Patrick H. Maxwell

55.1k total citations · 16 hit papers
213 papers, 34.6k citations indexed

About

Patrick H. Maxwell is a scholar working on Cancer Research, Molecular Biology and Genetics. According to data from OpenAlex, Patrick H. Maxwell has authored 213 papers receiving a total of 34.6k indexed citations (citations by other indexed papers that have themselves been cited), including 125 papers in Cancer Research, 105 papers in Molecular Biology and 48 papers in Genetics. Recurrent topics in Patrick H. Maxwell's work include Cancer, Hypoxia, and Metabolism (122 papers), High Altitude and Hypoxia (30 papers) and Erythropoietin and Anemia Treatment (22 papers). Patrick H. Maxwell is often cited by papers focused on Cancer, Hypoxia, and Metabolism (122 papers), High Altitude and Hypoxia (30 papers) and Erythropoietin and Anemia Treatment (22 papers). Patrick H. Maxwell collaborates with scholars based in United Kingdom, United States and Germany. Patrick H. Maxwell's co-authors include Peter J. Ratcliffe, Christopher W. Pugh, Michael S. Wiesener, David R. Mole, Adrian L. Harris, Charles C. Wykoff, Eamonn R. Maher, Panu Jaakkola, Christopher J. Schofield and Michael Wilson and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Patrick H. Maxwell

212 papers receiving 34.1k citations

Hit Papers

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylatio... 1993 2026 2004 2015 2001 1999 2001 1998 2000 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
    2001 4.5k citations Panu Jaakkola, David R. Mole et al. Science profile →
  2. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    1999 4.2k citations Patrick H. Maxwell, Michael S. Wiesener et al. Nature profile →
  3. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
    2001 2.7k citations David R. Mole, Mridul Mukherji et al. profile →
  4. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    1998 2.1k citations Peter Carmeliet, Yuval Dor et al. Nature profile →
  5. Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
    2000 1.1k citations Charles C. Wykoff, Helen Turley et al. profile →
  6. The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages
    2000 1.1k citations Helen Turley, Kevin C. Gatter et al. American Journal Of Pathology profile →
  7. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
    1997 919 citations Patrick H. Maxwell, Adrian L. Harris et al. Proceedings of the National Academy of Sciences profile →
  8. Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein
    2000 893 citations David R. Mole, Panu Jaakkola et al. profile →
  9. Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
    2001 856 citations Patrick H. Maxwell, Christopher W. Pugh et al. The EMBO Journal profile →
  10. Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma
    2005 760 citations Raju R. Raval, Maxine Tran et al. Molecular and Cellular Biology profile →
  11. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
    2002 611 citations Michael Wilson, Christopher J. Schofield et al. Nature profile →
  12. Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
    2002 582 citations Michael S. Wiesener, Stefano J. Mandriota et al. profile →
  13. Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α
    1998 539 citations Michael S. Wiesener, Helen Turley et al. profile →
  14. Expression of Hypoxia-Inducible Factor-1α and -2α in Hypoxic and Ischemic Rat Kidneys
    2002 480 citations Stefano J. Mandriota, Michael S. Wiesener et al. profile →
  15. HIF activation identifies early lesions in VHL kidneys
    2002 398 citations Stefano J. Mandriota, Heidi Sowter et al. Cancer Cell profile →
  16. Identification of the renal erythropoietin-producing cells using transgenic mice
    1993 301 citations Patrick H. Maxwell, Christopher W. Pugh et al. Kidney International profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Patrick H. Maxwell United Kingdom 76 21.6k 20.1k 5.3k 4.1k 3.9k 213 34.6k
Christopher W. Pugh United Kingdom 66 21.8k 1.0× 19.2k 1.0× 5.2k 1.0× 3.0k 0.7× 4.1k 1.0× 146 32.5k
M. Celeste Simon United States 105 21.1k 1.0× 26.3k 1.3× 4.2k 0.8× 4.5k 1.1× 5.1k 1.3× 262 47.7k
Chi V. Dang United States 100 24.2k 1.1× 38.9k 1.9× 3.1k 0.6× 3.3k 0.8× 3.2k 0.8× 310 53.3k
William G. Kaelin United States 117 22.6k 1.0× 35.6k 1.8× 6.0k 1.1× 6.0k 1.5× 3.2k 0.8× 246 50.2k
Bing‐Hua Jiang China 83 16.2k 0.7× 19.5k 1.0× 3.0k 0.6× 2.3k 0.6× 3.0k 0.8× 313 31.7k
Amato J. Giaccia United States 103 17.4k 0.8× 23.1k 1.2× 2.6k 0.5× 4.2k 1.0× 2.6k 0.7× 350 40.3k
Eamonn R. Maher United Kingdom 94 11.8k 0.5× 19.4k 1.0× 7.8k 1.5× 6.2k 1.5× 1.9k 0.5× 423 32.5k
Werner Risau Germany 84 9.3k 0.4× 27.2k 1.4× 1.7k 0.3× 2.9k 0.7× 1.8k 0.5× 149 38.3k
Richard G. Pestell United States 124 13.5k 0.6× 33.3k 1.7× 4.7k 0.9× 3.7k 0.9× 3.7k 0.9× 465 49.9k
Hiroyuki Aburatani Japan 98 7.6k 0.4× 24.4k 1.2× 3.6k 0.7× 6.1k 1.5× 2.0k 0.5× 531 38.1k

Countries citing papers authored by Patrick H. Maxwell

Since Specialization
Citations

This map shows the geographic impact of Patrick H. Maxwell's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick H. Maxwell with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick H. Maxwell more than expected).

Fields of papers citing papers by Patrick H. Maxwell

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick H. Maxwell. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick H. Maxwell. The network helps show where Patrick H. Maxwell may publish in the future.

Co-authorship network of co-authors of Patrick H. Maxwell

This figure shows the co-authorship network connecting the top 25 collaborators of Patrick H. Maxwell. A scholar is included among the top collaborators of Patrick H. Maxwell based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Patrick H. Maxwell. Patrick H. Maxwell is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Connor, Thomas M., Simon Hoer, Andrew J. Mallett, et al.. (2017). Mutations in mitochondrial DNA causing tubulointerstitial kidney disease. PLoS Genetics. 13(3). e1006620–e1006620. 40 indexed citations
2.
Mowat, Freya M., Francisco González, Ulrich F. O. Luhmann, et al.. (2012). Endogenous Erythropoietin Protects Neuroretinal Function in Ischemic Retinopathy. American Journal Of Pathology. 180(4). 1726–1739. 31 indexed citations
3.
Walmsley, Sarah R., Edwin R. Chilvers, A. A. Roger Thompson, et al.. (2011). Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. Journal of Clinical Investigation. 121(3). 1053–1063. 132 indexed citations
4.
Ashby, Damien, Daniel P. Gale, Mark Busbridge, et al.. (2009). Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Kidney International. 75(9). 976–981. 250 indexed citations
5.
Cantley, James, Colin Selman, Deepa Shukla, et al.. (2008). Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice. Journal of Clinical Investigation. 119(1). 125–35. 102 indexed citations
6.
Pollard, Patrick J., Bradley Spencer‐Dene, Deepa Shukla, et al.. (2007). Targeted Inactivation of Fh1 Causes Proliferative Renal Cyst Development and Activation of the Hypoxia Pathway. Cancer Cell. 11(4). 311–319. 129 indexed citations
7.
Maxwell, Patrick H. & M. Joan Curcio. (2007). Retrosequence formation restructures the yeast genome. Genes & Development. 21(24). 3308–3318. 23 indexed citations
8.
Boutet, Agnès, Cristina A. de Frutos, Patrick H. Maxwell, et al.. (2006). Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. The EMBO Journal. 25(23). 5603–5613. 281 indexed citations
9.
Percy, Melanie J., Quan Zhao, Adrian Flores, et al.. (2006). A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proceedings of the National Academy of Sciences. 103(3). 654–659. 252 indexed citations
10.
Tran, Maxine, Wei Zeng, Sven Gläsker, et al.. (2006). Evolution of VHL tumourigenesis in nerve root tissue. The Journal of Pathology. 210(3). 374–382. 35 indexed citations
11.
Raval, Raju R., Maxine Tran, Heidi Sowter, et al.. (2005). Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma. Molecular and Cellular Biology. 25(13). 5675–5686. 760 indexed citations breakdown →
12.
Brusselmans, Koen, Veerle Compernolle, Marc Tjwa, et al.. (2003). Heterozygous deficiency of hypoxia-inducible factor–2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. Journal of Clinical Investigation. 111(10). 1519–1527. 256 indexed citations
13.
Wiesener, Michael S. & Patrick H. Maxwell. (2003). HIF and oxygen sensing; as important to life as the air we breathe?. Annals of Medicine. 35(3). 183–190. 84 indexed citations
14.
Mole, David R., Christopher W. Pugh, Peter J. Ratcliffe, & Patrick H. Maxwell. (2002). Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex. Advances in Enzyme Regulation. 42. 333–347. 13 indexed citations
15.
Maxwell, Patrick H.. (2001). Activation of the HIF pathway in cancer. Current Opinion in Genetics & Development. 11(3). 293–299. 339 indexed citations
16.
Jaakkola, Panu, David R. Mole, Ya‐Min Tian, et al.. (2001). Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation. Science. 292(5516). 468–472. 4523 indexed citations breakdown →
17.
Wykoff, Charles C., Christopher W. Pugh, Adrian L. Harris, Patrick H. Maxwell, & Peter J. Ratcliffe. (2001). The HIF Pathway: Implications for Patterns of Gene Expression in Cancer. Novartis Foundation symposium. 240. 212–231. 40 indexed citations
18.
Turley, Helen, Kevin C. Gatter, Patrick H. Maxwell, et al.. (2000). The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages. American Journal Of Pathology. 157(2). 411–421. 1078 indexed citations breakdown →
19.
Carmeliet, Peter, Yuval Dor, Jean-Marc Herbert, et al.. (1998). Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394(6692). 485–490. 2119 indexed citations breakdown →
20.
Carmeliet, Peter, Yuval Dor, Dai Fukumura, et al.. (1998). Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998). UCL Discovery (University College London). 2 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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