Vamsi K. Mootha

125.4k citations

199 papers · 72.9k indexed · 25 hit papers · h-index 87

Molecular Biology top 0.01%
Cancer Research top 0.02%
Physiology top 0.05%
Immunology top 0.1%
Oncology top 0.2%

Co-authors: Eric S. Lander Todd R. Golub Jill P. Mesirov Pablo Tamayo Benjamin L. Ebert Amanda G. Paulovich Sayan Mukherjee Michael A. Gillette
Topics: Mitochondrial Function and Pathology (119 papers)Metabolism and Genetic Disorders (49 papers)ATP Synthase and ATPases Research (46 papers)
Cited by: Cancer Research Molecular Biology Clinical Biochemistry
Journals: Nature Science New England Journal of Medicine
Partner nations: United States Italy Australia

In The Last Decade

Vamsi K. Mootha

193 papers receiving 72.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 34.0k citations Vamsi K. Mootha, Eric S. Lander et al. Proceedings of the National Academy of Sciences profile →
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 3.4k citations Vamsi K. Mootha et al. profile →
Metabolite profiles and the risk of developing diabetes

2011 2.3k citations Thomas J. Wang, Vamsi K. Mootha et al. profile →
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

2008 1.6k citations David J. Pagliarini, Sarah E. Calvo et al. profile →
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

2011 1.5k citations Yasemin Sancak, Olga Goldberger et al. profile →
Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals

2005 1.5k citations Vamsi K. Mootha, Eric S. Lander et al. profile →
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

2007 1.2k citations Vamsi K. Mootha et al. profile →
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

2012 1.1k citations Mohit Jain, Roland Nilsson et al. Science profile →
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

2000 1.0k citations Vamsi K. Mootha et al. profile →
Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

2012 959 citations Jeffrey D. Martell, Alice Y. Ting et al. profile →
Directed evolution of APEX2 for electron microscopy and proximity labeling

2014 929 citations Jeffrey D. Martell, Kimberli J. Kamer et al. profile →
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

2015 903 citations Sarah E. Calvo, Vamsi K. Mootha et al. profile →
Integrated Analysis of Protein Composition, Tissue Diversity, and Gene Regulation in Mouse Mitochondria

2003 726 citations Vamsi K. Mootha, Jakob Bunkenborg et al. profile →
MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

2010 702 citations Vishal M. Gohil, Vamsi K. Mootha et al. profile →
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

2009 664 citations Sarah E. Calvo, David J. Pagliarini et al. Proceedings of the National Academy of Sciences profile →
Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

2001 620 citations Vamsi K. Mootha et al. Molecular Cell profile →
Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle

2004 572 citations Vamsi K. Mootha, Eric S. Lander et al. Proceedings of the National Academy of Sciences profile →
Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice

2000 564 citations Vamsi K. Mootha et al. profile →
Mitochondrial disorders as windows into an ancient organelle

2012 543 citations Vamsi K. Mootha et al. profile →
Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

2012 521 citations Jeffrey D. Martell, Yasemin Sancak et al. profile →
EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

2013 516 citations Yasemin Sancak, Toshimori Kitami et al. Science profile →
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

2020 483 citations Vamsi K. Mootha et al. profile →
Complementation of mitochondrial electron transport chain by manipulation of the NAD ⁺ /NADH ratio

2016 339 citations Zenon Grabarek, Vamsi K. Mootha et al. Science profile →
Mitochondrial dysfunction remodels one-carbon metabolism in human cells

2016 333 citations Olga Goldberger, Rohit Sharma et al. profile →
CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

2022 131 citations Vamsi K. Mootha et al. profile →

Peers

Countries citing papers authored by Vamsi K. Mootha

Since Specialization

Citations

This map shows the geographic impact of Vamsi K. Mootha's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Vamsi K. Mootha with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Vamsi K. Mootha more than expected).

Fields of papers citing papers by Vamsi K. Mootha

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Vamsi K. Mootha. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Vamsi K. Mootha. The network helps show where Vamsi K. Mootha may publish in the future.

Co-authorship network of co-authors of Vamsi K. Mootha

This figure shows the co-authorship network connecting the top 25 collaborators of Vamsi K. Mootha. A scholar is included among the top collaborators of Vamsi K. Mootha based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Vamsi K. Mootha. Vamsi K. Mootha is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease 2025 ·Nature Neuroscience ·Eizo Marutani,María Miranda,Timothy Durham,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),Haobo Li,Gary Ruvkun,Joshua D. Meisel,Laura A. Volpicelli‐Daley,Vamsi K. Mootha,Fumito Ichinose	1
2	PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics 2024 ·Nature Metabolism ·Tsz‐Leung To,Jason G. McCoy,(unknown),L Sandler,Carmen A. Mannella,Vamsi K. Mootha	4
3	Cytosolic N6AMT1- dependent translation supports mitochondrial RNA processing 2024 ·Proceedings of the National Academy of Sciences ·(unknown),(unknown),(unknown),(unknown),George E. Allen,Boris Zinshteyn,(unknown),Christian Münch,Vamsi K. Mootha,Alexis A. Jourdain	4
4	Mitochondrial genome copy number variation across tissues in mice and humans 2024 ·Proceedings of the National Academy of Sciences ·Sneha Rath,Rahul Gupta,Ellen Todres,Hong Wang,Alexis A. Jourdain,Kristin Ardlie,Sarah E. Calvo,Vamsi K. Mootha	9
5	Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS 2022 ·Nature Communications ·Xiaojian Shi,(unknown),Hardik Shah,Tsz‐Leung To,(unknown),(unknown),Sarah E. Calvo,Olga Goldberger,John G. Doench,Vamsi K. Mootha,Hongying Shen	60
6	Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS 2021 ·Molecular Cell ·Alexis A. Jourdain,Bridget E. Begg,Eran Mick,Hardik Shah,Sarah E. Calvo,Owen S. Skinner,Rohit Sharma,Steven M. Blue,G Yeo,Christopher B. Burge,Vamsi K. Mootha	56
7	An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter 2020 ·Proceedings of the National Academy of Sciences ·Sagnika Ghosh,Writoban Basu Ball,Travis R. Madaris,Subramanya Srikantan,Muniswamy Madesh,Vamsi K. Mootha,Vishal M. Gohil	71
8	Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism 2019 ·Proceedings of the National Academy of Sciences ·Kimberli J. Kamer,Wei Jiang,Virendar K. Kaushik,Vamsi K. Mootha,Zenon Grabarek	42
9	A patient with homozygous nonsense variants in two Leigh syndrome disease genes: Distinguishing a dual diagnosis from a hypomorphic protein‐truncating variant 2019 ·Human Mutation ·Nicole J. Lake,Luke E. Formosa,David A. Stroud,Michael T. Ryan,Sarah E. Calvo,Vamsi K. Mootha,Bharti Morar,Peter G. Procopis,John Christodoulou,Alison G. Compton,David R. Thorburn	7
10	Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair 2019 ·Science ·Markus Ruetz,Gregory C. Campanello,(unknown),Hongying Shen,(unknown),(unknown),Shoko Wakabayashi,Junhao Zhu,Eric J. Rubin,Kurt Warncke,Vamsi K. Mootha,Markos Koutmos,Ruma Banerjee	77
11	MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca ²⁺ and Mn ²⁺ 2018 ·Proceedings of the National Academy of Sciences ·Kimberli J. Kamer,Yasemin Sancak,(unknown),Joshua D. Meisel,Dipayan Chaudhuri,Zenon Grabarek,Vamsi K. Mootha	59
12	Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma 2018 ·Proceedings of the National Academy of Sciences ·Raj K. Gopal,Sarah E. Calvo,Angela Shih,Frances Cháves,Declan McGuone,Eran Mick,Kerry A. Pierce,Yang Li,Andrea Garofalo,Eliezer M. Van Allen,Clary B. Clish,Esther Oliva,Vamsi K. Mootha	69
13	Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome 2017 ·Proceedings of the National Academy of Sciences ·Michele Ferrari,Isha H. Jain,Olga Goldberger,Emanuele Rezoagli,Robrecht Thoonen,Kai‐Hung Cheng,David E. Sosnovik,Marielle Scherrer‐Crosbie,Vamsi K. Mootha,Warren M. Zapol	119
14	High‐affinity cooperative Ca ²⁺ binding by MICU 1– MICU 2 serves as an on–off switch for the uniporter 2017 ·EMBO Reports ·Kimberli J. Kamer,Zenon Grabarek,Vamsi K. Mootha	120
15	Titration of mitochondrial fusion rescues Mff -deficient cardiomyopathy 2015 ·The Journal of Cell Biology ·Hsiuchen Chen,Shuxun Ren,Clary B. Clish,Mohit Jain,Vamsi K. Mootha,J. Michael McCaffery,David C. Chan	133
16	Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging 2013 ·Science ·Hyun‐Woo Rhee,Peng Zou,Namrata D. Udeshi,Jeffrey D. Martell,Vamsi K. Mootha,Steven A. Carr,Alice Y. Ting	46
17	Circulating branched‐chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents 2012 ·Pediatric Obesity ·S. E. McCormack,Ohad Shaham,M.A. McCarthy,Amy Deik,Thomas J. Wang,Robert E. Gerszten,Clary B. Clish,Vamsi K. Mootha,Steven Grinspoon,Amy Fleischman	348
18	Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferationbreakdown → 2012 ·Science ·Mohit Jain,Roland Nilsson,Sonia Sharma,(unknown),Toshimori Kitami,Amanda L. Souza,Ran Kafri,Marc W. Kirschner,Clary B. Clish,Vamsi K. Mootha	1101
19	Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humansbreakdown → 2009 ·Proceedings of the National Academy of Sciences ·Sarah E. Calvo,David J. Pagliarini,Vamsi K. Mootha	664
20	Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics 2003 ·Proceedings of the National Academy of Sciences ·Vamsi K. Mootha,Patricia Lepage,Kathleen A. Miller,Jakob Bunkenborg,Michael Reich,Majbrit Hjerrild,Terrye Delmonte,(unknown),Robert Sladek,Fenghao Xu,Grant A. Mitchell,Charles Morin,Matthias Mann,Thomas J. Hudson,Brian Robinson,John D. Rioux,Eric S. Lander	452

About Vamsi K. Mootha

Vamsi K. Mootha is a scholar working on Clinical Biochemistry, Molecular Biology and Physiology, having authored 199 papers that have together received 72.9k indexed citations. Recurring topics across this work include Mitochondrial Function and Pathology (119 papers), Metabolism and Genetic Disorders (49 papers) and ATP Synthase and ATPases Research (46 papers). The work is most often cited by research in Cancer Research (11.6k citations), Molecular Biology (51.6k citations) and Clinical Biochemistry (4.8k citations). Vamsi K. Mootha has collaborated with scholars based in United States, Italy and Australia. Frequent co-authors include Eric S. Lander, Todd R. Golub, Jill P. Mesirov, Pablo Tamayo, Benjamin L. Ebert, Amanda G. Paulovich, Sayan Mukherjee, Michael A. Gillette, Scott L. Pomeroy and Aravind Subramanian. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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