John G. Doench

43.9k total citations · 14 hit papers
145 papers, 20.0k citations indexed

About

John G. Doench is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, John G. Doench has authored 145 papers receiving a total of 20.0k indexed citations (citations by other indexed papers that have themselves been cited), including 111 papers in Molecular Biology, 27 papers in Oncology and 21 papers in Genetics. Recurrent topics in John G. Doench's work include CRISPR and Genetic Engineering (60 papers), RNA and protein synthesis mechanisms (21 papers) and Advanced biosensing and bioanalysis techniques (17 papers). John G. Doench is often cited by papers focused on CRISPR and Genetic Engineering (60 papers), RNA and protein synthesis mechanisms (21 papers) and Advanced biosensing and bioanalysis techniques (17 papers). John G. Doench collaborates with scholars based in United States, Germany and United Kingdom. John G. Doench's co-authors include Phillip A. Sharp, David E. Root, Ella Hartenian, Benjamin L. Ebert, Mudra Hegde, Meagan E. Sullender, Tarjei S. Mikkelsen, Neville E. Sanjana, David Scott and Dirk Heckl and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

John G. Doench

141 papers receiving 19.8k citations

Hit Papers

Genome-Scale CRISPR-Cas9 Knockout Screening in H... 2003 2026 2010 2018 2013 2016 2004 2014 2003 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
    2013 3.7k citations Ophir Shalem, Neville E. Sanjana et al. Science profile →
  2. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
    2016 2.6k citations John G. Doench, Meagan E. Sullender et al. profile →
  3. Specificity of microRNA target selection in translational repression
    2004 1.3k citations John G. Doench et al. profile →
  4. Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation
    2014 1.2k citations John G. Doench, Ella Hartenian et al. profile →
  5. siRNAs can function as miRNAs
    2003 965 citations John G. Doench et al. profile →
  6. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
    2017 774 citations Robert T. Manguso, Flavian D. Brown et al. profile →
  7. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
    2019 663 citations Jesse S. Boehm, John G. Doench et al. Nature Communications profile →
  8. A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
    2018 567 citations Deng Pan, Aya Kobayashi et al. Science profile →
  9. Cytochrome P450 oxidoreductase contributes tophospholipid peroxidation in ferroptosis
    2020 565 citations John G. Doench et al. profile →
  10. Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
    2013 550 citations John G. Doench et al. profile →
  11. Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities
    2018 505 citations Mudra Hegde, Christine Strand et al. Nature Communications profile →
  12. Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
    2021 298 citations John G. Doench, Martin W. LaFleur et al. profile →
  13. Massively parallel assessment of human variants with base editor screens
    2021 202 citations Mudra Hegde, Peter C. DeWeirdt et al. profile →
  14. ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
    2023 76 citations Adam Brown, John G. Doench et al. Nature Communications profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
John G. Doench United States 51 15.7k 3.8k 3.2k 2.6k 2.1k 145 20.0k
Roderick L. Beijersbergen Netherlands 48 10.9k 0.7× 2.2k 0.6× 5.1k 1.6× 1.5k 0.6× 1.4k 0.7× 117 15.7k
Maarten van Lohuizen Netherlands 73 17.4k 1.1× 2.4k 0.6× 4.0k 1.2× 1.4k 0.5× 2.6k 1.2× 143 20.4k
Wen Xue China 49 10.7k 0.7× 3.8k 1.0× 2.5k 0.8× 1.4k 0.5× 1.5k 0.7× 204 13.9k
Joan Conaway United States 76 17.1k 1.1× 3.3k 0.9× 3.5k 1.1× 1.5k 0.6× 2.5k 1.2× 189 20.0k
Ronald Conaway United States 77 17.6k 1.1× 3.3k 0.9× 3.5k 1.1× 1.5k 0.6× 2.7k 1.3× 189 20.6k
Jesús Gil United Kingdom 54 9.7k 0.6× 3.1k 0.8× 2.2k 0.7× 2.7k 1.0× 951 0.4× 120 14.7k
David D.L. Bowtell Australia 71 11.6k 0.7× 3.5k 0.9× 5.4k 1.7× 2.2k 0.8× 2.1k 1.0× 221 18.4k
Frank J. Rauscher United States 71 15.4k 1.0× 1.9k 0.5× 2.9k 0.9× 2.2k 0.8× 2.8k 1.3× 178 19.9k
Lawrence A. Donehower United States 59 12.1k 0.8× 3.4k 0.9× 9.0k 2.8× 1.4k 0.5× 1.7k 0.8× 148 17.7k
Reuven Agami Netherlands 57 16.6k 1.1× 7.5k 2.0× 2.7k 0.8× 1.3k 0.5× 1.9k 0.9× 127 19.9k

Countries citing papers authored by John G. Doench

Since Specialization
Citations

This map shows the geographic impact of John G. Doench's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John G. Doench with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John G. Doench more than expected).

Fields of papers citing papers by John G. Doench

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John G. Doench. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John G. Doench. The network helps show where John G. Doench may publish in the future.

Co-authorship network of co-authors of John G. Doench

This figure shows the co-authorship network connecting the top 25 collaborators of John G. Doench. A scholar is included among the top collaborators of John G. Doench based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John G. Doench. John G. Doench is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Jain, Neha, Anna-Marie Marsh, Julie Boucau, et al.. (2025). VPS18 contributes to phagosome membrane integrity in Mycobacterium tuberculosis –infected macrophages. Science Advances. 11(5). eadr6166–eadr6166. 4 indexed citations
2.
Shirole, Nitin H., Yenarae Lee, Amy Goodale, et al.. (2025). Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer. Cancer Discovery. 15(7). 1484–1504. 2 indexed citations
3.
Misek, Sean A., Jérémie Kalfon, Javad Noorbakhsh, et al.. (2024). Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries. Nature Communications. 15(1). 4892–4892. 4 indexed citations
4.
Ito, Yoshinaga, Deng Pan, Wubing Zhang, et al.. (2023). Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell–Secreted Cytokines. Cancer Discovery. 13(5). 1186–1209. 13 indexed citations
5.
Matta, Sumit K., Pallavi Chandra, Adam Brown, et al.. (2023). Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cells. Proceedings of the National Academy of Sciences. 121(1). e2315865120–e2315865120. 18 indexed citations
6.
Lane-Reticker, Sarah Kate, Emily Kessler, Audrey J. Muscato, et al.. (2023). Protocol for in vivo CRISPR screening using selective CRISPR antigen removal lentiviral vectors. STAR Protocols. 4(1). 102082–102082. 2 indexed citations
7.
Li, Tianxia, Osamu Kikuchi, Jin Zhou, et al.. (2023). Developing SHP2-based combination therapy for KRAS-amplified cancer. JCI Insight. 8(3). 7 indexed citations
8.
Najm, Fadi J., Peter C. DeWeirdt, Samantha M. Bevill, et al.. (2023). Chromatin complex dependencies reveal targeting opportunities in leukemia. Nature Communications. 14(1). 448–448. 7 indexed citations
9.
Jutzi, Jonas S., Anna E. Marneth, Ángel Guerra-Moreno, et al.. (2022). Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs. Blood. 140(11). 1291–1304. 11 indexed citations
10.
Sateriale, Adam, Julie B. Engiles, Ryan D. Pardy, et al.. (2022). A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition. PLoS Pathogens. 18(5). e1010003–e1010003. 24 indexed citations
11.
Shi, Xiaojian, Hardik Shah, Tsz‐Leung To, et al.. (2022). Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nature Communications. 13(1). 2483–2483. 60 indexed citations
12.
Shen, Yu J., Yuji Mishima, Jiantao Shi, et al.. (2020). Progression signature underlies clonal evolution and dissemination of multiple myeloma. Blood. 137(17). 2360–2372. 32 indexed citations
13.
LaFleur, Martin W., Thao H. Nguyen, Kathleen B. Yates, et al.. (2019). A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nature Communications. 10(1). 1668–1668. 80 indexed citations
14.
Zdraljevic, Stefan, Bennett W. Fox, Christine Strand, et al.. (2019). Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism. eLife. 8. 49 indexed citations
15.
Nandakumar, Satish K., Sean McFarland, Caleb A. Lareau, et al.. (2019). Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis. eLife. 8. 12 indexed citations
16.
Orchard, Robert C., et al.. (2018). Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening. Journal of Virology. 93(1). 44 indexed citations
17.
Pacheco, Alline R., Jacob E. Lazarus, Brandon Sit, et al.. (2018). CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection. mBio. 9(3). 45 indexed citations
18.
Pan, Deng, Aya Kobayashi, Peng Jiang, et al.. (2018). A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing. Science. 359(6377). 770–775. 567 indexed citations breakdown →
19.
Orchard, Robert C., Craig B. Wilen, John G. Doench, et al.. (2016). Discovery of a proteinaceous cellular receptor for a norovirus. Science. 353(6302). 933–936. 206 indexed citations
20.
Shalem, Ophir, Neville E. Sanjana, Ella Hartenian, et al.. (2013). Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells. Science. 343(6166). 84–87. 3656 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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