Ajit Jadhav

19.3k citations

150 papers · 8.1k indexed · 1 hit paper · h-index 50

Impact in

Computational Theory and Mathematics top 0.2%
- Computational Drug Discovery Methods
Molecular Biology top 1%
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms

Papers in

Toxicology 6
Computational Theory and Mathematics 26
- Computational Drug Discovery Methods 26

Co-authors: Anton Simeonov Christopher P. Austin James Inglese David J. Maloney Adam Yasgar Douglas S. Auld Noel Southall Wei Zheng
Journals: Journal of Medicinal Chemistry (19 papers)PLoS ONE (13 papers)Scientific Reports (5 papers)Bioorganic & Medicinal Chemistry Letters (5 papers)Biochemistry (4 papers)
Partner nations: United States United Kingdom Sweden

In The Last Decade

Ajit Jadhav

148 papers receiving 8.0k citations

Hit Papers

align trajectories log scale

Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries 2006 · 623 citations

Peers

Countries citing papers authored by Ajit Jadhav

Since Specialization

Citations

This map shows the geographic impact of Ajit Jadhav's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ajit Jadhav with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ajit Jadhav more than expected).

Fields of papers citing papers by Ajit Jadhav

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ajit Jadhav. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ajit Jadhav. The network helps show where Ajit Jadhav may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Ajit Jadhav, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Ajit Jadhav Line = papers co-authored together Ajit Jadhav links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Small-Molecule Disruptors of the Interaction between Calcium- and Integrin-Binding Protein 1 and Integrin α_IIbβ₃ as Novel Antiplatelet Agents ACS Pharmacology & Translational Science ·N. V. Karpov, Adam Yasgar, Mohammad Hosseinzade Hesari, Meghna U. Naik, Bolormaa Baljinnyam, Alexey Zakharov, Sankalp Jain, Ganesha Rai, Ajit Jadhav, Anton Simeonov, Ulhas P. Naik	2024	0
2	AI for Oncology Drug Data Harmonization — Amazon versus OpenAI NEJM AI ·Jen Hao Cheng, Iñigo Narvaiza Cuervas-Mons, Timothy L. Wiemken, Ajit Jadhav, Stephen Watt, Magdia De Jesus, Aida Habtezion	2024	1
3	Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2 Bioorganic & Medicinal Chemistry ·Wan‐Chen Tsai, Nathaniel C. Gilbert, 孔明冨田, Bakar Aznan, Steve Perry, Chakrapani Kalyanaraman, Adam Yasgar, Ganesha Rai, Anton Simeonov, Ajit Jadhav, Melissa Standley, Hsiau‐Wei Lee, Phillip Crews, Anthony T. Iavarone, Matthew P. Jacobson, David B. Neau, Adam R. Offenbacher, Marcia E. Newcomer, Theodore R. Holman	2021	19
4	NCATS Inxight Drugs: a comprehensive and curated portal for translational research Nucleic Acids Research ·Vishal B. Siramshetty, Ivan Grishagin, Ðắc-Trung Nguyễn, Tyler Peryea, 栗原清二, Oleg V. Stroganov, Rafaele Germi, Timothy Sheils, Ajit Jadhav, Ewy A. Mathé, Noel Southall	2021	36
5	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors Proceedings of the National Academy of Sciences ·阿部由香, Adam Yasgar, T Teramoto, Myoung‐Hwa Lee, Dorjbal Dorjsuren, Richard T. Eastman, Nasir Malik, Alexey Zakharov, Wenxue Li, Muzna Bachani, Kyle R. Brimacombe, Joseph Steiner, Matthew D. Hall, Anuradha Balasubramanian, Ajit Jadhav, Radhakrishnan Padmanabhan, Anton Simeonov, Avindra Nath	2020	33
6	Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis ACS Infectious Diseases ·Haining Lyu, Pavel A. Petukhov, Payam Golshani, Ajit Jadhav, Wendy Lea, Qing Cheng, Elias S.J. Arnér, Anton Simeonov, Gregory R. J. Thatcher, Francesco Angelucci, David L. Williams	2020	25
7	Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases Bioorganic & Medicinal Chemistry Letters ·Shyh‐Ming Yang, Makoto Yoshioka, Jeffrey Strovel, Daniel J. Urban, Xin Hu, Matthew D. Hall, Ajit Jadhav, David J. Maloney	2019	10
8	Scaffold-Based Analytics: Enabling Hit-to-Lead Decisions by Visualizing Chemical Series Linked across Large Datasets Journal of Chemical Information and Modeling ·Deepak Bandyopadhyay, Constantine Kreatsoulas, Muhammad Farhan Dany, J. Gregory Boyer, Zangdong He, Genaro S. Scavello, Tyler Peryea, Ajit Jadhav, Ðắc-Trung Nguyễn, Rajarshi Guha	2019	6
9	Identification of Activators of Human Fumarate Hydratase by Quantitative High-Throughput Screening SLAS DISCOVERY ·Hu Zhu, Olivia W. Lee, Pranav Shah, Ajit Jadhav, Xin Xu, Samarjit Patnaik, Min Shen, Matthew D. Hall	2019	5
10	Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol eLife ·Kelly A. Manthei, Shyh‐Ming Yang, Bolormaa Baljinnyam, Louise Chang, Alisa Glukhova, Wenmin Yuan, Lita A. Freeman, David J. Maloney, Anna Schwendeman, Alan T. Remaley, Ajit Jadhav, J.J.G. Tesmer	2018	31
11	Discovery and lead identification of quinazoline-based BRD4 inhibitors Bioorganic & Medicinal Chemistry Letters ·Shyh‐Ming Yang, Daniel J. Urban, Makoto Yoshioka, Jeffrey Strovel, Steven Fletcher, Amy Q. Wang, Xin Xu, Pranav Shah, Xin Hu, Matthew D. Hall, Ajit Jadhav, David J. Maloney	2018	13
12	Biochemical Assays for the Discovery of TDP1 Inhibitors Molecular Cancer Therapeutics ·Christophe Marchand, Shar-yin N. Huang, Thomas S. Dexheimer, Wendy Lea, Bryan T. Mott, Adel Chergui, 贾娟娟, Andrew G. Stephen, Andrew S. Rosenthal, Ganesha Rai, Junko Murai, Rui Gao, David J. Maloney, Ajit Jadhav, William L. Jorgensen, Anton Simeonov, Yves Pommier	2014	17
13	A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ PLoS ONE ·S Socolovschi, Dorjbal Dorjsuren, Robert L. Eoff, Martin Egli, David J. Maloney, Ajit Jadhav, Anton Simeonov, R. Stephen Lloyd	2012	31
14	Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay Molecular Cancer Therapeutics ·Christophe Marchand, Wendy Lea, Ajit Jadhav, Thomas S. Dexheimer, Christopher P. Austin, James Inglese, Yves Pommier, Anton Simeonov	2009	68
15	A miniaturized screen for inhibitors of Jumonji histonedemethylases Molecular BioSystems ·Masaaki Sakurai, Nathan R. Rose, Lena Schultz, Amy Quinn, Ajit Jadhav, Stanley S. Ng, Udo Oppermann, Christopher J. Schofield, Anton Simeonov	2009	76
16	A quantitative high-throughput screen for modulators of IL-6signaling: a model for interrogating biological networks using chemical libraries Molecular BioSystems ·Ronald L. Johnson, Ruili Huang, Ajit Jadhav, Noel Southall, Stephanie Ruiz, Ryan MacArthur, Menghang Xia, Kun Bi, John A. Printen, Christopher P. Austin, James Inglese	2009	11
17	A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyltransferase Molecular BioSystems ·Adam Yasgar, Timothy L. Foley, Ajit Jadhav, James Inglese, Michael D. Burkart, Anton Simeonov	2009	24
18	A Robotic Platform for Quantitative High-Throughput Screening Assay and Drug Development Technologies ·Sam Michael, Douglas S. Auld, Mushraff Ali Khan, Ajit Jadhav, Wei Zheng, Natasha Thorne, Christopher P. Austin, James Inglese, Anton Simeonov	2008	108
19	A 1,536-Well-Based Kinetic HTS Assay for Inhibitors of Schistosoma mansoni Thioredoxin Glutathione Reductase Assay and Drug Development Technologies ·Wendy Lea, Ajit Jadhav, Ganesha Rai, Ahmed A. Sayed, Cynthia L. Cass, James Inglese, David L. Williams, Christopher P. Austin, Anton Simeonov	2008	16
20	Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries Proceedings of the National Academy of Sciences ·James Inglese, Douglas S. Auld, Ajit Jadhav, Ronald L. Johnson, Anton Simeonov, Adam Yasgar, Wei Zheng, Christopher P. Austin Hit paper breakdown →	2006	623

About Ajit Jadhav

Ajit Jadhav is a scholar working on Toxicology, Computational Theory and Mathematics, Molecular Biology, Pharmacology and Parasitology, having authored 150 papers that have together received 8.1k indexed citations. Recurring topics across this work include Computational Drug Discovery Methods (26 papers), DNA Repair Mechanisms (14 papers), Inflammatory mediators and NSAID effects (11 papers), Epigenetics and DNA Methylation (10 papers), Histone Deacetylase Inhibitors Research (9 papers), Protein Degradation and Inhibitors (9 papers), Ubiquitin and proteasome pathways (8 papers) and Cancer therapeutics and mechanisms (8 papers). The work is most often cited by research in Computational Theory and Mathematics (1.3k citations), Molecular Biology (5.1k citations), Toxicology (169 citations), Biophysics (233 citations) and Oncology (1.0k citations). Ajit Jadhav has collaborated with scholars based in United States, United Kingdom and Sweden. Frequent co-authors include Anton Simeonov, Christopher P. Austin, James Inglese, David J. Maloney, Adam Yasgar, Douglas S. Auld, Noel Southall, Wei Zheng, Ruili Huang and Ganesha Rai. Their work appears in journals such as Journal of Medicinal Chemistry, PLoS ONE, Scientific Reports, Bioorganic & Medicinal Chemistry Letters and Biochemistry.

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