Shimon Sakaguchi

99.7k total citations · 56 hit papers
308 papers, 68.3k citations indexed

About

Shimon Sakaguchi is a scholar working on Immunology, Oncology and Genetics. According to data from OpenAlex, Shimon Sakaguchi has authored 308 papers receiving a total of 68.3k indexed citations (citations by other indexed papers that have themselves been cited), including 269 papers in Immunology, 37 papers in Oncology and 34 papers in Genetics. Recurrent topics in Shimon Sakaguchi's work include Immune Cell Function and Interaction (228 papers), T-cell and B-cell Immunology (220 papers) and Immunotherapy and Immune Responses (133 papers). Shimon Sakaguchi is often cited by papers focused on Immune Cell Function and Interaction (228 papers), T-cell and B-cell Immunology (220 papers) and Immunotherapy and Immune Responses (133 papers). Shimon Sakaguchi collaborates with scholars based in Japan, United States and United Kingdom. Shimon Sakaguchi's co-authors include Takashi Nomura, Shohei Hori, Tomoyuki Yamaguchi, Jun Shimizu, Makoto Miyara, Atsushi Tanaka, Masahiro Ono, Takeshi Takahashi, Kajsa Wing and Sayuri Yamazaki and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Shimon Sakaguchi

299 papers receiving 67.2k citations

Hit Papers

Control of Regulatory T C... 1982 2026 1996 2011 2003 2008 2003 2008 2005 2.0k 4.0k 6.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Control of Regulatory T Cell Development by the Transcription Factor Foxp3
    2003 6.6k citations Shohei Hori, Takashi Nomura et al. Science profile →
  2. Regulatory T Cells and Immune Tolerance
    2008 4.0k citations Shimon Sakaguchi, Tomoyuki Yamaguchi et al. profile →
  3. NaturallyArisingCD4+RegulatoryT Cells forImmunologicSelf-Tolerance andNegativeControl ofImmuneResponses
    2003 2.7k citations Shimon Sakaguchi profile →
  4. CTLA-4 Control over Foxp3 + Regulatory T Cell Function
    2008 2.3k citations Kajsa Wing, Yasushi Onishi et al. Science profile →
  5. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    2005 2.2k citations Shimon Sakaguchi profile →
  6. FOXP3+ regulatory T cells in the human immune system
    2010 1.9k citations Shimon Sakaguchi, Makoto Miyara et al. profile →
  7. Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
    2000 1.8k citations Takeshi Takahashi, Noriko Sakaguchi et al. The Journal of Experimental Medicine profile →
  8. Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
    2009 1.8k citations Makoto Miyara, Kajsa Wing et al. Immunity profile →
  9. Regulatory T Cells
    2000 1.5k citations Shimon Sakaguchi profile →
  10. Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
    2002 1.4k citations Takeshi Takahashi, Shimon Sakaguchi et al. profile →
  11. Regulatory T cells in cancer immunotherapy
    2016 1.4k citations Atsushi Tanaka, Shimon Sakaguchi profile →
  12. Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
    2006 1.3k citations Shimon Sakaguchi, Masahiro Ono et al. profile →
  13. Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity
    1999 1.2k citations Shimon Sakaguchi et al. profile →
  14. Regulatory T cells in transplantation tolerance
    2003 1.1k citations Shimon Sakaguchi et al. profile →
  15. Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance
    1999 994 citations Takeshi Takahashi, Noriko Sakaguchi et al. profile →
  16. Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    2005 992 citations Ruka Setoguchi, Shohei Hori et al. The Journal of Experimental Medicine profile →
  17. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.
    1999 888 citations Shimon Sakaguchi et al. profile →
  18. Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    2009 857 citations Kajsa Wing, Shimon Sakaguchi profile →
  19. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    2007 749 citations Keiji Hirota, Hiroyuki Yoshitomi et al. The Journal of Experimental Medicine profile →
  20. Regulatory T cells in tumor immunity
    2010 746 citations Hiroyoshi Nishikawa, Shimon Sakaguchi profile →
  21. Regulatory T Cells and Human Disease
    2020 719 citations Shimon Sakaguchi, James B. Wing et al. profile →
  22. PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
    2019 692 citations Takahiro Kamada, Yosuke Togashi et al. Proceedings of the National Academy of Sciences profile →
  23. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    2004 673 citations Takashi Nomura, Shohei Hori et al. profile →
  24. Regulatory T cells: how do they suppress immune responses?
    2009 671 citations Shimon Sakaguchi, Kajsa Wing et al. profile →
  25. Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism
    2005 661 citations Shimon Sakaguchi et al. profile →
  26. The microbiota regulates type 2 immunity through RORγt + T cells
    2015 650 citations Caspar Ohnmacht, Sascha Cording et al. Science profile →
  27. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
    2003 647 citations Noriko Sakaguchi, Takeshi Takahashi et al. Nature profile →
  28. T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
    2012 570 citations Naganari Ohkura, Masahide Hamaguchi et al. Immunity profile →
  29. Natural regulatory T cells: mechanisms of suppression
    2007 562 citations Makoto Miyara, Shimon Sakaguchi profile →
  30. Development and Maintenance of Regulatory T cells
    2013 562 citations Naganari Ohkura, Shimon Sakaguchi et al. Immunity profile →
  31. Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
    2008 555 citations Yasushi Onishi, Zoltán Fehérvári et al. Proceedings of the National Academy of Sciences profile →
  32. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.
    1985 554 citations Shimon Sakaguchi et al. The Journal of Experimental Medicine profile →
  33. Regulatory T cells in cancer immunotherapy
    2014 547 citations Hiroyoshi Nishikawa, Shimon Sakaguchi profile →
  34. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    2007 533 citations Masahiro Ono, Hiroko Yaguchi et al. Nature profile →
  35. Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
    2019 517 citations James B. Wing, Atsushi Tanaka et al. Immunity profile →
  36. Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
    2013 505 citations Hiroyoshi Nishikawa, Eiichi Sato et al. Proceedings of the National Academy of Sciences profile →
  37. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine
    2016 482 citations Keiji Hirota, Noriko Sakaguchi et al. profile →
  38. A role for Dicer in immune regulation
    2006 452 citations Shimon Sakaguchi et al. The Journal of Experimental Medicine profile →
  39. Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061.
    2017 452 citations Shohei Hori, Takashi Nomura et al. profile →
  40. Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice.
    1994 449 citations Shimon Sakaguchi et al. The Journal of Experimental Medicine profile →
  41. Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation
    2014 419 citations Hiroyoshi Nishikawa, Shimon Sakaguchi et al. Immunity profile →
  42. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells
    2005 409 citations Keiji Hirota, Tomoyuki Yamaguchi et al. The Journal of Experimental Medicine profile →
  43. T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    2007 399 citations Keiji Hirota, Motomu Hashimoto et al. The Journal of Experimental Medicine profile →
  44. The plasticity and stability of regulatory T cells
    2013 392 citations Shimon Sakaguchi et al. profile →
  45. Targeting Treg cells in cancer immunotherapy
    2019 360 citations Atsushi Tanaka, Shimon Sakaguchi profile →
  46. A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
    2005 359 citations Hiroyuki Yoshitomi, Noriko Sakaguchi et al. The Journal of Experimental Medicine profile →
  47. Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
    2023 304 citations Christopher Tay, Atsushi Tanaka et al. profile →
  48. Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4
    2014 299 citations James B. Wing, Shimon Sakaguchi et al. Immunity profile →
  49. Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
    2021 286 citations James B. Wing, Motonao Osaki et al. Proceedings of the National Academy of Sciences profile →
  50. Human FoxP3+ regulatory T cells in systemic autoimmune diseases
    2011 273 citations Makoto Miyara, Shimon Sakaguchi et al. profile →
  51. Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment
    2016 262 citations Naganari Ohkura, Keiji Hirota et al. profile →
  52. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis.
    1982 259 citations Shimon Sakaguchi et al. The Journal of Experimental Medicine profile →
  53. Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases
    2020 232 citations Naganari Ohkura, Shimon Sakaguchi profile →
  54. Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
    2016 183 citations Shimon Sakaguchi, Kajsa Wing et al. Proceedings of the National Academy of Sciences profile →
  55. Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
    2018 135 citations Keiji Hirota, Motomu Hashimoto et al. Immunity profile →
  56. PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
    2022 85 citations Atsushi Tanaka, Shimon Sakaguchi et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Shimon Sakaguchi Japan 109 53.8k 15.6k 9.0k 5.3k 3.9k 308 68.3k
Vijay K. Kuchroo United States 133 59.0k 1.1× 20.6k 1.3× 13.2k 1.5× 4.7k 0.9× 5.2k 1.3× 426 79.1k
John J. O’Shea United States 110 31.2k 0.6× 15.2k 1.0× 11.2k 1.2× 3.2k 0.6× 3.6k 0.9× 323 49.8k
Alexander Y. Rudensky United States 114 47.3k 0.9× 10.1k 0.6× 14.3k 1.6× 4.7k 0.9× 4.0k 1.0× 246 63.6k
Jacques Banchereau United States 132 62.4k 1.2× 15.0k 1.0× 16.4k 1.8× 3.9k 0.7× 7.1k 1.8× 477 80.5k
Arlene H. Sharpe United States 130 47.7k 0.9× 28.8k 1.8× 16.3k 1.8× 5.8k 1.1× 5.9k 1.5× 408 75.8k
Hideo Yagita∥ Japan 128 43.5k 0.8× 21.7k 1.4× 18.2k 2.0× 4.1k 0.8× 5.2k 1.3× 912 67.3k
Kenneth M. Murphy United States 109 41.4k 0.8× 11.1k 0.7× 10.8k 1.2× 3.4k 0.6× 5.5k 1.4× 298 56.2k
Giorgio Trinchieri United States 136 46.8k 0.9× 11.6k 0.7× 13.0k 1.5× 3.9k 0.7× 10.2k 2.6× 434 67.5k
Kouji Matsushima Japan 116 25.6k 0.5× 12.9k 0.8× 11.8k 1.3× 2.3k 0.4× 4.2k 1.1× 562 49.2k
Andrew D. Luster United States 120 29.2k 0.5× 14.2k 0.9× 10.8k 1.2× 2.1k 0.4× 5.1k 1.3× 342 51.2k

Countries citing papers authored by Shimon Sakaguchi

Since Specialization
Citations

This map shows the geographic impact of Shimon Sakaguchi's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Shimon Sakaguchi with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Shimon Sakaguchi more than expected).

Fields of papers citing papers by Shimon Sakaguchi

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Shimon Sakaguchi. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Shimon Sakaguchi. The network helps show where Shimon Sakaguchi may publish in the future.

Co-authorship network of co-authors of Shimon Sakaguchi

This figure shows the co-authorship network connecting the top 25 collaborators of Shimon Sakaguchi. A scholar is included among the top collaborators of Shimon Sakaguchi based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Shimon Sakaguchi. Shimon Sakaguchi is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Søndergaard, Jonas Nørskov, et al.. (2025). Single cell suppression profiling of human regulatory T cells. Nature Communications. 16(1). 1325–1325. 4 indexed citations
2.
Osaki, Motonao & Shimon Sakaguchi. (2025). Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity. Immunity. 58(4). 889–908.e13. 8 indexed citations
3.
Yasumizu, Yoshiaki, Atsushi Hara, Shimon Sakaguchi, & Naganari Ohkura. (2020). VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data. Bioinformatics. 37(10). 1465–1467. 11 indexed citations
4.
Kamada, Takahiro, Yosuke Togashi, Christopher Tay, et al.. (2019). PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer. Proceedings of the National Academy of Sciences. 116(20). 9999–10008. 692 indexed citations breakdown →
5.
Cañete, Pablo F., Rebecca A. Sweet, Paula González-Figueroa, et al.. (2019). Regulatory roles of IL-10–producing human follicular T cells. The Journal of Experimental Medicine. 216(8). 1843–1856. 64 indexed citations
6.
Ureshino, Hiroshi, Takero Shindo, Hiroyoshi Nishikawa, et al.. (2016). Effector Regulatory T Cells Reflect the Equilibrium between Antitumor Immunity and Autoimmunity in Adult T-cell Leukemia. Cancer Immunology Research. 4(8). 644–649. 24 indexed citations
7.
Shimazu, Yutaka, Masakatsu Hishizawa, Masahide Hamaguchi, et al.. (2016). Hypomethylation of the Treg-Specific Demethylated Region in FOXP3 Is a Hallmark of the Regulatory T-cell Subtype in Adult T-cell Leukemia. Cancer Immunology Research. 4(2). 136–145. 19 indexed citations
8.
Ohnmacht, Caspar, Sascha Cording, James B. Wing, et al.. (2015). The microbiota regulates type 2 immunity through RORγt + T cells. Science. 349(6251). 989–993. 650 indexed citations breakdown →
9.
Pastille, Eva, Diana Fleissner, Alexandra Adamczyk, et al.. (2014). Transient Ablation of Regulatory T cells Improves Antitumor Immunity in Colitis-Associated Colon Cancer. Cancer Research. 74(16). 4258–4269. 80 indexed citations
10.
Yamaguchi, Tomoyuki, Motonao Osaki, Hiromasa Morikawa, et al.. (2013). Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression. Proceedings of the National Academy of Sciences. 110(23). E2116–25. 84 indexed citations
11.
Nishikawa, Hiroyoshi, Daisuke Muraoka, Linan Wang, et al.. (2010). Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals. Clinical Cancer Research. 16(10). 2781–2791. 106 indexed citations
12.
Teng, Michele W.L., Jeremy B. Swann, Bianca von Scheidt, et al.. (2010). Multiple Antitumor Mechanisms Downstream of Prophylactic Regulatory T-Cell Depletion. Cancer Research. 70(7). 2665–2674. 58 indexed citations
13.
Hashimoto, Motomu, Keiji Hirota, Hiroyuki Yoshitomi, et al.. (2010). Complement drives Th17 cell differentiation and triggers autoimmune arthritis. The Journal of Experimental Medicine. 207(6). 1135–1143. 165 indexed citations
14.
Duan, Fei, Yun Lin, Cailian Liu, et al.. (2009). Immune Rejection of Mouse Tumors Expressing Mutated Self. Cancer Research. 69(8). 3545–3553. 12 indexed citations
15.
Sharma, Sanjay, Ana Lucía Dominguez, Soraya Zorro Manrique, et al.. (2008). Systemic Targeting of CpG-ODN to the Tumor Microenvironment with Anti–neu-CpG Hybrid Molecule and T Regulatory Cell Depletion Induces Memory Responses in BALB-neuT Tolerant Mice. Cancer Research. 68(18). 7530–7540. 30 indexed citations
16.
Wing, Kajsa, Yasushi Onishi, Tomoyuki Yamaguchi, et al.. (2008). CTLA-4 Control over Foxp3 + Regulatory T Cell Function. Science. 322(5899). 271–275. 2260 indexed citations breakdown →
17.
Ko, Hyun‐Jeong, Yeon‐Jeong Kim, Yun-Sun Kim, et al.. (2007). A Combination of Chemoimmunotherapies Can Efficiently Break Self-Tolerance and Induce Antitumor Immunity in a Tolerogenic Murine Tumor Model. Cancer Research. 67(15). 7477–7486. 165 indexed citations
18.
Ono, Masahiro, Hiroko Yaguchi, Naganari Ohkura, et al.. (2007). Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature. 446(7136). 685–689. 533 indexed citations breakdown →
19.
Setoguchi, Ruka, Shohei Hori, Takeshi Takahashi, & Shimon Sakaguchi. (2005). Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. The Journal of Experimental Medicine. 201(5). 723–735. 992 indexed citations breakdown →
20.
Hori, Shohei, Takashi Nomura, & Shimon Sakaguchi. (2003). Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science. 299(5609). 1057–1061. 6569 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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