Ian Churcher

5.8k citations

42 papers · 3.4k indexed · 2 hit papers · h-index 26

Impact in

Organic Chemistry top 1%
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
Pharmaceutical Science top 2%

Papers in

Pharmacology 12
- Cholinesterase and Neurodegenerative Diseases 9
Computational Theory and Mathematics 10
- Computational Drug Discovery Methods 10

Co-authors: Andrew W. Thomas David C. Rees David M. Wilson Luis C. Misal Castro Anthony Wood David C. Blakemore Alan Nadin Channa K. Hattotuwagama
Journals: Journal of Medicinal Chemistry (4 papers)Chemical Communications (3 papers)Journal of Biological Chemistry (3 papers)Journal of Pharmacology and Experimental Therapeutics (2 papers)Journal of the American Chemical Society (2 papers)
Partner nations: United Kingdom United States Ireland

In The Last Decade

Ian Churcher

41 papers receiving 3.3k citations

Hit Papers

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Return to Flatland 2025 · 18 citations

Peers

Countries citing papers authored by Ian Churcher

Since Specialization

Citations

This map shows the geographic impact of Ian Churcher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ian Churcher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ian Churcher more than expected).

Fields of papers citing papers by Ian Churcher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ian Churcher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ian Churcher. The network helps show where Ian Churcher may publish in the future.

Co-authors

The 25 scholars most cited alongside Ian Churcher, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ian Churcher Line = papers co-authored together Ian Churcher links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Return to Flatland Nature Reviews Chemistry ·Ian Churcher, Léandra Muller-Segard, Christopher W. Murray Hit paper breakdown →	2025	18
2	Optimization of a Series of RIPK2 PROTACs Journal of Medicinal Chemistry ·Afjal H. Miah, Ian E. Smith, M.D. Rackham, N. Dibia, Aditya R. Thawani, Rakesh Nagilla, Pamela A. Haile, Bartholomew J. Votta, Laurie Gordon, Gillian F. Watt, Jane Denyer, Nukul Patil, L. U. Ndunagu, Natalie Arbid, Mesmer ted Mve essono, Ian Churcher, Paul Scott‐Stevens, John D. Harling	2021	49
3	The rise and rise of protein degradation: Opportunities and challenges ahead Drug Discovery Today ·Scott J. Hughes, Andrea Testa, Nicola Thompson, Ian Churcher	2021	57
4	Structural Insights into PROTAC-Mediated Degradation of Bcl-xL ACS Chemical Biology ·Chun‐wa Chung, Han Dai, Esther Fernández, Christopher P. Tinworth, Ian Churcher, Jenni Cryan, Jane Denyer, John D. Harling, Agnieszka Konopacka, Markus A. Queisser, 竹有章, Gillian F. Watt, Fan Jiang, Dongming Qian, Andrew B. Benowitz	2020	67
5	Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach ACS Chemical Biology ·Zuni I. Bassi, Lily Shipp, Afjal H. Miah, Trevor Chapman, 逯松荣, Jorge Andrés Ayala Acosta, Lauren Davis, Rafael López-Arteaga, N. W. Galwey, Kirsty E. Waddington, Valentino Parravicini, Patsy Sutton, Céline Gongora, P. G. Humphreys, Ian Churcher, Rab K. Prinjha, David F. Tough	2018	121
6	Synthesis and Demonstration of the Biological Relevance of sp³‐rich Scaffolds Distantly Related to Natural Product Frameworks Chemistry - A European Journal ·Daniel J. Foley, 昌彦渡邊, P.M. Collins, Richard G. Doveston, A. Aimon, R. Talon, Ian Churcher, (unknown), Ruchi Sahota, Adam Nelson	2017	52
7	A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool Chemical Communications ·Ignacio Colomer, F. Baer, 昌彦渡邊, Mary Koren Witting-Acuesa, Richard G. Doveston, Ian Churcher, Stephen P. Marsden, Adam Nelson	2016	75
8	Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines Angewandte Chemie International Edition ·Toni Moragas, E. Kassabji, J.-P. Callu, Hetvi R. Patel, Cheol-Kyu Lee, William Lewis, Ian Churcher, Ruhaimatu Abudu, José A. Souto, Robert A. Stockman	2016	27
9	Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines Angewandte Chemie ·Toni Moragas, E. Kassabji, J.-P. Callu, Hetvi R. Patel, Cheol-Kyu Lee, William Lewis, Ian Churcher, Ruhaimatu Abudu, José A. Souto, Robert A. Stockman	2016	10
10	A Phenotypic Screening Approach in Cord Blood–Derived Mast Cells to Identify Anti-Inflammatory Compounds SLAS DISCOVERY ·Rejbinder Kaur, G. Jaeger, Andy Blanchard, Janet L. Smith, Ian Churcher, Gareth Wayne, Steven B. Ludbrook	2013	4
11	A practical drug discovery project at the undergraduate level Drug Discovery Today ·M. Jonathan Fray, Simon J. F. Macdonald, G. Pantziou, 焦爽, Jack A. Brown, Ian B. Campbell, Ian Churcher, Diane M. Coe, Anthony W. J. Cooper, Philippe Mahaudens, Gail Fisher, Graham G. A. Inglis, Ryan Anthony Stermer, John Liddle, Aoife C. Maxwell, Vipulkumar K. Patel, Stephen Swanson, Tetiana Savchenko	2013	11
12	Lead‐Oriented Synthesis: A New Opportunity for Synthetic Chemistry Angewandte Chemie International Edition ·Alan Nadin, Channa K. Hattotuwagama, Ian Churcher	2012	342
13	On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines Chemical Communications ·光雄東中, Hiroko Tsuji Davis, Fernanda A. S. Tonolli, X.-M. Li, Ian Churcher, David T. MacPherson, Robert A. Stockman	2011	20
14	Stereoselective aza-Darzens reactions of tert-butanesulfinimines: convenient access to chiral aziridines Organic & Biomolecular Chemistry ·Hiroko Tsuji Davis, Ian Churcher, William Lewis, Robert A. Stockman	2011	30
15	The Novel γ Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse Journal of Pharmacology and Experimental Therapeutics ·Jonathan D. Best, David W. Smith, Michael Reilly, Ruth O’Donnell, Huw D. Lewis, Amss Cas, Neil Wilkie, Thomas W. Rosahl, In-Gyu Im, Takanobu SHIGETA, Ian Churcher, John Atack, Timothy Harrison, Mark S. Shearman	2006	64
16	Tau Therapeutic Strategies for the Treatment of Alzheimers Disease Current Topics in Medicinal Chemistry ·Ian Churcher	2006	114
17	Intra- or Intercomplex Binding to the γ-Secretase Enzyme Journal of Biological Chemistry ·Earl E. Clarke, Ian Churcher, Amss Cas, Jonathan D.J. Wrigley, Huw D. Lewis, Timothy Harrison, Mark S. Shearman, Dirk Beher	2006	30
18	γ-Secretase as a Therapeutic Target for the Treatment of Alzheimers Disease Current Pharmaceutical Design ·Ian Churcher, Dirk Beher	2005	40
19	Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site Journal of Biological Chemistry ·Dirk Beher, Earl E. Clarke, Jonathan D.J. Wrigley, Agnés C. L. Martin, Alan Nadin, Ian Churcher, Mark S. Shearman	2004	144
20	Synthesis of the Antitumor Agent Aglycon (±)-Calicheamicinone Using an o-Quinone Monoketal Strategy Journal of the American Chemical Society ·Ian Churcher, David J. Hallett, Philip Magnus	1998	14

About Ian Churcher

Ian Churcher is a scholar working on Pharmacology, Computational Theory and Mathematics, Organic Chemistry, Physiology and Pharmacology, having authored 42 papers that have together received 3.4k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (10 papers), Computational Drug Discovery Methods (10 papers), Cholinesterase and Neurodegenerative Diseases (9 papers), Chemical Synthesis and Analysis (8 papers), Catalytic C–H Functionalization Methods (6 papers), Protein Degradation and Inhibitors (6 papers), Ubiquitin and proteasome pathways (6 papers) and Synthesis and Catalytic Reactions (5 papers). The work is most often cited by research in Organic Chemistry (1.8k citations), Pharmaceutical Science (163 citations), Computational Theory and Mathematics (376 citations), Pharmacology (358 citations) and Molecular Biology (1.4k citations). Ian Churcher has collaborated with scholars based in United Kingdom, United States and Ireland. Frequent co-authors include Andrew W. Thomas, David C. Rees, David M. Wilson, Luis C. Misal Castro, Anthony Wood, David C. Blakemore, Alan Nadin, Channa K. Hattotuwagama, Dirk Beher and Mark S. Shearman. Their work appears in journals such as Journal of Medicinal Chemistry, Chemical Communications, Journal of Biological Chemistry, Journal of Pharmacology and Experimental Therapeutics and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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