Takehiko Sasaki

29.6k citations

306 papers · 20.1k indexed · 9 hit papers · h-index 66

Molecular Biology top 0.2%
Immunology top 0.2%
Oncology top 0.5%
Cell Biology top 0.2%
Cancer Research top 0.5%

Co-authors: Josef Penninger Akira Suzuki Tak W. Mak Andrew Wakeham José Luís de la Pompa Vuk Stambolic Junko Irie-Sasaki I. Kozieradzki
Topics: PI3K/AKT/mTOR signaling in cancer (34 papers)Cellular transport and secretion (27 papers)Intracranial Aneurysms: Treatment and Complications (25 papers)
Cited by: Immunology Molecular Biology Cell Biology
Journals: Nature Science Cell
Partner nations: Japan United States Canada

In The Last Decade

Takehiko Sasaki

283 papers receiving 19.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 2.1k citations Akira Suzuki, Takehiko Sasaki et al. profile →
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 1.1k citations Takehiko Sasaki et al. profile →
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 889 citations Takehiko Sasaki, Akira Suzuki et al. Science profile →
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

2006 887 citations Takehiko Sasaki, Akira Suzuki et al. profile →
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 665 citations Akira Suzuki, Takehiko Sasaki et al. profile →
The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

2000 596 citations Takehiko Sasaki et al. profile →
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 553 citations Takehiko Sasaki et al. profile →
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

2004 547 citations Yasuo Horie, Akira Suzuki et al. Journal of Clinical Investigation profile →
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 463 citations Akira Suzuki, Takehiko Sasaki et al. profile →

Peers

Countries citing papers authored by Takehiko Sasaki

Since Specialization

Citations

This map shows the geographic impact of Takehiko Sasaki's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Takehiko Sasaki with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Takehiko Sasaki more than expected).

Fields of papers citing papers by Takehiko Sasaki

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Takehiko Sasaki. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Takehiko Sasaki. The network helps show where Takehiko Sasaki may publish in the future.

Co-authorship network of co-authors of Takehiko Sasaki

This figure shows the co-authorship network connecting the top 25 collaborators of Takehiko Sasaki. A scholar is included among the top collaborators of Takehiko Sasaki based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Takehiko Sasaki. Takehiko Sasaki is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	PI 5 P 4 K inhibitors: promising opportunities and challenges 2025 ·FEBS Journal ·Koh Takeuchi,Lisa Nagase,Shun Kageyama,(unknown),Masashi Oshima,(unknown),Yoshiki Ikeda,Yuki Fujii,Sei Kondo,(unknown),Takeshi Masuda,Tsukasa Ishihara,Yoshikazu Nakamura,Yoshihisa Hirota,Takehiko Sasaki,Toshiya Senda,Atsuo T. Sasaki	0
2	Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice 2020 ·Cancer Science ·Miki Nishio,(unknown),Tomohiko Maehama,(unknown),Junji Otani,Hiroki Hikasa,(unknown),Koshi Mimori,Takehiko Sasaki,Hiroshi Nishina,Shinya Toyokuni,John P. Lydon,Kazuwa Nakao,Tak W. Mak,Tohru Kiyono,Hidetaka Katabuchi,Hironori Tashiro,Akira Suzuki	24
3	Immersive 3-Dimensional Virtual Reality Modeling for Case-Specific Presurgical Discussions in Cerebrovascular Neurosurgery 2020 ·Operative Neurosurgery ·Taku Sugiyama,Tod R. Clapp,(unknown),(unknown),Hiroaki Motegi,Naoki Nakayama,Takehiko Sasaki,Kikutaro Tokairin,Masaki Ito,Ken Kazumata,Kiyohiro Houkin	24
4	Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma 2018 ·Cancer Research ·Hideki Makinoshima,Shigeki Umemura,Ayako Suzuki,Hiroki Nakanishi,Ami Maruyama,Hibiki Udagawa,Sachiyo Mimaki,Shingo Matsumoto,Seiji Niho,Genichiro Ishii,Masahiro Tsuboi,Atsushi Ochiai,Hiroyasu Esumi,Takehiko Sasaki,Kōichi Goto,Katsuya Tsuchihara	33
5	Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders 2018 ·Schizophrenia ·M. Nishioka,Miki Bundo,Junko Ueda,Akane Yoshikawa,Fumichika Nishimura,Takehiko Sasaki,Chihiro Kakiuchi,Kiyoto Kasai,Tadafumi Kato,Kazuya Iwamoto	19
6	DNA methylation analyses of the candidate genes identified by a methylome‐wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder 2018 ·Psychiatry and Clinical Neurosciences ·Hiroko Sugawara,Y. Murata,Tempei Ikegame,Rie Sawamura,(unknown),(unknown),Takeo Saito,Masashi Ikeda,Akane Yoshikawa,Fumichika Nishimura,Yoshiya Kawamura,Chihiro Kakiuchi,Takehiko Sasaki,Nakao Iwata,Mamoru Hashimoto,Kiyoto Kasai,Tadafumi Kato,Miki Bundo,Kazuya Iwamoto	22
7	An epigenome-wide methylation study of healthy individuals with or without depressive symptoms 2018 ·Journal of Human Genetics ·Mihoko Shimada,Takeshi Otowa,Taku Miyagawa,Tadashi Umekage,Yoshiya Kawamura,Miki Bundo,Kazuya Iwamoto,Tempei Ikegame,Mamoru Tochigi,Kiyoto Kasai,Hisanobu Kaiya,Hisashi Tanii,Yuji Okazaki,Katsushi Tokunaga,Takehiko Sasaki	8
8	Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes 2017 ·Psychiatry and Clinical Neurosciences ·Akane Yoshikawa,Fumichika Nishimura,(unknown),Yosuke Eriguchi,M. Nishioka,(unknown),Mamoru Tochigi,Yoshiya Kawamura,Tadashi Umekage,Kayoko Kato,Takehiko Sasaki,Yoshiaki Ohashi,Kazuya Iwamoto,Kiyoto Kasai,Chihiro Kakiuchi	5
9	In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K–AKT Signaling at Endosomes 2015 ·Cancer Discovery ·Chen Li Chew,Andrea Lunardi,Federico Gulluni,Daniel T. Ruan,Ming Chen,Leonardo Salmena,Michiya Nishino,Antonella Papa,Christopher Ng,Jacqueline Fung,John G. Clohessy,Junko Sasaki,Takehiko Sasaki,Roderick T. Bronson,Emilio Hirsch,Pier Paolo Pandolfi	72
10	INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor 2015 ·Cancer Discovery ·Satoshi Kofuji,Hirotaka Kimura,Hiroki Nakanishi,Hiroshi Nanjo,Shunsuke Takasuga,Hui Liu,Satoshi Eguchi,Ryotaro Nakamura,Reietsu Itoh,Noriko Ueno,Ken Asanuma,Mingguo Huang,Atsushi Koizumi,Tomonori Habuchi,Masakazu Yamazaki,Akira Suzuki,Junko Sasaki,Takehiko Sasaki	57
11	Localizing the lipid products of PI3Kγ in neutrophils 2015 ·Advances in Biological Regulation ·(unknown),Yvonne Lindsay,(unknown),Tamara Chessa,Hervé Guillou,Sabine Suire,John M. Lucocq,Simon Walker,Simon Andrews,Anne Segonds-Pichon,Oliver Rausch,Peter M. Finan,Takehiko Sasaki,Cheng‐Jin Du,Till Bretschneider,Gail Ferguson,Phillip T. Hawkins,Len Stephens	11
12	PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE IS AN ESSENTIAL REGULATOR OF LYSOSOME MORPHOLOGY 2012 ·Ken Asanuma,Shunsuke Takasuga,Junko Sasaki,Takehiko Sasaki	1
13	Operative Findings of Unruptured Cerebral Aneurysms That Grew During Follow-up Periods 2011 ·Surgery for Cerebral Stroke ·(unknown),Takehiko Sasaki,(unknown),(unknown),(unknown),(unknown),Kenji Kamiyama,Toshiaki Osato,Jyoji Nakagawara,Hirohiko Nakamura	0
14	Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis 2009 ·Science ·Akihiko Nishikimi,Hideo Fukuhara,Wenjuan Su,Tsunaki Hongu,Shunsuke Takasuga,Hisashi Mihara,Qinhong Cao,Fumiyuki Sanematsu,Motomu Kanai,Hiroshi Hasegawa,Yoshihiko Tanaka,Masakatsu Shibasaki,Yasunori Kanaho,Takehiko Sasaki,Michael A. Frohman,Yoshinori Fukui	223
15	Pten Deficiency in Melanocytes Results in Resistance to Hair Graying and Susceptibility to Carcinogen-Induced Melanomagenesis 2008 ·Cancer Research ·(unknown),Koichi Hamada,Takehiko Sasaki,(unknown),Sachiko Fujita,Kohichi Kawahara,Masato Sasaki,Hiroyuki Kishimoto,Satoshi Eguchi,Itaru Kojima,Friedrich Beermann,Tetsunori Kimura,Masatake Osawa,Satoshi Itami,Tak W. Mak,Toru Nakano,Motomu Manabe,Akira Suzuki	46
16	Mammalian Type III Phosphatidylinositol Phosphate Kinase is Dispensable for Cell Growth and Survival 2008 ·(unknown),Shunsuke Takasuga,Yoshiko Sato,Ken Asanuma,Junko Sasaki,Takehiko Sasaki	1
17	Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice 2007 ·Journal of Clinical Investigation ·Shigehisa Yanagi,Hiroyuki Kishimoto,Kohichi Kawahara,Takehiko Sasaki,Masato Sasaki,Miki Nishio,Nobuyuki Yajima,Koichi Hamada,Yasuo Horie,Hiroshi Kubo,Jeffrey A. Whitsett,Tak W. Mak,Toru Nakano,Masamitsu Nakazato,Akira Suzuki	125
18	Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients 2006 ·Cancer Research ·Hiroshi Tsuruta,Hiroyuki Kishimoto,Takehiko Sasaki,Yasuo Horie,Miyuki Natsui,(unknown),Koichi Hamada,Nobuyuki Yajima,Koichi Kawahara,Masato Sasaki,Norihiko Tsuchiya,Katsuhiko Enomoto,Tak W. Mak,Toru Nakano,Tomonori Habuchi,Akira Suzuki	82
19	Effects of timed bright light exposure on the arousal level during simulated nightwork 1996 ·Takehiko Sasaki,(unknown),Tetsuo Katsuura,(unknown),Koichi Iwanaga,Yasuyuki Kikuchi	1
20	A New Rice Cultivar HITOMEBORE and the Cultivation Technique. : 1 Breeding of a New Rice Cultivar HITOMEBORE 1992 ·Takehiko Sasaki	1

About Takehiko Sasaki

Takehiko Sasaki is a scholar working on Cell Biology, Physiology and Immunology, having authored 306 papers that have together received 20.1k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (34 papers), Cellular transport and secretion (27 papers) and Intracranial Aneurysms: Treatment and Complications (25 papers). The work is most often cited by research in Immunology (4.7k citations), Molecular Biology (12.2k citations) and Cell Biology (2.5k citations). Takehiko Sasaki has collaborated with scholars based in Japan, United States and Canada. Frequent co-authors include Josef Penninger, Akira Suzuki, Tak W. Mak, Andrew Wakeham, José Luís de la Pompa, Vuk Stambolic, Junko Irie-Sasaki, I. Kozieradzki, Junko Sasaki and David P. Siderovski. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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