Masayuki Yamamoto

159.8k total citations · 44 hit papers
1.4k papers, 119.9k citations indexed

About

Masayuki Yamamoto is a scholar working on Molecular Biology, Physiology and Immunology. According to data from OpenAlex, Masayuki Yamamoto has authored 1.4k papers receiving a total of 119.9k indexed citations (citations by other indexed papers that have themselves been cited), including 917 papers in Molecular Biology, 131 papers in Physiology and 119 papers in Immunology. Recurrent topics in Masayuki Yamamoto's work include Genomics, phytochemicals, and oxidative stress (418 papers), Glutathione Transferases and Polymorphisms (175 papers) and Epigenetics and DNA Methylation (114 papers). Masayuki Yamamoto is often cited by papers focused on Genomics, phytochemicals, and oxidative stress (418 papers), Glutathione Transferases and Polymorphisms (175 papers) and Epigenetics and DNA Methylation (114 papers). Masayuki Yamamoto collaborates with scholars based in Japan, United States and United Kingdom. Masayuki Yamamoto's co-authors include Ken Itoh, Hozumi Motohashi, Thomas W. Kensler, Takafumi Suzuki, James Douglas Engel, Nobunao Wakabayashi, Akira Kobayashi, Keiko Taguchi, Norio Suzuki and Yasutake Katoh and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Masayuki Yamamoto

1.3k papers receiving 118.5k citations

Hit Papers

Keap1 represses nuclear activation of antioxidant respons... 1990 2026 2002 2014 1999 2017 2010 2004 2002 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    1999 3.0k citations James Douglas Engel, Masayuki Yamamoto et al. profile →
  2. Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression
    2017 2.3k citations Norio Suzuki, Masayuki Yamamoto et al. profile →
  3. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
    2010 2.0k citations H. Kurokawa, Keiko Taguchi et al. profile →
  4. Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
    2004 1.8k citations Tomoki Chiba, Masayuki Yamamoto et al. Molecular and Cellular Biology profile →
  5. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    2002 1.6k citations Masayuki Yamamoto et al. Proceedings of the National Academy of Sciences profile →
  6. Nrf2–Keap1 defines a physiologically important stress response mechanism
    2004 1.5k citations Hozumi Motohashi, Masayuki Yamamoto profile →
  7. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
    2016 1.4k citations Takafumi Suzuki, Takashi Moriguchi et al. profile →
  8. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
    2018 1.4k citations Masayuki Yamamoto, Hozumi Motohashi et al. profile →
  9. Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
    2000 1.3k citations Masayuki Yamamoto et al. profile →
  10. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
    2011 1.2k citations Keiko Taguchi, Hozumi Motohashi et al. profile →
  11. Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
    2012 1.1k citations Keiko Taguchi, Masayuki Yamamoto et al. profile →
  12. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
    2022 1.1k citations Helmut Sies, Vsevolod V. Belousov et al. Nature Reviews Molecular Cell Biology profile →
  13. The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway
    2020 1.1k citations Liam Baird, Masayuki Yamamoto Molecular and Cellular Biology profile →
  14. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
    2002 1.0k citations Masayuki Yamamoto et al. profile →
  15. Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
    2003 957 citations Masayuki Yamamoto et al. profile →
  16. Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
    2013 950 citations Hozumi Motohashi, Masayuki Yamamoto et al. profile →
  17. Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation
    2005 937 citations Makoto Kobayashi, Masayuki Yamamoto Antioxidants and Redox Signaling profile →
  18. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    2001 928 citations Masayuki Yamamoto et al. Proceedings of the National Academy of Sciences profile →
  19. Molecular basis of the Keap1–Nrf2 system
    2015 824 citations Takafumi Suzuki, Masayuki Yamamoto Free Radical Biology and Medicine profile →
  20. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers
    2004 823 citations Masayuki Yamamoto et al. Proceedings of the National Academy of Sciences profile →
  21. Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1
    2005 779 citations Masayuki Yamamoto et al. Molecular and Cellular Biology profile →
  22. Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling
    2014 768 citations Tomoaki Ida, Tomohiro Sawa et al. Proceedings of the National Academy of Sciences profile →
  23. Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles
    2004 759 citations Masayuki Yamamoto et al. Free Radical Biology and Medicine profile →
  24. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
    2004 740 citations Masayuki Yamamoto et al. profile →
  25. Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    2006 730 citations Makoto Kobayashi, Masayuki Yamamoto profile →
  26. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
    2003 728 citations Junko Wakabayashi, Hozumi Motohashi et al. profile →
  27. Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles
    2003 703 citations Masayuki Yamamoto et al. profile →
  28. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
    2004 696 citations Masayuki Yamamoto et al. profile →
  29. Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model
    2006 607 citations Toshiyuki Tanaka, Masayuki Yamamoto et al. Molecular and Cellular Biology profile →
  30. Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    2008 602 citations Masayuki Yamamoto et al. Proceedings of the National Academy of Sciences profile →
  31. Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer
    2006 594 citations Masayuki Yamamoto et al. profile →
  32. Toward clinical application of the Keap1–Nrf2 pathway
    2013 586 citations Takafumi Suzuki, Hozumi Motohashi et al. profile →
  33. Modulation of Gene Expression by Cancer Chemopreventive Dithiolethiones through the Keap1-Nrf2 Pathway
    2003 571 citations Hozumi Motohashi, Masayuki Yamamoto et al. profile →
  34. Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice
    2002 570 citations Masayuki Yamamoto et al. profile →
  35. Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.
    1990 569 citations Masayuki Yamamoto et al. profile →
  36. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
    2001 560 citations Masayuki Yamamoto et al. profile →
  37. The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds
    2008 558 citations Makoto Kobayashi, Yoshito Kumagai et al. Molecular and Cellular Biology profile →
  38. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene
    2002 556 citations Masayuki Yamamoto et al. The EMBO Journal profile →
  39. Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site
    1996 548 citations Hozumi Motohashi, Masayuki Yamamoto et al. Molecular and Cellular Biology profile →
  40. Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
    2008 526 citations Takafumi Suzuki, Masayuki Yamamoto et al. Cancer Research profile →
  41. Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter
    2002 516 citations Masayuki Yamamoto et al. Molecular and Cellular Biology profile →
  42. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
    2011 496 citations Masayuki Yamamoto et al. profile →
  43. The KEAP1–NRF2 System in Cancer
    2017 407 citations Keiko Taguchi, Masayuki Yamamoto profile →
  44. Molecular Basis of the KEAP1-NRF2 Signaling Pathway
    2023 168 citations Takafumi Suzuki, Masayuki Yamamoto et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Masayuki Yamamoto Japan 169 85.7k 11.1k 10.4k 9.2k 9.1k 1.4k 119.9k
Steven P. Gygi United States 166 88.4k 1.0× 7.9k 0.7× 15.6k 1.5× 14.5k 1.6× 18.1k 2.0× 695 121.5k
Bharat B. Aggarwal United States 166 48.7k 0.6× 16.0k 1.4× 7.7k 0.7× 5.8k 0.6× 3.1k 0.3× 574 104.9k
John C. Reed United States 161 73.3k 0.9× 20.4k 1.8× 4.6k 0.4× 10.6k 1.2× 10.1k 1.1× 799 107.5k
Ronald M. Evans United States 187 96.0k 1.1× 15.1k 1.4× 20.1k 1.9× 11.6k 1.3× 6.0k 0.7× 629 148.1k
Christopher K. Glass United States 149 61.4k 0.7× 19.3k 1.7× 10.0k 1.0× 8.8k 1.0× 3.4k 0.4× 375 96.6k
Roger J. Davis United States 146 62.3k 0.7× 13.6k 1.2× 8.3k 0.8× 7.5k 0.8× 11.7k 1.3× 572 92.6k
Douglas R. Green United States 178 80.9k 0.9× 35.3k 3.2× 6.9k 0.7× 18.8k 2.0× 9.0k 1.0× 613 125.1k
Lewis C. Cantley United States 183 104.9k 1.2× 16.8k 1.5× 11.7k 1.1× 8.7k 0.9× 19.6k 2.1× 710 150.4k
Harvey F. Lodish United States 150 49.1k 0.6× 8.7k 0.8× 15.7k 1.5× 11.1k 1.2× 12.2k 1.3× 646 82.0k
Frank J. Gonzalez United States 171 56.6k 0.7× 5.1k 0.5× 16.8k 1.6× 19.1k 2.1× 3.6k 0.4× 1.3k 119.2k

Countries citing papers authored by Masayuki Yamamoto

Since Specialization
Citations

This map shows the geographic impact of Masayuki Yamamoto's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Masayuki Yamamoto with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Masayuki Yamamoto more than expected).

Fields of papers citing papers by Masayuki Yamamoto

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Masayuki Yamamoto. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Masayuki Yamamoto. The network helps show where Masayuki Yamamoto may publish in the future.

Co-authorship network of co-authors of Masayuki Yamamoto

This figure shows the co-authorship network connecting the top 25 collaborators of Masayuki Yamamoto. A scholar is included among the top collaborators of Masayuki Yamamoto based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Masayuki Yamamoto. Masayuki Yamamoto is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Wang, Ke, Liam Baird, & Masayuki Yamamoto. (2025). The clinical-grade CBP/ p300 inhibitor CCS1477 represses the global NRF2-dependent cytoprotective transcription program and re-sensitizes cancer cells to chemotherapeutic drugs. Free Radical Biology and Medicine. 233. 102–117. 2 indexed citations
2.
Okada, Hikaru, Masakazu Hachisu, Miki Ando, et al.. (2023). A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice. Frontiers in Nutrition. 10. 1081263–1081263. 3 indexed citations
3.
Sies, Helmut, Vsevolod V. Belousov, Navdeep S. Chandel, et al.. (2022). Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nature Reviews Molecular Cell Biology. 23(7). 499–515. 1095 indexed citations breakdown →
4.
Touat‐Todeschini, Leila, Yuichi Shichino, Nicolas Thierry‐Mieg, et al.. (2017). Selective termination of lnc RNA transcription promotes heterochromatin silencing and cell differentiation. The EMBO Journal. 36(17). 2626–2641. 42 indexed citations
5.
Koshiba, S., Ikuko N. Motoike, Daisuke Saigusa, et al.. (2017). Japanese Multi Omics Reference Panel 2017 (jMorp2017). 1 indexed citations
6.
Hamanaka, Teruhiko, Nobuo Ishida, Jun Yasuda, et al.. (2017). A Histologic Categorization of Aqueous Outflow Routes in Familial Open-Angle Glaucoma and Associations With Mutations in the MYOC Gene in Japanese Patients. Investigative Ophthalmology & Visual Science. 58(5). 2818–2818. 11 indexed citations
7.
Hamada, Shin, Tooru Shimosegawa, Keiko Taguchi, et al.. (2017). Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma. American Journal of Physiology-Gastrointestinal and Liver Physiology. 314(1). G65–G74. 19 indexed citations
8.
Zheng, Hongzhi, Jingqi Fu, Peng Xue, et al.. (2015). CNC-bZIP Protein Nrf1-Dependent Regulation of Glucose-Stimulated Insulin Secretion. Antioxidants and Redox Signaling. 22(10). 819–831. 56 indexed citations
9.
Canet, Mark J., Matthew D. Merrell, Bryan Harder, et al.. (2014). Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene. Drug Metabolism and Disposition. 43(1). 93–99. 19 indexed citations
10.
Ida, Tomoaki, Tomohiro Sawa, Hideshi Ihara, et al.. (2014). Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proceedings of the National Academy of Sciences. 111(21). 7606–7611. 768 indexed citations breakdown →
11.
Satoh, Hironori, Takashi Moriguchi, Jun Takai, Masahito Ebina, & Masayuki Yamamoto. (2013). Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis. Cancer Research. 73(13). 4158–4168. 203 indexed citations
12.
Ohkoshi, Akira, Takafumi Suzuki, Masao Ono, Toshimitsu Kobayashi, & Masayuki Yamamoto. (2012). Roles of Keap1–Nrf2 System in Upper Aerodigestive Tract Carcinogenesis. Cancer Prevention Research. 6(2). 149–159. 60 indexed citations
13.
Narita, Masato, et al.. (2009). Tumescent local anesthesia in inguinal herniorrhaphy with a PROLENE Hernia System: original technique and results. The American Journal of Surgery. 198(2). e27–e31. 13 indexed citations
14.
Kurokawa, H., et al.. (2009). Structural Basis of Alternative DNA Recognition by Maf Transcription Factors. Molecular and Cellular Biology. 29(23). 6232–6244. 64 indexed citations
15.
Li, Jinqing, Tomonaga Ichikawa, Luis Villacorta, et al.. (2009). Nrf2 Protects Against Maladaptive Cardiac Responses to Hemodynamic Stress. Arteriosclerosis Thrombosis and Vascular Biology. 29(11). 1843–1850. 221 indexed citations
16.
Shibuya, Masato, et al.. (2007). Effectiveness of Odd Order Aspherical Surface. 36(11). 646–660. 4 indexed citations
17.
Satoh, Kimio, Yutaka Kagaya, Makoto Nakano, et al.. (2006). Important Role of Endogenous Erythropoietin System in Recruitment of Endothelial Progenitor Cells in Hypoxia-Induced Pulmonary Hypertension in Mice. Circulation. 113(11). 1442–1450. 151 indexed citations
18.
Yoshida, Shosei, Ayumi Takakura, Kazuyuki Ohbo, et al.. (2004). Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis. Developmental Biology. 269(2). 447–458. 210 indexed citations
19.
Kobayashi, Makoto, Keizo Nishikawa, Takafumi Suzuki, & Masayuki Yamamoto. (2001). The Homeobox Protein Six3 Interacts with the Groucho Corepressor and Acts as a Transcriptional Repressor in Eye and Forebrain Formation. Developmental Biology. 232(2). 315–326. 152 indexed citations
20.
Chiba, Tomoki, Yasunobu Nagata, Kazuhiro Sakamaki, et al.. (1993). Induction of erythroid-specific gene expression in lymphoid cells.. Proceedings of the National Academy of Sciences. 90(24). 11593–11597. 68 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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