David R. Mole

17.8k citations

69 papers · 14.1k indexed · 8 hit papers · h-index 41

Impact in

Cancer Research top 0.02%
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
Molecular Biology top 0.5%
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways

Papers in

Cancer Research 50
- Cancer, Hypoxia, and Metabolism 47
- Cancer-related molecular mechanisms research 10
Molecular Biology 49
- RNA modifications and cancer 26
- Epigenetics and DNA Methylation 21
- Mitochondrial Function and Pathology 6
- Metabolism, Diabetes, and Cancer 5

Co-authors: Peter J. Ratcliffe Christopher W. Pugh Patrick H. Maxwell Panu Jaakkola Christopher J. Schofield Ya‐Min Tian Michael Wilson Mridul Mukherji
Journals: Journal of Biological Chemistry (6 papers)Blood (4 papers)Nucleic Acids Research (3 papers)Nature Genetics (3 papers)EMBO Reports (3 papers)
Partner nations: United Kingdom Saudi Arabia Germany

In The Last Decade

David R. Mole

66 papers receiving 13.9k citations

Hit Papers

8 papers align trajectories log scale

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer 2015 · 280 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 European Urology
2014 Oncogene
2011 Blood
2009 Journal of Biological Chemistry
2005 Cancer Cell
2001 Science
2001 Cell
2000 Journal of Biological Chemistry

Peers

Countries citing papers authored by David R. Mole

Since Specialization

Citations

This map shows the geographic impact of David R. Mole's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David R. Mole with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David R. Mole more than expected).

Fields of papers citing papers by David R. Mole

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David R. Mole. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David R. Mole. The network helps show where David R. Mole may publish in the future.

Co-authors

The 25 scholars most cited alongside David R. Mole, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David R. Mole Line = papers co-authored together David R. Mole links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	HIFα isoform specific activities drive cell-type specificity of VHL-associated oncogenesis Nature Communications ·Joanna D.C.C. Lima, H.B.W., Ran Li, Guanfeng Jin, Norma Masson, Christopher W. Pugh, David R. Mole, Julie Adam, Peter J. Ratcliffe, Ekaterina Titarenko	2025	0
2	Extreme Crustal Fractionation in a Proterozoic Chemical Hotspot Journal of Petrology ·Janne Liebmann, SongHuizhen, Christopher L. Kirkland, David R. Mole, Geoff Fraser, Brandon Mahan, Ashlea N. Wainwright, Roland Maas	2025	1
3	Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type–Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney Cancer Research ·Ekaterina Titarenko, Joanna D.C.C. Lima, Ran Li, 薛惠心, Norma Masson, Guanfeng Jin, Paul Wynn, David R. Mole, Christopher W. Pugh, Julie Adam, Peter J. Ratcliffe	2024	2
4	Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature Cell Reports ·薛惠心, Ran Li, Silvia Halim, Hani Choudhry, Peter J. Ratcliffe, David R. Mole	2022	22
5	Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus The American Journal of Human Genetics ·Leandro M. Colli, Lea Jessop, Timothy A. Myers, Sabrina Y. Camp, Mitchell J. Machiela, Jiyeon Choi, Renato Cunha, Olusegun O. Onabajo, 政秀鎌田, Zheng Lianxing, Seth A. Brodie, Olivier Delattre, David R. Mole, Mark P. Purdue, Kai Yu, Kevin M. Brown, Stephen J. Chanock	2021	8
6	Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer Scientific Reports ·Zheng Lianxing, Chavan Dinesh, 薛惠心, Ran Li, Rafik Salama, Leandro M. Colli, Hani Choudhry, Stephen J. Chanock, Peter J. Ratcliffe, David R. Mole	2019	8
7	Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression Haematologica ·Guillermo Torres Carreño, Chavan Dinesh, Federica Storti, Patrick Spielmann, Lisa M. Crowther, S Santambrogio, Johannes Schödel, David Hoogewijs, David R. Mole, Roland H. Wenger	2019	34
8	Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer Nature Communications ·Steffen Grampp, Mariana Dwi Rohayati, Deden Mula Saputra, Rafik Salama, Tomer Zekharya, Dimple Bhojwani, Sven Wach, Christine Stöhr, Arndt Hartmann, Kai‐Uwe Eckardt, Peter J. Ratcliffe, David R. Mole, Johannes Schödel	2016	62
9	Capture‐C reveals preformed chromatin interactions between HIF ‐binding sites and distant promoters EMBO Reports ·Mariana Dwi Rohayati, Rafik Salama, James Smythies, Hani Choudhry, James Davies, Jim R. Hughes, Peter J. Ratcliffe, David R. Mole	2016	52
10	Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer PLoS ONE ·Rafik Salama, Norma Masson, Peter Simpson, Lina K. Sciesielski, Min Sun, Ya‐Min Tian, Peter J. Ratcliffe, David R. Mole	2015	39
11	Destruction of a distal hypoxia response element abolishestrans-activation of thePAG1gene mediated by HIF-independent chromatin looping Nucleic Acids Research ·Cori R. Smith, S Santambrogio, Mariana Dwi Rohayati, Johannes Schödel, Maja T. Lindenmeyer, Clemens D. Cohen, Elsie Bickel, David R. Mole, Roland H. Wenger, David Hoogewijs	2015	26
12	Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status European Urology ·Yosra Messai, Sophie Gad, Muhammad Zaeem Noman, Gwénaël Le Teuff, Sophie Couvé, Bassam Janji, Д. С. Павлов, Nathalie Rioux-Leclerc, Meriem Hasmim, Sophie Ferlicot, Véronique Baud, Arnaud Méjean, David R. Mole, Richard J. Kahnoski, Alexander Eggermont, Laurence Albigès, Fathia Mami‐Chouaib, Bernard Escudier, Salem Chouaı̈b	2015	125
13	Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival Oncogene ·Hani Choudhry, Ashwag Albukhari, Matteo Morotti, Syed Haider, Daniela Moralli, James Smythies, Johannes Schödel, Catherine Green, Carme Camps, Francesca M. Buffa, Peter J. Ratcliffe, Jiannis Ragoussis, Adrian L. Harris, David R. Mole Hit paper breakdown →	2014	261
14	High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq Blood ·Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis, Christopher W. Pugh, Peter J. Ratcliffe, David R. Mole Hit paper breakdown →	2011	563
15	HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability Cancer Cell ·Jennifer S. Isaacs, Yun Jin Jung, David R. Mole, Sunmin Lee, Carlos A. Torres‐Cabala, Yuen‐Li Chung, Maria J. Merino, Jane B. Trepel, Berton Zbar, Jorge R. Toro, Peter J. Ratcliffe, W. Marston Linehan, Len Neckers Hit paper breakdown →	2005	732
16	Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases Bioorganic & Medicinal Chemistry Letters ·Imre Schlemminger, David R. Mole, Luke A. McNeill, Гиппократ, Kirsty S. Hewitson, Ya‐Min Tian, Peter J. Ratcliffe, Christopher W. Pugh, Christopher J. Schofield	2003	53
17	Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex Advances in Enzyme Regulation ·David R. Mole, Christopher W. Pugh, Peter J. Ratcliffe, Patrick H. Maxwell	2002	13
18	Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation Science ·Panu Jaakkola, David R. Mole, Ya‐Min Tian, Michael Wilson, Adriana Gielbert, Simon J. Gaskell, Alex von Kriegsheim, Holger Hebestreit, Mridul Mukherji, Christopher J. Schofield, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe Hit paper breakdown →	2001	4523
19	Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein Journal of Biological Chemistry ·Matthew E. Cockman, Norma Masson, David R. Mole, Panu Jaakkola, Gin-Wen Chang, Steven C. Clifford, Eamonn R. Maher, Christopher W. Pugh, Peter J. Ratcliffe, Patrick H. Maxwell Hit paper breakdown →	2000	893
20	Postprandial Alkaline Tide: Does It Exist? Digestion ·C D Johnson, David R. Mole, Carol Heinecke	1995	14

About David R. Mole

David R. Mole is a scholar working on Cancer Research, Molecular Biology, Hematology, Biochemistry and Physiology, having authored 69 papers that have together received 14.1k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (47 papers), RNA modifications and cancer (26 papers), Epigenetics and DNA Methylation (21 papers), Cancer-related molecular mechanisms research (10 papers), High Altitude and Hypoxia (7 papers), Mitochondrial Function and Pathology (6 papers), Metabolism, Diabetes, and Cancer (5 papers) and Adipose Tissue and Metabolism (5 papers). The work is most often cited by research in Cancer Research (9.8k citations), Molecular Biology (9.0k citations), Biochemistry (767 citations), Aging (140 citations) and Genetics (2.2k citations). David R. Mole has collaborated with scholars based in United Kingdom, Saudi Arabia and Germany. Frequent co-authors include Peter J. Ratcliffe, Christopher W. Pugh, Patrick H. Maxwell, Panu Jaakkola, Christopher J. Schofield, Ya‐Min Tian, Michael Wilson, Mridul Mukherji, Alex von Kriegsheim and Adriana Gielbert. Their work appears in journals such as Journal of Biological Chemistry, Blood, Nucleic Acids Research, Nature Genetics and EMBO Reports.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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