David C. Chan

39.7k total citations · 21 hit papers
128 papers, 30.7k citations indexed

About

David C. Chan is a scholar working on Molecular Biology, Clinical Biochemistry and Epidemiology. According to data from OpenAlex, David C. Chan has authored 128 papers receiving a total of 30.7k indexed citations (citations by other indexed papers that have themselves been cited), including 113 papers in Molecular Biology, 45 papers in Clinical Biochemistry and 20 papers in Epidemiology. Recurrent topics in David C. Chan's work include Mitochondrial Function and Pathology (92 papers), ATP Synthase and ATPases Research (57 papers) and Metabolism and Genetic Disorders (45 papers). David C. Chan is often cited by papers focused on Mitochondrial Function and Pathology (92 papers), ATP Synthase and ATPases Research (57 papers) and Metabolism and Genetic Disorders (45 papers). David C. Chan collaborates with scholars based in United States, Italy and China. David C. Chan's co-authors include Hsiuchen Chen, Scott A. Detmer, Peter S. Kim, Prashant Mishra, J. Michael McCaffery, Hui Chen, Zhiyin Song, Anne Chomyn, Erik E. Griffin and James M. Berger and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David C. Chan

124 papers receiving 30.4k citations

Hit Papers

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondr... 1997 2026 2006 2016 2003 2006 1997 2009 2007 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    2003 2.0k citations Hsiuchen Chen, David C. Chan et al. The Journal of Cell Biology profile →
  2. Mitochondria: Dynamic Organelles in Disease, Aging, and Development
    2006 1.6k citations David C. Chan Cell profile →
  3. Core Structure of gp41 from the HIV Envelope Glycoprotein
    1997 1.6k citations David C. Chan, Peter S. Kim et al. Cell profile →
  4. Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases
    2009 1.2k citations David C. Chan et al. profile →
  5. Functions and dysfunctions of mitochondrial dynamics
    2007 1.1k citations David C. Chan et al. profile →
  6. Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
    2005 1.1k citations Hsiuchen Chen, David C. Chan et al. profile →
  7. HIV Entry and Its Inhibition
    1998 1.0k citations David C. Chan, Peter S. Kim Cell profile →
  8. Mitochondrial Dynamics and Its Involvement in Disease
    2019 959 citations David C. Chan Annual Review of Pathology Mechanisms of Disease profile →
  9. Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
    2013 959 citations Oliver C. Losón, Hsiuchen Chen et al. profile →
  10. Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
    2011 943 citations David C. Chan profile →
  11. Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations
    2010 941 citations Hsiuchen Chen, J. Michael McCaffery et al. Cell profile →
  12. Metabolic regulation of mitochondrial dynamics
    2016 860 citations Prashant Mishra, David C. Chan The Journal of Cell Biology profile →
  13. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
    2016 857 citations Sébastien Herzig, Julien Courchet et al. Science profile →
  14. Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy
    2011 804 citations Michael J. Sweredoski, Sonja Hess et al. profile →
  15. Mitochondrial Fusion and Fission in Mammals
    2006 802 citations David C. Chan profile →
  16. Mitochondrial dynamics and inheritance during cell division, development and disease
    2014 789 citations Prashant Mishra, David C. Chan profile →
  17. Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum
    2007 718 citations Hsiuchen Chen, J. Michael McCaffery et al. Cell profile →
  18. Structural Basis of Mitochondrial Tethering by Mitofusin Complexes
    2004 717 citations Hsiuchen Chen, J. Michael McCaffery et al. Science profile →
  19. OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L
    2007 651 citations Hsiuchen Chen, David C. Chan et al. The Journal of Cell Biology profile →
  20. SLP‐2 is required for stress‐induced mitochondrial hyperfusion
    2009 609 citations Mariusz Karbowski, Sébastien Herzig et al. profile →
  21. Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species
    2024 53 citations Shun‐ichi Yamashita, Yuki Sugiura et al. Cell Death and Differentiation profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
David C. Chan United States 68 23.9k 5.4k 5.3k 4.6k 2.7k 128 30.7k
Mary‐Ellen Harper Canada 67 8.7k 0.4× 711 0.1× 2.8k 0.5× 7.6k 1.7× 1.7k 0.6× 243 18.6k
Richard J. Youle United States 103 43.9k 1.8× 5.0k 0.9× 20.3k 3.8× 7.5k 1.7× 292 0.1× 239 63.1k
Bruce E. Kemp Australia 112 31.0k 1.3× 736 0.1× 5.2k 1.0× 11.1k 2.4× 461 0.2× 451 44.8k
Junying Yuan United States 103 36.5k 1.5× 965 0.2× 10.9k 2.1× 4.3k 0.9× 407 0.2× 254 52.9k
Akitsugu Yamamoto Japan 76 14.1k 0.6× 615 0.1× 15.2k 2.9× 3.6k 0.8× 479 0.2× 210 29.5k
Jean‐Claude Martinou Switzerland 79 22.0k 0.9× 1.9k 0.3× 3.1k 0.6× 2.2k 0.5× 135 0.1× 194 27.9k
Keiji Tanaka Japan 112 37.9k 1.6× 847 0.2× 19.9k 3.7× 4.3k 0.9× 454 0.2× 428 55.1k
Paul Säftig Germany 104 18.9k 0.8× 677 0.1× 6.5k 1.2× 11.5k 2.5× 241 0.1× 333 39.2k
Eiki Kominami Japan 78 14.9k 0.6× 689 0.1× 15.9k 3.0× 5.0k 1.1× 415 0.2× 313 31.3k
Marco E. Bianchi Italy 88 13.2k 0.6× 11.2k 2.1× 2.8k 0.5× 1.6k 0.4× 152 0.1× 225 31.0k

Countries citing papers authored by David C. Chan

Since Specialization
Citations

This map shows the geographic impact of David C. Chan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David C. Chan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David C. Chan more than expected).

Fields of papers citing papers by David C. Chan

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David C. Chan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David C. Chan. The network helps show where David C. Chan may publish in the future.

Co-authorship network of co-authors of David C. Chan

This figure shows the co-authorship network connecting the top 25 collaborators of David C. Chan. A scholar is included among the top collaborators of David C. Chan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David C. Chan. David C. Chan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Deng, Yamei, Jie Zhu, Emily M. Walker, et al.. (2025). LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes. Nature Metabolism. 7(8). 1570–1592. 1 indexed citations
2.
Rosencrans, William M., et al.. (2025). Putative PINK1/Parkin activators lower the threshold for mitophagy by sensitizing cells to mitochondrial stress. Science Advances. 11(35). eady0240–eady0240. 2 indexed citations
3.
Yamada, Tatsuya, Daisuke Murata, Hu Wang, et al.. (2025). Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1. Nature. 639(8055). 776–783. 12 indexed citations
4.
Yamashita, Shun‐ichi, Yuki Sugiura, Keiichi Inoue, et al.. (2024). Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species. Cell Death and Differentiation. 31(5). 651–661. 53 indexed citations breakdown →
5.
Yang, Huan, Raymond Liu, Jina Yun, et al.. (2022). Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria. Nature Communications. 13(1). 1582–1582. 45 indexed citations
6.
Dai, Wenting, Zhichao Wang, Qiong Wang, David C. Chan, & Lei Jiang. (2022). Metabolic reprogramming in the OPA1-deficient cells. Cellular and Molecular Life Sciences. 79(10). 517–517. 6 indexed citations
7.
Seo, Seungwoon, Jaemoon Yang, Ki Sook Oh, et al.. (2021). ER-associated CTRP1 regulates mitochondrial fission via interaction with DRP1. Experimental & Molecular Medicine. 53(11). 1769–1780. 12 indexed citations
8.
Chan, David C.. (2019). Mitochondrial Dynamics and Its Involvement in Disease. Annual Review of Pathology Mechanisms of Disease. 15(1). 235–259. 959 indexed citations breakdown →
9.
Varuzhanyan, Grigor, et al.. (2019). Mitochondrial fusion is required for spermatogonial differentiation and meiosis. eLife. 8. 68 indexed citations
10.
Li, Yujie, Yu-Lu Cao, Jian-Xiong Feng, et al.. (2019). Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nature Communications. 10(1). 4914–4914. 119 indexed citations
11.
Zhang, Ting, Prashant Mishra, Bruce A. Hay, David C. Chan, & Ming Guo. (2017). Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. eLife. 6. 69 indexed citations
12.
Mishra, Prashant, Jeramie D. Watrous, Valério Carelli, et al.. (2017). The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nature Communications. 8(1). 15074–15074. 232 indexed citations
13.
Herzig, Sébastien, Julien Courchet, Tommy L. Lewis, et al.. (2016). AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science. 351(6270). 275–281. 857 indexed citations breakdown →
14.
Cheng, Chun-Ting, Ching‐Ying Kuo, Ching Ouyang, et al.. (2016). Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells. Cancer Research. 76(17). 5006–5018. 54 indexed citations
15.
Chen, Hsiuchen, Shuxun Ren, Clary B. Clish, et al.. (2015). Titration of mitochondrial fusion rescues Mff -deficient cardiomyopathy. The Journal of Cell Biology. 211(4). 795–805. 133 indexed citations
16.
Ngo, Huu, et al.. (2014). Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation. Nature Communications. 5(1). 3077–3077. 193 indexed citations
17.
Shirihai, Orian S., Anthony Molina, Linsey Stiles, et al.. (2011). Mitochondrial dynamics and metabolic regulation. The FASEB Journal. 25.
18.
Karbowski, Mariusz, Damien Arnoult, Hsiuchen Chen, et al.. (2004). Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. The Journal of Cell Biology. 164(4). 493–499. 357 indexed citations
19.
Chan, David C. & Peter S. Kim. (1998). HIV Entry and Its Inhibition. Cell. 93(5). 681–684. 1022 indexed citations breakdown →
20.
Wynshaw‐Boris, Anthony, Gabriella Ryan, Chu‐Xia Deng, et al.. (1997). The Role of a Single Formin Isoform in the Limb and Renal Phenotypes of Limb Deformity. Molecular Medicine. 3(6). 372–384. 32 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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