Bryan Goodwin

17.2k total citations · 11 hit papers
69 papers, 14.1k citations indexed

About

Bryan Goodwin is a scholar working on Oncology, Pharmacology and Molecular Biology. According to data from OpenAlex, Bryan Goodwin has authored 69 papers receiving a total of 14.1k indexed citations (citations by other indexed papers that have themselves been cited), including 33 papers in Oncology, 32 papers in Pharmacology and 17 papers in Molecular Biology. Recurrent topics in Bryan Goodwin's work include Drug Transport and Resistance Mechanisms (33 papers), Pharmacogenetics and Drug Metabolism (32 papers) and Cholesterol and Lipid Metabolism (13 papers). Bryan Goodwin is often cited by papers focused on Drug Transport and Resistance Mechanisms (33 papers), Pharmacogenetics and Drug Metabolism (32 papers) and Cholesterol and Lipid Metabolism (13 papers). Bryan Goodwin collaborates with scholars based in United States, Australia and Netherlands. Bryan Goodwin's co-authors include Steven A. Kliewer, Timothy M. Willson, Stacey A. Jones, Linda B. Moore, Christopher Liddle, Jon L. Collins, Guizhen Luo, David D. McKee, Jodi M. Maglich and Michael A. Watson and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Bryan Goodwin

69 papers receiving 13.7k citations

Hit Papers

A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1,... 1999 2026 2008 2017 2000 2005 2001 2002 2002 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
    2000 1.6k citations Bryan Goodwin, Stacey A. Jones et al. Molecular Cell profile →
  2. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    2005 1.5k citations Mihwa Choi, Li Peng et al. Cell Metabolism profile →
  3. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    2001 1.1k citations Bryan Goodwin, Stacey A. Jones et al. profile →
  4. The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism
    2002 736 citations Steven A. Kliewer, Bryan Goodwin et al. profile →
  5. Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor
    2002 723 citations Heidi R. Kast-Woelbern, Bryan Goodwin et al. Journal of Biological Chemistry profile →
  6. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
    2000 706 citations Linda B. Moore, Bryan Goodwin et al. profile →
  7. Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands
    2000 684 citations Linda B. Moore, Stacey A. Jones et al. Journal of Biological Chemistry profile →
  8. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
    2003 563 citations Guizhen Luo, Traci A. Mansfield et al. profile →
  9. The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation ofCYP3A4by Rifampicin through a Distal Enhancer Module
    1999 558 citations Bryan Goodwin, Christopher Liddle et al. profile →
  10. Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification
    2002 555 citations Jodi M. Maglich, Bryan Goodwin et al. profile →
  11. A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
    2016 406 citations Saswata Talukdar, Yingjiang Zhou et al. Cell Metabolism profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Bryan Goodwin United States 43 6.5k 4.9k 4.6k 3.5k 2.5k 69 14.1k
Stacey A. Jones United States 28 6.8k 1.0× 3.5k 0.7× 5.4k 1.2× 4.3k 1.2× 2.6k 1.0× 37 14.0k
Linda B. Moore United States 33 4.5k 0.7× 3.3k 0.7× 7.2k 1.6× 3.1k 0.9× 2.9k 1.2× 45 13.8k
John Y.L. Chiang United States 68 7.8k 1.2× 2.2k 0.5× 6.3k 1.4× 6.1k 1.7× 1.0k 0.4× 164 16.3k
Erin G. Schuetz United States 77 9.7k 1.5× 9.8k 2.0× 4.7k 1.0× 1.6k 0.5× 2.3k 0.9× 198 19.9k
Christopher Liddle Australia 57 3.0k 0.5× 2.5k 0.5× 4.5k 1.0× 1.8k 0.5× 1.6k 0.6× 156 14.4k
Joyce J. Repa United States 55 8.0k 1.2× 1.2k 0.2× 10.2k 2.2× 10.8k 3.1× 1.9k 0.8× 101 21.1k
Edward L. LeCluyse United States 58 3.2k 0.5× 4.5k 0.9× 3.0k 0.7× 1.3k 0.4× 808 0.3× 135 11.3k
Grace L. Guo United States 52 3.8k 0.6× 1.1k 0.2× 3.0k 0.7× 2.4k 0.7× 764 0.3× 157 8.7k
Folkert Kuipers Netherlands 80 9.6k 1.5× 1.3k 0.3× 8.7k 1.9× 9.5k 2.7× 1.0k 0.4× 461 23.8k
John T. Moore United States 34 2.8k 0.4× 3.4k 0.7× 3.5k 0.8× 947 0.3× 3.2k 1.3× 68 9.1k

Countries citing papers authored by Bryan Goodwin

Since Specialization
Citations

This map shows the geographic impact of Bryan Goodwin's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bryan Goodwin with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bryan Goodwin more than expected).

Fields of papers citing papers by Bryan Goodwin

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bryan Goodwin. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bryan Goodwin. The network helps show where Bryan Goodwin may publish in the future.

Co-authorship network of co-authors of Bryan Goodwin

This figure shows the co-authorship network connecting the top 25 collaborators of Bryan Goodwin. A scholar is included among the top collaborators of Bryan Goodwin based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bryan Goodwin. Bryan Goodwin is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Ratziu, Vlad, Mary E. Rinella, Brent A. Neuschwander‐Tetri, et al.. (2021). EDP-305 in patients with NASH: A phase II double-blind placebo-controlled dose-ranging study. Journal of Hepatology. 76(3). 506–517. 87 indexed citations
2.
Amin, Neeta B., Santos Carvajal‐Gonzalez, Julie J. Purkal, et al.. (2019). Targeting diacylglycerol acyltransferase 2 for the treatment of nonalcoholic steatohepatitis. Science Translational Medicine. 11(520). 48 indexed citations
3.
Talukdar, Saswata, Yingjiang Zhou, Dongmei Li, et al.. (2016). A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects. Cell Metabolism. 23(3). 427–440. 406 indexed citations breakdown →
4.
Clark, Ronald W., Nicholas B. Vera, Kou Kou, et al.. (2015). Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis. Journal of Biological Chemistry. 291(6). 2602–2615. 29 indexed citations
5.
Talukdar, Saswata, Bryn M. Owen, Parkyong Song, et al.. (2015). FGF21 Regulates Sweet and Alcohol Preference. Cell Metabolism. 23(2). 344–349. 240 indexed citations
6.
Carpino, Philip A. & Bryan Goodwin. (2010). Diabetes area participation analysis: a review of companies and targets described in the 2008 – 2010 patent literature. Expert Opinion on Therapeutic Patents. 20(12). 1627–1651. 40 indexed citations
7.
Lee, Youn‐Kyoung, Daniel R. Schmidt, Carolyn L. Cummins, et al.. (2008). Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis. Molecular Endocrinology. 22(6). 1345–1356. 117 indexed citations
8.
Fiorucci, Stefano, Carlo Clerici, Elisabetta Antonelli, et al.. (2005). Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis. Journal of Pharmacology and Experimental Therapeutics. 313(2). 604–612. 164 indexed citations
9.
Mitchell, B.F., Jana M. Mitchell, Sanne Engelen, et al.. (2005). Metabolites of progesterone and the pregnane X receptor: A novel pathway regulating uterine contractility in pregnancy?. American Journal of Obstetrics and Gynecology. 192(4). 1304–1313. 35 indexed citations
10.
Liu, Yaping, Jane G. Binz, S. R. Dennis, et al.. (2003). Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. Journal of Clinical Investigation. 112(11). 1678–1687. 318 indexed citations
11.
Goodwin, Bryan, Michael A. Watson, Hwajin Kim, et al.. (2003). Differential Regulation of Rat and HumanCYP7A1by the Nuclear Oxysterol Receptor Liver X Receptor-α. Molecular Endocrinology. 17(3). 386–394. 161 indexed citations
12.
Nallani, Srikanth C., Bryan Goodwin, Jodi M. Maglich, et al.. (2003). Induction of Cytochrome P450 3A by Paclitaxel in Mice: Pivotal Role of the Nuclear Xenobiotic Receptor, Pregnane X Receptor. Drug Metabolism and Disposition. 31(5). 681–684. 41 indexed citations
13.
Spurdle, Amanda B., Bryan Goodwin, John L. Hopper, et al.. (2002). The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer. Pharmacogenetics. 12(5). 355–366. 112 indexed citations
14.
Kast-Woelbern, Heidi R., Bryan Goodwin, Paul T. Tarr, et al.. (2002). Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor. Journal of Biological Chemistry. 277(4). 2908–2915. 723 indexed citations breakdown →
15.
Desai, Pankaj B., Srikanth C. Nallani, Rucha Sane, et al.. (2002). Induction of Cytochrome P450 3A4 in Primary Human Hepatocytes and Activation of the Human Pregnane X Receptor by Tamoxifen and 4-Hydroxytamoxifen. Drug Metabolism and Disposition. 30(5). 608–612. 106 indexed citations
16.
Liddle, Christopher & Bryan Goodwin. (2002). Regulation of Hepatic Drug Metabolism: Role of the Nuclear Receptors PXR and CAR. Seminars in Liver Disease. 22(2). 115–122. 39 indexed citations
17.
Goodwin, Bryan, Stacey A. Jones, Michael A. Watson, et al.. (2000). A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis. Molecular Cell. 6(3). 517–526. 1598 indexed citations breakdown →
18.
Ellis, Ewa, Bryan Goodwin, Anna Abrahamsson, et al.. (1998). Bile acid synthesis in primary cultures of rat and human hepatocytes. Hepatology. 27(2). 615–620. 41 indexed citations
19.
Liddle, Christopher, Bryan Goodwin, & Michael Tapner. (1998). Culture and transfection of mammalian primary hepatocytes and hepatocyte‐derived cell lines. Journal of Gastroenterology and Hepatology. 13(8). 855–858. 4 indexed citations
20.
George, Jacob, Bryan Goodwin, Christopher Liddle, Michael Tapner, & Geoffrey C. Farrell. (1997). Time-dependent expression of cytochrome p450 genes in primary cultures of well-differentiated human hepatocytes. Journal of Laboratory and Clinical Medicine. 129(6). 638–648. 33 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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