Tak W. Mak

129.3k total citations · 40 hit papers
710 papers, 96.1k citations indexed

About

Tak W. Mak is a scholar working on Immunology, Molecular Biology and Oncology. According to data from OpenAlex, Tak W. Mak has authored 710 papers receiving a total of 96.1k indexed citations (citations by other indexed papers that have themselves been cited), including 312 papers in Immunology, 311 papers in Molecular Biology and 173 papers in Oncology. Recurrent topics in Tak W. Mak's work include Immune Cell Function and Interaction (134 papers), T-cell and B-cell Immunology (121 papers) and Immune Response and Inflammation (80 papers). Tak W. Mak is often cited by papers focused on Immune Cell Function and Interaction (134 papers), T-cell and B-cell Immunology (121 papers) and Immune Response and Inflammation (80 papers). Tak W. Mak collaborates with scholars based in Canada, United States and Japan. Tak W. Mak's co-authors include Isaac S. Harris, Rob A. Cairns, Andrew Wakeham, Chiara Gorrini, Andrew Elia, Gordon S. Duncan, Dirk Brenner, Akira Suzuki, Jürgen Ruland and Yasunobu Yoshikai and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Tak W. Mak

703 papers receiving 94.1k citations

Hit Papers

Regulation of cancer cell... 1984 2026 1998 2012 2011 2013 1999 2002 1998 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Regulation of cancer cell metabolism
    2011 3.9k citations Rob A. Cairns, Tak W. Mak et al. profile →
  2. Modulation of oxidative stress as an anticancer strategy
    2013 2.8k citations Chiara Gorrini, Tak W. Mak et al. profile →
  3. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    1999 2.7k citations Andrew Wakeham, Tak W. Mak et al. profile →
  4. Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts
    2002 2.2k citations Tak W. Mak et al. profile →
  5. Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
    1998 2.1k citations Vuk Stambolic, Akira Suzuki et al. profile →
  6. Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
    2000 1.8k citations Tak W. Mak et al. The Journal of Experimental Medicine profile →
  7. Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
    2011 1.1k citations Mauricio Rosas‐Ballina, Peder S. Olofsson et al. Science profile →
  8. A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains
    1984 1.1k citations Tak W. Mak et al. profile →
  9. DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2
    2000 1.0k citations Atsushi Hirao, Andrew Wakeham et al. Science profile →
  10. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
    2003 1.0k citations Yasuo Horie, Junya Masumoto et al. profile →
  11. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
    2006 984 citations Tak W. Mak et al. profile →
  12. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    2004 930 citations Atsushi Hirao, Tak W. Mak et al. profile →
  13. Profound block in thymocyte development in mice lacking p56lck
    1992 867 citations Andrew Wakeham, Tak W. Mak et al. profile →
  14. Pathways of apoptotic and non-apoptotic death in tumour cells
    2004 803 citations Hitoshi Okada, Tak W. Mak profile →
  15. TNF and ROS Crosstalk in Inflammation
    2016 802 citations Heiko Blaser, Tak W. Mak et al. profile →
  16. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    2005 796 citations Gordon S. Duncan, Tak W. Mak et al. profile →
  17. FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
    1998 759 citations Andrew Elia, Andrew Wakeham et al. Science profile →
  18. Regulation of tumour necrosis factor signalling: live or let die
    2015 758 citations Dirk Brenner, Heiko Blaser et al. profile →
  19. Regulation of PTEN Transcription by p53
    2001 753 citations Vuk Stambolic, Samuel Benchimol et al. profile →
  20. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
    1998 747 citations Razqallah Hakem, Tak W. Mak et al. profile →
  21. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis
    2005 731 citations Tak W. Mak et al. The Journal of Experimental Medicine profile →
  22. Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages
    1994 727 citations T. Matsuyama, Tohru Kimura et al. Science profile →
  23. Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice
    1997 705 citations Andrew Wakeham, Pamela S. Ohashi et al. profile →
  24. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
    2006 679 citations Tak W. Mak et al. Proceedings of the National Academy of Sciences profile →
  25. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
    1998 665 citations Akira Suzuki, Vuk Stambolic et al. profile →
  26. Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4
    1991 603 citations Andrew Wakeham, Tak W. Mak et al. profile →
  27. Direct Neural Fate Specification from Embryonic Stem Cells
    2001 579 citations Tak W. Mak et al. profile →
  28. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
    2005 566 citations Raymond H. Kim, Hossein Aleyasin et al. Proceedings of the National Academy of Sciences profile →
  29. Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
    1993 566 citations T. Matsuyama, Tohru Kimura et al. profile →
  30. Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition
    1999 559 citations Razqallah Hakem, Tak W. Mak et al. Science profile →
  31. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
    2010 558 citations Stefan Größ, Rob A. Cairns et al. The Journal of Experimental Medicine profile →
  32. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    2004 547 citations Yasuo Horie, Akira Suzuki et al. profile →
  33. The development of inflammatory TH-17 cells requires interferon-regulatory factor 4
    2007 540 citations Anne Brüstle, Enrico Arpaia et al. profile →
  34. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    2002 536 citations Andrew Elia, Tak W. Mak et al. profile →
  35. The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse
    1996 530 citations Razqallah Hakem, Andrew Wakeham et al. profile →
  36. Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
    1998 517 citations Andrew Elia, Julia M. Potter et al. profile →
  37. Conservation of the Notch signalling pathway in mammalian neurogenesis
    1997 513 citations Andrew Wakeham, Toru Nakano et al. profile →
  38. Lipocalin-2 Resistance Confers an Advantage to Salmonella enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine
    2009 419 citations Thorsten Berger, Tak W. Mak et al. profile →
  39. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    2001 399 citations Vuk Stambolic, Akira Suzuki et al. profile →
  40. Beyond immune checkpoint blockade: emerging immunological strategies
    2021 326 citations Thorsten Berger, Tak W. Mak et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Tak W. Mak Canada 156 49.6k 34.0k 22.6k 17.0k 7.3k 710 96.1k
John C. Reed United States 161 73.3k 1.5× 20.4k 0.6× 21.4k 0.9× 12.2k 0.7× 10.6k 1.4× 799 107.5k
Vishva M. Dixit United States 141 62.4k 1.3× 32.9k 1.0× 13.0k 0.6× 15.7k 0.9× 9.2k 1.3× 315 88.1k
Douglas R. Green United States 178 80.9k 1.6× 35.3k 1.0× 18.8k 0.8× 15.1k 0.9× 18.8k 2.6× 613 125.1k
Stanley J. Korsmeyer United States 132 59.5k 1.2× 15.2k 0.4× 15.3k 0.7× 7.6k 0.4× 8.0k 1.1× 230 84.0k
Zena Werb United States 151 45.6k 0.9× 18.5k 0.5× 35.3k 1.6× 33.6k 2.0× 4.6k 0.6× 416 110.4k
George D. Yancopoulos United States 161 55.1k 1.1× 16.0k 0.5× 14.3k 0.6× 11.9k 0.7× 4.5k 0.6× 430 103.1k
Josef Penninger Austria 133 40.9k 0.8× 18.0k 0.5× 14.8k 0.7× 7.5k 0.4× 5.1k 0.7× 582 78.3k
Roderick T. Bronson United States 139 46.0k 0.9× 11.5k 0.3× 23.2k 1.0× 11.6k 0.7× 4.2k 0.6× 544 77.8k
Shigekazu Nagata Japan 119 42.4k 0.9× 32.9k 1.0× 10.8k 0.5× 6.6k 0.4× 7.8k 1.1× 615 76.5k
Peter Carmeliet Belgium 151 53.1k 1.1× 11.7k 0.3× 15.0k 0.7× 27.4k 1.6× 5.5k 0.7× 729 100.0k

Countries citing papers authored by Tak W. Mak

Since Specialization
Citations

This map shows the geographic impact of Tak W. Mak's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tak W. Mak with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tak W. Mak more than expected).

Fields of papers citing papers by Tak W. Mak

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tak W. Mak. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tak W. Mak. The network helps show where Tak W. Mak may publish in the future.

Co-authorship network of co-authors of Tak W. Mak

This figure shows the co-authorship network connecting the top 25 collaborators of Tak W. Mak. A scholar is included among the top collaborators of Tak W. Mak based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tak W. Mak. Tak W. Mak is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Song, Erfei, James W.S. Jahng, Hye Kyoung Sung, et al.. (2017). Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge.. Queensland's institutional digital repository (The University of Queensland). 9(6). 2723–2735. 45 indexed citations
2.
Bassi, C., Jason Ho, Tharan Srikumar, et al.. (2013). Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress. Science. 341(6144). 395–399. 322 indexed citations
3.
Reardon, Colin, Gordon S. Duncan, Anne Brüstle, et al.. (2013). Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proceedings of the National Academy of Sciences. 110(4). 1410–1415. 179 indexed citations
4.
Reilly, Patrick T. & Tak W. Mak. (2012). Molecular Pathways: Tumor Cells Co-opt the Brain-Specific Metabolism Gene CPT1C to Promote Survival. Clinical Cancer Research. 18(21). 5850–5855. 52 indexed citations
5.
Wong, Gladys W., Gisele Knowles, Tak W. Mak, Adolfo A. Ferrando, & Juan Carlos Zúñiga‐Pflücker. (2012). HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood. 120(7). 1439–1448. 91 indexed citations
6.
Rousseaux, Maxime W.C., Paul C. Marcogliese, Dianbo Qu, et al.. (2012). Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Proceedings of the National Academy of Sciences. 109(39). 15918–15923. 64 indexed citations
7.
Magalhães, João G., Stephen Rubino, Leonardo H. Travassos, et al.. (2011). Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proceedings of the National Academy of Sciences. 108(36). 14896–14901. 64 indexed citations
8.
Hayashi, Hideki, Tomoko Kohno, Kiyoshi Yasui, et al.. (2011). Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 ( Irf2 ) in trypsinogen5 gene transcription. Proceedings of the National Academy of Sciences. 108(46). 18766–18771. 14 indexed citations
9.
Größ, Stefan, Rob A. Cairns, Mark D. Minden, et al.. (2010). Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. The Journal of Experimental Medicine. 207(2). 339–344. 558 indexed citations breakdown →
10.
McIlwain, David R., Qun Pan, Patrick T. Reilly, et al.. (2010). Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay. Proceedings of the National Academy of Sciences. 107(27). 12186–12191. 154 indexed citations
11.
Aleyasin, Hossein, Maxime W.C. Rousseaux, Paul C. Marcogliese, et al.. (2010). DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proceedings of the National Academy of Sciences. 107(7). 3186–3191. 145 indexed citations
12.
Ueda, Takeshi, Masato Sasaki, Andrew Elia, et al.. (2010). Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proceedings of the National Academy of Sciences. 107(32). 13984–13990. 165 indexed citations
13.
Quintela-Fandiño, Miguel, Enrico Arpaia, Dirk Brenner, et al.. (2010). HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proceedings of the National Academy of Sciences. 107(6). 2622–2627. 37 indexed citations
14.
Hamada, Koichi, Takehiko Sasaki, Sachiko Fujita, et al.. (2008). Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis. Cancer Research. 68(14). 5760–5768. 46 indexed citations
15.
Mahoney, Douglas J., Herman H. Cheung, Stéphanie Plenchette, et al.. (2008). Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation. Proceedings of the National Academy of Sciences. 105(33). 11778–11783. 426 indexed citations
16.
Tsuruta, Hiroshi, Hiroyuki Kishimoto, Takehiko Sasaki, et al.. (2006). Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients. Cancer Research. 66(17). 8389–8396. 82 indexed citations
17.
Masumoto, Junya, Kangkang Yang, Sooryanarayana Varambally, et al.. (2006). Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. The Journal of Experimental Medicine. 203(1). 203–213. 176 indexed citations
18.
Tsuchihara, Katsuya, Chris Bakal, Hitoshi Okada, et al.. (2005). Ckap2 Regulates Aneuploidy, Cell Cycling, and Cell Death in a p53-Dependent Manner. Cancer Research. 65(15). 6685–6691. 42 indexed citations
19.
Ho, Andrew Tri Van, et al.. (2004). Coupling of caspase‐9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell‐type‐specific. The EMBO Journal. 23(2). 460–472. 41 indexed citations
20.
Peters, Malte, Carmela DeLuca, Atsushi Hirao, et al.. (2002). Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila. Proceedings of the National Academy of Sciences. 99(17). 11305–11310. 78 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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