Dirk Beher

5.2k total citations · 1 hit paper
58 papers, 4.1k citations indexed

About

Dirk Beher is a scholar working on Physiology, Molecular Biology and Pharmacology. According to data from OpenAlex, Dirk Beher has authored 58 papers receiving a total of 4.1k indexed citations (citations by other indexed papers that have themselves been cited), including 47 papers in Physiology, 36 papers in Molecular Biology and 19 papers in Pharmacology. Recurrent topics in Dirk Beher's work include Alzheimer's disease research and treatments (42 papers), Cholinesterase and Neurodegenerative Diseases (18 papers) and Computational Drug Discovery Methods (14 papers). Dirk Beher is often cited by papers focused on Alzheimer's disease research and treatments (42 papers), Cholinesterase and Neurodegenerative Diseases (18 papers) and Computational Drug Discovery Methods (14 papers). Dirk Beher collaborates with scholars based in United Kingdom, United States and Germany. Dirk Beher's co-authors include Colin L. Masters, Lars Hesse, Gerd Multhaup, Mark S. Shearman, Konrad Beyreuther, Andrea Schlicksupp, Thomas Ruppert, Earl E. Clarke, Sascha Weggen and Jonathan D.J. Wrigley and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Dirk Beher

58 papers receiving 4.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

1996 596 citations Gerd Multhaup, Andrea Schlicksupp et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Dirk Beher United Kingdom	32	2.4k	2.0k	761	511	473	58	4.1k
Cristina Cecchi Italy	36	2.4k 1.0×	2.4k 1.2×	353 0.5×	263 0.5×	148 0.3×	97	4.3k
Elżbieta Kojro Germany	25	1.9k 0.8×	1.9k 1.0×	552 0.7×	353 0.7×	182 0.4×	44	3.9k
Malcolm A. Leissring United States	36	3.1k 1.3×	2.4k 1.2×	881 1.2×	346 0.7×	230 0.5×	65	5.0k
Fuyuki Kametani Japan	39	3.1k 1.3×	3.4k 1.7×	737 1.0×	353 0.7×	407 0.9×	196	6.6k
Carlos Opazo Chile	32	1.9k 0.8×	1.2k 0.6×	853 1.1×	441 0.9×	658 1.4×	54	3.4k
Claus U. Pietrzik Germany	42	4.0k 1.7×	2.6k 1.3×	1.1k 1.5×	642 1.3×	369 0.8×	111	6.6k
G. Simms Australia	5	4.5k 1.9×	2.7k 1.4×	866 1.1×	696 1.4×	397 0.8×	6	5.3k
Roberta Cascella Italy	30	1.6k 0.7×	1.7k 0.9×	291 0.4×	183 0.4×	159 0.3×	57	3.3k
Yungui Zhou United States	22	2.2k 0.9×	1.5k 0.7×	435 0.6×	137 0.3×	124 0.3×	29	4.3k

Countries citing papers authored by Dirk Beher

Since Specialization

Citations

This map shows the geographic impact of Dirk Beher's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Dirk Beher with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Dirk Beher more than expected).

Fields of papers citing papers by Dirk Beher

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Dirk Beher. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Dirk Beher. The network helps show where Dirk Beher may publish in the future.

Co-authorship network of co-authors of Dirk Beher

This figure shows the co-authorship network connecting the top 25 collaborators of Dirk Beher. A scholar is included among the top collaborators of Dirk Beher based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Dirk Beher. Dirk Beher is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Permanne, Bruno, et al.. (2022). O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies. ACS Chemical Neuroscience. 13(8). 1296–1314. 52 indexed citations

Ryan, J. Michael, Anna Quattropani, Izaak den Daas, et al.. (2018). O1‐12‐05: PHASE 1 STUDY IN HEALTHY VOLUNTEERS OF THE O‐GLCNACASE INHIBITOR ASN120290 AS A NOVEL THERAPY FOR PROGRESSIVE SUPRANUCLEAR PALSY AND RELATED TAUOPATHIES. Alzheimer s & Dementia. 14(7S_Part_4). 25 indexed citations

Cameron, Andrew, John A. Joyce, Audrey Gray, et al.. (2013). Generation and characterization of a rabbit monoclonal antibody site‐specific for tau O‐GlcNAcylated at serine 400. FEBS Letters. 587(22). 3722–3728. 28 indexed citations

Baguet, Aurélie, Christophe Losberger, Stéphane Genoud, et al.. (2012). Substrate determinants in the C99 juxtamembrane domains differentially affect γ–secretase cleavage specificity and modulator pharmacology. Journal of Neurochemistry. 125(4). 610–619. 20 indexed citations

Beher, Dirk, et al.. (2009). Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity. Chemical Biology & Drug Design. 74(6). 619–624. 352 indexed citations

Lewis, Huw D., Peter R. Strack, Jennifer O’Neil, et al.. (2007). Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling. Chemistry & Biology. 14(2). 209–219. 110 indexed citations

Leuchtenberger, Stefanie, Dirk Beher, & Sascha Weggen. (2006). Selective Modulation of Aβ42 Production in Alzheimers Disease: Non-Steroidal Anti-Inflammatory Drugs and Beyond. Current Pharmaceutical Design. 12(33). 4337–4355. 30 indexed citations

Jelley, Richard A., Jason Elliott, Karl R. Gibson, et al.. (2006). 3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity. Bioorganic & Medicinal Chemistry Letters. 16(14). 3839–3842. 14 indexed citations

Lewis, Huw D., Dirk Beher, Natalie Cookson, et al.. (2006). Quantification of Alzheimer pathology in ageing and dementia: age‐related accumulation of amyloid‐β(42) peptide in vascular dementia. Neuropathology and Applied Neurobiology. 32(2). 103–118. 125 indexed citations

10.

Beher, Dirk, et al.. (2005). C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation. Journal of Neurochemistry. 96(1). 218–227. 78 indexed citations

11.

Grimwood, S., Joanne E. Hogg, Fraser Murray, et al.. (2005). Determination of guinea-pig cortical γ-secretase activity ex vivo following the systemic administration of a γ-secretase inhibitor. Neuropharmacology. 48(7). 1002–1011. 21 indexed citations

12.

Liu, Yanzhu, Lin Yang, Karin Conde‐Knape, et al.. (2004). Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells. Journal of Lipid Research. 45(12). 2368–2376. 28 indexed citations

13.

Lewis, Stephen J., Adrian L. Smith, Joseph G. Neduvelil, et al.. (2004). A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core. Bioorganic & Medicinal Chemistry Letters. 15(2). 373–378. 35 indexed citations

14.

Lewis, Huw D., Dirk Beher, David W. Smith, et al.. (2004). Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD. Neurobiology of Aging. 25(9). 1175–1185. 17 indexed citations

15.

Beher, Dirk, Earl E. Clarke, Jonathan D.J. Wrigley, et al.. (2004). Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site. Journal of Biological Chemistry. 279(42). 43419–43426. 144 indexed citations

16.

Wrigley, Jonathan D.J., Irina Schurov, Agnés C. L. Martin, et al.. (2004). Functional Overexpression of γ-Secretase Reveals Protease-independent Trafficking Functions and a Critical Role of Lipids for Protease Activity. Journal of Biological Chemistry. 280(13). 12523–12535. 35 indexed citations

17.

Grimm, Heike S., Dirk Beher, Stefan F. Lichtenthaler, et al.. (2003). γ-Secretase Cleavage Site Specificity Differs for Intracellular and Secretory Amyloid β. Journal of Biological Chemistry. 278(15). 13077–13085. 39 indexed citations

18.

Harrison, Timothy & Dirk Beher. (2003). γ-Secretase Inhibitors – from Molecular Probes to New Therapeutics?. Progress in medicinal chemistry. 41. 99–127. 4 indexed citations

19.

Ruppert, Thomas, Andrea Schlicksupp, Lars Hesse, et al.. (1997). Reactive oxygen species and Alzheimer's disease. Biochemical Pharmacology. 54(5). 533–539. 186 indexed citations

20.

Beyreuther, Konrad, Gerd Multhaup, U. Mönning, et al.. (1996). Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokinesa. Annals of the New York Academy of Sciences. 777(1). 74–76. 19 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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