Michael Downes

38.3k total citations · 12 hit papers
169 papers, 21.0k citations indexed

About

Michael Downes is a scholar working on Molecular Biology, Physiology and Genetics. According to data from OpenAlex, Michael Downes has authored 169 papers receiving a total of 21.0k indexed citations (citations by other indexed papers that have themselves been cited), including 102 papers in Molecular Biology, 40 papers in Physiology and 37 papers in Genetics. Recurrent topics in Michael Downes's work include Adipose Tissue and Metabolism (34 papers), Estrogen and related hormone effects (26 papers) and Retinoids in leukemia and cellular processes (21 papers). Michael Downes is often cited by papers focused on Adipose Tissue and Metabolism (34 papers), Estrogen and related hormone effects (26 papers) and Retinoids in leukemia and cellular processes (21 papers). Michael Downes collaborates with scholars based in United States, Australia and France. Michael Downes's co-authors include Ronald M. Evans, Ruth T. Yu, Christopher Liddle, Annette R. Atkins, David J. Mangelsdorf, Angie L. Bookout, Nasun Hah, Grant D. Barish, Jae Myoung Suh and Maryam Ahmadian and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Michael Downes

168 papers receiving 20.7k citations

Hit Papers

PPARγ signaling and metabolism: the good, t... 2000 2026 2008 2017 2013 2011 2008 2006 2012 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. PPARγ signaling and metabolism: the good, the bad and the future
    2013 1.5k citations Maryam Ahmadian, Jae Myoung Suh et al. profile →
  2. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
    2011 1.1k citations Michael Downes, Ruth T. Yu et al. Nature profile →
  3. AMPK and PPARδ Agonists Are Exercise Mimetics
    2008 968 citations Michael Downes, Ruth T. Yu et al. profile →
  4. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    2006 924 citations Takeshi Inagaki, Antonio Moschetta et al. Proceedings of the National Academy of Sciences profile →
  5. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
    2012 831 citations Ruth T. Yu, Annette R. Atkins et al. Nature profile →
  6. Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network
    2006 811 citations Michael Downes, Ruth T. Yu et al. profile →
  7. Nuclear Receptor Expression Links the Circadian Clock to Metabolism
    2006 770 citations Michael Downes, Ruth T. Yu et al. profile →
  8. Humanized xenobiotic response in mice expressing nuclear receptor SXR
    2000 545 citations Michael Downes, Ronald M. Evans et al. Nature profile →
  9. A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response
    2013 490 citations Ning Ding, Ruth T. Yu et al. profile →
  10. FXR Regulates Intestinal Cancer Stem Cell Proliferation
    2019 331 citations Sally Coulter, Eiji Yoshihara et al. profile →
  11. Immune-evasive human islet-like organoids ameliorate diabetes
    2020 253 citations Eiji Yoshihara, Carolyn O’Connor et al. Nature profile →
  12. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis
    2020 240 citations Tae Gyu Oh, Ruth T. Yu et al. Cell Metabolism profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Michael Downes United States 68 11.4k 5.2k 3.2k 3.0k 3.0k 169 21.0k
Ruth T. Yu United States 61 10.1k 0.9× 5.3k 1.0× 2.5k 0.8× 2.2k 0.7× 1.7k 0.6× 107 17.8k
Kazuyuki Tobe Japan 70 9.9k 0.9× 4.8k 0.9× 3.7k 1.1× 1.8k 0.6× 1.6k 0.5× 307 18.5k
E. Dale Abel United States 90 13.9k 1.2× 7.9k 1.5× 3.4k 1.0× 1.2k 0.4× 1.7k 0.6× 278 28.7k
Kohjiro Ueki Japan 73 10.0k 0.9× 6.8k 1.3× 7.2k 2.2× 1.7k 0.6× 1.7k 0.6× 240 22.6k
Oksana Gavrilova United States 66 9.3k 0.8× 8.0k 1.6× 4.9k 1.5× 1.4k 0.5× 1.2k 0.4× 188 18.6k
Béatrice Desvergne Switzerland 68 15.1k 1.3× 6.2k 1.2× 3.1k 1.0× 1.9k 0.6× 1.6k 0.5× 156 22.7k
Jason K. Kim United States 82 13.5k 1.2× 9.4k 1.8× 6.6k 2.0× 1.6k 0.5× 1.5k 0.5× 197 25.4k
Yasuo Terauchi Japan 60 7.8k 0.7× 3.9k 0.7× 4.3k 1.3× 1.8k 0.6× 1.4k 0.5× 377 17.3k
Tomoichiro Asano Japan 69 10.3k 0.9× 2.9k 0.6× 3.0k 0.9× 1.5k 0.5× 1.4k 0.5× 313 17.8k
Thomas P. Burris United States 64 6.4k 0.6× 3.0k 0.6× 1.1k 0.3× 2.5k 0.8× 1.7k 0.6× 190 13.4k

Countries citing papers authored by Michael Downes

Since Specialization
Citations

This map shows the geographic impact of Michael Downes's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael Downes with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael Downes more than expected).

Fields of papers citing papers by Michael Downes

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael Downes. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael Downes. The network helps show where Michael Downes may publish in the future.

Co-authorship network of co-authors of Michael Downes

This figure shows the co-authorship network connecting the top 25 collaborators of Michael Downes. A scholar is included among the top collaborators of Michael Downes based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael Downes. Michael Downes is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Hong, Suk-Hyun, Glenda Castro, Dan Wang, et al.. (2024). Targeting nuclear receptor corepressors for reversible male contraception. Proceedings of the National Academy of Sciences. 121(9). e2320129121–e2320129121. 2 indexed citations
2.
Abe, Yohei, Eric Kofman, Zhengyu Ouyang, et al.. (2024). A TLR4/TRAF6-dependent signaling pathway mediates NCoR coactivator complex formation for inflammatory gene activation. Proceedings of the National Academy of Sciences. 121(2). e2316104121–e2316104121. 10 indexed citations
3.
Zhang, Xiong, Demin Cai, Xingling Zheng, et al.. (2024). Functional inversion of circadian regulator REV-ERBα leads to tumorigenic gene reprogramming. Proceedings of the National Academy of Sciences. 121(42). e2411321121–e2411321121. 1 indexed citations
4.
Kim, Hyeonhui, Tae Gyu Oh, Minki Kim, et al.. (2023). PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. Proceedings of the National Academy of Sciences. 120(21). e2217826120–e2217826120. 21 indexed citations
5.
Yang, Lifeng, Tara TeSlaa, Serina Ng, et al.. (2022). Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med. 3(2). 119–136.e8. 72 indexed citations
6.
Kim, Ju Youn, Valentina C. Sladky, Tae Gyu Oh, et al.. (2022). PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metabolism. 34(10). 1548–1560.e6. 24 indexed citations
7.
Ishibashi, Tomoka, Keitaro Suyama, Takeru Nose, et al.. (2021). Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β. Journal of Biological Chemistry. 297(5). 101173–101173. 19 indexed citations
8.
Keinan, Omer, Joseph M. Valentine, Haopeng Xiao, et al.. (2021). Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature. 599(7884). 296–301. 51 indexed citations
9.
Yoshihara, Eiji, Carolyn O’Connor, Emanuel Gasser, et al.. (2020). Immune-evasive human islet-like organoids ameliorate diabetes. Nature. 586(7830). 606–611. 253 indexed citations breakdown →
10.
Wang, Lirui, Magdalena Mazagova, Chuyue Pan, et al.. (2019). YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proceedings of the National Academy of Sciences. 116(30). 15184–15193. 29 indexed citations
11.
Wu, Chyuan-Chuan, T.J. Baiga, Michael Downes, et al.. (2017). Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. Proceedings of the National Academy of Sciences. 114(13). E2563–E2570. 52 indexed citations
12.
DelGiorno, Kathleen E., Tejia Zhang, Randall P. French, et al.. (2017). Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS ONE. 12(12). e0189051–e0189051. 29 indexed citations
13.
Arensman, Michael D., Phillip Nguyen, Kathleen M. Kershaw, et al.. (2015). Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. Molecular Cancer Research. 13(11). 1509–1519. 37 indexed citations
14.
Ding, Ning, Nasun Hah, Ruth T. Yu, et al.. (2015). BRD4 is a novel therapeutic target for liver fibrosis. Proceedings of the National Academy of Sciences. 112(51). 15713–15718. 171 indexed citations
15.
Subramaniam, Nanthakumar, Mara H. Sherman, Renuka Rao, et al.. (2012). Metformin-Mediated Bambi Expression in Hepatic Stellate Cells Induces Prosurvival Wnt/β-Catenin Signaling. Cancer Prevention Research. 5(4). 553–561. 28 indexed citations
16.
Jonker, Johan W., Jae Myoung Suh, Annette R. Atkins, et al.. (2012). A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature. 485(7398). 391–394. 223 indexed citations
17.
Fan, Weiwei, et al.. (2011). Nuclear Receptors and AMPK: Resetting Metabolism. Cold Spring Harbor Symposia on Quantitative Biology. 76(0). 17–22. 14 indexed citations
18.
Inagaki, Takeshi, Antonio Moschetta, Li Peng, et al.. (2006). Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proceedings of the National Academy of Sciences. 103(10). 3920–3925. 924 indexed citations breakdown →
19.
Stedman, Catherine, Christopher Liddle, Sally Coulter, et al.. (2006). Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proceedings of the National Academy of Sciences. 103(30). 11323–11328. 148 indexed citations
20.
Burke, Leslie, Michael Downes, Vincent Laudet, & George E.O. Muscat. (1998). Identification and Characterization of a Novel Corepressor Interaction Region in RVR and Rev-erbAα. Molecular Endocrinology. 12(2). 248–262. 41 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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