Adrian L. Harris

156.2k total citations · 38 hit papers
1.2k papers, 109.9k citations indexed

About

Adrian L. Harris is a scholar working on Molecular Biology, Cancer Research and Oncology. According to data from OpenAlex, Adrian L. Harris has authored 1.2k papers receiving a total of 109.9k indexed citations (citations by other indexed papers that have themselves been cited), including 749 papers in Molecular Biology, 560 papers in Cancer Research and 381 papers in Oncology. Recurrent topics in Adrian L. Harris's work include Cancer, Hypoxia, and Metabolism (379 papers), Angiogenesis and VEGF in Cancer (255 papers) and Estrogen and related hormone effects (77 papers). Adrian L. Harris is often cited by papers focused on Cancer, Hypoxia, and Metabolism (379 papers), Angiogenesis and VEGF in Cancer (255 papers) and Estrogen and related hormone effects (77 papers). Adrian L. Harris collaborates with scholars based in United Kingdom, United States and Greece. Adrian L. Harris's co-authors include Kevin C. Gatter, Russell Leek, Stephen B. Fox, Helen Turley, Peter J. Ratcliffe, Alexandra Giatromanolaki, Roy Bicknell, Michael I. Koukourakis, Efthimios Sivridis and Francesca M. Buffa and has published in prestigious journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Adrian L. Harris

1.2k papers receiving 107.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hypoxia — a key regulatory factor in tumour growth

2002 4.3k citations Adrian L. Harris profile →
Breast cancer classification and prognosis based on gene expression profiles from a population-based study

2003 1.5k citations Christos Sotiriou, Stephen B. Fox et al. profile →
Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

2006 1.5k citations Christos Sotiriou, Adrian L. Harris et al. profile →
Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma

2008 1.4k citations Alison H. Banham, Francesco Pezzella et al. profile →
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

2000 1.1k citations Helen Turley, Adrian L. Harris et al. profile →
The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

2000 1.1k citations Helen Turley, Kevin C. Gatter et al. profile →
Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

2011 1.1k citations David Ferguson, Adrian L. Harris et al. profile →
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

1996 1.0k citations Russell Leek, Adrian L. Harris et al. profile →
Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 933 citations Adrian L. Harris et al. profile →
Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late Relapse

2006 921 citations Gaynor J. Bates, Stephen B. Fox et al. profile →
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 919 citations Adrian L. Harris et al. profile →
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

2004 884 citations Helen Turley, Adrian L. Harris et al. profile →
Validation and Clinical Utility of a 70-Gene Prognostic Signature for Women With Node-Negative Breast Cancer

2006 842 citations Adrian L. Harris, Christos Sotiriou et al. profile →
Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

2005 760 citations Jiliang Li, Adrian L. Harris et al. profile →
EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 756 citations Adrian L. Harris et al. profile →
How cancer metabolism is tuned for proliferation and vulnerable to disruption

2012 741 citations Almut Schulze, Adrian L. Harris profile →
Strong Time Dependence of the 76-Gene Prognostic Signature for Node-Negative Breast Cancer Patients in the TRANSBIG Multicenter Independent Validation Series

2007 726 citations Adrian L. Harris, Christos Sotiriou et al. Clinical Cancer Research profile →
Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.

1997 700 citations Stephen B. Fox, Russell Leek et al. profile →
Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer

1992 697 citations Russell Leek, Adrian L. Harris et al. profile →
Phase I Safety, Pharmacokinetic, and Pharmacodynamic Trial of ZD1839, a Selective Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients With Five Selected Solid Tumor Types

2002 683 citations Adrian L. Harris et al. profile →
Advances in Hypoxia-Inducible Factor Biology

2017 649 citations Adrian L. Harris et al. profile →
Antiangiogenic therapy in oncology: current status and future directions

2016 644 citations Robert S. Kerbel, Adrian L. Harris et al. profile →
Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation

1996 631 citations Stephen B. Fox, Francesco Pezzella et al. profile →
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

2001 607 citations Adrian L. Harris et al. profile →
Definition of Clinically Distinct Molecular Subtypes in Estrogen Receptor–Positive Breast Carcinomas Through Genomic Grade

2007 599 citations Adrian L. Harris, Christos Sotiriou et al. profile →
bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 585 citations Francesco Pezzella, Helen Turley et al. profile →
hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

2008 540 citations Francesca M. Buffa, Christos Sotiriou et al. Clinical Cancer Research profile →
Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α

1998 539 citations Helen Turley, Kevin C. Gatter et al. profile →
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

2014 525 citations Barrie Peck, Simon Wigfield et al. profile →
Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 523 citations Adrian L. Harris et al. profile →
EPIDERMAL-GROWTH-FACTOR RECEPTORS IN HUMAN BLADDER CANCER: COMPARISON OF INVASIVE AND SUPERFICIAL TUMOURS

1985 522 citations Adrian L. Harris et al. profile →
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

2011 508 citations Francesca M. Buffa, Jiannis Ragoussis et al. profile →
Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix.

2001 403 citations Adrian L. Harris, Catharine West et al. profile →
HIF activation identifies early lesions in VHL kidneys

2002 398 citations Adrian L. Harris et al. profile →
Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma

2001 364 citations Russell Leek, Kevin C. Gatter et al. profile →
Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

2014 261 citations Syed Haider, Francesca M. Buffa et al. profile →
HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer

2020 256 citations Adrian L. Harris et al. profile →
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?

2023 82 citations Adrian L. Harris et al. British Journal of Cancer profile →

Peers

Countries citing papers authored by Adrian L. Harris

Since Specialization

Citations

This map shows the geographic impact of Adrian L. Harris's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Adrian L. Harris with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Adrian L. Harris more than expected).

Fields of papers citing papers by Adrian L. Harris

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Adrian L. Harris. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Adrian L. Harris. The network helps show where Adrian L. Harris may publish in the future.

Co-authorship network of co-authors of Adrian L. Harris

This figure shows the co-authorship network connecting the top 25 collaborators of Adrian L. Harris. A scholar is included among the top collaborators of Adrian L. Harris based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Adrian L. Harris. Adrian L. Harris is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The impact of survivorship bias in glioblastoma research 2023 ·Critical Reviews in Oncology/Hematology ·Francesco Pasqualetti, Alessandro Barberis, (unknown), Nicola Montemurro, Gian Luca De Salvo, Riccardo Soffietti, Chiara Maria Mazzanti, Tamara Ius, Maria Caffo, Fabiola Paiar, Guido Bocci, Giuseppe Lombardi, Adrian L. Harris, Francesca M. Buffa	14
2	Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy 2019 ·Molecular Cancer Therapeutics ·Massimo Masiero, Demin Li, Pat Whiteman, (unknown), (unknown), (unknown), Sarah Watts, Stephen M. Stribbling, (unknown), (unknown), Ji‐Liang Li, Chandramouli Chillakuri, Devon Sheppard, Sébastien Serres, Manuel Sarmiento Soto, James Larkin, Nicola R. Sibson, Penny A. Handford, Adrian L. Harris, Alison H. Banham	31
3	3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers 2018 ·Molecular Cancer Therapeutics ·Dylan T. Jones, Alessandro Valli, Syed Haider, Qifeng Zhang, Elizabeth A. Smethurst, Zachary T. Schug, Barrie Peck, Eric O. Aboagye, Susan E. Critchlow, Almut Schulze, Eyal Gottlieb, Michael J.O. Wakelam, Adrian L. Harris	20
4	miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense 2017 ·Cancer Research ·Marina Pajic, Danielle Froio, Sheridan Daly, (unknown), Ewan K.A. Millar, Peter Graham, Alison Drury, Angela Steinmann, Charles E. de Bock, Alice Boulghourjian, Anaiis Zaratzian, Susan Carroll, Joanne Toohey, Sandra O’Toole, Adrian L. Harris, Francesca M. Buffa, Harriet E. Gee, Georgina E. Hollway, Timothy J. Molloy	110
5	Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors 2015 ·Cancer Research ·Ferdia A. Gallagher, (unknown), Mikko I. Kettunen, Eva Serrão, Tiago B. Rodrigues, Alan J. Wright, Andrew B. Gill, Sarah McGuire, Thomas C. Booth, Joan Boren, Alan McIntyre, Jodi L. Miller, Shen‐Han Lee, Davina J. Honess, Sam E. Day, De‐En Hu, William Howat, Adrian L. Harris, Kevin M. Brindle	36
6	A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors 2015 ·Clinical Cancer Research ·E. Gabriela Chiorean, Patricia LoRusso, Robert Matthew Strother, Jennifer R. Diamond, (unknown), Wells A. Messersmith, Lieve Adriaens, Li Liu, Richard Kao, (unknown), Ana Kostić, Russell Leek, Adrian L. Harris, Antonio Jimeno	114
7	TRAP1 Regulates Proliferation, Mitochondrial Function, and Has Prognostic Significance in NSCLC 2014 ·Molecular Cancer Research ·Jackeline Agorreta, (unknown), (unknown), Domenico Delia, Helen Turley, David Ferguson, Francisco J. Iborra, (unknown), Marta Larráyoz, Isabel Zudaire, Rubén Pı́o, Luis M. Montuenga, Adrian L. Harris, Kevin C. Gatter, Francesco Pezzella	63
8	The G-Protein–Coupled Receptor CLR Is Upregulated in an Autocrine Loop with Adrenomedullin in Clear Cell Renal Cell Carcinoma and Associated with Poor Prognosis 2013 ·Clinical Cancer Research ·Leonid L. Nikitenko, Russell Leek, Stephen Henderson, Nischalan Pillay, Helen Turley, Daniele Generali, Sarah Gunningham, Helen Morrin, Andrea Pellagatti, Margaret Rees, Adrian L. Harris, Stephen B. Fox	16
9	A 26-Gene Hypoxia Signature Predicts Benefit from Hypoxia-Modifying Therapy in Laryngeal Cancer but Not Bladder Cancer 2013 ·Clinical Cancer Research ·Amanda Eustace, Navin Mani, Paul N. Span, Joely J. Irlam, Janet Taylor, Guy Betts, Helen Denley, Crispin Miller, Jarrod J. Homer, Ana M. Rojas, Peter Hoskin, Francesca M. Buffa, Adrian L. Harris, Johannes H.A.M. Kaanders, Catharine West	167
10	Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy 2012 ·Clinical Cancer Research ·Alan McIntyre, Shalini Patiar, Simon Wigfield, Jiliang Li, Ioanna Ledaki, Helen Turley, Russell Leek, Cameron Snell, Kevin C. Gatter, William S. Sly, Richard D. Vaughan‐Jones, Pawel Swietach, Adrian L. Harris	188
11	Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability 2010 ·Cancer Research ·Isabel M. Pires, Zuzana Bencokova, Manuela Milani, Lisa K. Folkes, Jiliang Li, Mike R. Stratford, Adrian L. Harris, Ester M. Hammond	155
12	The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor α and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth 2010 ·Cancer Research ·Jun Yang, Adrian M. Jubb, Luke Pike, Francesca M. Buffa, Helen Turley, Dilair Baban, Russell Leek, Kevin C. Gatter, Jiannis Ragoussis, Adrian L. Harris	143
13	6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance 2010 ·Cancer Research ·Natalia Issaeva, Huw D. Thomas, (unknown), Janneke E. Jaspers, Ivaylo Stoimenov, Suzanne Kyle, Nicholas Pedley, Ponnari Gottipati, Rafal Zur, Kate Sleeth, (unknown), Evan A. Mulligan, Cecilia Lundin, (unknown), Ariena Kersbergen, Adrian L. Harris, Ricky A. Sharma, Sven Rottenberg, Nicola J. Curtin, Thomas Helleday	80
14	Immunomodulation of FOXP3+ Regulatory T Cells by the Aromatase Inhibitor Letrozole in Breast Cancer Patients 2009 ·Clinical Cancer Research ·Daniele Generali, Gaynor J. Bates, (unknown), Maria Pia Brizzi, Leticia Campo, Simone Bonardi, Alessandra Bersiga, Giovanni Allevi, Manuela Milani, Sergio Aguggini, Luigi Dogliotti, Alison H. Banham, Adrian L. Harris, Alberto Bottini, Stephen B. Fox	129
15	Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents 2009 ·Cancer Research ·Yuval Shaked, Terence Tang, Jill Woloszynek, Laura G.M. Daenen, Shan Man, Ping Xu, Shi-Rong Cai, Jeffrey M. Arbeit, Emile E. Voest, David J. Chaplin, Jon Smythe, Adrian L. Harris, Paul Nathan, Ian Judson, Gordon Rustin, Francesco Bertolini, Daniel C. Link, Robert S. Kerbel	64
16	The Role of ATF4 Stabilization and Autophagy in Resistance of Breast Cancer Cells Treated with Bortezomib 2009 ·Cancer Research ·Manuela Milani, Tomasz Rzymski, Howard R. Mellor, Luke Pike, Alberto Bottini, Daniele Generali, Adrian L. Harris	255
17	A Five-Gene Molecular Grade Index and HOXB13:IL17BR Are Complementary Prognostic Factors in Early Stage Breast Cancer 2008 ·Clinical Cancer Research ·Xiaojun Ma, Ranelle Salunga, Sonika Dahiya, Wilson Wang, Erin Carney, Virginie Durbecq, Adrian L. Harris, Paul E. Goss, Christos Sotiriou, Mark G. Erlander, Dennis C. Sgroi	227
18	Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo 2007 ·Cancer Research ·Jiliang Li, Richard C.A. Sainson, Wen Shi, Russell Leek, Laura Harrington, Matthias Preusser, Swethajit Biswas, Helen Turley, Emily Heikamp, Johannes A. Hainfellner, Adrian L. Harris	242
19	Breast Cancer Researh Protocols 2006 ·Humana Press eBooks ·Susan A. Brooks, Adrian L. Harris	4
20	First annual meeting of the Association of Cancer Physicians (in conjunction with the 27th AGM of the British Association for Cancer Research). March 24-25, 1986, Bristol, UK. Abstracts 1986 ·British Journal of Cancer ·D Veale, B.M.J. Cantwell, Naseem Kerr, (unknown), (unknown), Adrian L. Harris, Mark Slevin, P. Clark, MA Richards, Richard H. Osborne, S. Malik, Christopher S. Wood, V. Harvey, (unknown), J. S. Malpas, P. F. M. Wrigley	1

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