Dirk Beher

5.2k citations

58 papers · 4.1k indexed · 1 hit paper · h-index 32

Physiology top 0.5%
- Alzheimer's disease research and treatments 42
- Lysosomal Storage Disorders Research 5
Geriatrics and Gerontology top 1%
Pharmacology top 1%
- Cholinesterase and Neurodegenerative Diseases 18
Computational Theory and Mathematics top 1%
- Computational Drug Discovery Methods 14
Nutrition and Dietetics top 2%
Oncology
- Drug Transport and Resistance Mechanisms 9
Molecular Biology
- Amyloidosis: Diagnosis, Treatment, Outcomes 8
- Prion Diseases and Protein Misfolding 7
- Glycosylation and Glycoproteins Research 6

Co-authors: Colin L. Masters Lars Hesse Gerd Multhaup Mark S. Shearman Konrad Beyreuther Andrea Schlicksupp Thomas Ruppert Earl E. Clarke
Cited by: Physiology Geriatrics and Gerontology Pharmacology
Journals: Journal of Biological Chemistry (11 papers)Journal of Neurochemistry (6 papers)Bioorganic & Medicinal Chemistry Letters (5 papers)
Partner nations: United Kingdom United States Germany

In The Last Decade

Dirk Beher

58 papers receiving 4.0k citations

Hit Papers

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Peers

Countries citing papers authored by Dirk Beher

Since Specialization

Citations

This map shows the geographic impact of Dirk Beher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dirk Beher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dirk Beher more than expected).

Fields of papers citing papers by Dirk Beher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dirk Beher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dirk Beher. The network helps show where Dirk Beher may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Dirk Beher, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Dirk Beher Line = papers co-authored together Dirk Beher links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production Nature Communications ·Mitko Dimitrov,H. G. Akkamma,Thomas Lemmin,Rajwinder Lehal,Harish Tuli,Brianna Latremouille,Ishrut Hussain,Freddy Radtke,Matteo Dal Peraro,Dirk Beher,Patrick C. Fraering	2013	73
2	Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease Alzheimer s Research & Therapy ·Sascha Weggen,Dirk Beher	2012	137
3	Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity Chemical Biology & Drug Design ·Dirk Beher,John Y. Wu,Nathan Dal Bon,Ki Won Kim,Cihan Özdemir,Larissa Atangan,Minghan Wang	2009	352
4	γ-Secretase Modulation and its Promise for Alzheimers Disease: a Rationale for Drug Discovery Current Topics in Medicinal Chemistry ·Dirk Beher	2008	13
5	3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity Bioorganic & Medicinal Chemistry Letters ·Richard A. Jelley,Jason Elliott,Karl R. Gibson,Timothy Harrison,Dirk Beher,Earl E. Clarke,Huw D. Lewis,Mark S. Shearman,Jonathan D.J. Wrigley	2006	14
6	Quantification of Alzheimer pathology in ageing and dementia: age‐related accumulation of amyloid‐β(42) peptide in vascular dementia Neuropathology and Applied Neurobiology ·Huw D. Lewis,Dirk Beher,Natalie Cookson,Arthur E. Oakley,Margaret A. Piggott,Christopher M. Morris,Evelyn Jaros,Robert Perry,Paul G. Ince,Rose Anne Kenny,Clive Ballard,M. S. Shearman,Raj N. Kalaria	2006	125
7	The geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer’s disease modifying agent Bioorganic & Medicinal Chemistry Letters ·Nicholas Stock,Benito Muñoz,Jonathan D.J. Wrigley,Mark S. Shearman,Dirk Beher,Samuel Njoroge,Toni Williamson,Gretchen Bain,Weichao Chen,Xiaohui Jiang,Hans F. M. Reijnders,Peppi Prasit	2006	19
8	Intra- or Intercomplex Binding to the γ-Secretase Enzyme Journal of Biological Chemistry ·Earl E. Clarke,Ian Churcher,Amss Cas,Jonathan D.J. Wrigley,Huw D. Lewis,Timothy Harrison,Mark S. Shearman,Dirk Beher	2006	30
9	Selective Modulation of Aβ42 Production in Alzheimers Disease: Non-Steroidal Anti-Inflammatory Drugs and Beyond Current Pharmaceutical Design ·Stefanie Leuchtenberger,Dirk Beher,Sascha Weggen	2006	30
10	γ-Secretase as a Therapeutic Target for the Treatment of Alzheimers Disease Current Pharmaceutical Design ·Ian Churcher,Dirk Beher	2005	40
11	C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation Journal of Neurochemistry ·M Mahiboobsa,Dirk Beher,Andrew C. Nyborg,Mark S. Shearman,Todd E. Golde,Alison Goate	2005	78
12	Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells Journal of Lipid Research ·Yanzhu Liu,Lin Yang,Karin Conde‐Knape,Dirk Beher,Mark S. Shearman,Neil S. Shachter	2004	28
13	A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core Bioorganic & Medicinal Chemistry Letters ·Stephen J. Lewis,Adrian L. Smith,Joseph G. Neduvelil,Graeme I. Stevenson,Matthew Lindon,A. Brian Jones,Mark S. Shearman,Dirk Beher,Earl E. Clarke,Jonathan D. Best,Samuel Njoroge,Timothy Harrison,José L. Castro	2004	35
14	Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD Neurobiology of Aging ·Huw D. Lewis,Dirk Beher,David W. Smith,Louise Hewson,Natalie Cookson,David S. Reynolds,Gerard R. Dawson,Michael Jiang,Lex H.T. Van der Ploeg,Su Qian,Thomas W. Rosahl,Raj N. Kalaria,Mark S. Shearman	2004	17
15	Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site Journal of Biological Chemistry ·Dirk Beher,Earl E. Clarke,Jonathan D.J. Wrigley,Agnés C. L. Martin,Alan Nadin,Ian Churcher,Mark S. Shearman	2004	144
16	γ-Secretase Cleavage Site Specificity Differs for Intracellular and Secretory Amyloid β Journal of Biological Chemistry ·Heike S. Grimm,Dirk Beher,Stefan F. Lichtenthaler,Mark S. Shearman,Konrad Beyreuther,Tobias Hartmann	2003	39
17	Homodimerization of Amyloid Precursor Protein and Its Implication in the Amyloidogenic Pathway of Alzheimer's Disease Journal of Biological Chemistry ·Stefan Scheuermann,Boris Hambsch,Lars Hesse,Vanessa Teles Teixeira de Castro,Carsten Schmidt,Dirk Beher,Thomas A. Bayer,Konrad Beyreuther,Gerd Multhaup	2001	181
18	Proteolytic Fragments of Alzheimer’s Disease‐Associated Presenilin 1 Are Present in Synaptic Organelles and Growth Cone Membranes of Rat Brain Journal of Neurochemistry ·Dirk Beher,Tianyang Dou,John R. Underwood,John B. Davis,Robyn L. Ward,Eric Karran,Colin L. Masters,Konrad Beyreuther,Gerd Multhaup	1999	52
19	Reactive oxygen species and Alzheimer's disease Biochemical Pharmacology ·Ma LiCui,Thomas Ruppert,Andrea Schlicksupp,Lars Hesse,Dirk Beher,Colin L. Masters,Konrad Beyreuther	1997	186
20	Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokinesa Annals of the New York Academy of Sciences ·Konrad Beyreuther,Gerd Multhaup,U. Mönning,Rupert Sandbrink,Dirk Beher,Lars Hesse,David H. Small,Colin L. Masters	1996	19

About Dirk Beher

Dirk Beher is a scholar working on Physiology, Pharmacology and Computational Theory and Mathematics, having authored 58 papers that have together received 4.1k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (42 papers), Cholinesterase and Neurodegenerative Diseases (18 papers), Computational Drug Discovery Methods (14 papers), Drug Transport and Resistance Mechanisms (9 papers), Amyloidosis: Diagnosis, Treatment, Outcomes (8 papers), Prion Diseases and Protein Misfolding (7 papers), Glycosylation and Glycoproteins Research (6 papers) and Lysosomal Storage Disorders Research (5 papers). The work is most often cited by research in Physiology (2.4k citations), Geriatrics and Gerontology (249 citations) and Pharmacology (761 citations). Dirk Beher has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include Colin L. Masters, Lars Hesse, Gerd Multhaup, Mark S. Shearman, Konrad Beyreuther, Andrea Schlicksupp, Thomas Ruppert, Earl E. Clarke, Sascha Weggen and Jonathan D.J. Wrigley. Their work appears in journals such as Journal of Biological Chemistry, Journal of Neurochemistry, Bioorganic & Medicinal Chemistry Letters, Alzheimer s & Dementia and Neurobiology of Aging.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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