William L. Holland

15.2k total citations · 7 hit papers
119 papers, 10.6k citations indexed

About

William L. Holland is a scholar working on Molecular Biology, Physiology and Surgery. According to data from OpenAlex, William L. Holland has authored 119 papers receiving a total of 10.6k indexed citations (citations by other indexed papers that have themselves been cited), including 69 papers in Molecular Biology, 41 papers in Physiology and 33 papers in Surgery. Recurrent topics in William L. Holland's work include Sphingolipid Metabolism and Signaling (31 papers), Adipose Tissue and Metabolism (31 papers) and Pancreatic function and diabetes (25 papers). William L. Holland is often cited by papers focused on Sphingolipid Metabolism and Signaling (31 papers), Adipose Tissue and Metabolism (31 papers) and Pancreatic function and diabetes (25 papers). William L. Holland collaborates with scholars based in United States, United Kingdom and Singapore. William L. Holland's co-authors include Scott A. Summers, Philipp E. Scherer, Kai Sun, Trina A. Knotts, Christine M. Kusminski, Joseph T. Brozinick, Liping Wang, Ruth Gordillo, Kyle L. Hoehn and Morris J. Birnbaum and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

William L. Holland

110 papers receiving 10.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance

2007 973 citations William L. Holland, Liping Wang et al. Cell Metabolism profile →
The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

2013 730 citations William L. Holland et al. Cell Metabolism profile →
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

2010 730 citations William L. Holland, Zhao V. Wang et al. profile →
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

2011 558 citations William L. Holland, Benjamin T. Bikman et al. Journal of Clinical Investigation profile →
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

2013 455 citations William L. Holland, Christine M. Kusminski et al. Cell Metabolism profile →
Ceramides and other sphingolipids as drivers of cardiovascular disease

2021 250 citations Scott A. Summers, William L. Holland et al. profile →
Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

2023 162 citations Md Torikul Islam, William L. Holland et al. Aging Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
William L. Holland United States	45	5.4k	4.1k	3.2k	1.5k	1.3k	119	10.6k
Andrea L. Hevener United States	45	5.3k 1.0×	5.0k 1.2×	3.7k 1.2×	1.4k 0.9×	1.9k 1.5×	80	12.0k
Gary Sweeney Canada	57	3.7k 0.7×	3.8k 0.9×	3.5k 1.1×	1.3k 0.8×	987 0.8×	180	9.9k
Naoto Kubota Japan	57	5.6k 1.0×	3.1k 0.8×	2.9k 0.9×	2.0k 1.3×	1.7k 1.3×	155	11.0k
Philippe Valet France	63	5.1k 0.9×	3.4k 0.8×	2.0k 0.6×	3.0k 2.0×	1.1k 0.9×	236	13.1k
Scott A. Summers United States	55	9.1k 1.7×	5.0k 1.2×	3.5k 1.1×	2.1k 1.4×	1.8k 1.4×	127	14.5k
Nora Klöting Germany	52	3.2k 0.6×	5.3k 1.3×	4.7k 1.5×	1.1k 0.7×	1.4k 1.1×	203	11.7k
Theodore P. Ciaraldi United States	55	5.7k 1.1×	3.9k 1.0×	2.6k 0.8×	1.7k 1.1×	2.2k 1.7×	141	10.7k
Kurt Højlund Denmark	54	4.9k 0.9×	6.6k 1.6×	2.4k 0.8×	1.0k 0.7×	1.6k 1.3×	214	11.5k
Harald Staiger Germany	54	3.2k 0.6×	2.9k 0.7×	3.0k 0.9×	2.0k 1.3×	2.0k 1.6×	176	9.3k
Paul Cohen United States	48	3.8k 0.7×	7.2k 1.8×	4.4k 1.4×	1.4k 0.9×	780 0.6×	83	12.7k

Countries citing papers authored by William L. Holland

Since Specialization

Citations

This map shows the geographic impact of William L. Holland's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William L. Holland with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William L. Holland more than expected).

Fields of papers citing papers by William L. Holland

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William L. Holland. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William L. Holland. The network helps show where William L. Holland may publish in the future.

Co-authorship network of co-authors of William L. Holland

This figure shows the co-authorship network connecting the top 25 collaborators of William L. Holland. A scholar is included among the top collaborators of William L. Holland based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William L. Holland. William L. Holland is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Trott, Nick, William L. Holland, Mohamed G. Shiha, et al.. (2025). Food Related Quality of Life and Associations With Demographic and Clinical Characteristics in People With Coeliac Disease. Journal of Human Nutrition and Dietetics. 38(3). e70051–e70051. 1 indexed citations

Liou, Willisa, et al.. (2025). A long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin secretion in mice. Science Advances. 11(38). eadx2752–eadx2752.

Islam, Md Torikul, Jinjin Cai, Samuel I. Bloom, et al.. (2024). Endothelial-Specific Reduction in Arf6 Impairs Insulin-Stimulated Vasodilation and Skeletal Muscle Blood Flow Resulting in Systemic Insulin Resistance in Mice. Arteriosclerosis Thrombosis and Vascular Biology. 44(5). 1101–1113. 4 indexed citations

Holland, William L., et al.. (2024). Ceramide microdomains: the major influencers of the sphingolipid media platform. Biochemical Society Transactions. 52(4). 1765–1776.

Emfinger, Christopher H., Kathryn L. Schueler, Sarah M. King, et al.. (2023). Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population. Journal of Lipid Research. 64(12). 100471–100471. 2 indexed citations

Stapleton, Donnie S., Kathryn L. Schueler, Brian W. Parks, et al.. (2023). Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin. PLoS Genetics. 19(7). e1010713–e1010713. 4 indexed citations

Petrocelli, Jonathan J., Alec I. McKenzie, Paul T. Reidy, et al.. (2023). Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment. Aging Cell. 22(11). e13936–e13936. 33 indexed citations

Poss, Annelise M., J. Alan Maschek, Benjamin Haaland, et al.. (2022). Following Roux-en-Y gastric bypass surgery, serum ceramides demarcate patients that will fail to achieve normoglycemia and diabetes remission. Med. 3(7). 452–467.e4. 10 indexed citations

Holland, William L., et al.. (2022). CE: Pain and Mental Health Symptoms After Traumatic Orthopedic Injury. AJN American Journal of Nursing. 122(9). 26–37.

10.

Yang, Chaofeng, Lisa Hahner, Joshua A. Johnson, et al.. (2021). Perilipin 5 links mitochondrial uncoupled respiration in brown fat to healthy white fat remodeling and systemic glucose tolerance. Nature Communications. 12(1). 3320–3320. 40 indexed citations

11.

Montefusco, David, et al.. (2020). Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease. Journal of Lipid Research. 61(10). 1328–1340. 20 indexed citations

12.

Zheng, Nan, Michael A. VandenBerg, Jin Hwan Kim, et al.. (2019). Synthesis and Characterization of an A6-A11 Methylene Thioacetal Human Insulin Analogue with Enhanced Stability. Journal of Medicinal Chemistry. 62(24). 11437–11443. 22 indexed citations

13.

Xiong, Xiaochun, Michael A. VandenBerg, Frank G. Whitby, et al.. (2019). Novel four-disulfide insulin analog with high aggregation stability and potency. Chemical Science. 11(1). 195–200. 26 indexed citations

14.

Caron, Alexandre, Carlos M. Castorena, Teppei Fujikawa, et al.. (2018). POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels. eLife. 7. 88 indexed citations

15.

Shao, Mengle, Lavanya Vishvanath, Chelsea Hepler, et al.. (2018). De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nature Communications. 9(1). 890–890. 125 indexed citations

16.

Hepler, Chelsea, Mengle Shao, Jonathan Y. Xia, et al.. (2017). Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice. eLife. 6. 37 indexed citations

17.

Shao, Mengle, Jeff Ishibashi, Christine M. Kusminski, et al.. (2016). Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. Cell Metabolism. 23(6). 1167–1184. 174 indexed citations

18.

Deng, Yingfeng, Zhao V. Wang, Caroline Tao, et al.. (2012). The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. Journal of Clinical Investigation. 123(1). 455–468. 108 indexed citations

19.

Holland, William L., Benjamin T. Bikman, Liping Wang, et al.. (2011). Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice. Journal of Clinical Investigation. 121(5). 1858–1870. 558 indexed citations breakdown →

20.

Holland, William L., Trina A. Knotts, Jose A. Chavez, et al.. (2008). Lipid Mediators of Insulin Resistance. Nutrition Reviews. 65(6 Pt 2). S39–S46. 110 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact