, Tony Pawson, Mike Tyers, Julie D. Forman‐Kay, Hue Sun Chan	198
17	Genome‐Wide Surveys for Phosphorylation‐Dependent Substrates of SCF Ubiquitin Ligases 2005 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Xiaojing Tang, Stephen Orlicky, Qingquan Liu, Andrew Willems, Frank Sicheri, Mike Tyers	27
18	11 Forging the Factory: Ribosome Synthesis and Growth Control in Budding Yeast 2004 ·Cold Spring Harbor Monograph Archive ·Paul Jorgensen, Mike Tyers, Jonathan R. Warner	17
19	Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast breakdown → 2002 ·Science ·Paul Jorgensen, Joy L. Nishikawa, Bobby‐Joe Breitkreutz, Mike Tyers	602
20	Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants breakdown → 2001 ·Science ·Amy H.Y. Tong, Marie Evangelista, Ainslie B. Parsons, Hong Xu, Gary D. Bader, Nicholas F. Page, Mark D. Robinson, (unknown), Christopher W.V. Hogue, Howard Bussey, Brenda Andrews, Mike Tyers, Charles Boone	1620

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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