Gary Ruvkun

56.3k total citations · 31 hit papers
218 papers, 42.8k citations indexed

About

Gary Ruvkun is a scholar working on Aging, Molecular Biology and Endocrine and Autonomic Systems. According to data from OpenAlex, Gary Ruvkun has authored 218 papers receiving a total of 42.8k indexed citations (citations by other indexed papers that have themselves been cited), including 146 papers in Aging, 124 papers in Molecular Biology and 33 papers in Endocrine and Autonomic Systems. Recurrent topics in Gary Ruvkun's work include Genetics, Aging, and Longevity in Model Organisms (146 papers), CRISPR and Genetic Engineering (38 papers) and Circadian rhythm and melatonin (33 papers). Gary Ruvkun is often cited by papers focused on Genetics, Aging, and Longevity in Model Organisms (146 papers), CRISPR and Genetic Engineering (38 papers) and Circadian rhythm and melatonin (33 papers). Gary Ruvkun collaborates with scholars based in United States, Canada and United Kingdom. Gary Ruvkun's co-authors include Ilho Ha, Bruce Wightman, Heidi A. Tissenbaum, Amy E. Pasquinelli, Frank J. Slack, H. Robert Horvitz, Michael Finney, Brenda J. Reinhart, Frederick M. Ausubel and Michael Basson and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Gary Ruvkun

217 papers receiving 41.7k citations

Hit Papers

The 21-nucleotide let-7 RNA regulates developmen... 1980 2026 1995 2010 2000 1993 2000 1997 1997 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    2000 3.7k citations Amy E. Pasquinelli, Ann E. Rougvie et al. profile →
  2. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    1993 3.2k citations Gary Ruvkun et al. Cell profile →
  3. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    2000 1.9k citations Amy E. Pasquinelli, Gary Ruvkun et al. profile →
  4. daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
    1997 1.8k citations Heidi A. Tissenbaum, Gary Ruvkun et al. Science profile →
  5. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    1997 1.6k citations Scott Ogg, Heidi A. Tissenbaum et al. profile →
  6. Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
    2001 1.5k citations Amy E. Pasquinelli, Andrew Fire et al. Cell profile →
  7. A uniform system for microRNA annotation
    2003 1.4k citations Victor Ambros, Bonnie Bartel et al. RNA profile →
  8. Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis
    1982 846 citations Gary Ruvkun et al. profile →
  9. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
    2003 810 citations Ravi S. Kamath, Gary Ruvkun et al. profile →
  10. A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
    2002 750 citations Ravi S. Kamath, Gary Ruvkun et al. profile →
  11. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    1996 707 citations Heidi A. Tissenbaum, Gary Ruvkun et al. profile →
  12. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
    1988 659 citations Michael Finney, Gary Ruvkun et al. profile →
  13. The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor
    2000 595 citations Victor Ambros, H. Robert Horvitz et al. profile →
  14. A general method for site-directed mutagenesis in prokaryotes
    1981 577 citations Gary Ruvkun, Frederick M. Ausubel profile →
  15. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    1998 572 citations Gary Ruvkun et al. profile →
  16. DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
    2003 548 citations Scott Kennedy, Gary Ruvkun et al. Science profile →
  17. The unc-86 gene product couples cell lineage and cell identity in C. elegans
    1990 540 citations Michael Finney, Gary Ruvkun Cell profile →
  18. Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
    2000 535 citations Gary Ruvkun et al. Science profile →
  19. Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
    2000 521 citations Gary Ruvkun et al. profile →
  20. Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family
    2001 505 citations Amy E. Pasquinelli, Gary Ruvkun et al. profile →
  21. High-Resolution Mapping Reveals a Conserved, Widespread, Dynamic mRNA Methylation Program in Yeast Meiosis
    2013 503 citations Gary Ruvkun et al. Cell profile →
  22. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    2003 470 citations Gabriel D. Hayes, Gary Ruvkun et al. Proceedings of the National Academy of Sciences profile →
  23. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
    2004 466 citations Scott Kennedy, Gary Ruvkun et al. profile →
  24. C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles
    2009 368 citations Eyleen J. O’Rourke, Christopher E. Carr et al. profile →
  25. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
    2009 318 citations Christopher E. Carr, Gary Ruvkun et al. profile →
  26. The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors
    1988 301 citations Michael Finney, Gary Ruvkun et al. Cell profile →
  27. Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
    2012 295 citations Gary Ruvkun et al. Cell profile →
  28. Caenorhabditis elegans responses to bacteria from its natural habitats
    2016 261 citations Gary Ruvkun et al. Proceedings of the National Academy of Sciences profile →
  29. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
    2013 246 citations Eyleen J. O’Rourke, Gary Ruvkun profile →
  30. Interspecies homology of nitrogenase genes.
    1980 246 citations Gary Ruvkun, Frederick M. Ausubel Proceedings of the National Academy of Sciences profile →
  31. Caenorhabditis elegans pathways that surveil and defend mitochondria
    2014 245 citations Gary Ruvkun et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Gary Ruvkun United States 93 26.8k 17.5k 11.0k 6.1k 4.8k 218 42.8k
H. Robert Horvitz United States 107 31.7k 1.2× 21.2k 1.2× 12.6k 1.1× 8.3k 1.4× 4.6k 1.0× 252 51.6k
Leonard Guarente United States 106 28.9k 1.1× 9.2k 0.5× 4.1k 0.4× 3.5k 0.6× 17.1k 3.6× 205 55.1k
Ronald H.A. Plasterk Netherlands 90 23.7k 0.9× 5.3k 0.3× 9.0k 0.8× 1.3k 0.2× 914 0.2× 193 31.6k
Victor Ambros United States 55 31.8k 1.2× 6.1k 0.3× 25.2k 2.3× 1.5k 0.2× 1.1k 0.2× 107 42.0k
Jan H.J. Hoeijmakers Netherlands 107 38.1k 1.4× 2.6k 0.2× 8.4k 0.8× 2.2k 0.4× 5.2k 1.1× 399 48.0k
Marı́a A. Blasco Spain 100 29.1k 1.1× 8.4k 0.5× 3.6k 0.3× 1.4k 0.2× 24.6k 5.2× 290 49.4k
John B. Hogenesch United States 74 13.2k 0.5× 3.6k 0.2× 3.1k 0.3× 15.1k 2.5× 8.1k 1.7× 171 33.4k
Paolo Sassone‐Corsi France 118 23.4k 0.9× 4.1k 0.2× 2.4k 0.2× 14.5k 2.4× 9.7k 2.0× 433 48.2k
Anne Brunet United States 79 26.6k 1.0× 5.7k 0.3× 3.8k 0.3× 1.3k 0.2× 6.0k 1.3× 144 38.7k
Kunihiro Matsumoto Japan 87 20.1k 0.7× 3.3k 0.2× 5.4k 0.5× 1.2k 0.2× 1.4k 0.3× 233 29.2k

Countries citing papers authored by Gary Ruvkun

Since Specialization
Citations

This map shows the geographic impact of Gary Ruvkun's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gary Ruvkun with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gary Ruvkun more than expected).

Fields of papers citing papers by Gary Ruvkun

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gary Ruvkun. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gary Ruvkun. The network helps show where Gary Ruvkun may publish in the future.

Co-authorship network of co-authors of Gary Ruvkun

This figure shows the co-authorship network connecting the top 25 collaborators of Gary Ruvkun. A scholar is included among the top collaborators of Gary Ruvkun based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gary Ruvkun. Gary Ruvkun is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kniazeva, Marina & Gary Ruvkun. (2025). Translation elongation defects activate the Caenorhabditis elegans ZIP-2 bZIP transcription factor–mediated toxin defense. Proceedings of the National Academy of Sciences. 122(6). e2423578122–e2423578122.
2.
Ambros, Victor, Martin Chalfie, Andrew Fire, et al.. (2025). From nematode to Nobel: How community-shared resources fueled the rise of Caenorhabditis elegans as a research organism. Proceedings of the National Academy of Sciences. 122(48). e2522808122–e2522808122. 1 indexed citations
3.
Meisel, Joshua D., María Miranda, Owen S. Skinner, et al.. (2024). Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism. Cell. 187(3). 659–675.e18. 20 indexed citations
4.
Charlesworth, Amanda, Uri Seroussi, Nicolas J. Lehrbach, et al.. (2021). Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Nucleic Acids Research. 49(15). 8836–8865. 30 indexed citations
5.
Smith, Alvin L., Rocco L. Mancinelli, Wayne Schubert, et al.. (2021). Biological safety in the context of backward planetary protection and Mars Sample Return: conclusions from the Sterilization Working Group. International Journal of Astrobiology. 20(1). 1–28. 18 indexed citations
6.
Fischer, Sylvia E. J. & Gary Ruvkun. (2020). Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons. Proceedings of the National Academy of Sciences. 117(11). 5987–5996. 36 indexed citations
7.
Kniazeva, Marina & Gary Ruvkun. (2019). Rhizobium induces DNA damage in Caenorhabditis elegans intestinal cells. Proceedings of the National Academy of Sciences. 116(9). 3784–3792. 18 indexed citations
8.
Bailey, Ryan C., et al.. (2019). Nucleic Acid Extraction and Sequencing from Low-Biomass Synthetic Mars Analog Soils for In Situ Life Detection. Astrobiology. 19(9). 1139–1152. 18 indexed citations
9.
Pontefract, A., et al.. (2017). Understanding Habitability and Biosignature Preservation in a Hypersaline Mars Analog Environment: Lessons from Spotted Lake. Lunar and Planetary Science Conference. 1124. 1 indexed citations
10.
Shi, Zhen & Gary Ruvkun. (2012). The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proceedings of the National Academy of Sciences. 109(12). 4568–4573. 25 indexed citations
11.
Wang, Meng C., Eyleen J. O’Rourke, & Gary Ruvkun. (2008). Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans. Science. 322(5903). 957–960. 299 indexed citations
12.
Isenbarger, Thomas A., et al.. (2007). Miniprimer PCR, a New Lens for Viewing the Microbial World. Applied and Environmental Microbiology. 74(3). 840–849. 83 indexed citations
13.
Samuelson, Andrew V., R. R. Klimczak, D B Thompson, Christopher E. Carr, & Gary Ruvkun. (2007). Identification ofCaenorhabditis elegansGenes Regulating Longevity Using Enhanced RNAi-sensitive Strains. Cold Spring Harbor Symposia on Quantitative Biology. 72(1). 489–497. 23 indexed citations
14.
Hayes, Gabriel D., Alison R. Frand, & Gary Ruvkun. (2006). The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 133(23). 4631–4641. 89 indexed citations
15.
Hayes, Gabriel D. & Gary Ruvkun. (2006). Misexpression of the Caenorhabditis elegans miRNA let-7 Is Sufficient to Drive Developmental Programs. Cold Spring Harbor Symposia on Quantitative Biology. 71(0). 21–27. 21 indexed citations
16.
Kim, John K., Harrison W. Gabel, Ravi S. Kamath, et al.. (2005). Functional Genomic Analysis of RNA Interference in C. elegans. Science. 308(5725). 1164–1167. 223 indexed citations
17.
Ambros, Victor, Bonnie Bartel, David P. Bartel, et al.. (2003). A uniform system for microRNA annotation. RNA. 9(3). 277–279. 1449 indexed citations breakdown →
18.
Garsin, Danielle A., Jakob Begun, Dennis H. Kim, et al.. (2003). Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens. Science. 300(5627). 1921–1921. 465 indexed citations
19.
Cahill, Catherine M., Guri Tzivion, Nargis Nasrin, et al.. (2001). Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways. Journal of Biological Chemistry. 276(16). 13402–13410. 185 indexed citations
20.
Tissenbaum, Heidi A. & Gary Ruvkun. (1998). An Insulin-like Signaling Pathway Affects Both Longevity and Reproduction in Caenorhabditis elegans. Genetics. 148(2). 703–717. 287 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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