Tak W. Mak

129.3k citations

710 papers · 96.1k indexed · 40 hit papers · h-index 156

Molecular Biology top 0.01%
Immunology top 0.01%
Oncology top 0.01%
Cancer Research top 0.01%
Epidemiology top 0.1%

Co-authors: Isaac S. Harris Rob A. Cairns Andrew Wakeham Chiara Gorrini Andrew Elia Gordon S. Duncan Dirk Brenner Akira Suzuki
Topics: Immune Cell Function and Interaction (134 papers)T-cell and B-cell Immunology (121 papers)Immune Response and Inflammation (80 papers)
Cited by: Immunology Cancer Research Oncology
Journals: Nature Science New England Journal of Medicine
Partner nations: Canada United States Japan

In The Last Decade

Tak W. Mak

703 papers receiving 94.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Regulation of cancer cell metabolism

2011 3.9k citations Rob A. Cairns, Tak W. Mak et al. profile →
Modulation of oxidative stress as an anticancer strategy

2013 2.8k citations Chiara Gorrini, Tak W. Mak et al. profile →
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 2.7k citations Andrew Wakeham, Tak W. Mak et al. profile →
Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

2002 2.2k citations Tak W. Mak et al. profile →
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 2.1k citations Vuk Stambolic, Akira Suzuki et al. profile →
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 1.8k citations Tak W. Mak et al. The Journal of Experimental Medicine profile →
Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

2011 1.1k citations Mauricio Rosas‐Ballina, Peder S. Olofsson et al. Science profile →
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

1984 1.1k citations Tak W. Mak et al. profile →
DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 1.0k citations Atsushi Hirao, Andrew Wakeham et al. Science profile →
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

2003 1.0k citations Yasuo Horie, Junya Masumoto et al. profile →
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

2006 984 citations Tak W. Mak et al. profile →
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

2004 930 citations Atsushi Hirao, Tak W. Mak et al. profile →
Profound block in thymocyte development in mice lacking p56lck

1992 867 citations Andrew Wakeham, Tak W. Mak et al. profile →
Pathways of apoptotic and non-apoptotic death in tumour cells

2004 803 citations Hitoshi Okada, Tak W. Mak profile →
TNF and ROS Crosstalk in Inflammation

2016 802 citations Heiko Blaser, Tak W. Mak et al. profile →
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

2005 796 citations Gordon S. Duncan, Tak W. Mak et al. profile →
FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 759 citations Andrew Elia, Andrew Wakeham et al. Science profile →
Regulation of tumour necrosis factor signalling: live or let die

2015 758 citations Dirk Brenner, Heiko Blaser et al. profile →
Regulation of PTEN Transcription by p53

2001 753 citations Vuk Stambolic, Samuel Benchimol et al. profile →
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

1998 747 citations Tak W. Mak et al. profile →
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

2005 731 citations Tak W. Mak et al. The Journal of Experimental Medicine profile →
Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 727 citations T. Matsuyama, Tohru Kimura et al. Science profile →
Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 705 citations Andrew Wakeham, Pamela S. Ohashi et al. profile →
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

2006 679 citations Tak W. Mak et al. Proceedings of the National Academy of Sciences profile →
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 665 citations Akira Suzuki, Vuk Stambolic et al. profile →
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 603 citations Andrew Wakeham, Tak W. Mak et al. profile →
Direct Neural Fate Specification from Embryonic Stem Cells

2001 579 citations Tak W. Mak et al. profile →
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

2005 566 citations Raymond H. Kim, Hossein Aleyasin et al. Proceedings of the National Academy of Sciences profile →
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

1993 566 citations T. Matsuyama, Tohru Kimura et al. profile →
Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 559 citations Tak W. Mak et al. Science profile →
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

2010 558 citations Stefan Größ, Rob A. Cairns et al. The Journal of Experimental Medicine profile →
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

2004 547 citations Yasuo Horie, Akira Suzuki et al. profile →
The development of inflammatory TH-17 cells requires interferon-regulatory factor 4

2007 540 citations Anne Brüstle, Enrico Arpaia et al. profile →
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

2002 536 citations Andrew Elia, Tak W. Mak et al. profile →
The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse

1996 530 citations Andrew Wakeham, Julia M. Potter et al. profile →
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 517 citations Andrew Elia, Julia M. Potter et al. profile →
Conservation of the Notch signalling pathway in mammalian neurogenesis

1997 513 citations Andrew Wakeham, Toru Nakano et al. profile →
Lipocalin-2 Resistance Confers an Advantage to Salmonella enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine

2009 419 citations Thorsten Berger, Tak W. Mak et al. profile →
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

2001 399 citations Vuk Stambolic, Akira Suzuki et al. profile →
Beyond immune checkpoint blockade: emerging immunological strategies

2021 326 citations Thorsten Berger, Tak W. Mak et al. profile →

Peers

Countries citing papers authored by Tak W. Mak

Since Specialization

Citations

This map shows the geographic impact of Tak W. Mak's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tak W. Mak with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tak W. Mak more than expected).

Fields of papers citing papers by Tak W. Mak

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tak W. Mak. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tak W. Mak. The network helps show where Tak W. Mak may publish in the future.

Co-authorship network of co-authors of Tak W. Mak

This figure shows the co-authorship network connecting the top 25 collaborators of Tak W. Mak. A scholar is included among the top collaborators of Tak W. Mak based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tak W. Mak. Tak W. Mak is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Lymphocyte-derived ACh regulates local innate but not adaptive immunity 2013 ·Proceedings of the National Academy of Sciences ·Colin Reardon,Gordon S. Duncan,Anne Brüstle,Dirk Brenner,Michael W. Tusche,Peder S. Olofsson,Mauricio Rosas‐Ballina,Kevin J. Tracey,Tak W. Mak	179
2	Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress 2013 ·Science ·C. Bassi,Jason Ho,Tharan Srikumar,Ryan J.O. Dowling,Chiara Gorrini,S.J. Miller,Tak W. Mak,Benjamin G. Neel,Brian Raught,Vuk Stambolic	322
3	Molecular Pathways: Tumor Cells Co-opt the Brain-Specific Metabolism Gene CPT1C to Promote Survival 2012 ·Clinical Cancer Research ·Patrick T. Reilly,Tak W. Mak	52
4	HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes 2012 ·Blood ·Gladys W. Wong,Gisele Knowles,Tak W. Mak,Adolfo A. Ferrando,Juan Carlos Zúñiga‐Pflücker	91
5	Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease 2012 ·Proceedings of the National Academy of Sciences ·Maxime W.C. Rousseaux,Paul C. Marcogliese,Dianbo Qu,(unknown),(unknown),Raymond H. Kim,Ruth S. Slack,Michael G. Schlossmacher,Diane C. Lagace,Tak W. Mak,David S. Park	64
6	Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation 2011 ·Proceedings of the National Academy of Sciences ·João G. Magalhães,Stephen Rubino,Leonardo H. Travassos,Lionel Le Bourhis,Wei Duan,Gernot Sellge,Kaoru Geddes,Colin Reardon,Matthias Lechmann,Letícia A. M. Carneiro,Thirumahal Selvanantham,Jörg H. Fritz,Betsy C. Taylor,David Artis,Tak W. Mak,Michael R. Comeau,Michael Croft,Stephen E. Girardin,Dana J. Philpott	64
7	Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 ( Irf2 ) in trypsinogen5 gene transcription 2011 ·Proceedings of the National Academy of Sciences ·Hideki Hayashi,Tomoko Kohno,Kiyoshi Yasui,Hiroyuki Murota,Tohru Kimura,Gordon S. Duncan,Tomoki Nakashima,Kazuo Yamamoto,(unknown),Yuhua Ma,Koon Jiew Chua,Takashi Suematsu,Isao Shimokawa,Shizuo Akira,Yoshinao Kubo,Tak W. Mak,T. Matsuyama	14
8	HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1 2010 ·Proceedings of the National Academy of Sciences ·Miguel Quintela-Fandiño,Enrico Arpaia,Dirk Brenner,(unknown),(unknown),Heiko Blaser,Roumiana Alexandrova,Evan Lind,(unknown),Andrew Wakeham,Pamela S. Ohashi,Tak W. Mak	37
9	Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutationsbreakdown → 2010 ·The Journal of Experimental Medicine ·Stefan Größ,Rob A. Cairns,Mark D. Minden,Edward M. Driggers,Mark Bittinger,Hyun Gyung Jang,Masato Sasaki,Shengfang Jin,David P. Schenkein,Shinsan M. Su,Lenny Dang,Valeria R. Fantin,Tak W. Mak	558
10	Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay 2010 ·Proceedings of the National Academy of Sciences ·David R. McIlwain,Qun Pan,Patrick T. Reilly,Andrew Elia,Susan McCracken,Andrew Wakeham,Annick Itie-YouTen,Benjamin J. Blencowe,Tak W. Mak	154
11	DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway 2010 ·Proceedings of the National Academy of Sciences ·Hossein Aleyasin,Maxime W.C. Rousseaux,Paul C. Marcogliese,(unknown),Isabella Irrcher,Alvin Joselin,(unknown),Raymond H. Kim,Patrizia Rizzu,Steve Callaghan,Ruth S. Slack,Tak W. Mak,David S. Park	145
12	Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development 2010 ·Proceedings of the National Academy of Sciences ·Takeshi Ueda,Masato Sasaki,Andrew Elia,Iok In Christine Chio,Koichi Hamada,Rikiro Fukunaga,Tak W. Mak	165
13	Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis 2008 ·Cancer Research ·(unknown),Koichi Hamada,Takehiko Sasaki,(unknown),Sachiko Fujita,Kohichi Kawahara,Masato Sasaki,Hiroyuki Kishimoto,Satoshi Eguchi,Itaru Kojima,Friedrich Beermann,Tetsunori Kimura,Masatake Osawa,Satoshi Itami,Tak W. Mak,Toru Nakano,Motomu Manabe,Akira Suzuki	46
14	Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation 2008 ·Proceedings of the National Academy of Sciences ·Douglas J. Mahoney,Herman H. Cheung,(unknown),Stéphanie Plenchette,Carl Simard,Emeka K. Enwere,Vinay A. Arora,Tak W. Mak,Eric C. LaCasse,Jeffrey F. Waring,Robert G. Korneluk	426
15	Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo 2006 ·The Journal of Experimental Medicine ·Junya Masumoto,Kangkang Yang,Sooryanarayana Varambally,Mizuho Hasegawa,Scott A. Tomlins,Su Qiu,Yukari Fujimoto,Akiko Kawasaki,Simon J. Foster,Yasuo Horie,Tak W. Mak,Gabriel Núñez,Arul M. Chinnaiyan,Koichi Fukase,Naohiro Inohara	176
16	Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury 2006 ·Proceedings of the National Academy of Sciences ·Thorsten Berger,Atsushi Togawa,Gordon S. Duncan,Andrew Elia,Annick You-Ten,Andrew Wakeham,(unknown),Carol C. Cheung,Tak W. Mak	380
17	Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients 2006 ·Cancer Research ·Hiroshi Tsuruta,Hiroyuki Kishimoto,Takehiko Sasaki,Yasuo Horie,Miyuki Natsui,(unknown),Koichi Hamada,Nobuyuki Yajima,Koichi Kawahara,Masato Sasaki,Norihiko Tsuchiya,Katsuhiko Enomoto,Tak W. Mak,Toru Nakano,Tomonori Habuchi,Akira Suzuki	82
18	Ckap2 Regulates Aneuploidy, Cell Cycling, and Cell Death in a p53-Dependent Manner 2005 ·Cancer Research ·Katsuya Tsuchihara,(unknown),Chris Bakal,Hitoshi Okada,Lauren M. Brown,(unknown),Kathrin Zaugg,Alexandra Ho,Annick Itie-YouTen,Marees Harris-Brandts,Robert Rottapel,Christopher D. Richardson,Samuel Benchimol,Tak W. Mak	42
19	Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice 2004 ·Molecular and Cellular Biology ·L. Miguel Martins,Alastair Morrison,Kristina Klupsch,Valentina Fedele,Nicoleta Moisoi,Peter Teismann,Alejandro Abuin,Evelyn Grau,Martin Geppert,George P. Livi,Caretha L. Creasy,Alison Martin,Iain P. Hargreaves,Simon Heales,Hitoshi Okada,Sebastian Brandner,Jörg B. Schulz,Tak W. Mak,Julian Downward	315
20	Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila 2002 ·Proceedings of the National Academy of Sciences ·Malte Peters,Carmela DeLuca,Atsushi Hirao,Vuk Stambolic,Julia M. Potter,Lily Zhou,(unknown),Bryan E. Snow,Sudha Arya,(unknown),Denis Bouchard,Richard Binari,Armen S. Manoukian,Tak W. Mak	78

About Tak W. Mak

Tak W. Mak is a scholar working on Immunology, Cancer Research and Oncology, having authored 710 papers that have together received 96.1k indexed citations. Recurring topics across this work include Immune Cell Function and Interaction (134 papers), T-cell and B-cell Immunology (121 papers) and Immune Response and Inflammation (80 papers). The work is most often cited by research in Immunology (34.0k citations), Cancer Research (17.0k citations) and Oncology (22.6k citations). Tak W. Mak has collaborated with scholars based in Canada, United States and Japan. Frequent co-authors include Isaac S. Harris, Rob A. Cairns, Andrew Wakeham, Chiara Gorrini, Andrew Elia, Gordon S. Duncan, Dirk Brenner, Akira Suzuki, Jürgen Ruland and Yasunobu Yoshikai. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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