Richard K. Bruick

13.0k total citations · 7 hit papers
47 papers, 9.7k citations indexed

About

Richard K. Bruick is a scholar working on Molecular Biology, Cancer Research and Surgery. According to data from OpenAlex, Richard K. Bruick has authored 47 papers receiving a total of 9.7k indexed citations (citations by other indexed papers that have themselves been cited), including 32 papers in Molecular Biology, 30 papers in Cancer Research and 7 papers in Surgery. Recurrent topics in Richard K. Bruick's work include Cancer, Hypoxia, and Metabolism (30 papers), RNA modifications and cancer (8 papers) and Iron Metabolism and Disorders (7 papers). Richard K. Bruick is often cited by papers focused on Cancer, Hypoxia, and Metabolism (30 papers), RNA modifications and cancer (8 papers) and Iron Metabolism and Disorders (7 papers). Richard K. Bruick collaborates with scholars based in United States, Australia and Germany. Richard K. Bruick's co-authors include Steven L. McKnight, David Lando, Jeffrey J. Gorman, Murray L. Whitelaw, Daniel J. Peet, Kosaku Uyeda, Abdullah Ozer, Yingming Zhao, Yue Chen and Kevin H. Gardner and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Richard K. Bruick

47 papers receiving 9.5k citations

Hit Papers

A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF 2000 2026 2008 2017 2001 2002 2000 2004 2001 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
    2001 2.1k citations Richard K. Bruick, Steven L. McKnight Science profile →
  2. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
    2002 1.2k citations Richard K. Bruick et al. Genes & Development profile →
  3. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    2000 655 citations Richard K. Bruick Proceedings of the National Academy of Sciences profile →
  4. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    2004 606 citations Richard K. Bruick et al. Proceedings of the National Academy of Sciences profile →
  5. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
    2001 545 citations Richard K. Bruick et al. Proceedings of the National Academy of Sciences profile →
  6. JMJD6 Is a Histone Arginine Demethylase
    2007 524 citations Yue Chen, Yingming Zhao et al. Science profile →
  7. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
    2016 336 citations Hyejin Cho, Xinlin Du et al. Nature profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Richard K. Bruick United States 36 5.9k 5.0k 1.2k 1.2k 1.0k 47 9.7k
Panu Jaakkola Finland 28 6.4k 1.1× 7.0k 1.4× 1.7k 1.3× 1.3k 1.1× 662 0.6× 64 10.2k
Michael Wilson United Kingdom 19 5.9k 1.0× 5.9k 1.2× 1.5k 1.2× 1.3k 1.1× 497 0.5× 33 9.7k
Michael Ohh Canada 44 7.7k 1.3× 6.9k 1.4× 1.4k 1.1× 1.0k 0.9× 679 0.7× 99 11.2k
Mircea Ivan United States 37 8.3k 1.4× 8.3k 1.7× 1.4k 1.1× 1.2k 1.0× 580 0.6× 80 11.9k
Ya‐Min Tian United Kingdom 25 7.1k 1.2× 8.1k 1.6× 2.0k 1.6× 1.5k 1.3× 576 0.6× 32 11.2k
Eric Huang United States 38 6.2k 1.0× 6.1k 1.2× 1.4k 1.1× 1.7k 1.5× 511 0.5× 99 10.0k
Edurne Berra France 43 6.0k 1.0× 4.7k 0.9× 1.1k 0.9× 1.1k 0.9× 528 0.5× 69 9.4k
Mridul Mukherji United States 21 6.2k 1.0× 5.5k 1.1× 1.5k 1.2× 1.1k 0.9× 402 0.4× 40 9.3k
David R. Mole United Kingdom 41 9.0k 1.5× 9.8k 2.0× 2.2k 1.8× 1.7k 1.5× 779 0.8× 69 14.1k
Kıvanç Birsoy United States 37 6.7k 1.1× 3.1k 0.6× 611 0.5× 1.5k 1.3× 636 0.6× 73 9.9k

Countries citing papers authored by Richard K. Bruick

Since Specialization
Citations

This map shows the geographic impact of Richard K. Bruick's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Richard K. Bruick with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Richard K. Bruick more than expected).

Fields of papers citing papers by Richard K. Bruick

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Richard K. Bruick. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Richard K. Bruick. The network helps show where Richard K. Bruick may publish in the future.

Co-authorship network of co-authors of Richard K. Bruick

This figure shows the co-authorship network connecting the top 25 collaborators of Richard K. Bruick. A scholar is included among the top collaborators of Richard K. Bruick based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Richard K. Bruick. Richard K. Bruick is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Cheng, Xiaotong, Minghao Zhang, Alana Burrell, et al.. (2020). Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control. Journal of Clinical Investigation. 130(5). 2237–2251. 42 indexed citations
2.
Souza, Rhonda F., Liela Bayeh, Stuart J. Spechler, Uttam K. Tambar, & Richard K. Bruick. (2017). A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis. Current Opinion in Pharmacology. 37. 93–99. 46 indexed citations
3.
Cho, Hyejin, Xinlin Du, James P. Rizzi, et al.. (2016). On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature. 539(7627). 107–111. 336 indexed citations breakdown →
4.
Huo, Xiaofang, Agoston T. Agoston, Kerry B. Dunbar, et al.. (2016). Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD. Gut. 66(9). 1542–1554. 43 indexed citations
5.
Scheuermann, Thomas H., Liela Bayeh, Hanzhi Wang, et al.. (2015). Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. Journal of Medicinal Chemistry. 58(15). 5930–5941. 61 indexed citations
6.
Ruiz, Julio C. & Richard K. Bruick. (2014). F-box and leucine-rich repeat protein 5 (FBXL5): Sensing intracellular iron and oxygen. Journal of Inorganic Biochemistry. 133. 73–77. 38 indexed citations
7.
Scheuermann, Thomas H., Qiming Li, Jason Key, et al.. (2013). Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nature Chemical Biology. 9(4). 271–276. 238 indexed citations
8.
Bayeh, Liela, Thomas H. Scheuermann, Jamie Longgood, et al.. (2013). Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor. Journal of Medicinal Chemistry. 56(4). 1739–1747. 105 indexed citations
9.
Guo, Yirui, Carrie L. Partch, Jason Key, et al.. (2012). Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules. ACS Chemical Biology. 8(3). 626–635. 30 indexed citations
10.
Thompson, Joel W. & Richard K. Bruick. (2012). Protein degradation and iron homeostasis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823(9). 1484–1490. 38 indexed citations
11.
Salahudeen, Ameen A., Joel W. Thompson, Julio C. Ruiz, et al.. (2009). An E3 Ligase Possessing an Iron-Responsive Hemerythrin Domain Is a Regulator of Iron Homeostasis. Science. 326(5953). 722–726. 327 indexed citations
12.
Scheuermann, Thomas H., Diana R. Tomchick, Mischa Machius, et al.. (2009). Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor. Proceedings of the National Academy of Sciences. 106(2). 450–455. 225 indexed citations
13.
Chen, Yue, et al.. (2007). JMJD6 Is a Histone Arginine Demethylase. Science. 318(5849). 444–447. 524 indexed citations breakdown →
14.
Scheuermann, Thomas H., Jinsong Yang, Lei Zhang, Kevin H. Gardner, & Richard K. Bruick. (2007). Hypoxia‐Inducible Factors Per/ARNT/Sim Domains: Structure and Function. Methods in enzymology on CD-ROM/Methods in enzymology. 435. 1–24. 19 indexed citations
15.
Yang, Jinsong, Lei Zhang, P. Erbel, et al.. (2005). Functions of the Per/ARNT/Sim Domains of the Hypoxia-inducible Factor. Journal of Biological Chemistry. 280(43). 36047–36054. 70 indexed citations
16.
Ozer, Abdullah & Richard K. Bruick. (2005). Regulation of HIF by Prolyl hydroxylases: Recruitment of the Candidate Tumor Suppressor Protein ING4. Cell Cycle. 4(9). 1153–1156. 32 indexed citations
17.
Hossain, Chowdhury Faiz, Scott R. Baerson, Lei Zhang, et al.. (2005). Saururus cernuus lignans—Potent small molecule inhibitors of hypoxia-inducible factor-1. Biochemical and Biophysical Research Communications. 333(3). 1026–1033. 61 indexed citations
18.
Bruick, Richard K.. (2003). Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Genes & Development. 17(21). 2614–2623. 360 indexed citations
19.
Erbel, P., et al.. (2003). Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor. Proceedings of the National Academy of Sciences. 100(26). 15504–15509. 190 indexed citations
20.
Bruick, Richard K. & Steven L. McKnight. (2001). A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF. Science. 294(5545). 1337–1340. 2096 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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