Luke A. McNeill

9.6k citations

29 papers · 5.7k indexed · 2 hit papers · h-index 24

Cancer Research top 0.2%
Molecular Biology top 2%
Genetics top 2%
Physiology top 5%
Biochemistry top 0.5%

Co-authors: Christopher J. Schofield Kirsty S. Hewitson Peter J. Ratcliffe Christopher W. Pugh Jonathan Gleadle Ya‐Min Tian David R. Mole Patrick H. Maxwell
Topics: Cancer, Hypoxia, and Metabolism (20 papers)Mitochondrial Function and Pathology (9 papers)High Altitude and Hypoxia (6 papers)
Cited by: Cancer Research Biochemistry Aging
Journals: Cell Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United Kingdom United States Germany

In The Last Decade

Luke A. McNeill

29 papers receiving 5.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 2.7k citations Andrew Epstein, Jonathan Gleadle et al. Cell profile →
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

2002 602 citations Kirsty S. Hewitson, Luke A. McNeill et al. Journal of Biological Chemistry profile →

Peers

Countries citing papers authored by Luke A. McNeill

Since Specialization

Citations

This map shows the geographic impact of Luke A. McNeill's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Luke A. McNeill with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Luke A. McNeill more than expected).

Fields of papers citing papers by Luke A. McNeill

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Luke A. McNeill. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Luke A. McNeill. The network helps show where Luke A. McNeill may publish in the future.

Co-authorship network of co-authors of Luke A. McNeill

This figure shows the co-authorship network connecting the top 25 collaborators of Luke A. McNeill. A scholar is included among the top collaborators of Luke A. McNeill based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Luke A. McNeill. Luke A. McNeill is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern 2019 ·Nature Communications ·Inga Pfeffer,Lennart Brewitz,T. Krojer,Sacha A. Jensen,Grazyna Kochan,Nadia J. Kershaw,Kirsty S. Hewitson,Luke A. McNeill,Holger Kramer,Martin Münzel,Richard J. Hopkinson,Udo Oppermann,Penny A. Handford,M.A. McDonough,Christopher J. Schofield	42
2	Crystal structure of an invertebrate cytolysin pore reveals unique properties and mechanism of assembly 2016 ·Nature Communications ·Marjetka Podobnik,Peter Savory,Nejc Rojko,Matic Kisovec,(unknown),(unknown),Jonathan Pugh,E. Jayne Wallace,Luke A. McNeill,(unknown),Idlir Liko,Timothy M. Allison,Shahid Mehmood,Neval Yilmaz,Toshihide Kobayashi,Robert J.C. Gilbert,Carol V. Robinson,Lakmal Jayasinghe,Gregor Anderluh	72
3	Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion 2012 ·Organic & Biomolecular Chemistry ·Kar Kheng Yeoh,Mun Chiang Chan,Armin Thalhammer,Marina Demetriades,Rasheduzzaman Chowdhury,Ya‐Min Tian,Ineke Stolze,Luke A. McNeill,Myung Kyu Lee,Esther C. Y. Woon,Mukram Mohamed Mackeen,Akane Kawamura,Peter J. Ratcliffe,Jasmin Mecinović,Christopher J. Schofield	25
4	Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor 2010 ·Bioorganic & Medicinal Chemistry Letters ·Ana Conejo‐García,M.A. McDonough,Christoph Loenarz,Luke A. McNeill,Kirsty S. Hewitson,Wei Ge,Benoît M. R. Liénard,Christopher J. Schofield,I.J. Clifton	20
5	Evidence for a Stereoelectronic Effect in Human Oxygen Sensing 2009 ·Angewandte Chemie International Edition ·Christoph Loenarz,Jasmin Mecinović,Rasheduzzaman Chowdhury,Luke A. McNeill,Emily Flashman,Christopher J. Schofield	54
6	Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) 2006 ·Proceedings of the National Academy of Sciences ·M.A. McDonough,Vivian Li,Emily Flashman,Rasheduzzaman Chowdhury,Christopher Mohr,Benoît M. R. Liénard,James Zondlo,Neil J. Oldham,I.J. Clifton,Jeffrey Lewis,Luke A. McNeill,Robert J. Kurzeja,Kirsty S. Hewitson,Evelyn Yang,Steven R. Jordan,Rashid Syed,Christopher J. Schofield	295
7	Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates 2006 ·Journal of Biological Chemistry ·Kirsty S. Hewitson,Benoît M. R. Liénard,M.A. McDonough,I.J. Clifton,Danica Butler,Alexei S. Soares,Neil J. Oldham,Luke A. McNeill,Christopher J. Schofield	190
8	Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate 2005 ·Molecular BioSystems ·Luke A. McNeill,Emily Flashman,Matthew R. Buck,Kirsty S. Hewitson,I.J. Clifton,Gunnar Jeschke,Timothy D. W. Claridge,(unknown),Neil J. Oldham,Christopher J. Schofield	100
9	The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids 2005 ·Chemical Communications ·Biswadip Banerji,Ana Conejo‐García,Luke A. McNeill,M.A. McDonough,Matthew R. Buck,Kirsty S. Hewitson,Neil J. Oldham,Christopher J. Schofield	27
10	Incorporation of oxygen into the succinate co‐product of iron(II) and 2‐oxoglutarate dependent oxygenases from bacteria, plants and humans 2005 ·FEBS Letters ·Richard W.D. Welford,Joanna Kirkpatrick,Luke A. McNeill,Munish Puri,Neil J. Oldham,Christopher J. Schofield	31
11	Modulating the Hypoxia-Inducible Factor Signaling Pathway: Applications From Cardiovascular Disease to Cancer 2004 ·Current Pharmaceutical Design ·Kirsty S. Hewitson,Luke A. McNeill,Christopher J. Schofield	57
12	A fluorescence-based assay for 2-oxoglutarate-dependent oxygenases 2004 ·Analytical Biochemistry ·Luke A. McNeill,Lucas Bethge,Kirsty S. Hewitson,Christopher J. Schofield	55
13	Glyco- and Peptidomimetics from Three-Component Joullié−Ugi Coupling Show Selective Antiviral Activity 2004 ·Journal of the American Chemical Society ·Timothy M. Chapman,(unknown),Baohua Gu,Timothy M. Block,D. I. C. SCOPES,(unknown),Stephen M. Courtney,Luke A. McNeill,Christopher J. Schofield,Benjamin G. Davis	71
14	Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases 2003 ·Bioorganic & Medicinal Chemistry Letters ·Imre Schlemminger,David R. Mole,Luke A. McNeill,(unknown),Kirsty S. Hewitson,Ya‐Min Tian,Peter J. Ratcliffe,Christopher W. Pugh,Christopher J. Schofield	53
15	Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α 2003 ·Journal of Biological Chemistry ·Jonathan M. Elkins,Kirsty S. Hewitson,Luke A. McNeill,Jürgen Seibel,Imre Schlemminger,Christopher W. Pugh,Peter J. Ratcliffe,Christopher J. Schofield	326
16	2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase 2003 ·Bioorganic & Medicinal Chemistry Letters ·David R. Mole,Imre Schlemminger,Luke A. McNeill,Kirsty S. Hewitson,Christopher W. Pugh,Peter J. Ratcliffe,Christopher J. Schofield	126
17	Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Familybreakdown → 2002 ·Journal of Biological Chemistry ·Kirsty S. Hewitson,Luke A. McNeill,(unknown),Ya‐Min Tian,Alex N. Bullock,Richard W.D. Welford,Jonathan M. Elkins,Neil J. Oldham,Shoumo Bhattacharya,Jonathan Gleadle,Peter J. Ratcliffe,Christopher W. Pugh,Christopher J. Schofield	602
18	The use of dioxygen by HIF prolyl hydroxylase (PHD1) 2002 ·Bioorganic & Medicinal Chemistry Letters ·Luke A. McNeill,Kirsty S. Hewitson,Jonathan Gleadle,Louise Horsfall,Neil J. Oldham,Patrick H. Maxwell,Christopher W. Pugh,Peter J. Ratcliffe,Christopher J. Schofield	95
19	Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803 2002 ·Biochemical Journal ·Luke A. McNeill,Kirsty S. Hewitson,Timothy D. W. Claridge,Jürgen Seibel,Louise Horsfall,Christopher J. Schofield	181
20	C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylationbreakdown → 2001 ·Cell ·Andrew Epstein,Jonathan Gleadle,Luke A. McNeill,Kirsty S. Hewitson,John P. O’Rourke,David R. Mole,Mridul Mukherji,Eric Metzen,Michael Wilson,(unknown),Ya‐Min Tian,Norma Masson,Donald L. Hamilton,Panu Jaakkola,Robert Barstead,Jonathan Hodgkin,Patrick H. Maxwell,Christopher W. Pugh,Christopher J. Schofield,Peter J. Ratcliffe	2746

About Luke A. McNeill

Luke A. McNeill is a scholar working on Cancer Research, Biochemistry and Cell Biology, having authored 29 papers that have together received 5.7k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (20 papers), Mitochondrial Function and Pathology (9 papers) and High Altitude and Hypoxia (6 papers). The work is most often cited by research in Cancer Research (4.0k citations), Biochemistry (480 citations) and Aging (104 citations). Luke A. McNeill has collaborated with scholars based in United Kingdom, United States and Germany. Frequent co-authors include Christopher J. Schofield, Kirsty S. Hewitson, Peter J. Ratcliffe, Christopher W. Pugh, Jonathan Gleadle, Ya‐Min Tian, David R. Mole, Patrick H. Maxwell, Norma Masson and Michael Wilson. Their work appears in journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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