Brian K. Coombes

9.3k total citations · 4 hit papers
121 papers, 6.8k citations indexed

About

Brian K. Coombes is a scholar working on Endocrinology, Molecular Biology and Food Science. According to data from OpenAlex, Brian K. Coombes has authored 121 papers receiving a total of 6.8k indexed citations (citations by other indexed papers that have themselves been cited), including 52 papers in Endocrinology, 42 papers in Molecular Biology and 41 papers in Food Science. Recurrent topics in Brian K. Coombes's work include Escherichia coli research studies (44 papers), Salmonella and Campylobacter epidemiology (39 papers) and Vibrio bacteria research studies (29 papers). Brian K. Coombes is often cited by papers focused on Escherichia coli research studies (44 papers), Salmonella and Campylobacter epidemiology (39 papers) and Vibrio bacteria research studies (29 papers). Brian K. Coombes collaborates with scholars based in Canada, United States and United Kingdom. Brian K. Coombes's co-authors include B. Brett Finlay, James B. Mahony, Nat F. Brown, Sarah A. Reid‐Yu, Eric D. Brown, Gerard D. Wright, Mark E. Wickham, Caressa N. Tsai, Joseph B. McPhee and Maya A. Farha and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Brian K. Coombes

114 papers receiving 6.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A draft genome of Yersinia pestis from victims of the Black Death

2011 442 citations Kirsten I. Bos, Verena J. Schuenemann et al. Nature profile →
Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

2014 429 citations Sarah A. Reid‐Yu, Brian K. Coombes et al. Nature profile →
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii

2023 183 citations Gary Liu, Denise B. Catacutan et al. Nature Chemical Biology profile →
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

2025 24 citations Manoj Jangra, Dmitrii Y. Travin et al. Nature profile →

Peers

Countries citing papers authored by Brian K. Coombes

Since Specialization

Citations

This map shows the geographic impact of Brian K. Coombes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian K. Coombes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian K. Coombes more than expected).

Fields of papers citing papers by Brian K. Coombes

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian K. Coombes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian K. Coombes. The network helps show where Brian K. Coombes may publish in the future.

Co-authorship network of co-authors of Brian K. Coombes

This figure shows the co-authorship network connecting the top 25 collaborators of Brian K. Coombes. A scholar is included among the top collaborators of Brian K. Coombes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Brian K. Coombes. Brian K. Coombes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation 2026 ·Disease Models & Mechanisms ·(unknown), Almer M. van der Sloot, (unknown), (unknown), Naseer Sangwan, (unknown), Bushra Ilyas, Haley L. Zubyk, Michael A. Cook, Gerard D. Wright, Brian K. Coombes, Mike Tyers	0
2	Adherent-invasive Escherichia coli in Crohn’s disease: the 25th anniversary 2025 ·Gut ·Nicolas Barnich, Janelle C. Arthur, Anthony Buisson, Barry J. Campbell, Franck Carbonnel, Benoît Chassaing, Brian K. Coombes, Jérémy Denizot, Belgin Dogan, Jeremiah J. Faith, Nobuhiko Kamada, Randy Longman, Margarita Martínez-Medina, Claire O’Brien, R. Balfour Sartor, Zhang Shi-ying, Jean‐Frédéric Colombel, Kenneth W. Simpson	0
3	Hyperglycemia worsens gut bacterial infection through intestinal Wnt, but independent of endotoxemia or obesity 2025 ·American Journal of Physiology-Endocrinology and Metabolism ·(unknown), Trevor C. Lau, Joseph B. McPhee, Fernando F. Anhê, Gabriel Forato Anhê, Han Fang, Nicole G. Barra, (unknown), Brittany M. Duggan, (unknown), Elizabeth Gunn, Claudia Gagnon, André Tchernof, André Marette, Katherine M. Morrison, Brian K. Coombes, Jonathan D. Schertzer	0
4	A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome breakdown → 2025 ·Nature ·Manoj Jangra, Dmitrii Y. Travin, Elena V. Aleksandrova, Manpreet Kaur, (unknown), Kalinka Koteva, Dorota Klepacki, Wenliang Wang, (unknown), (unknown), (unknown), (unknown), (unknown), Brian K. Coombes, Nora Vázquez‐Laslop, Yury S. Polikanov, Alexander S. Mankin, Gerard D. Wright	24
5	Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii breakdown → 2023 ·Nature Chemical Biology ·Gary Liu, Denise B. Catacutan, (unknown), Kyle Swanson, Wengong Jin, (unknown), Anush Chiappino-Pepe, Saad A. Syed, (unknown), Kenneth Rachwalski, Jakob Magolan, Michael G. Surette, Brian K. Coombes, Tommi Jaakkola, Regina Barzilay, James J. Collins, J Stokes	183
6	A32 PHAGE TREATMENT DELAYS ONSET OF CROHN’S-ASSOCIATED E. COLI DRIVEN COLITIS IN MICE COLONIZED WITH A DEFINED MICROBIOTA 2023 ·Journal of the Canadian Association of Gastroenterology ·(unknown), (unknown), (unknown), Brian K. Coombes, (unknown), (unknown)	1
7	High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn’s disease-associated Escherichia coli 2021 ·Nature Communications ·Wael Elhenawy, (unknown), Steven J. Gould, (unknown), Caressa N. Tsai, Troy P. Hubbard, Matthew K. Waldor, Brian K. Coombes	42
8	Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis 2019 ·Science ·Mark S. Ladinsky, Leandro P. Araújo, Xiao Zhang, (unknown), Marta Galán-Díez, Salima Soualhi, Carolyn Lee, Koichiro Irie, (unknown), Seiko Narushima, Sheila Bandyopadhyay, Manabu Nagayama, Wael Elhenawy, Brian K. Coombes, Ronaldo P. Ferraris, Kenya Honda, Iliyan D. Iliev, Nan Gao, Pamela J. Björkman, Ivaylo I. Ivanov	132
9	The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella 2017 ·PLoS Pathogens ·Deyanira Pérez‐Morales, (unknown), (unknown), Heladia Salgado, Irma Martínez‐Flores, J. Antonio Ibarra, Bushra Ilyas, Brian K. Coombes, Vı́ctor H. Bustamante	46
10	Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period 2016 ·PLoS Pathogens ·(unknown), (unknown), Joseph B. McPhee, Hong T. Law, Brian K. Coombes	29
11	Identification of the Docking Site between a Type III Secretion System ATPase and a Chaperone for Effector Cargo 2014 ·Journal of Biological Chemistry ·Sarah E. Allison, (unknown), (unknown), Seiji N. Sugiman‐Marangos, Kun Zhang, M.S. Junop, Brian K. Coombes	29
12	Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis 2013 ·Nature Communications ·Cherrie-Lee Small, Sarah A. Reid‐Yu, Joseph B. McPhee, Brian K. Coombes	136
13	Type VI Secretion System-Associated Gene Clusters Contribute to Pathogenesis of Salmonella enterica Serovar Typhimurium 2012 ·Infection and Immunity ·David T. Mulder, (unknown), Brian K. Coombes	80
14	Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death 2011 ·Proceedings of the National Academy of Sciences ·Verena J. Schuenemann, Kirsten I. Bos, Sharon N. DeWitte, Sarah E. Schmedes, (unknown), Alissa Mittnik, Stephen Forrest, Brian K. Coombes, James W. Wood, David J. D. Earn, William E. White, Johannes Krause, Hendrik N. Poinar	145
15	Quantitative Mass Spectrometry Catalogues Salmonella Pathogenicity Island-2 Effectors and Identifies Their Cognate Host Binding Partners 2011 ·Journal of Biological Chemistry ·Sigrid Auweter, Amit P. Bhavsar, Carmen L. de Hoog, Yuling Li, Yujia A. Chan, Joris van der Heijden, Michael J. Lowden, Brian K. Coombes, Lindsay D. Rogers, Nikolay Stoynov, Leonard J. Foster, B. Brett Finlay	54
16	A General Approach to the Construction of Structure‐Switching Reporters from RNA Aptamers 2010 ·Angewandte Chemie International Edition ·(unknown), Brian K. Coombes, Yingfu Li	52
17	Analysis of the Contribution of Salmonella Pathogenicity Islands 1 and 2 to Enteric Disease Progression Using a Novel Bovine Ileal Loop Model and a Murine Model of Infectious Enterocolitis 2005 ·Infection and Immunity ·Brian K. Coombes, Bryan Coburn, Andrew Potter, Susantha Gomis, (unknown), Yuling Li, B. Brett Finlay	131
18	Negative regulation of Salmonella pathogenicity island 2 is required for contextual control of virulence during typhoid 2005 ·Proceedings of the National Academy of Sciences ·Brian K. Coombes, Mark E. Wickham, Michael J. Lowden, Nat F. Brown, B. Brett Finlay	81
19	Expression and Secretion of Salmonella Pathogenicity Island-2 Virulence Genes in Response to Acidification Exhibit Differential Requirements of a Functional Type III Secretion Apparatus and SsaL 2004 ·Journal of Biological Chemistry ·Brian K. Coombes, Nat F. Brown, Yanet Valdez, John H. Brumell, B. Brett Finlay	154
20	SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells 2003 ·Microbes and Infection ·Brian K. Coombes, Nat F. Brown, (unknown), Bruce A. Vallance, B. Brett Finlay	32

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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