Richard K. Bruick

13.0k citations

47 papers · 9.7k indexed · 7 hit papers · h-index 36

Molecular Biology top 1%
Cancer Research top 0.1%
Genetics top 1%
Physiology top 2%
Surgery top 5%

Co-authors: Steven L. McKnight Jeffrey J. Gorman Murray L. Whitelaw Daniel J. Peet David Lando Kosaku Uyeda Abdullah Ozer Kevin H. Gardner
Topics: Cancer, Hypoxia, and Metabolism (30 papers)RNA modifications and cancer (8 papers)Iron Metabolism and Disorders (7 papers)
Cited by: Cancer Research Molecular Biology Biochemistry
Journals: Nature Science Proceedings of the National Academy of Sciences
Partner nations: United States Australia Germany

In The Last Decade

Richard K. Bruick

47 papers receiving 9.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

2001 2.1k citations Richard K. Bruick, Steven L. McKnight Science profile →
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 1.2k citations Richard K. Bruick et al. profile →
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

2000 655 citations Richard K. Bruick Proceedings of the National Academy of Sciences profile →
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

2004 606 citations Richard K. Bruick et al. Proceedings of the National Academy of Sciences profile →
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver

2001 545 citations Richard K. Bruick et al. Proceedings of the National Academy of Sciences profile →
JMJD6 Is a Histone Arginine Demethylase

2007 524 citations Yue Chen, Yingming Zhao et al. Science profile →
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

2016 336 citations Hyejin Cho, Xinlin Du et al. Nature profile →

Peers

Countries citing papers authored by Richard K. Bruick

Since Specialization

Citations

This map shows the geographic impact of Richard K. Bruick's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard K. Bruick with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard K. Bruick more than expected).

Fields of papers citing papers by Richard K. Bruick

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard K. Bruick. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard K. Bruick. The network helps show where Richard K. Bruick may publish in the future.

Co-authorship network of co-authors of Richard K. Bruick

This figure shows the co-authorship network connecting the top 25 collaborators of Richard K. Bruick. A scholar is included among the top collaborators of Richard K. Bruick based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard K. Bruick. Richard K. Bruick is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD 2016 ·Gut ·Xiaofang Huo,Agoston T. Agoston,Kerry B. Dunbar,Daisha J. Cipher,Xi Zhang,Chunhua Yu,Edaire Cheng,Qiuyang Zhang,Thai Pham,Uttam K. Tambar,Richard K. Bruick,David H. Wang,Robert D. Odze,Stuart J. Spechler,Rhonda F. Souza	43
2	On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer modelsbreakdown → 2016 ·Nature ·Hyejin Cho,Xinlin Du,James P. Rizzi,Ella Liberzon,Abhishek A. Chakraborty,Wenhua Gao,Ingrid Carvo,Sabina Signoretti,Richard K. Bruick,John A. Josey,Eli M. Wallace,William G. Kaelin	336
3	Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling 2016 ·Nature Cell Biology ·Ming Ding,Richard K. Bruick,Yonghao Yu	57
4	Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2 2015 ·Journal of Medicinal Chemistry ·Thomas H. Scheuermann,(unknown),(unknown),Liela Bayeh,(unknown),Hanzhi Wang,Charles G. Caldwell,Jamie Longgood,John B. MacMillan,Richard K. Bruick,Kevin H. Gardner,Uttam K. Tambar	61
5	F-box and leucine-rich repeat protein 5 (FBXL5): Sensing intracellular iron and oxygen 2014 ·Journal of Inorganic Biochemistry ·Julio C. Ruiz,Richard K. Bruick	38
6	Allosteric inhibition of hypoxia inducible factor-2 with small molecules 2013 ·Nature Chemical Biology ·Thomas H. Scheuermann,Qiming Li,(unknown),Jason Key,Lei Zhang,Rui Chen,Joseph A. Garcia,Jacinth Naidoo,Jamie Longgood,Doug E. Frantz,Uttam K. Tambar,Kevin H. Gardner,Richard K. Bruick	238
7	Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules 2012 ·ACS Chemical Biology ·Yirui Guo,Carrie L. Partch,Jason Key,Paul B. Card,(unknown),Anjana Patel,Richard K. Bruick,Heiko Wurdak,Kevin H. Gardner	30
8	Protein degradation and iron homeostasis 2012 ·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ·Joel W. Thompson,Richard K. Bruick	38
9	Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5) 2012 ·Journal of Biological Chemistry ·Joel W. Thompson,Ameen A. Salahudeen,Srinivas Chollangi,Julio C. Ruiz,Chad A. Brautigam,Thomas M. Makris,John D. Lipscomb,Diana R. Tomchick,Richard K. Bruick	55
10	Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2 2011 ·Cell Metabolism ·Anjali Nandal,Julio C. Ruiz,Poorna Subramanian,Sudipa Ghimire-Rijal,(unknown),Timothy L. Stemmler,Richard K. Bruick,Caroline C. Philpott	174
11	An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis 2009 ·Science ·Ameen A. Salahudeen,Joel W. Thompson,Julio C. Ruiz,(unknown),Lisa N. Kinch,Qiming Li,Nick V. Grishin,Richard K. Bruick	327
12	Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor 2009 ·Proceedings of the National Academy of Sciences ·Thomas H. Scheuermann,Diana R. Tomchick,Mischa Machius,Yan Guo,Richard K. Bruick,Kevin H. Gardner	225
13	Maintaining Mammalian Iron and Oxygen Homeostasis 2009 ·Annals of the New York Academy of Sciences ·Ameen A. Salahudeen,Richard K. Bruick	38
14	JMJD6 Is a Histone Arginine Demethylasebreakdown → 2007 ·Science ·(unknown),Yue Chen,Yingming Zhao,Richard K. Bruick	524
15	Hypoxia‐Inducible Factors Per/ARNT/Sim Domains: Structure and Function 2007 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Thomas H. Scheuermann,Jinsong Yang,Lei Zhang,Kevin H. Gardner,Richard K. Bruick	19
16	Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? 2007 ·Nature Chemical Biology ·Abdullah Ozer,Richard K. Bruick	189
17	Regulation of HIF by Prolyl hydroxylases: Recruitment of the Candidate Tumor Suppressor Protein ING4 2005 ·Cell Cycle ·Abdullah Ozer,Richard K. Bruick	32
18	Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor 2003 ·Proceedings of the National Academy of Sciences ·P. Erbel,Paul B. Card,(unknown),Richard K. Bruick,Kevin H. Gardner	190
19	A Conserved Family of Prolyl-4-Hydroxylases That Modify HIFbreakdown → 2001 ·Science ·Richard K. Bruick,Steven L. McKnight	2096
20	Template-directed ligation of peptides to oligonucleotides 1996 ·Chemistry & Biology ·Richard K. Bruick,(unknown),Stephen B. H. Kent,Nassim Usman,Gerald F. Joyce	83

About Richard K. Bruick

Richard K. Bruick is a scholar working on Cancer Research, Hematology and Genetics, having authored 47 papers that have together received 9.7k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (30 papers), RNA modifications and cancer (8 papers) and Iron Metabolism and Disorders (7 papers). The work is most often cited by research in Cancer Research (5.0k citations), Molecular Biology (5.9k citations) and Biochemistry (622 citations). Richard K. Bruick has collaborated with scholars based in United States, Australia and Germany. Frequent co-authors include Steven L. McKnight, Jeffrey J. Gorman, Murray L. Whitelaw, Daniel J. Peet, David Lando, Kosaku Uyeda, Abdullah Ozer, Kevin H. Gardner, Yingming Zhao and Yue Chen. Their work appears in journals such as Nature, Science and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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