David V. Goeddel

77.8k citations

194 papers · 64.8k indexed · 48 hit papers · h-index 106

Molecular Biology top 0.02%
Immunology top 0.01%
Cancer Research top 0.01%
Oncology top 0.05%
Genetics top 0.1%

Co-authors: Hailing Hsu Mike Rothe G H Wong Louis A. Tartaglia David W. M. Leung Wun-Jing Kuang Guoqing Chen George Cachianes
Topics: Immune Response and Inflammation (53 papers)interferon and immune responses (39 papers)NF-κB Signaling Pathways (35 papers)
Cited by: Immunology Cancer Research Molecular Biology
Journals: Nature Science Cell
Partner nations: United States France Japan

In The Last Decade

David V. Goeddel

189 papers receiving 61.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 4.1k citations David W. M. Leung, George Cachianes et al. profile →
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 2.4k citations David V. Goeddel et al. profile →
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 1.7k citations David V. Goeddel et al. Cell profile →
TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 1.7k citations David V. Goeddel et al. Cell profile →
The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 1.7k citations David V. Goeddel et al. Cell profile →
TNF-R1 Signaling: A Beautiful Pathway

2002 1.5k citations Guoqing Chen, David V. Goeddel profile →
Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 1.5k citations David V. Goeddel et al. Nature profile →
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 1.4k citations Glenn E. Nedwin, Joel S. Hayflick et al. Nature profile →
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

1990 1.2k citations Thomas J. Schall, Kevin B. Bacon et al. Nature profile →
TRAF6 is a signal transducer for interleukin-1

1996 1.1k citations Zhaodan Cao, David V. Goeddel et al. Nature profile →
A novel domain within the 55 kd TNF receptor signals cell death

1993 1.1k citations Louis A. Tartaglia, T. Merrill Ayres et al. Cell profile →
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 1.1k citations William J. Henzel, David V. Goeddel et al. Nature profile →
Identification and Characterization of an IκB Kinase

1997 1.1k citations Catherine H. Régnier, Ho Yeong Song et al. Cell profile →
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

1997 1.0k citations Xiong Gao, Zhaodan Cao et al. profile →
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 1.0k citations Mike Rothe, William J. Henzel et al. Cell profile →
Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 1.0k citations William J. Kohr, Elizabeth Yelverton et al. Nature profile →
TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

1996 966 citations David V. Goeddel et al. Immunity profile →
TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 928 citations Mike Rothe, David V. Goeddel et al. profile →
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

1994 909 citations Mike Rothe, William J. Henzel et al. Cell profile →
Two TNF receptors

1992 901 citations Louis A. Tartaglia, David V. Goeddel profile →
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

1983 896 citations Peter H. Seeburg, David V. Goeddel et al. Nature profile →
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor

1989 873 citations Ming‐Shi Chang, David Lowe et al. Nature profile →
Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 852 citations Thomas J. Schall, Kerry J. Koller et al. Cell profile →
Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 845 citations William J. Henzel, Helga Raab et al. profile →
Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 804 citations David V. Goeddel et al. profile →
Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 803 citations G H Wong, David V. Goeddel profile →
Human tumor necrosis factor. Production, purification, and characterization.

1985 777 citations William J. Kohr, William J. Henzel et al. profile →
Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 775 citations David V. Goeddel et al. Cell profile →
FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

1998 759 citations Wen‐Chen Yeh, Hong‐Bing Shu et al. profile →
Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 720 citations G H Wong, David V. Goeddel et al. Cell profile →
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 711 citations David V. Goeddel et al. profile →
Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 705 citations Andrew Wakeham, David A. Ferrick et al. Immunity profile →
The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 695 citations Louis A. Tartaglia, Michael A. Palladino et al. profile →
Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 640 citations G H Wong, David V. Goeddel Nature profile →
Selective Activation of the B Natriuretic Peptide Receptor by C-Type Natriuretic Peptide (CNP)

1991 626 citations Kerry J. Koller, David Lowe et al. profile →
Comparative biochemical properties of normal and activated human ras p21 protein

1984 602 citations David V. Goeddel et al. Nature profile →
Expression of human immune interferon cDNA in E. coli and monkey cells

1982 594 citations David W. M. Leung, Elizabeth Yelverton et al. Nature profile →
Expression in Escherichia coli of chemically synthesized genes for human insulin.

1979 548 citations David V. Goeddel, Herbert L. Heyneker et al. profile →
Rational Design of Potent Antagonists to the Human Growth Hormone Receptor

1992 527 citations David V. Goeddel et al. profile →
Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 519 citations David V. Goeddel et al. Nature profile →
Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases

1989 514 citations Ming‐Shi Chang, David Lowe et al. Nature profile →
Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

1991 507 citations Louis A. Tartaglia, Glenn C. Rice et al. profile →
Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 500 citations Ho Yeong Song, Catherine H. Régnier et al. profile →
Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 494 citations Peter H. Seeburg, David V. Goeddel et al. Nature profile →
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 473 citations Peter H. Seeburg, Joel S. Hayflick et al. Nature profile →
The structure of eight distinct cloned human leukocyte interferon cDNAs

1981 427 citations David V. Goeddel, David W. M. Leung et al. Nature profile →
Human leukocyte interferon produced by E. coli is biologically active

1980 413 citations David V. Goeddel, Elizabeth Yelverton et al. Nature profile →
Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

1979 389 citations David V. Goeddel, Herbert L. Heyneker et al. Nature profile →

Peers

Countries citing papers authored by David V. Goeddel

Since Specialization

Citations

This map shows the geographic impact of David V. Goeddel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David V. Goeddel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David V. Goeddel more than expected).

Fields of papers citing papers by David V. Goeddel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David V. Goeddel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David V. Goeddel. The network helps show where David V. Goeddel may publish in the future.

Co-authorship network of co-authors of David V. Goeddel

This figure shows the co-authorship network connecting the top 25 collaborators of David V. Goeddel. A scholar is included among the top collaborators of David V. Goeddel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David V. Goeddel. David V. Goeddel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo 2005 ·Molecular and Cellular Biology ·Dietrich B. Conze,Lori Albert,David A. Ferrick,David V. Goeddel,Wen‐Chen Yeh,Tak W. Mak,Jonathan D. Ashwell	151
2	TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90 2002 ·Molecular Cell ·Guoqing Chen,Ping Cao,David V. Goeddel	313
3	Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development 2000 ·Immunity ·Wen‐Chen Yeh,Annick Itié,Andrew Elia,Michelle Ng,Hong‐Bing Shu,Andrew Wakeham,Christine Mirtsos,Nobutaka Suzuki,Madeleine Bonnard,David V. Goeddel,Tak W. Mak	409
4	Identification and Characterization of an IκB Kinasebreakdown → 1997 ·Cell ·Catherine H. Régnier,Ho Yeong Song,Xiong Gao,David V. Goeddel,Zhaodan Cao,Mike Rothe	1055
5	The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteinsbreakdown → 1995 ·Cell ·Mike Rothe,(unknown),William J. Henzel,T. Merrill Ayres,David V. Goeddel	1030
6	[20] One-day northern blotting for detection of mRNA: NDGA inhibits the induction of MnSOD mRNA by agonists of type 1 TNF receptor 1994 ·Methods in enzymology on CD-ROM/Methods in enzymology ·G H Wong,David V. Goeddel	3
7	A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptorbreakdown → 1994 ·Cell ·Mike Rothe,(unknown),William J. Henzel,David V. Goeddel	909
8	A novel domain within the 55 kd TNF receptor signals cell deathbreakdown → 1993 ·Cell ·Louis A. Tartaglia,T. Merrill Ayres,G H Wong,David V. Goeddel	1075
9	Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes. 1993 ·The Journal of Experimental Medicine ·Thomas J. Schall,Kevin B. Bacon,R.D.R. Camp,(unknown),David V. Goeddel	457
10	Tumor necrosis factor-α pretreatment is protective in a rat model of myocardial ischemia-reperfusion injury 1992 ·Biochemical and Biophysical Research Communications ·Lynne J. Eddy,David V. Goeddel,G H Wong	114
11	[1] Systems for heterologous gene expression 1990 ·Methods in enzymology on CD-ROM/Methods in enzymology ·David V. Goeddel	31
12	Molecular cloning and expression of a receptor for human tumor necrosis factorbreakdown → 1990 ·Cell ·Thomas J. Schall,(unknown),Kerry J. Koller,Angela Lee,Glenn C. Rice,G H Wong,Tetsuya Gatanaga,Gale A. Granger,Rigdon Lentz,Helga Raab,William J. Kohr,David V. Goeddel	852
13	Genomic Cloning and Heterologous Expression of Human Differentiation-Stimulating Factor 1989 ·DNA ·David Lowe,Wylla M. Nunes,(unknown),Susan McCabe,Gerald Ranges,William J. Henzel,Mikio Tomida,Yuri Yamamoto-Yamaguchi,Motoo Hozumi,David V. Goeddel	69
14	Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclasesbreakdown → 1989 ·Nature ·Ming‐Shi Chang,David Lowe,Martyn Lewis,Renate Hellmiss,(unknown),David V. Goeddel	514
15	In vitro anti-human immunodeficiency virus activities of tumor necrosis factor- alpha and interferon- gamma . 1988 ·The Journal of Immunology ·G H Wong,John F. Krowka,D P Stites,David V. Goeddel	112
16	Nucleotide Sequence of the Partition Function of Escherichia coli Plasmid ColE1 1985 ·DNA ·David W. M. Leung,Ellson Chen,George Cachianes,David V. Goeddel	12
17	Interferon-gamma enhances induction of lymphotoxin in recombinant interleukin 2-stimulated peripheral blood mononuclear cells. 1985 ·The Journal of Immunology ·L P Svedersky,Glenn E. Nedwin,David V. Goeddel,Michael A. Palladino	44
18	Efficient Bacterial Expression of Bovine and Porcine Growth Hormones 1983 ·DNA ·Peter H. Seeburg,(unknown),John P. Adelman,Herman A. de Boer,Joel S. Hayflick,Parkash Jhurani,David V. Goeddel,Herbert L. Heyneker	120
19	Carboxyterminal Region of Hybrid Leukocyte Interferons Affects Antiviral Specificity 1982 ·DNA ·Arthur E. Franke,H. Michael Shepard,Catherine M. Houck,David W. M. Leung,David V. Goeddel,Richard M. Lawn	21
20	Increased Synthesis in E. coli of Fibroblast and Leukocyte Interferons Through Alterations in Ribosome Binding Sites 1982 ·DNA ·H. Michael Shepard,Elizabeth Yelverton,David V. Goeddel	92

About David V. Goeddel

David V. Goeddel is a scholar working on Immunology, Cancer Research and Immunology and Allergy, having authored 194 papers that have together received 64.8k indexed citations. Recurring topics across this work include Immune Response and Inflammation (53 papers), interferon and immune responses (39 papers) and NF-κB Signaling Pathways (35 papers). The work is most often cited by research in Immunology (24.1k citations), Cancer Research (16.6k citations) and Molecular Biology (34.7k citations). David V. Goeddel has collaborated with scholars based in United States, France and Japan. Frequent co-authors include Hailing Hsu, Mike Rothe, G H Wong, Louis A. Tartaglia, David W. M. Leung, Wun-Jing Kuang, Guoqing Chen, George Cachianes, Napoleone Ferrara and Zhaodan Cao. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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