Len Neckers

31.6k total citations · 6 hit papers
248 papers, 24.9k citations indexed

About

Len Neckers is a scholar working on Molecular Biology, Immunology and Oncology. According to data from OpenAlex, Len Neckers has authored 248 papers receiving a total of 24.9k indexed citations (citations by other indexed papers that have themselves been cited), including 213 papers in Molecular Biology, 41 papers in Immunology and 26 papers in Oncology. Recurrent topics in Len Neckers's work include Heat shock proteins research (115 papers), ATP Synthase and ATPases Research (33 papers) and Ubiquitin and proteasome pathways (28 papers). Len Neckers is often cited by papers focused on Heat shock proteins research (115 papers), ATP Synthase and ATPases Research (33 papers) and Ubiquitin and proteasome pathways (28 papers). Len Neckers collaborates with scholars based in United States, Japan and United Kingdom. Len Neckers's co-authors include Jane B. Trepel, Edward G. Mimnaugh, Mehdi Mollapour, Wanping Xu, Jennifer S. Isaacs, Luke Whitesell, Giuseppe Giaccone, Sunmin Lee, Mikhail V. Blagosklonny and Shinji Tsutsumi and has published in prestigious journals such as Proceedings of the National Academy of Sciences, The Lancet and Journal of the American Chemical Society.

In The Last Decade

Len Neckers

245 papers receiving 24.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Targeting the dynamic HSP90 complex in cancer

2010 1.2k citations Jane B. Trepel, Mehdi Mollapour et al. profile →
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 1.2k citations Luke Whitesell, Edward G. Mimnaugh et al. profile →
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

2005 732 citations Yun Jin Jung, Sunmin Lee et al. profile →
Characterization of oligonucleotide transport into living cells.

1989 613 citations Len Neckers et al. profile →
IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

2003 586 citations Sunmin Lee, Jane B. Trepel et al. profile →
Hsp90 inhibitors as novel cancer chemotherapeutic agents

2002 549 citations Len Neckers profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Len Neckers United States	85	19.4k	4.0k	3.1k	3.0k	3.0k	248	24.9k
Jane B. Trepel United States	74	11.8k 0.6×	2.2k 0.6×	4.4k 1.4×	3.2k 1.1×	1.4k 0.5×	290	17.6k
Luke Whitesell United States	59	10.3k 0.5×	4.2k 1.0×	1.7k 0.6×	917 0.3×	2.1k 0.7×	147	15.8k
Marja Jäättelä Denmark	80	15.2k 0.8×	3.0k 0.8×	2.5k 0.8×	2.1k 0.7×	4.7k 1.6×	182	23.8k
Stuart K. Calderwood United States	72	12.4k 0.6×	3.4k 0.8×	1.5k 0.5×	1.6k 0.5×	3.4k 1.2×	230	16.4k
William B. Pratt United States	82	16.1k 0.8×	3.4k 0.9×	1.6k 0.5×	813 0.3×	1.9k 0.6×	208	21.2k
Matthias Gaestel Germany	70	11.6k 0.6×	3.4k 0.8×	2.4k 0.8×	1.9k 0.6×	2.1k 0.7×	259	16.7k
Lorenzo A. Pinna Italy	74	15.9k 0.8×	1.4k 0.4×	3.4k 1.1×	757 0.3×	2.8k 0.9×	448	21.6k
Alexander Levitzki Israel	74	14.3k 0.7×	2.2k 0.6×	5.9k 1.9×	1.8k 0.6×	2.2k 0.7×	328	22.3k
Larry A. Sklar United States	71	10.5k 0.5×	2.8k 0.7×	2.1k 0.7×	801 0.3×	1.6k 0.5×	319	19.1k
Laurent Meijer France	84	15.7k 0.8×	1.1k 0.3×	6.3k 2.0×	1.0k 0.3×	4.0k 1.3×	378	27.8k

Countries citing papers authored by Len Neckers

Since Specialization

Citations

This map shows the geographic impact of Len Neckers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Len Neckers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Len Neckers more than expected).

Fields of papers citing papers by Len Neckers

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Len Neckers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Len Neckers. The network helps show where Len Neckers may publish in the future.

Co-authorship network of co-authors of Len Neckers

This figure shows the co-authorship network connecting the top 25 collaborators of Len Neckers. A scholar is included among the top collaborators of Len Neckers based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Len Neckers. Len Neckers is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Joshi, Abhinav, Li Dai, Sunmin Lee, et al.. (2025). Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT. Molecular Cancer Research. 23(9). 792–806.

Xu, Wanping, Kristin Beebe, Juan D. Chavez, et al.. (2019). Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1. Nature Communications. 10(1). 2574–2574. 47 indexed citations

Shao, Hao, Xiaokai Li, Michael A. Moses, et al.. (2018). Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70). Journal of Medicinal Chemistry. 61(14). 6163–6177. 88 indexed citations

Zuehlke, Abbey D., Michael Reidy, Paul LaPointe, et al.. (2017). An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans. Nature Communications. 8(1). 15328–15328. 33 indexed citations

Prince, Thomas L., Toshiki Kijima, Manabu Tatokoro, et al.. (2015). Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants. PLoS ONE. 10(10). e0141786–e0141786. 47 indexed citations

Miyajima, Naoto, Shinji Tsutsumi, Carole Sourbier, et al.. (2013). The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models. Cancer Research. 73(23). 7022–7033. 48 indexed citations

Mollapour, Mehdi, Shinji Tsutsumi, Thomas L. Prince, et al.. (2012). Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90- Targeted Therapy. Current Molecular Medicine. 12(9). 1125–1141. 36 indexed citations

Shim, Joong Sup, Rajini Rao, Kristin Beebe, et al.. (2012). Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir. JNCI Journal of the National Cancer Institute. 104(20). 1576–1590. 66 indexed citations

Tatokoro, Manabu, Fumitaka Koga, Soichiro Yoshida, et al.. (2011). Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer‐initiating cells. International Journal of Cancer. 131(4). 987–996. 56 indexed citations

10.

Sourbier, Carole, Alessio Giubellino, Youfeng Yang, et al.. (2010). Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma. Cell Cycle. 9(20). 4183–4189. 25 indexed citations

11.

Conejo-García, José R., Sofía Barluenga, Kristin Beebe, Len Neckers, & Nicolas Winssinger. (2010). Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action. Chemistry - A European Journal. 16(32). 9767–9771. 30 indexed citations

12.

Floor, Karijn, Paul Roepman, José Antonio Rodríguez, et al.. (2008). Integration of Gene Dosage and Gene Expression in Non-Small Cell Lung Cancer, Identification of HSP90 as Potential Target. PLoS ONE. 3(3). e0001722–e0001722. 87 indexed citations

13.

Xu, Weiguo, Shiro Soga, Kristen Beebe, et al.. (2007). Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition. British Journal of Cancer. 97(6). 741–744. 33 indexed citations

14.

Neckers, Len, Adam Witkowski, & Shinji Tsutsumi. (2007). Hsp90 Inhibitors Disrupt Mitochondrial Homeostasis in Cancer Cells. Chemistry & Biology. 14(11). 1204–1206. 40 indexed citations

15.

Xu, Wanping, Xitong Yuan, Zhexin Xiang, et al.. (2005). Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. Nature Structural & Molecular Biology. 12(2). 120–126. 127 indexed citations

16.

Xu, Wanping, Xitong Yuan, Yun Jin Jung, et al.. (2003). The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.. PubMed. 63(22). 7777–84. 85 indexed citations

17.

Mimnaugh, Edward G., Christine Chavany, & Len Neckers. (1996). Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin. Journal of Biological Chemistry. 271(37). 22796–22801. 397 indexed citations

18.

Chavany, Christine, Edward G. Mimnaugh, Roberto Bitton, et al.. (1996). p185erbB2 Binds to GRP94 in Vivo. Journal of Biological Chemistry. 271(9). 4974–4977. 226 indexed citations

19.

Geselowitz, Daniel A. & Len Neckers. (1992). Analysis of Oligonucleotide Binding, Internalization, and Intracellular Trafficking Utilizing a Novel Radiolabeled Crosslinker. PubMed. 2(1). 17–25. 82 indexed citations

20.

Smith, Malcolm A., Paul M. Sondel, Andrea Gillespie, et al.. (1992). A Phase I Study of Interleukin-2 in Children with Cancer. Journal of Pediatric Hematology/Oncology. 14(4). 305–311. 23 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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