Brian T. Chait

73.3k citations

434 papers · 55.5k indexed · 22 hit papers · h-index 112

Impact in

Spectroscopy top 0.01%
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Analytical Chemistry and Chromatography
Molecular Biology top 0.02%
- Ion channel regulation and function
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Nuclear Structure and Function
- RNA and protein synthesis mechanisms

Papers in

Spectroscopy 135
- Mass Spectrometry Techniques and Applications 124
- Advanced Proteomics Techniques and Applications 66
- Analytical Chemistry and Chromatography 37
Molecular Biology 287
- RNA Research and Splicing 55
- RNA and protein synthesis mechanisms 45
- Nuclear Structure and Function 42
- RNA modifications and cancer 36
- Genomics and Chromatin Dynamics 36

Co-authors: Roderick MacKinnon Steven L. Cohen Ronald C. Beavis Martine Cadène Michael P. Rout Viswanatham Katta Anling Kuo João H. Morais‐Cabral
Journals: Journal of Biological Chemistry (32 papers)Analytical Chemistry (32 papers)Proceedings of the National Academy of Sciences (29 papers)Journal of the American Chemical Society (17 papers)The Journal of Cell Biology (15 papers)
Partner nations: United States Canada United Kingdom

In The Last Decade

Brian T. Chait

430 papers receiving 54.1k citations

Hit Papers

15 papers align trajectories log scale

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex 2020 · 320 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2020 Cell
2007 Nature
2006 Nature
2005 Cell
2003 Nature
2002 The Journal of Cell Biology
2002 The Plant Journal
2002 Nature
2002 Nature
2002 Nature
2001 Nature Biotechnology
2000 The Journal of Cell Biology
1999 Proceedings of the National Academy of Sciences
1998 Cell
1998 Science
1998 Science
1996 Analytical Chemistry
1995 Science
1991 Analytical Chemistry
1991 Analytical Chemistry
1990 Journal of the American Chemical Society
1985 Science

Peers

Countries citing papers authored by Brian T. Chait

Since Specialization

Citations

This map shows the geographic impact of Brian T. Chait's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian T. Chait with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian T. Chait more than expected).

Fields of papers citing papers by Brian T. Chait

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian T. Chait. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian T. Chait. The network helps show where Brian T. Chait may publish in the future.

Co-authors

The 25 scholars most cited alongside Brian T. Chait, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brian T. Chait Line = papers co-authored together Brian T. Chait links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Targeted detection of endogenous LINE-1 proteins and ORF2p interactions Mobile DNA ·Mathias I. Nielsen, Justina C. Wolters, Omar G. Rosas Bringas, Hua Jiang, Luciano H. Di Stefano, Mehrnoosh Oghbaie, Samira Hozeifi, Mats J. Nitert, Alienke van Pijkeren, Marieke Smit, Lars ter Morsche, Apostolos Mourtzinos, Vikram Deshpande, Martin S. Taylor, Brian T. Chait, John LaCava	2025	1
2	Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus eLife ·Natalia E. Ketaren, Fred D. Mast, Peter C. Fridy, Jean Paul Olivier, Tanmoy Sanyal, Andrej Săli, Brian T. Chait, Michael P. Rout, John D. Aitchison	2024	2
3	The molecular architecture of the nuclear basket Cell ·Digvijay Singh, Neelesh Soni, Joshua Hutchings, Ignacia Echeverria, Farhaz Shaikh, Madeleine Duquette, Sergey Suslov, Zhixun Li, Trevor van Eeuwen, Kelly R. Molloy, Yi Shi, Junjie Wang, Qiang Guo, Brian T. Chait, Javier Fernández-Martı́nez, Michael P. Rout, Andrej Săli, Elizabeth Villa	2024	37
4	Differential dynamics specify MeCP2 function at nucleosomes and methylated DNA Nature Structural & Molecular Biology ·Gabriella N. L. Chua, John W. Watters, Paul Dominic B. Olinares, Masuda Begum, Lauren E. Vostal, Joshua A. Luo, Brian T. Chait, Shixin Liu	2024	4
5	Using a Function-First “Scout Fragment”-Based Approach to Develop Allosteric Covalent Inhibitors of Conformationally Dynamic Helicase Mechanoenzymes Journal of the American Chemical Society ·J Ramsey, Patrick M. M. Shelton, Tyler K. Heiss, Paul Dominic B. Olinares, Lauren E. Vostal, Heather Soileau, Michael Grasso, Sara W. Casebeer, Stephanie M. Adaniya, Michael B. Miller, Shan Sun, David J. Huggins, Robert W. Myers, Brian T. Chait, Ekaterina V. Vinogradova, Tarun M. Kapoor	2023	9
6	Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virus eLife ·Natalia E. Ketaren, Fred D. Mast, Peter C. Fridy, Jean Paul Olivier, Tanmoy Sanyal, Andrej Săli, Brian T. Chait, Michael P. Rout, John D. Aitchison	2023	1
7	Expanding and improving nanobody repertoires using a yeast display method: Targeting SARS-CoV-2 Journal of Biological Chemistry ·Frederick R. Cross, Peter C. Fridy, Natalia E. Ketaren, Fred D. Mast, Song Li, Jean Paul Olivier, Kresti Pecani, Brian T. Chait, John D. Aitchison, Michael P. Rout	2023	14
8	Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain Molecular Cell ·Gabriel I. Small, Olga Fedorova, Paul Dominic B. Olinares, Joshua Chandanani, Anoosha Banerjee, Young Joo Choi, Henrik Molina, Brian T. Chait, Seth A. Darst, Elizabeth A. Campbell	2023	14
9	Comprehensive Structure and Functional Adaptations of the Yeast Nuclear Pore Complex Zenodo (CERN European Organization for Nuclear Research) ·Christopher W. Akey, Digvijay Singh, Christna Ouch, Ignacia Echeverria, Ilona Nudelman, Brian T. Chait, Andrej Săli, Javier Fernández-Martı́nez, Steven J. Ludtke, Elizabeth Villa, Michael P. Rout	2021	1
10	Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function The Journal of Cell Biology ·Michał W. Wieczorek, Shih-Chieh Ti, L. Urnavicius, Kelly R. Molloy, Amol Aher, Brian T. Chait, Tarun M. Kapoor	2021	23
11	Affinity proteomic dissection of the human nuclear cap-binding complex interactome Nucleic Acids Research ·Yuhui Dou, Svetlana Kalmykova, Maria Pashkova, Mehrnoosh Oghbaie, Hua Jiang, Kelly R. Molloy, Brian T. Chait, Michael P. Rout, David Fenyö, Torben Heick Jensen, Ilya Altukhov, John LaCava	2020	22
12	Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex Cell ·James Chen, Brandon Malone, Eliza Llewellyn, Michael Grasso, Patrick M. M. Shelton, Paul Dominic B. Olinares, Kashyap Maruthi, Edward T. Eng, Hasan Vatandaslar, Brian T. Chait, Tarun M. Kapoor, Seth A. Darst, Elizabeth A. Campbell Hit paper breakdown →	2020	320
13	Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM Structure ·Paul Dominic B. Olinares, Jin Young Kang, Eliza Llewellyn, Courtney Chiu, James Chen, Brandon Malone, Ruth M. Saecker, Elizabeth A. Campbell, Seth A. Darst, Brian T. Chait	2020	21
14	Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression Proceedings of the National Academy of Sciences ·Ryan Mayle, Lance D. Langston, Kelly R. Molloy, Dan Zhang, Brian T. Chait, Mike O’Donnell	2018	35
15	Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis Proceedings of the National Academy of Sciences ·Marion Lussignol, Martina Kopp, Kelly R. Molloy, Gema Vizcay‐Barrena, Roland A. Fleck, Marcus Dorner, Kierstin L. Bell, Brian T. Chait, Charles M. Rice, Maria Teresa Catanese	2016	54
16	Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching Science ·Michela Di Virgilio, Elsa Callén, Arito Yamane, Wenzhu Zhang, Mila Janković, Alexander D. Gitlin, Niklas Feldhahn, Wolfgang Resch, Thiago Y. Oliveira, Brian T. Chait, André Nussenzweig, Rafael Casellas, Davide F. Robbiani, Michel C. Nussenzweig	2013	309
17	SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action Cell ·Yong‐Seok Oh, Pu Gao, Ko-Woon Lee, Ilaria Ceglia, Ji‐Seon Seo, Xiaozhu Zhang, Jung‐Hyuck Ahn, Brian T. Chait, Dinshaw J. Patel, Yong Kim, Paul Greengard	2013	85
18	Simple fold composition and modular architecture of the nuclear pore complex Proceedings of the National Academy of Sciences ·Damien P. Devos, Svetlana Dokudovskaya, Rosemary Williams, Frank Alber, Narayanan Eswar, Brian T. Chait, Michael P. Rout, Andrej Săli	2006	215
19	Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation Proceedings of the National Academy of Sciences ·Kevin M. McBride, Anna Gazumyan, Eileen M. Woo, Vasco M. Barreto, Davide F. Robbiani, Brian T. Chait, Michel C. Nussenzweig	2006	117
20	[22] Matrix-assisted laser desorption ionization mass-spectrometry of proteins Methods in enzymology on CD-ROM/Methods in enzymology ·Ronald C. Beavis, Brian T. Chait	1996	122

About Brian T. Chait

Brian T. Chait is a scholar working on Spectroscopy, Molecular Biology, Structural Biology, Cell Biology and Genetics, having authored 434 papers that have together received 55.5k indexed citations. Recurring topics across this work include Mass Spectrometry Techniques and Applications (124 papers), Advanced Proteomics Techniques and Applications (66 papers), RNA Research and Splicing (55 papers), RNA and protein synthesis mechanisms (45 papers), Nuclear Structure and Function (42 papers), Analytical Chemistry and Chromatography (37 papers), RNA modifications and cancer (36 papers) and Genomics and Chromatin Dynamics (36 papers). The work is most often cited by research in Spectroscopy (12.7k citations), Molecular Biology (36.6k citations), Endocrine and Autonomic Systems (3.1k citations), Cellular and Molecular Neuroscience (5.6k citations) and Cell Biology (3.7k citations). Brian T. Chait has collaborated with scholars based in United States, Canada and United Kingdom. Frequent co-authors include Roderick MacKinnon, Steven L. Cohen, Ronald C. Beavis, Martine Cadène, Michael P. Rout, Viswanatham Katta, Anling Kuo, João H. Morais‐Cabral, Wenzhu Zhang and Richard A. Pfuetzner. Their work appears in journals such as Journal of Biological Chemistry, Analytical Chemistry, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and The Journal of Cell Biology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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