Michael Willem

5.1k total citations · 1 hit paper
35 papers, 3.3k citations indexed

About

Michael Willem is a scholar working on Physiology, Molecular Biology and Pharmacology. According to data from OpenAlex, Michael Willem has authored 35 papers receiving a total of 3.3k indexed citations (citations by other indexed papers that have themselves been cited), including 28 papers in Physiology, 20 papers in Molecular Biology and 6 papers in Pharmacology. Recurrent topics in Michael Willem's work include Alzheimer's disease research and treatments (27 papers), Cholinesterase and Neurodegenerative Diseases (6 papers) and Prion Diseases and Protein Misfolding (4 papers). Michael Willem is often cited by papers focused on Alzheimer's disease research and treatments (27 papers), Cholinesterase and Neurodegenerative Diseases (6 papers) and Prion Diseases and Protein Misfolding (4 papers). Michael Willem collaborates with scholars based in Germany, United States and Switzerland. Michael Willem's co-authors include Christian Haass, Harald Steiner, Sven Lammich, Laure Bally‐Cuif, Alistair N. Garratt, Paul Säftig, Jochen Walter, Gerd Multhaup, Carmen Birchmeier and Anja Capell and has published in prestigious journals such as Science, Journal of Biological Chemistry and The EMBO Journal.

In The Last Decade

Michael Willem

33 papers receiving 3.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

2006 527 citations Michael Willem, Alistair N. Garratt et al. Science profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Michael Willem Germany	22	2.1k	1.6k	766	579	562	35	3.3k
Oksana Berezovska United States	38	2.5k 1.2×	2.2k 1.4×	653 0.9×	889 1.5×	590 1.0×	85	4.1k
Keiro Shirotani Japan	26	2.4k 1.2×	1.7k 1.1×	706 0.9×	864 1.5×	487 0.9×	51	3.7k
Sven Lammich Germany	19	2.5k 1.2×	2.0k 1.3×	720 0.9×	644 1.1×	724 1.3×	24	4.0k
Maho Morishima‐Kawashima Japan	32	3.5k 1.7×	2.3k 1.5×	870 1.1×	852 1.5×	859 1.5×	45	4.3k
Xiangyou Hu United States	30	1.5k 0.7×	926 0.6×	518 0.7×	789 1.4×	420 0.7×	56	2.6k
Katrien Horré Belgium	20	1.5k 0.7×	2.0k 1.3×	416 0.5×	573 1.0×	292 0.5×	25	3.2k
Gopal Thinakaran United States	14	2.1k 1.0×	1.5k 0.9×	598 0.8×	644 1.1×	474 0.8×	21	2.8k
Martina K. Brückner Germany	33	1.5k 0.7×	1.6k 1.0×	552 0.7×	961 1.7×	422 0.8×	65	3.4k
Wanxia He United States	24	1.2k 0.6×	824 0.5×	417 0.5×	587 1.0×	438 0.8×	42	2.1k
Russell E. Rydel United States	23	3.2k 1.5×	1.9k 1.2×	862 1.1×	1.1k 1.9×	342 0.6×	28	4.2k

Countries citing papers authored by Michael Willem

Since Specialization

Citations

This map shows the geographic impact of Michael Willem's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael Willem with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael Willem more than expected).

Fields of papers citing papers by Michael Willem

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael Willem. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael Willem. The network helps show where Michael Willem may publish in the future.

Co-authorship network of co-authors of Michael Willem

This figure shows the co-authorship network connecting the top 25 collaborators of Michael Willem. A scholar is included among the top collaborators of Michael Willem based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Michael Willem. Michael Willem is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kunze, Lea H., M. Haertel, Yeqian Zhu, et al.. (2025). Image-Derived Blood Normalization of Antibody-Based TREM2 PET in Mouse Models of Amyloidosis and Myocardial Infarction. Journal of Nuclear Medicine. 66(9). 1419–1424.

Vukicevic, Marija, Emma Fiorini, Stephan A. Müller, et al.. (2022). Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model. Cells. 12(1). 79–79. 7 indexed citations

Vitale, Paola, Carmen Alina Lupaşcu, Michael Willem, et al.. (2021). Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer’s Disease. Frontiers in Aging Neuroscience. 13. 668948–668948. 13 indexed citations

Mohammadi, Behnam, Luise Linsenmeier, Mohsin Shafiq, et al.. (2020). Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation. Molecular Neurobiology. 57(6). 2812–2829. 12 indexed citations

Schölvinck, Marieke L., et al.. (2019). Lack of β-amyloid cleaving enzyme-1 (BACE1) impairs long-term synaptic plasticity but enhances granule cell excitability and oscillatory activity in the dentate gyrus in vivo. Brain Structure and Function. 224(3). 1279–1290. 9 indexed citations

Hong, Wei, Zemin Wang, Wen Liu, et al.. (2018). Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’s disease brain. Acta Neuropathologica. 136(1). 19–40. 105 indexed citations

Brettschneider, Johannes, Jochen K. Lennerz, Daniel Walcher, et al.. (2018). Amyloid precursor protein-fragments-containing inclusions in cardiomyocytes with basophilic degeneration and its association with cerebral amyloid angiopathy and myocardial fibrosis. Scientific Reports. 8(1). 16594–16594. 13 indexed citations

Brendel, Matthias, Anna Jaworska, Felix Overhoff, et al.. (2018). Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation. Theranostics. 8(18). 4957–4968. 21 indexed citations

Mishra, Sabyashachi, K. Muruga Poopathi Raja, Michael Willem, et al.. (2016). Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein. Cell Reports. 14(9). 2127–2141. 82 indexed citations

10.

Busche, Marc Aurel, M. Staufenbiel, Michael Willem, Christian Haass, & Hans Förstl. (2016). Mechanismen der Alzheimer-Krankheit. Der Nervenarzt. 87(11). 1163–1174. 6 indexed citations

11.

Chéret, Cyril, Michael Willem, Florence R. Fricker, et al.. (2013). Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. The EMBO Journal. 32(14). 2015–2028. 106 indexed citations

12.

Kuhn, Peer‐Hendrik, Sebastian Hogl, Alessio Colombo, et al.. (2012). Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. The EMBO Journal. 31(14). 3157–3168. 258 indexed citations

13.

Willem, Michael, Alistair N. Garratt, Božidar Novak, et al.. (2006). Control of Peripheral Nerve Myelination by the ß-Secretase BACE1. Science. 314(5799). 664–666. 527 indexed citations breakdown →

14.

Willem, Michael, Ilse Dewachter, Neil Smyth, et al.. (2004). β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE × APP[V717I] Double-Transgenic Mice. American Journal Of Pathology. 165(5). 1621–1631. 40 indexed citations

15.

Fluhrer, Regina, Gerd Multhaup, Andrea Schlicksupp, et al.. (2003). Identification of a β-Secretase Activity, Which Truncates Amyloid β-Peptide after Its Presenilin-dependent Generation. Journal of Biological Chemistry. 278(8). 5531–5538. 64 indexed citations

16.

Fluhrer, Regina, Anja Capell, Gil G. Westmeyer, et al.. (2002). A non‐amyloidogenic function of BACE‐2 in the secretory pathway. Journal of Neurochemistry. 81(5). 1011–1020. 87 indexed citations

17.

Steiner, Harald, et al.. (2002). A γ‐secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Reports. 3(7). 688–694. 418 indexed citations

18.

Edbauer, Dieter, Michael Willem, Sven Lammich, Harald Steiner, & Christian Haass. (2002). Insulin-degrading Enzyme Rapidly Removes the β-Amyloid Precursor Protein Intracellular Domain (AICD). Journal of Biological Chemistry. 277(16). 13389–13393. 174 indexed citations

19.

Walter, Jochen, Regina Fluhrer, Michael Willem, et al.. (2001). Phosphorylation Regulates Intracellular Trafficking of β-Secretase. Journal of Biological Chemistry. 276(18). 14634–14641. 237 indexed citations

20.

Capell, Anja, Harald Steiner, Michael Willem, et al.. (2000). Maturation and Pro-peptide Cleavage of β-Secretase. Journal of Biological Chemistry. 275(40). 30849–30854. 216 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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