Alan Aderem

52.7k total citations · 21 hit papers
217 papers, 38.8k citations indexed

About

Alan Aderem is a scholar working on Immunology, Molecular Biology and Epidemiology. According to data from OpenAlex, Alan Aderem has authored 217 papers receiving a total of 38.8k indexed citations (citations by other indexed papers that have themselves been cited), including 131 papers in Immunology, 102 papers in Molecular Biology and 41 papers in Epidemiology. Recurrent topics in Alan Aderem's work include Immune Response and Inflammation (67 papers), interferon and immune responses (26 papers) and Immune Cell Function and Interaction (25 papers). Alan Aderem is often cited by papers focused on Immune Response and Inflammation (67 papers), interferon and immune responses (26 papers) and Immune Cell Function and Interaction (25 papers). Alan Aderem collaborates with scholars based in United States, Japan and United Kingdom. Alan Aderem's co-authors include David M. Underhill, Kelly D. Smith, Richard J. Ulevitch, Adrian Ozinsky, Edward A. Miao, Thomas R. Hawn, Lee‐Ann H. Allen, Fumitaka Hayashi, Adeline M. Hajjar and Christopher B. Wilson and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Alan Aderem

214 papers receiving 38.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 2.8k citations Fumitaka Hayashi, Kelly D. Smith et al. profile →
Toll-like receptors in the induction of the innate immune response

2000 2.5k citations Alan Aderem et al. profile →
MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

1999 2.1k citations Alan Aderem, David M. Underhill profile →
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 1.6k citations David M. Underhill, Kelly D. Smith et al. Proceedings of the National Academy of Sciences profile →
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

2004 1.4k citations Kelly D. Smith, Roland K. Strong et al. profile →
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 1.1k citations David M. Underhill, Alan Aderem et al. profile →
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

2010 1.1k citations Edward A. Miao, Irina A. Leaf et al. profile →
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 938 citations Edward A. Miao, Alan Aderem et al. profile →
Caspase‐1‐induced pyroptotic cell death

2011 923 citations Edward A. Miao, Alan Aderem et al. profile →
The evolution of vertebrate Toll-like receptors

2005 916 citations Kelly D. Smith, Alan Aderem et al. Proceedings of the National Academy of Sciences profile →
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

2008 809 citations Kathleen A. Kennedy, Alan Aderem et al. profile →
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages

1999 673 citations David M. Underhill, Kelly D. Smith et al. Proceedings of the National Academy of Sciences profile →
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

2003 642 citations Kelly D. Smith, Erica Andersen‐Nissen et al. profile →
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium–calmodulin

1992 630 citations Alan Aderem et al. profile →
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4

2006 630 citations Mark Gilchrist, Kathleen A. Kennedy et al. profile →
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

2010 629 citations Edward A. Miao, Dat P. Mao et al. Proceedings of the National Academy of Sciences profile →
Systems biology of vaccination for seasonal influenza in humans

2011 587 citations Alan Aderem et al. profile →
The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1995 575 citations Alan Aderem et al. profile →
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism

2001 558 citations Fumitaka Hayashi, David M. Underhill et al. profile →
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

2003 467 citations Thomas R. Hawn, Alex Nachman et al. profile →
Caspase-11 Protects Against Bacteria That Escape the Vacuole

2013 435 citations Irina A. Leaf, Alan Aderem et al. profile →

Peers

Countries citing papers authored by Alan Aderem

Since Specialization

Citations

This map shows the geographic impact of Alan Aderem's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alan Aderem with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alan Aderem more than expected).

Fields of papers citing papers by Alan Aderem

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alan Aderem. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alan Aderem. The network helps show where Alan Aderem may publish in the future.

Co-authorship network of co-authors of Alan Aderem

This figure shows the co-authorship network connecting the top 25 collaborators of Alan Aderem. A scholar is included among the top collaborators of Alan Aderem based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alan Aderem. Alan Aderem is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection 2024 ·PLoS Pathogens ·Dat Mai, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Johannes Nemeth, Kevin B. Urdahl, Alan H. Diercks, Alan Aderem, Alissa C. Rothchild	23
2	A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection 2022 ·Cell chemical biology ·Kamalakannan Vijayan, Nadia Arang, Ling Wei, Robert Morrison, (unknown), K. Rachael Parks, Adam Lewis, Fred D. Mast, Alyse N. Douglass, Heather S. Kain, John D. Aitchison, Jarrod S. Johnson, Alan Aderem, Alexis Kaushansky	12
3	Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality 2020 ·The Journal of Cell Biology ·Fred D. Mast, (unknown), Almer M. van der Sloot, Jasmin Coulombe‐Huntington, Michael P. Rout, Nitin S. Baliga, Alexis Kaushansky, Brian T. Chait, Alan Aderem, Charles M. Rice, Andrej Săli, Mike Tyers, John D. Aitchison	16
4	Alveolar macrophages generate a noncanonical NRF2-driven transcriptional response to Mycobacterium tuberculosis in vivo 2019 ·Science Immunology ·Alissa C. Rothchild, Gregory S. Olson, Johannes Nemeth, Lynn M. Amon, Dat Mai, Elizabeth S. Gold, Alan H. Diercks, Alan Aderem	108
5	Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome breakdown → 2010 ·Proceedings of the National Academy of Sciences ·Edward A. Miao, Dat P. Mao, Natalya Yudkovsky, Richard Bonneau, Cynthia G. Lorang, Sarah Warren, Irina A. Leaf, Alan Aderem	629
6	A key role for ATF3 in regulating mast cell survival and mediator release 2010 ·Blood ·Mark Gilchrist, William R. Henderson, (unknown), Carrie D. Johnson, Alex Nachman, Frank Schmitz, Kelly D. Smith, Alan Aderem	30
7	Characterizing the connectivity of poly-ubiquitin chains by selected reaction monitoring mass spectrometry 2010 ·Molecular BioSystems ·Hamid Mirzaei, Richard S. Rogers, (unknown), Jimmy K. Eng, Alan Aderem, Ruedi Aebersold	29
8	A New Triggering Receptor Expressed on Myeloid Cells (Trem) Family Member, Trem-Like 4, Binds to Dead Cells and Is a DNAX Activation Protein 12-Linked Marker for Subsets of Mouse Macrophages and Dendritic Cells 2009 ·The Journal of Immunology ·Hiroaki Hemmi, Juliana Idoyaga, Koji Suda, (unknown), Kathleen A. Kennedy, Masaki Noda, Alan Aderem, Ralph M. Steinman	45
9	Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection 2008 ·The Journal of Immunology ·Sarah Warren, Dat P. Mao, (unknown), Edward A. Miao, Alan Aderem	153
10	A common human TLR1 polymorphism regulates the innate immune response to lipopeptides 2007 ·European Journal of Immunology ·Thomas R. Hawn, Elizabeth Ann Misch, Sarah J. Dunstan, Guy Thwaites, Nguyễn Thị Ngọc Lan, Hoang Thi Quy, Tran Thi Hong Chau, (unknown), Alex Nachman, Marta Janer, Trần Thị Hiền, Jeremy Farrar, Alan Aderem	159
11	Cutting Edge: Tlr5 −/− Mice Are More Susceptible to Escherichia coli Urinary Tract Infection 2007 ·The Journal of Immunology ·Erica Andersen‐Nissen, Thomas R. Hawn, Kelly D. Smith, Alex Nachman, Aaron Lampano, Satoshi Uematsu, Shizuo Akira, Alan Aderem	154
12	The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2 2006 ·Proceedings of the National Academy of Sciences ·Michael A. Fischbach, Hening Lin, Lu Zhou, Yang Yu, Rebecca J. Abergel, David R. Liu, Kenneth N. Raymond, Barry L. Wanner, Roland K. Strong, Christopher T. Walsh, Alan Aderem, Kelly D. Smith	246
13	Evasion of Toll-like receptor 5 by flagellated bacteria 2005 ·Proceedings of the National Academy of Sciences ·Erica Andersen‐Nissen, Kelly D. Smith, (unknown), Sara L. Rassoulian Barrett, Brad T. Cookson, Susan M. Logan, Alan Aderem	496
14	Simvastatin Augments Lipopolysaccharide-Induced Proinflammatory Responses in Macrophages by Differential Regulation of the c-Fos and c-Jun Transcription Factors 2004 ·The Journal of Immunology ·Makoto Matsumoto, (unknown), Elizabeth S. Gold, Alan Aderem	88
15	The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells 2003 ·The Journal of Immunology ·Terry K. Means, Fumitaka Hayashi, Kelly D. Smith, Alan Aderem, Andrew D. Luster	335
16	Cutting Edge: A Toll-Like Receptor 2 Polymorphism That Is Associated with Lepromatous Leprosy Is Unable to Mediate Mycobacterial Signaling 2003 ·The Journal of Immunology ·Pierre–Yves Bochud, Thomas R. Hawn, Alan Aderem	207
17	Generation of Diversity in the Innate Immune System: Macrophage Heterogeneity Arises from Gene-Autonomous Transcriptional Probability of Individual Inducible Genes 2002 ·The Journal of Immunology ·Timothy Ravasi, Christine A. Wells, (unknown), David M. Underhill, Brandon J. Wainwright, Alan Aderem, Sean M. Grimmond, David Hume	83
18	Generation of diversity in the innate immune system. Macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. 2001 ·Journal of Leukocyte Biology ·Timothy Ravasi, Christine A. Wells, Alistair R. R. Forrest, David M. Underhill, Brandon J. Wainwright, Alan Aderem, Sean M. Grimmond, David Hume	20
19	Functional Transitions in Macrophages During In Vivo Infection with Mycobacterium bovis Bacillus Calmette-Guerin 2001 ·The Journal of Immunology ·Jessica A. Hamerman, Alan Aderem	25
20	Bacterial Lipopolysaccharides Modify Signal Transduction in the Arachidonic Acid Cascade in Macrophages 1986 ·Novartis Foundation symposium ·Alan Aderem, (unknown)	8

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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