Bart De Strooper

77.3k total citations · 22 hit papers
392 papers, 51.6k citations indexed

About

Bart De Strooper is a scholar working on Physiology, Molecular Biology and Cellular and Molecular Neuroscience. According to data from OpenAlex, Bart De Strooper has authored 392 papers receiving a total of 51.6k indexed citations (citations by other indexed papers that have themselves been cited), including 229 papers in Physiology, 219 papers in Molecular Biology and 83 papers in Cellular and Molecular Neuroscience. Recurrent topics in Bart De Strooper's work include Alzheimer's disease research and treatments (225 papers), Cholinesterase and Neurodegenerative Diseases (47 papers) and Neuroinflammation and Neurodegeneration Mechanisms (46 papers). Bart De Strooper is often cited by papers focused on Alzheimer's disease research and treatments (225 papers), Cholinesterase and Neurodegenerative Diseases (47 papers) and Neuroinflammation and Neurodegeneration Mechanisms (46 papers). Bart De Strooper collaborates with scholars based in Belgium, United Kingdom and United States. Bart De Strooper's co-authors include Eric Karran, Wim Annaert, Paul Säftig, Katleen Craessaerts, Iryna Benilova, Marc Mercken, Sébastien S. Hébert, Lutgarde Serneels, Dieter Hartmann and Stephen Salloway and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Bart De Strooper

377 papers receiving 50.9k citations

Hit Papers

Alzheimer's disease 1998 2026 2007 2016 2016 1999 2011 2012 1998 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Alzheimer's disease
    2016 2.4k citations Bart De Strooper et al. profile →
  2. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
    1999 1.7k citations Bart De Strooper, Paul Säftig et al. profile →
  3. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
    2011 1.7k citations Eric Karran, Bart De Strooper et al. profile →
  4. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
    2012 1.6k citations Eric Karran, Bart De Strooper et al. Nature Neuroscience profile →
  5. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
    1998 1.5k citations Bart De Strooper, Paul Säftig et al. profile →
  6. OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
    2006 1.3k citations Christian Frezza, Bart De Strooper et al. profile →
  7. The Cellular Phase of Alzheimer’s Disease
    2016 1.3k citations Bart De Strooper, Eric Karran profile →
  8. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
    1998 986 citations Bart De Strooper et al. Proceedings of the National Academy of Sciences profile →
  9. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
    2008 951 citations Katrien Horré, Wim Mandemakers et al. Proceedings of the National Academy of Sciences profile →
  10. Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex
    2003 794 citations Bart De Strooper Neuron profile →
  11. The secretases: enzymes with therapeutic potential in Alzheimer disease
    2010 599 citations Bart De Strooper, Robert Vassar et al. profile →
  12. Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
    2006 587 citations Dieter Hartmann, Lutgarde Serneels et al. profile →
  13. Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations
    2006 565 citations Lutgarde Serneels, Bart De Strooper et al. profile →
  14. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and β-catenin translocation
    2005 539 citations Thorsten Maretzky, Andreas Ludwig et al. Proceedings of the National Academy of Sciences profile →
  15. The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
    2019 539 citations Leen Wolfs, Nicola Fattorelli et al. profile →
  16. Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
    2006 527 citations Michael Willem, Alistair N. Garratt et al. Science profile →
  17. APP mouse models for Alzheimer's disease preclinical studies
    2017 500 citations Hiroki Sasaguri, Per Nilsson et al. The EMBO Journal profile →
  18. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
    2022 472 citations Eric Karran, Bart De Strooper profile →
  19. Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
    2010 421 citations Bart De Strooper et al. The EMBO Journal profile →
  20. Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons
    2022 145 citations Bart De Strooper, Dietmar Rudolf Thal et al. profile →
  21. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
    2023 128 citations Sriram Balusu, Katrien Horré et al. Science profile →
  22. Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology
    2024 55 citations Renzo Mancuso, Nicola Fattorelli et al. Nature Neuroscience profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Bart De Strooper Belgium 122 28.1k 26.7k 9.2k 7.6k 6.3k 392 51.6k
Rudolph E. Tanzi United States 109 32.5k 1.2× 22.9k 0.9× 9.1k 1.0× 7.0k 0.9× 7.6k 1.2× 483 57.5k
Christian Haass Germany 112 29.7k 1.1× 24.0k 0.9× 9.7k 1.1× 7.6k 1.0× 7.0k 1.1× 384 49.9k
Takaomi C. Saido Japan 98 19.6k 0.7× 16.3k 0.6× 8.2k 0.9× 4.5k 0.6× 6.6k 1.1× 504 36.1k
Todd E. Golde United States 94 18.8k 0.7× 14.2k 0.5× 5.7k 0.6× 5.3k 0.7× 5.4k 0.9× 314 32.1k
Konrad Beyreuther Germany 98 27.0k 1.0× 21.0k 0.8× 6.5k 0.7× 5.8k 0.8× 4.1k 0.7× 439 40.9k
Sangram S. Sisodia United States 91 20.9k 0.7× 15.8k 0.6× 8.4k 0.9× 5.5k 0.7× 4.6k 0.7× 240 33.5k
Takeshi Iwatsubo Japan 99 23.2k 0.8× 14.9k 0.6× 10.3k 1.1× 5.4k 0.7× 6.1k 1.0× 463 41.9k
Guojun Bu United States 101 14.8k 0.5× 12.1k 0.5× 4.6k 0.5× 2.4k 0.3× 6.8k 1.1× 336 30.8k
Frank M. LaFerla United States 97 23.2k 0.8× 13.1k 0.5× 10.1k 1.1× 6.3k 0.8× 8.0k 1.3× 248 36.7k
Lennart Mucke United States 97 20.8k 0.7× 12.4k 0.5× 13.4k 1.5× 4.8k 0.6× 9.1k 1.5× 172 38.9k

Countries citing papers authored by Bart De Strooper

Since Specialization
Citations

This map shows the geographic impact of Bart De Strooper's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bart De Strooper with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bart De Strooper more than expected).

Fields of papers citing papers by Bart De Strooper

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bart De Strooper. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bart De Strooper. The network helps show where Bart De Strooper may publish in the future.

Co-authorship network of co-authors of Bart De Strooper

This figure shows the co-authorship network connecting the top 25 collaborators of Bart De Strooper. A scholar is included among the top collaborators of Bart De Strooper based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bart De Strooper. Bart De Strooper is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Serneels, Lutgarde, Annerieke Sierksma, Emanuela Pasciuto, et al.. (2025). A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases. Molecular Neurodegeneration. 20(1). 29–29.
2.
Albertini, Giulia, An Snellinx, Suresh Poovathingal, et al.. (2025). The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia. Nature Neuroscience. 29(1). 100–110.
3.
Strooper, Bart De & Eric Karran. (2024). New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of γ-secretases. The EMBO Journal. 43(6). 887–903. 15 indexed citations
4.
Mancuso, Renzo, Nicola Fattorelli, Anna Martínez‐Muriana, et al.. (2024). Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology. Nature Neuroscience. 27(5). 886–900. 55 indexed citations breakdown →
5.
Lalli, Giovanna, Jonathan M. Schott, John Hardy, & Bart De Strooper. (2021). Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?. EMBO Molecular Medicine. 13(8). e14781–e14781. 50 indexed citations
6.
Preman, Pranav, Julia TCW, Sara Calafate, et al.. (2021). Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques. Molecular Neurodegeneration. 16(1). 44 indexed citations
7.
Lievens, Sam, Luís F. Ribeiro, Katrien Horré, et al.. (2019). Nuclear import of the DSCAM ‐cytoplasmic domain drives signaling capable of inhibiting synapse formation. The EMBO Journal. 38(6). 38 indexed citations
8.
Rice, Heather C., An Schreurs, Samuel Frère, et al.. (2019). Secreted amyloid-β precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission. Science. 363(6423). 206 indexed citations
9.
McInnes, Joseph, Keimpe Wierda, An Snellinx, et al.. (2018). Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. 97(4). 823–835.e8. 157 indexed citations
10.
Spinazzi, Marco, Enrico Radaelli, Katrien Horré, et al.. (2018). PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proceedings of the National Academy of Sciences. 116(1). 277–286. 69 indexed citations
11.
Sasaguri, Hiroki, Per Nilsson, Shoko Hashimoto, et al.. (2017). APP mouse models for Alzheimer's disease preclinical studies. The EMBO Journal. 36(17). 2473–2487. 500 indexed citations breakdown →
12.
Morais, Vanessa A., Dominik Haddad, Katleen Craessaerts, et al.. (2014). PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling. Science. 344(6180). 203–207. 278 indexed citations
13.
Vos, Melissa, Giovanni Esposito, Janaka N. Edirisinghe, et al.. (2012). Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency. Science. 336(6086). 1306–1310. 289 indexed citations
14.
Qi, Xiaoping, Jun Cai, Lutgarde Serneels, et al.. (2012). Inhibition of β-secretase Results in a Retinal Phenotype Involving Both the Vasculature and the RPE. Investigative Ophthalmology & Visual Science. 53(14). 1145–1145. 1 indexed citations
15.
Morais, Vanessa A., Patrik Verstreken, Joél Smet, et al.. (2009). Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Molecular Medicine. 1(2). 99–111. 326 indexed citations
16.
Ferjentsik, Zoltán, Shinichi Hayashi, J. Kim Dale, et al.. (2009). Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites. PLoS Genetics. 5(9). e1000662–e1000662. 88 indexed citations
17.
Thathiah, Amantha, Kurt Spittaels, Marcel Hoffmann, et al.. (2009). The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons. Science. 323(5916). 946–951. 134 indexed citations
18.
Schulte, Marc, Marcus Lettau, Thorsten Maretzky, et al.. (2007). ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death and Differentiation. 14(5). 1040–1049. 147 indexed citations
19.
Willem, Michael, Alistair N. Garratt, Božidar Novak, et al.. (2006). Control of Peripheral Nerve Myelination by the ß-Secretase BACE1. Science. 314(5799). 664–666. 527 indexed citations breakdown →
20.
George‐Hyslop, Peter St, Georges Lévesque, Gang Yu, et al.. (1997). Biology and genetics of the presenilin proteins associated with alzheimer disease. The FASEB Journal. 11(9). 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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