Daniel S. Sem

2.3k total citations · 1 hit paper
86 papers, 1.8k citations indexed

About

Daniel S. Sem is a scholar working on Molecular Biology, Genetics and Computational Theory and Mathematics. According to data from OpenAlex, Daniel S. Sem has authored 86 papers receiving a total of 1.8k indexed citations (citations by other indexed papers that have themselves been cited), including 58 papers in Molecular Biology, 17 papers in Genetics and 16 papers in Computational Theory and Mathematics. Recurrent topics in Daniel S. Sem's work include Computational Drug Discovery Methods (16 papers), Estrogen and related hormone effects (15 papers) and Protein Structure and Dynamics (13 papers). Daniel S. Sem is often cited by papers focused on Computational Drug Discovery Methods (16 papers), Estrogen and related hormone effects (15 papers) and Protein Structure and Dynamics (13 papers). Daniel S. Sem collaborates with scholars based in United States, Thailand and Zimbabwe. Daniel S. Sem's co-authors include Maurizio Pellecchia, Kurt Wüthrich, Charles B. Kasper, Phani Kumar Pullela, Taurai Chiku, Michael J. Carvan, John E. Thomas, R M Jack, Anna L. Shen and David Meininger and has published in prestigious journals such as Journal of the American Chemical Society, Nucleic Acids Research and Journal of Biological Chemistry.

In The Last Decade

Daniel S. Sem

86 papers receiving 1.8k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Nmr in drug discovery

2002 313 citations Maurizio Pellecchia, Daniel S. Sem et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Daniel S. Sem United States	24	1.1k	286	238	215	186	86	1.8k
Ivanov As Russia	22	944 0.9×	138 0.5×	259 1.1×	107 0.5×	209 1.1×	183	1.8k
Abhinav Nath United States	23	1.3k 1.2×	178 0.6×	153 0.6×	183 0.9×	234 1.3×	51	1.8k
Tove Sjögren Sweden	20	698 0.7×	175 0.6×	269 1.1×	180 0.8×	528 2.8×	28	1.8k
Laurence H. Patterson United Kingdom	28	1.2k 1.2×	177 0.6×	114 0.5×	145 0.7×	236 1.3×	89	2.2k
Nicole Bec France	26	1.2k 1.1×	153 0.5×	66 0.3×	110 0.5×	129 0.7×	71	2.3k
Robert X. Xu United States	22	1.5k 1.4×	168 0.6×	111 0.5×	247 1.1×	132 0.7×	30	2.3k
Gildas Bertho France	23	1.0k 1.0×	139 0.5×	89 0.4×	137 0.6×	140 0.8×	87	1.9k
Reetta Raag United States	15	965 0.9×	181 0.6×	193 0.8×	218 1.0×	629 3.4×	19	1.8k
Robert T. Gampe United States	22	2.0k 1.9×	364 1.3×	157 0.7×	210 1.0×	61 0.3×	49	2.9k
Luigi Di Costanzo Italy	30	1.6k 1.5×	383 1.3×	137 0.6×	601 2.8×	96 0.5×	75	2.9k

Countries citing papers authored by Daniel S. Sem

Since Specialization

Citations

This map shows the geographic impact of Daniel S. Sem's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Daniel S. Sem with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Daniel S. Sem more than expected).

Fields of papers citing papers by Daniel S. Sem

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Daniel S. Sem. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Daniel S. Sem. The network helps show where Daniel S. Sem may publish in the future.

Co-authorship network of co-authors of Daniel S. Sem

This figure shows the co-authorship network connecting the top 25 collaborators of Daniel S. Sem. A scholar is included among the top collaborators of Daniel S. Sem based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Daniel S. Sem. Daniel S. Sem is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Frick, Karyn M., et al.. (2025). Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief. Hormones and Behavior. 173. 105773–105773. 1 indexed citations

Sweeney, Noreena L., Robert D. Bongard, Ankan Gupta, et al.. (2024). Structural and kinetic characterization of DUSP5 with a Di-phosphorylated tripeptide substrate from the ERK activation loop. SHILAP Revista de lepidopterología. 3. 3 indexed citations

York, Jason, et al.. (2024). The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model. Frontiers in Aging Neuroscience. 16. 1477045–1477045. 3 indexed citations

Sem, Daniel S., et al.. (2023). Real-time thiol detection in iPSC-derived neuron cultures using SemKur-IM, a novel fluorescent dithio probe. SLAS DISCOVERY. 29(3). 100127–100127. 1 indexed citations

Lindeman, Sergey V., et al.. (2022). Discovery of two novel (4-hydroxyphenyl) substituted polycyclic carbocycles as potent and selective estrogen receptor beta agonists. Bioorganic & Medicinal Chemistry Letters. 73. 128906–128906. 1 indexed citations

Sem, Daniel S.. (2014). Repurposing - Finding New Uses for Old (and Patented) Drugs: Bridging the "Valley of Death," to Translate Academic Research Into New Medicines. 18(1). 139. 1 indexed citations

Gastonguay, Adam, Marat R. Talipov, Padmanabhan Vakeel, et al.. (2014). Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins. BMC Biochemistry. 15(1). 27–27. 13 indexed citations

Sem, Daniel S., et al.. (2011). An In Vitro Spectroscopic Analysis to Determine the Chemical Composition of the Precipitate Formed by Mixing Sodium Hypochlorite and Chlorhexidine. Journal of Endodontics. 37(7). 983–988. 48 indexed citations

Pullela, Phani Kumar, et al.. (2009). 13C-Methyl isocyanide as an NMR probe for cytochrome P450 active sites. Journal of Biomolecular NMR. 43(3). 171–178. 7 indexed citations

10.

Ge, Xia, Bassam T. Wakim, & Daniel S. Sem. (2008). Chemical Proteomics-Based Drug Design: Target and Antitarget Fishing with a Catechol−Rhodanine Privileged Scaffold for NAD(P)(H) Binding Proteins. Journal of Medicinal Chemistry. 51(15). 4571–4580. 31 indexed citations

11.

Yao, Huili, et al.. (2007). Structural evidence for a functionally relevant second camphor binding site in P450cam: Model for substrate entry into a P450 active site. Proteins Structure Function and Bioinformatics. 69(1). 125–138. 36 indexed citations

12.

Chiku, Taurai, Phani Kumar Pullela, & Daniel S. Sem. (2006). A Dithio-Coupled Kinase and ATPase Assay. SLAS DISCOVERY. 11(7). 844–853. 4 indexed citations

13.

Sem, Daniel S., et al.. (2004). Systems-Based Design of Bi-Ligand Inhibitors of OxidoreductasesFilling the Chemical Proteomic Toolbox. Chemistry & Biology. 11(2). 185–194. 13 indexed citations

14.

Pellecchia, Maurizio, et al.. (2002). NMR-based structural characterization of large protein-ligand interactions. Journal of Biomolecular NMR. 22(2). 165–173. 86 indexed citations

15.

Sem, Daniel S., et al.. (2001). Object-oriented approach to drug design enabled by NMR SOLVE: First real-time structural tool for characterizing protein-ligand interactions. Journal of Cellular Biochemistry. 84(S37). 99–105. 13 indexed citations

16.

Sem, Daniel S., et al.. (1999). Application of fluorescence polarization to the steady‐state enzyme kinetic analysis of calpain II. FEBS Letters. 443(1). 17–19. 13 indexed citations

17.

Sem, Daniel S., et al.. (1997). NMR Spectroscopic Studies of the DNA-binding Domain of the Monomer-binding Nuclear Orphan Receptor, Human Estrogen Related Receptor-2. Journal of Biological Chemistry. 272(29). 18038–18043. 26 indexed citations

18.

Sem, Daniel S. & Charles B. Kasper. (1995). Effect of Ionic Strength on the Kinetic Mechanism and Relative Rate Limitation of Steps in the Model NADPH-Cytochrome P450 Oxidoreductase Reaction with Cytochrome c. Biochemistry. 34(39). 12768–12774. 31 indexed citations

19.

Sem, Daniel S. & Charles B. Kasper. (1994). Kinetic Mechanism for the Model Reaction of NADPH-Cytochrome P450 Oxidoreductase with Cytochrome c. Biochemistry. 33(40). 12012–12021. 22 indexed citations

20.

Sem, Daniel S. & W. W. Cleland. (1991). Phosphorylated aminosugars; synthesis, properties, and reactivity in enzymic reactions. Biochemistry. 30(20). 4978–4984. 21 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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