Mathias Heikenwälder

45.9k total citations · 15 hit papers
224 papers, 21.6k citations indexed

About

Mathias Heikenwälder is a scholar working on Molecular Biology, Immunology and Epidemiology. According to data from OpenAlex, Mathias Heikenwälder has authored 224 papers receiving a total of 21.6k indexed citations (citations by other indexed papers that have themselves been cited), including 82 papers in Molecular Biology, 80 papers in Immunology and 61 papers in Epidemiology. Recurrent topics in Mathias Heikenwälder's work include Immunotherapy and Immune Responses (32 papers), Liver Disease Diagnosis and Treatment (32 papers) and Prion Diseases and Protein Misfolding (30 papers). Mathias Heikenwälder is often cited by papers focused on Immunotherapy and Immune Responses (32 papers), Liver Disease Diagnosis and Treatment (32 papers) and Prion Diseases and Protein Misfolding (30 papers). Mathias Heikenwälder collaborates with scholars based in Germany, Switzerland and United States. Mathias Heikenwälder's co-authors include Adriano Aguzzi, Eli Pikarsky, Marc Ringelhan, Marco Prinz, Dominik Pfister, Tracy O’Connor, Helen L. Reeves, Quentin M. Anstee, Elena Kotsiliti and Olivier Govaere and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Mathias Heikenwälder

220 papers receiving 21.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Immunotherapies for hepatocellular carcinoma

2021 1.1k citations Mathias Heikenwälder, David J. Pinato et al. profile →
From NASH to HCC: current concepts and future challenges

2019 965 citations Mathias Heikenwälder et al. profile →
The maternal microbiota drives early postnatal innate immune development

2016 860 citations Mercedes Gomez de Agüero, Stephanie C. Ganal‐Vonarburg et al. Science profile →
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

2007 855 citations Mathias Heikenwälder, Marco Prinz et al. profile →
The immunology of hepatocellular carcinoma

2018 755 citations Marc Ringelhan, Mathias Heikenwälder et al. profile →
Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

2010 598 citations Siegfried Hapfelmeier, Melissa A. Lawson et al. Science profile →
NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

2016 569 citations Michèle Egger, Achim Weber et al. profile →
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

2013 516 citations Tom Luedde, Mathias Heikenwälder et al. profile →
Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

2016 447 citations Tetyana Yevsa, Mathias Heikenwälder et al. profile →
The immunological and metabolic landscape in primary and metastatic liver cancer

2021 392 citations Pierluigi Ramadori, Mathias Heikenwälder et al. profile →
Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits

2022 325 citations Mathias Heikenwälder et al. profile →
SpaceM reveals metabolic states of single cells

2021 231 citations Luca Rappez, Mira Stadler et al. Nature Methods profile →
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment

2023 203 citations Mathias Heikenwälder et al. profile →
A researcher’s guide to preclinical mouse NASH models

2022 105 citations Suchira Gallage, Jose Efren Barragan Avila et al. profile →
Role of immune responses in the development of NAFLD-associated liver cancer and prospects for therapeutic modulation

2023 77 citations Mathias Heikenwälder et al. profile →

Peers

Countries citing papers authored by Mathias Heikenwälder

Since Specialization

Citations

This map shows the geographic impact of Mathias Heikenwälder's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Mathias Heikenwälder with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Mathias Heikenwälder more than expected).

Fields of papers citing papers by Mathias Heikenwälder

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Mathias Heikenwälder. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Mathias Heikenwälder. The network helps show where Mathias Heikenwälder may publish in the future.

Co-authorship network of co-authors of Mathias Heikenwälder

This figure shows the co-authorship network connecting the top 25 collaborators of Mathias Heikenwälder. A scholar is included among the top collaborators of Mathias Heikenwälder based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Mathias Heikenwälder. Mathias Heikenwälder is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma 2024 ·Molecular Cell ·(unknown), Juan F. Linares, Antoine L’Hermitte, Ángeles Durán, (unknown), Anxo Martínez-Ordóñez, Marc Ruíz-Martínez, Yotaro Kudo, Antonio Marzio, Mathias Heikenwälder, Lewis R. Roberts, María T. Díaz‐Meco, Jorge Moscat	5
2	Detection of senescence using machine learning algorithms based on nuclear features 2024 ·Nature Communications ·(unknown), Joaquim Pombo, Bin Sun, Suchira Gallage, Hiromi Kudo, Domhnall McHugh, (unknown), Jose Efren Barragan Avila, Roberta Forlano, Pinelopi Manousou, Mathias Heikenwälder, Dominic J. Withers, Santiago Vernia, Robert Goldin, Jesús Gil	39
3	Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome 2024 ·Nature Aging ·Suchira Gallage, Elaine E. Irvine, Jose Efren Barragan Avila, (unknown), Silvia M.A. Pedroni, (unknown), (unknown), Sanjay Khadayate, Joaquim Pombo, Sharon Brookes, Danijela Heide, (unknown), Agharul I. Choudhury, Indrabahadur Singh, Nicolás Herranz, Santiago Vernia, Mathias Heikenwälder, Jesús Gil, Dominic J. Withers	11
4	Bovine meat and milk factor protein expression in tumor‐free mucosa of colorectal cancer patients coincides with macrophages and might interfere with patient survival 2023 ·Molecular Oncology ·Ekaterina Nikitina, (unknown), Manuel Wiesenfarth, Elizabeth Alwers, Danijela Heide, Claudia Tessmer, Claudia Ernst, Damir Krunic, Petra Schrotz‐King, Jenny Chang‐Claude, Moritz von Winterfeld, Esther Herpel, Alexander Brobeil, Hermann Brenner, Mathias Heikenwälder, Michael Hoffmeister, Annette Kopp‐Schneider, Timo Bund	5
5	Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice 2023 ·Developmental Cell ·Maja C. Funk, Jan Gleixner, Florian Heigwer, Dominik Vonficht, Erica Valentini, Zeynep Gökçe Gayretli Aydın, Elena Tonin, (unknown), Sylvia Mahara, (unknown), Jenny Hetzer, Danijela Heide, Oliver Stegle, Duncan T. Odom, Angelika Feldmann, Simon Haas, Mathias Heikenwälder, Michael Boutros	24
6	NASH and Hepatocellular Carcinoma: Immunology and Immunotherapy 2022 ·Clinical Cancer Research ·Matthias Pinter, David J. Pinato, Pierluigi Ramadori, Mathias Heikenwälder	57
7	Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma 2021 ·Cancers ·Rouven Hoefflin, Sabine Harlander, Behnaz Ahangarian Abhari, (unknown), Mojca Adlesic, Philipp Seidel, (unknown), Stefan Haug, (unknown), Yong Li, Bernd Lahrmann, Niels Grabe, Danijela Heide, Melanie Boerries, Anna Köttgen, Mathias Heikenwälder, Ian J. Frew	9
8	SpaceM reveals metabolic states of single cells breakdown → 2021 ·Nature Methods ·Luca Rappez, Mira Stadler, Sergio Triana, Rose M. Gathungu, Katja Ovchinnikova, Prasad Phapale, Mathias Heikenwälder, Theodore Alexandrov	231
9	Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach 2019 ·Molecular Cancer Research ·Juliane Friemel, Lukas Frick, Kristian Unger, Michèle Egger, Rossella Parrotta, (unknown), Arlind Adili, Michael Karin, Tom Luedde, Mathias Heikenwälder, Achim Weber	22
10	CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis 2018 ·Molecular Cancer Research ·Marko Roblek, (unknown), (unknown), Cristina Ştefănescu, Christian Gorzelanny, (unknown), Lucia Knopfová, Mathias Heikenwälder, Bruno Luckow, Stefan W. Schneider, Lubor Borsig	45
11	Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation 2017 ·Gut ·Gitta Seleznik, Theresia Reding, (unknown), Anurag Gupta, (unknown), Sabrina Sonda, Caroline S. Verbeke, Emmanuel Dejardin, Igor Khatkov, Stephan Segerer, Mathias Heikenwälder, Rolf Graf	16
12	Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma 2016 ·Cancer Research ·Benita Wolf, (unknown), Christine S. Falk, Kai Breuhahn, Hildegard Keppeler, Tilo Biedermann, Evi Schmid, Steven W. Warmann, Jörg Fuchs, (unknown), Dennis J. Thiele, (unknown), Meltem Avci‐Adali, (unknown), Lüdger Schöls, Stefan Hauser, Marc Ringelhan, Tetyana Yevsa, Mathias Heikenwälder, Uta Kossatz-Boehlert	13
13	The maternal microbiota drives early postnatal innate immune development breakdown → 2016 ·Science ·Mercedes Gomez de Agüero, Stephanie C. Ganal‐Vonarburg, Tobias Fuhrer, (unknown), Yasuhiro Uchimura, Hai Li, Anna Steinert, Mathias Heikenwälder, Siegfried Hapfelmeier, Uwe Sauer, Kathy D. McCoy, Andrew J. Macpherson	860
14	Endothelial cells translate pathogen signals into G-CSF–driven emergency granulopoiesis 2014 ·Blood ·Steffen Boettcher, Rahel Gerosa, Ramin Radpour, Judith Bauer, Franziska Ampenberger, Mathias Heikenwälder, Manfred Köpf, Markus G. Manz	211
15	Intratumor Heterogeneity in Hepatocellular Carcinoma 2014 ·Clinical Cancer Research ·Juliane Friemel, Markus Rechsteiner, Lukas Frick, Friederike Böhm, Kirsten Struckmann, Michèle Egger, Holger Moch, Mathias Heikenwälder, Achim Weber	236
16	Nonredundant Function of Soluble LTα ₃ Produced by Innate Lymphoid Cells in Intestinal Homeostasis 2013 ·Science ·Andrey Kruglov, Sergei I. Grivennikov, Dmitry V. Kuprash, (unknown), (unknown), Gitta Seleznik, Gérard Eberl, Dan R. Littman, Mathias Heikenwälder, Alexei V. Tumanov, Sergei A. Nedospasov	203
17	Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses breakdown → 2010 ·Science ·Siegfried Hapfelmeier, Melissa A. Lawson, Emma Slack, Jorum Kirundi, Maaike Stoel, Mathias Heikenwälder, Julia Cahenzli, Yuliya Velykoredko, Maria L. Balmer, Kathrin Endt, Markus B. Geuking, Roy Curtiss, Kathy D. McCoy, Andrew J. Macpherson	598
18	De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis 2008 ·Proceedings of the National Academy of Sciences ·Christina J. Sigurdson, K. Peter R. Nilsson, Simone Hornemann, Mathias Heikenwälder, Giuseppe Manco, Petra Schwarz, David E. Ott, Thomas Rülicke, Paweł P. Liberski, Christian Julius, Jeppe Falsig, Lothar Stitz, Kurt Wüthrich, Adriano Aguzzi	158
19	Disseminated and sustained HIV infection in CD34 ⁺ cord blood cell-transplanted Rag2 ^−/− γ _c ^−/− mice 2006 ·Proceedings of the National Academy of Sciences ·Stefan Baenziger, Roxane Tussiwand, Erika Schlaepfer, Luca Mazzucchelli, Mathias Heikenwälder, Michael Kurrer, Silvia Behnke, Joachim Frey, Annette Oxenius, Helen Joller, Adriano Aguzzi, Markus G. Manz, Roberto F. Speck	191
20	Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions 2005 ·Science ·Mathias Heikenwälder, Nicolas Zeller, Harald Seeger, Marco Prinz, Peter‐Christian Klöhn, Petra Schwarz, Nancy H. Ruddle, Charles Weissmann, Adriano Aguzzi	141

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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