Huw D. Lewis

3.5k citations

46 papers · 2.1k indexed · h-index 23

Physiology top 2%
- Alzheimer's disease research and treatments 21
Pharmacology top 2%
- Cholinesterase and Neurodegenerative Diseases 11
Computational Theory and Mathematics top 2%
- Computational Drug Discovery Methods 7
Cellular and Molecular Neuroscience top 5%
- Neuroscience and Neuropharmacology Research 6
- Nuclear Receptors and Signaling 5
Neurology top 10%
Molecular Biology
- S100 Proteins and Annexins 5
- Histone Deacetylase Inhibitors Research 3
- Prion Diseases and Protein Misfolding 3

Co-authors: Mark S. Shearman Dirk Beher Earl E. Clarke Alan Nadin José L. Castro Thomas W. Rosahl Tim J. Harrison Scott J. Pollack
Cited by: Physiology Pharmacology Computational Theory and Mathematics
Journals: Proceedings of the National Academy of Sciences (1 paper)Journal of Biological Chemistry (2 papers)The Journal of Experimental Medicine (1 paper)
Partner nations: United Kingdom United States Netherlands

In The Last Decade

Huw D. Lewis

45 papers receiving 2.1k citations

Peers

Countries citing papers authored by Huw D. Lewis

Since Specialization

Citations

This map shows the geographic impact of Huw D. Lewis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Huw D. Lewis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Huw D. Lewis more than expected).

Fields of papers citing papers by Huw D. Lewis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Huw D. Lewis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Huw D. Lewis. The network helps show where Huw D. Lewis may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Huw D. Lewis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Huw D. Lewis Line = papers co-authored together Huw D. Lewis links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Preclinical models of arthritis for studying immunotherapy and immune tolerance Annals of the Rheumatic Diseases ·Gavin R. Meehan,Ranjeny Thomas,Shaima Al‐Khabouri,Pascale Wehr,Catharien M. U. Hilkens,David C. Wraith,Daniela Sieghart,Michael Bonelli,György Nagy,Paul Garside,David F. Tough,Huw D. Lewis,James M. Brewer	2021	23
2	Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease Bioorganic & Medicinal Chemistry Letters ·Michael D. Barker,John Liddle,Francis Atkinson,David M. Wilson,Marion C. Dickson,César Ramírez-Molina,Huw D. Lewis,Rob P. Davis,D.O. Somers,Margarete Neu,Emma J. Jones,Robert J. Watson	2018	18
3	iPAD or PADi — ‘tablets’ with therapeutic disease potential? Current Opinion in Chemical Biology ·Huw D. Lewis,Mariana Nacht	2016	18
4	Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors Bioorganic & Medicinal Chemistry Letters ·Neil Garton,Michael D. Barker,Rob P. Davis,Clement Douault,Edward Hooper‐Greenhill,Emma J. Jones,Huw D. Lewis,John Liddle,Dave Lugo,Scott McCleary,Alex Preston,César Ramírez-Molina,Margarete Neu,Tracy J. Shipley,Don O. Somers,Robert J. Watson,David M. Wilson	2016	8
5	In Vivo Imaging of Disseminated Intravascular Coagulation in Sepsis Reveals a Pathological Role for Neutrophil Extracellular Traps (NETs) CHEST Journal ·Braedon McDonald,Rachelle P. Davis,Huw D. Lewis,Paul Kubes,Craig N. Jenne	2015	1
6	Creation of a novel peptide with enhanced nuclear localization in prostate and pancreatic cancer cell lines BMC Biotechnology ·Huw D. Lewis,Ali Husain,Robert Donnelly,Dimitrios Barlos,Sheraz Riaz,Kalyani Ginjupalli,Adetola Shodeinde,Beverly E. Barton	2010	17
7	Fenton chemistry and oxidative stress mediate the toxicity of the β‐amyloid peptide in a Drosophila model of Alzheimer’s disease European Journal of Neuroscience ·Thomas Rival,Richard Page,Dhianjali Chandraratna,Timothy J. Sendall,Edward J. Ryder,Beinan Liu,Huw D. Lewis,Thomas W. Rosahl,Robert C. Hider,Luiz Miguel Camargo,Mark S. Shearman,Damian C. Crowther,David A. Lomas	2009	144
8	Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI Inflammatory Bowel Diseases ·Andreas Pohlmann,Lorna Tilling,Alison Robinson,Olga Woolmer,Scott McCleary,Laurens Kruidenier,Linda C. Warnock,Huw D. Lewis,Anthony Hobson,Michael F. James	2008	17
9	Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling Chemistry & Biology ·Huw D. Lewis,Matthew Leveridge,Peter R. Strack,Christine Haldon,Jennifer O’Neil,Hellen Kim,Andrew Madin,Joanne C. Hannam,A. Thomas Look,Nancy E. Kohl,Giulio Draetta,Timothy Harrison,Julie Kerby,Mark S. Shearman,Dirk Beher	2007	110
10	3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity Bioorganic & Medicinal Chemistry Letters ·Richard A. Jelley,Jason Elliott,Karl R. Gibson,Timothy Harrison,Dirk Beher,Earl E. Clarke,Huw D. Lewis,Mark S. Shearman,Jonathan D.J. Wrigley	2006	14
11	The Novel γ Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) Reduces Amyloid Plaque Deposition without Evidence of Notch-Related Pathology in the Tg2576 Mouse Journal of Pharmacology and Experimental Therapeutics ·Jonathan D. Best,David W. Smith,Michael Reilly,Ruth O’Donnell,Huw D. Lewis,Semantha Ellis,Neil Wilkie,Thomas W. Rosahl,Philippe A Laroque,Christine Boussiquet-Leroux,Ian Churcher,John Atack,Timothy Harrison,Mark S. Shearman	2006	64
12	A comparative assessment of γ-secretase activity in transgenic and non-transgenic rodent brain Journal of Neuroscience Methods ·Julian Goggi,Huw D. Lewis,Joanie Mok,Tim J. Harrison,Mark S. Shearman,John Atack,Jonathan D. Best	2006	4
13	Quantification of Alzheimer pathology in ageing and dementia: age‐related accumulation of amyloid‐β(42) peptide in vascular dementia Neuropathology and Applied Neurobiology ·Huw D. Lewis,Dirk Beher,Natalie Cookson,Arthur E. Oakley,Margaret A. Piggott,Christopher M. Morris,Evelyn Jaros,Robert Perry,Paul G. Ince,Rose Anne Kenny,Clive Ballard,M. S. Shearman,Raj N. Kalaria	2006	125
14	Intra- or Intercomplex Binding to the γ-Secretase Enzyme Journal of Biological Chemistry ·Earl E. Clarke,Ian Churcher,Semantha Ellis,Jonathan D.J. Wrigley,Huw D. Lewis,Timothy Harrison,Mark S. Shearman,Dirk Beher	2006	30
15	Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease. PubMed ·Scott J. Pollack,Huw D. Lewis	2005	51
16	Cyclic sulfamide γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Tim Sparey,Dirk Beher,Jonathan D. Best,Mirlinda Biba,José L. Castro,Earl E. Clarke,Joanne C. Hannam,Timothy Harrison,Huw D. Lewis,Andrew Madin,Mark S. Shearman,Bindi Sohal,Nancy N. Tsou,Christopher J. Welch,Jonathan D.J. Wrigley	2005	44
17	Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide] Journal of Pharmacology and Experimental Therapeutics ·Jonathan D. Best,Mark T. Jay,Franklin Otu,Jerome Ma,Alan Nadin,Semantha Ellis,Huw D. Lewis,Christine Pattison,Michael Reilly,Timothy Harrison,Mark S. Shearman,Toni Williamson,John Atack	2005	76
18	Novel aspects of accumulation dynamics and Aβ composition in transgenic models of AD Neurobiology of Aging ·Huw D. Lewis,Dirk Beher,David W. Smith,Louise Hewson,Natalie Cookson,David S. Reynolds,Gerard R. Dawson,Michael Jiang,Lex H.T. Van der Ploeg,Su Qian,Thomas W. Rosahl,Raj N. Kalaria,Mark S. Shearman	2004	17
19	High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Andrew P. Owens,Alan Nadin,Adam C. Talbot,Earl E. Clarke,Timothy Harrison,Huw D. Lewis,Michael Reilly,Jonathan D.J. Wrigley,José L. Castro	2003	25
20	A new series of potent benzodiazepine γ-secretase inhibitors Bioorganic & Medicinal Chemistry Letters ·Ian Churcher,Kate Ashton,John W. Butcher,Earl E. Clarke,Timothy Harrison,Huw D. Lewis,Andrew P. Owens,Martin Teall,Susie Williams,Jonathan D.J. Wrigley	2003	47

About Huw D. Lewis

Huw D. Lewis is a scholar working on Physiology, Pharmacology and Cellular and Molecular Neuroscience, having authored 46 papers that have together received 2.1k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (21 papers), Cholinesterase and Neurodegenerative Diseases (11 papers), Computational Drug Discovery Methods (7 papers), Neuroscience and Neuropharmacology Research (6 papers), S100 Proteins and Annexins (5 papers), Nuclear Receptors and Signaling (5 papers), Histone Deacetylase Inhibitors Research (3 papers) and Prion Diseases and Protein Misfolding (3 papers). The work is most often cited by research in Physiology (978 citations), Pharmacology (417 citations) and Computational Theory and Mathematics (290 citations). Huw D. Lewis has collaborated with scholars based in United Kingdom, United States and Netherlands. Frequent co-authors include Mark S. Shearman, Dirk Beher, Earl E. Clarke, Alan Nadin, José L. Castro, Thomas W. Rosahl, Tim J. Harrison, Scott J. Pollack, Graeme I. Stevenson and Adrian L. Smith. Their work appears in journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and The Journal of Experimental Medicine.

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