Steven A. Kliewer

68.5k total citations · 35 hit papers
168 papers, 56.3k citations indexed

About

Steven A. Kliewer is a scholar working on Molecular Biology, Genetics and Oncology. According to data from OpenAlex, Steven A. Kliewer has authored 168 papers receiving a total of 56.3k indexed citations (citations by other indexed papers that have themselves been cited), including 109 papers in Molecular Biology, 47 papers in Genetics and 43 papers in Oncology. Recurrent topics in Steven A. Kliewer's work include Drug Transport and Resistance Mechanisms (41 papers), Peroxisome Proliferator-Activated Receptors (39 papers) and Fibroblast Growth Factor Research (36 papers). Steven A. Kliewer is often cited by papers focused on Drug Transport and Resistance Mechanisms (41 papers), Peroxisome Proliferator-Activated Receptors (39 papers) and Fibroblast Growth Factor Research (36 papers). Steven A. Kliewer collaborates with scholars based in United States, Netherlands and United Kingdom. Steven A. Kliewer's co-authors include Timothy M. Willson, David J. Mangelsdorf, Jürgen M. Lehmann, Linda B. Moore, Ronald M. Evans, Bryan Goodwin, Stacey A. Jones, Kazuhiko Umesono, John T. Moore and David D. McKee and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Steven A. Kliewer

168 papers receiving 55.0k citations

Hit Papers

An Antidiabetic Thiazolidinedione Is a High Affinity Liga... 1990 2026 2002 2014 1995 1999 1997 1995 2000 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
    1995 3.1k citations Jürgen M. Lehmann, Linda B. Moore et al. Journal of Biological Chemistry profile →
  2. Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
    1999 1.9k citations Derek J. Parks, Steven G. Blanchard et al. profile →
  3. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
    1997 1.8k citations Steven A. Kliewer, Stacey A. Jones et al. Proceedings of the National Academy of Sciences profile →
  4. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
    1995 1.8k citations Steven A. Kliewer, Timothy M. Willson et al. Cell profile →
  5. A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
    2000 1.6k citations Bryan Goodwin, Stacey A. Jones et al. Molecular Cell profile →
  6. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
    1992 1.5k citations Steven A. Kliewer, Ronald M. Evans et al. profile →
  7. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    2005 1.5k citations Takeshi Inagaki, Mihwa Choi et al. Cell Metabolism profile →
  8. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
    1998 1.3k citations J�rgen Lehmann, David D. McKee et al. Journal of Clinical Investigation profile →
  9. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling
    1992 1.3k citations Steven A. Kliewer, David J. Mangelsdorf et al. profile →
  10. An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
    1998 1.3k citations Steven A. Kliewer, John T. Moore et al. Cell profile →
  11. Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
    2007 1.3k citations Takeshi Inagaki, Paul A. Dutchak et al. Cell Metabolism profile →
  12. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
    1994 1.2k citations Steven A. Kliewer, David J. Mangelsdorf et al. Proceedings of the National Academy of Sciences profile →
  13. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    2001 1.1k citations Jeff L. Staudinger, Bryan Goodwin et al. Proceedings of the National Academy of Sciences profile →
  14. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
    1990 1.1k citations Steven A. Kliewer, Ronald M. Evans et al. Cell profile →
  15. Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway
    1997 1.0k citations Jürgen M. Lehmann, Steven A. Kliewer et al. Journal of Biological Chemistry profile →
  16. Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs
    1997 960 citations Jürgen M. Lehmann, Steven A. Kliewer et al. Journal of Biological Chemistry profile →
  17. Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors
    1999 938 citations H. Eric Xu, Millard H. Lambert et al. Molecular Cell profile →
  18. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    2006 924 citations Takeshi Inagaki, Antonio Moschetta et al. Proceedings of the National Academy of Sciences profile →
  19. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport
    2001 876 citations Michael C. Lewis, Millard H. Lambert et al. Proceedings of the National Academy of Sciences profile →
  20. Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
    1999 774 citations Stacey A. Jones, G. Bruce Wisely et al. Proceedings of the National Academy of Sciences profile →
  21. The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism
    2002 736 citations Steven A. Kliewer, Bryan Goodwin et al. profile →
  22. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
    2000 706 citations Linda B. Moore, Bryan Goodwin et al. Proceedings of the National Academy of Sciences profile →
  23. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands
    2000 684 citations Linda B. Moore, Derek J. Parks et al. Journal of Biological Chemistry profile →
  24. Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21
    2007 620 citations Mihwa Choi, Regina Goetz et al. Journal of Biological Chemistry profile →
  25. The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity
    2001 609 citations G. Bruce Wisely, Linda B. Moore et al. profile →
  26. FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    2009 590 citations Takeshi Inagaki, Xunshan Ding et al. Proceedings of the National Academy of Sciences profile →
  27. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR
    1991 584 citations David J. Mangelsdorf, Steven A. Kliewer et al. Cell profile →
  28. The Structure−Activity Relationship between Peroxisome Proliferator-Activated Receptor γ Agonism and the Antihyperglycemic Activity of Thiazolidinediones
    1996 569 citations Timothy M. Willson, Linda B. Moore et al. profile →
  29. Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
    2010 568 citations Xunshan Ding, Regina Goetz et al. Molecular Endocrinology profile →
  30. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
    2003 563 citations Steven A. Kliewer, Bryan Goodwin et al. profile →
  31. Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification
    2002 555 citations Bryan Goodwin, John T. Moore et al. profile →
  32. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα
    2002 521 citations H. Eric Xu, Valerie G. Montana et al. profile →
  33. Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease
    2001 514 citations Timothy M. Willson, Millard H. Lambert et al. profile →
  34. FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
    2011 503 citations H. Eric Xu, Steven A. Kliewer et al. profile →
  35. Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
    2014 488 citations David J. Mangelsdorf, Steven A. Kliewer et al. profile →

Peers

Steven A. Kliewer
Timothy M. Willson United States
David J. Mangelsdorf United States
Bart Staels France
David D. Moore United States
Peter Tontonoz United States
Kristina Schoonjans Switzerland
Morris F. White United States
Masahiko Negishi United States
Walter Wahli Switzerland
Mitchell A. Lazar United States
Timothy M. Willson United States
Steven A. Kliewer
Citations per year, relative to Steven A. Kliewer Steven A. Kliewer (= 1×) peers Timothy M. Willson

Countries citing papers authored by Steven A. Kliewer

Since Specialization
Citations

This map shows the geographic impact of Steven A. Kliewer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Steven A. Kliewer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Steven A. Kliewer more than expected).

Fields of papers citing papers by Steven A. Kliewer

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Steven A. Kliewer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Steven A. Kliewer. The network helps show where Steven A. Kliewer may publish in the future.

Co-authorship network of co-authors of Steven A. Kliewer

This figure shows the co-authorship network connecting the top 25 collaborators of Steven A. Kliewer. A scholar is included among the top collaborators of Steven A. Kliewer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Steven A. Kliewer. Steven A. Kliewer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Mackowiak, Bryan, Genaro Hernandez, Tulip Nandu, et al.. (2025). Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate. Proceedings of the National Academy of Sciences. 122(22). e2505263122–e2505263122. 2 indexed citations
2.
Choi, Mihwa, Marc Schneeberger, Abhijit Bugde, et al.. (2023). FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system. Cell Metabolism. 35(3). 429–437.e5. 23 indexed citations
3.
Lok, James B., Steven A. Kliewer, & David J. Mangelsdorf. (2022). The ‘nuclear option’ revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections. Molecular and Biochemical Parasitology. 250. 111490–111490. 4 indexed citations
4.
Wang, Zhu, Jet Tsien, Tian Qin, et al.. (2021). Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis. eLife. 10. 13 indexed citations
5.
Wang, Zhu, et al.. (2021). Identification of a nuclear receptor/coactivator developmental signaling pathway in the nematode parasite Strongyloides stercoralis. Proceedings of the National Academy of Sciences. 118(8). 22 indexed citations
6.
Hernandez, Genaro, Ting Luo, Tanveer A. Javed, et al.. (2020). Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy. Science Translational Medicine. 12(525). 34 indexed citations
7.
Morgan, Donald A., Kamal Rahmouni, Junichiro Sonoda, et al.. (2017). FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia. Cell Metabolism. 26(5). 709–718.e3. 206 indexed citations
8.
Coate, Katie C., Genaro Hernandez, Curtis A. Thorne, et al.. (2017). FGF21 Is an Exocrine Pancreas Secretagogue. Cell Metabolism. 25(2). 472–480. 92 indexed citations
9.
Lee, Youn‐Kyoung, Daniel R. Schmidt, Carolyn L. Cummins, et al.. (2008). Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis. Molecular Endocrinology. 22(6). 1345–1356. 117 indexed citations
10.
Jung, Diana, Takeshi Inagaki, Robert D. Gerard, et al.. (2007). FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. Journal of Lipid Research. 48(12). 2693–2700. 92 indexed citations
11.
Inagaki, Takeshi, Paul A. Dutchak, Guixiang Zhao, et al.. (2007). Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21. Cell Metabolism. 5(6). 415–425. 1265 indexed citations breakdown →
12.
Inagaki, Takeshi, Antonio Moschetta, Li Peng, et al.. (2006). Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proceedings of the National Academy of Sciences. 103(10). 3920–3925. 924 indexed citations breakdown →
13.
Jones, Stacey A., Derek J. Parks, & Steven A. Kliewer. (2003). Cell-Free Ligand Binding Assays for Nuclear Receptors. Methods in enzymology on CD-ROM/Methods in enzymology. 364. 53–71. 3 indexed citations
14.
Jones, Stacey A., Linda B. Moore, G. Bruce Wisely, & Steven A. Kliewer. (2002). Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates. Methods in enzymology on CD-ROM/Methods in enzymology. 357. 161–170. 10 indexed citations
15.
Goodwin, Bryan, Stacey A. Jones, Michael A. Watson, et al.. (2000). A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis. Molecular Cell. 6(3). 517–526. 1598 indexed citations breakdown →
16.
Gampe, Robert T., Valerie G. Montana, Millard H. Lambert, et al.. (2000). Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors. Molecular Cell. 5(3). 545–555. 489 indexed citations
17.
Xu, H. Eric, Millard H. Lambert, Valerie G. Montana, et al.. (1999). Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors. Molecular Cell. 3(3). 397–403. 938 indexed citations breakdown →
18.
Kliewer, Steven A., John T. Moore, Jeff L. Staudinger, et al.. (1998). An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway. Cell. 92(1). 73–82. 1299 indexed citations breakdown →
19.
Lehmann, J�rgen, David D. McKee, M. A. Watson, et al.. (1998). The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.. Journal of Clinical Investigation. 102(5). 1016–1023. 1314 indexed citations breakdown →
20.
Sem, Daniel S., et al.. (1997). NMR Spectroscopic Studies of the DNA-binding Domain of the Monomer-binding Nuclear Orphan Receptor, Human Estrogen Related Receptor-2. Journal of Biological Chemistry. 272(29). 18038–18043. 26 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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