Steven A. Kliewer

68.5k citations

168 papers · 56.3k indexed · 35 hit papers · h-index 102

Molecular Biology top 0.02%
Oncology top 0.05%
Surgery top 0.05%
Genetics top 0.02%
Physiology top 0.05%

Co-authors: Timothy M. Willson David J. Mangelsdorf Jürgen M. Lehmann Linda B. Moore Ronald M. Evans Bryan Goodwin Stacey A. Jones Kazuhiko Umesono
Topics: Drug Transport and Resistance Mechanisms (41 papers)Peroxisome Proliferator-Activated Receptors (39 papers)Fibroblast Growth Factor Research (36 papers)
Cited by: Pharmacology Oncology Biochemistry
Journals: Nature Science Cell
Partner nations: United States Netherlands United Kingdom

In The Last Decade

Steven A. Kliewer

168 papers receiving 55.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 3.1k citations Jürgen M. Lehmann, Linda B. Moore et al. Journal of Biological Chemistry profile →
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 1.9k citations Derek J. Parks, Steven G. Blanchard et al. profile →
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 1.8k citations Steven A. Kliewer, Stacey A. Jones et al. Proceedings of the National Academy of Sciences profile →
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 1.8k citations Steven A. Kliewer, Timothy M. Willson et al. Cell profile →
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis

2000 1.6k citations Bryan Goodwin, Stacey A. Jones et al. Molecular Cell profile →
Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 1.5k citations Steven A. Kliewer, Ronald M. Evans et al. profile →
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

2005 1.5k citations Takeshi Inagaki, Mihwa Choi et al. Cell Metabolism profile →
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 1.3k citations J�rgen Lehmann, David D. McKee et al. Journal of Clinical Investigation profile →
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 1.3k citations Steven A. Kliewer, David J. Mangelsdorf et al. profile →
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 1.3k citations Steven A. Kliewer, John T. Moore et al. Cell profile →
Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

2007 1.3k citations Takeshi Inagaki, Paul A. Dutchak et al. Cell Metabolism profile →
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 1.2k citations Steven A. Kliewer, David J. Mangelsdorf et al. Proceedings of the National Academy of Sciences profile →
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 1.1k citations Jeff L. Staudinger, Bryan Goodwin et al. Proceedings of the National Academy of Sciences profile →
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

1990 1.1k citations Steven A. Kliewer, Ronald M. Evans et al. Cell profile →
Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 1.0k citations Jürgen M. Lehmann, Steven A. Kliewer et al. Journal of Biological Chemistry profile →
Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 960 citations Jürgen M. Lehmann, Steven A. Kliewer et al. Journal of Biological Chemistry profile →
Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

1999 938 citations H. Eric Xu, Millard H. Lambert et al. Molecular Cell profile →
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

2006 924 citations Takeshi Inagaki, Antonio Moschetta et al. Proceedings of the National Academy of Sciences profile →
A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 876 citations Michael C. Lewis, Millard H. Lambert et al. Proceedings of the National Academy of Sciences profile →
Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

1999 774 citations Stacey A. Jones, G. Bruce Wisely et al. Proceedings of the National Academy of Sciences profile →
The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism

2002 736 citations Steven A. Kliewer, Bryan Goodwin et al. profile →
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 706 citations Linda B. Moore, Bryan Goodwin et al. Proceedings of the National Academy of Sciences profile →
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 684 citations Linda B. Moore, Derek J. Parks et al. Journal of Biological Chemistry profile →
Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21

2007 620 citations Mihwa Choi, Regina Goetz et al. Journal of Biological Chemistry profile →
The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

2001 609 citations G. Bruce Wisely, Linda B. Moore et al. profile →
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

2009 590 citations Takeshi Inagaki, Xunshan Ding et al. Proceedings of the National Academy of Sciences profile →
A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 584 citations David J. Mangelsdorf, Steven A. Kliewer et al. Cell profile →
The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones

1996 569 citations Timothy M. Willson, Linda B. Moore et al. profile →
Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

2010 568 citations Xunshan Ding, Regina Goetz et al. Molecular Endocrinology profile →
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

2003 563 citations Steven A. Kliewer, Bryan Goodwin et al. profile →
Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

2002 555 citations Bryan Goodwin, John T. Moore et al. profile →
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

2002 521 citations H. Eric Xu, Valerie G. Montana et al. profile →
Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease

2001 514 citations Timothy M. Willson, Millard H. Lambert et al. profile →
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

2011 503 citations H. Eric Xu, Steven A. Kliewer et al. profile →
Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

2014 488 citations David J. Mangelsdorf, Steven A. Kliewer et al. profile →

Peers

Countries citing papers authored by Steven A. Kliewer

Since Specialization

Citations

This map shows the geographic impact of Steven A. Kliewer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven A. Kliewer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven A. Kliewer more than expected).

Fields of papers citing papers by Steven A. Kliewer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven A. Kliewer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven A. Kliewer. The network helps show where Steven A. Kliewer may publish in the future.

Co-authorship network of co-authors of Steven A. Kliewer

This figure shows the co-authorship network connecting the top 25 collaborators of Steven A. Kliewer. A scholar is included among the top collaborators of Steven A. Kliewer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Steven A. Kliewer. Steven A. Kliewer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate 2025 ·Proceedings of the National Academy of Sciences ·(unknown),Bryan Mackowiak,(unknown),Genaro Hernandez,Tulip Nandu,(unknown),Yuan Zhang,Lauren G. Zacharias,Thomas P. Mathews,Bin Gao,W. Lee Kraus,Steven A. Kliewer,David J. Mangelsdorf	2
2	FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system 2023 ·Cell Metabolism ·Mihwa Choi,Marc Schneeberger,(unknown),Abhijit Bugde,Laurent Gautron,(unknown),Robert E. Hammer,Yuan Zhang,Jeffrey M. Friedman,David J. Mangelsdorf,Steven A. Kliewer	23
3	The ‘nuclear option’ revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections 2022 ·Molecular and Biochemical Parasitology ·James B. Lok,Steven A. Kliewer,David J. Mangelsdorf	4
4	Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis 2021 ·eLife ·Zhu Wang,(unknown),Jet Tsien,(unknown),Tian Qin,(unknown),(unknown),Xinshe Li,James B. Lok,Steven A. Kliewer,David J. Mangelsdorf	13
5	Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis 2021 ·Proceedings of the National Academy of Sciences ·(unknown),Zhu Wang,(unknown),Xinshe Li,James B. Lok,Steven A. Kliewer,David J. Mangelsdorf	22
6	Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy 2020 ·Science Translational Medicine ·Genaro Hernandez,Ting Luo,Tanveer A. Javed,Li Wen,Michael A. Kalwat,(unknown),(unknown),Sohail Z. Husain,Steven A. Kliewer,David J. Mangelsdorf	34
7	FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia 2017 ·Cell Metabolism ·(unknown),Donald A. Morgan,Kamal Rahmouni,Junichiro Sonoda,Xiaorong Fu,Shawn C. Burgess,William L. Holland,Steven A. Kliewer,David J. Mangelsdorf	206
8	FGF21 Is an Exocrine Pancreas Secretagogue 2017 ·Cell Metabolism ·Katie C. Coate,Genaro Hernandez,Curtis A. Thorne,Shengyi Sun,(unknown),(unknown),Steven A. Kliewer,David J. Mangelsdorf	92
9	Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis 2008 ·Molecular Endocrinology ·Youn‐Kyoung Lee,Daniel R. Schmidt,Carolyn L. Cummins,Mihwa Choi,Li Peng,Yuan Zhang,Bryan Goodwin,Robert E. Hammer,David J. Mangelsdorf,Steven A. Kliewer	117
10	FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption 2007 ·Journal of Lipid Research ·Diana Jung,Takeshi Inagaki,Robert D. Gerard,Paul A. Dawson,Steven A. Kliewer,David J. Mangelsdorf,Antonio Moschetta	92
11	Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21breakdown → 2007 ·Cell Metabolism ·Takeshi Inagaki,Paul A. Dutchak,Guixiang Zhao,Xunshan Ding,Laurent Gautron,Vinay Parameswara,Yong Li,Regina Goetz,Moosa Mohammadi,Victoria Esser,Joel K. Elmquist,Robert D. Gerard,Shawn C. Burgess,Robert E. Hammer,David J. Mangelsdorf,Steven A. Kliewer	1265
12	Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptorbreakdown → 2006 ·Proceedings of the National Academy of Sciences ·Takeshi Inagaki,Antonio Moschetta,(unknown),Li Peng,Guixiang Zhao,Michael Downes,Ruth T. Yu,John M. Shelton,James A. Richardson,Joyce J. Repa,David J. Mangelsdorf,Steven A. Kliewer	924
13	Cell-Free Ligand Binding Assays for Nuclear Receptors 2003 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Stacey A. Jones,Derek J. Parks,Steven A. Kliewer	3
14	Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates 2002 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Stacey A. Jones,Linda B. Moore,G. Bruce Wisely,Steven A. Kliewer	10
15	A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesisbreakdown → 2000 ·Molecular Cell ·Bryan Goodwin,Stacey A. Jones,(unknown),Michael A. Watson,David D. McKee,Linda B. Moore,Cristin M. Galardi,Joan G. Wilson,Michael C. Lewis,Matthew E. Roth,Patrick Maloney,Timothy M. Willson,Steven A. Kliewer	1598
16	Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors 2000 ·Molecular Cell ·Robert T. Gampe,Valerie G. Montana,Millard H. Lambert,Aaron B. Miller,Randy K. Bledsoe,Michael V. Milburn,Steven A. Kliewer,Timothy M. Willson,H. Eric Xu	489
17	Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptorsbreakdown → 1999 ·Molecular Cell ·H. Eric Xu,Millard H. Lambert,Valerie G. Montana,Derek J. Parks,Steven G. Blanchard,Peter J. Brown,Daniel D. Sternbach,Jürgen M. Lehmann,G. Bruce Wisely,Timothy M. Willson,Steven A. Kliewer,Michael V. Milburn	938
18	An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathwaybreakdown → 1998 ·Cell ·Steven A. Kliewer,John T. Moore,(unknown),Jeff L. Staudinger,(unknown),Stacey A. Jones,David D. McKee,(unknown),Timothy M. Willson,Rolf Zetterström,Thomas Perlmann,Jürgen M. Lehmann	1299
19	The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.breakdown → 1998 ·Journal of Clinical Investigation ·J�rgen Lehmann,David D. McKee,M. A. Watson,Timothy M. Willson,John T. Moore,Steven A. Kliewer	1314
20	NMR Spectroscopic Studies of the DNA-binding Domain of the Monomer-binding Nuclear Orphan Receptor, Human Estrogen Related Receptor-2 1997 ·Journal of Biological Chemistry ·Daniel S. Sem,Danilo R. Casimiro,Steven A. Kliewer,(unknown),Ronald M. Evans,Peter E. Wright	26

About Steven A. Kliewer

Steven A. Kliewer is a scholar working on Pharmacology, Aging and Genetics, having authored 168 papers that have together received 56.3k indexed citations. Recurring topics across this work include Drug Transport and Resistance Mechanisms (41 papers), Peroxisome Proliferator-Activated Receptors (39 papers) and Fibroblast Growth Factor Research (36 papers). The work is most often cited by research in Pharmacology (8.0k citations), Oncology (14.4k citations) and Biochemistry (3.6k citations). Steven A. Kliewer has collaborated with scholars based in United States, Netherlands and United Kingdom. Frequent co-authors include Timothy M. Willson, David J. Mangelsdorf, Jürgen M. Lehmann, Linda B. Moore, Ronald M. Evans, Bryan Goodwin, Stacey A. Jones, Kazuhiko Umesono, John T. Moore and David D. McKee. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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