Lester I. Binder

24.1k citations

133 papers · 19.9k indexed · 6 hit papers · h-index 72

Physiology top 0.02%
Molecular Biology top 0.5%
Cellular and Molecular Neuroscience top 0.1%
Cell Biology top 0.1%
Neurology top 0.1%

Co-authors: Robert W. Berry Anthony Frankfurter H. M. Wiśniewski Y C Tung Inge Grundke‐Iqbal Khurshid Iqbal L I Rebhun Jeff Kuret
Topics: Alzheimer's disease research and treatments (84 papers)Microtubule and mitosis dynamics (29 papers)Neuroscience and Neuropharmacology Research (29 papers)
Cited by: Physiology Neurology Cellular and Molecular Neuroscience
Journals: Science Cell Proceedings of the National Academy of Sciences
Partner nations: United States Mexico Germany

In The Last Decade

Lester I. Binder

132 papers receiving 19.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 2.9k citations Lester I. Binder et al. profile →
The distribution of tau in the mammalian central nervous system.

1985 1.3k citations Lester I. Binder et al. profile →
Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

2003 685 citations Sarita Lagalwar, Yifan Fu et al. profile →
Tau is essential to β-amyloid-induced neurotoxicity

2002 651 citations Lester I. Binder et al. profile →
Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 590 citations Lester I. Binder et al. profile →
The periodic association of MAP2 with brain microtubules in vitro.

1979 465 citations Lester I. Binder et al. profile →

Peers

Countries citing papers authored by Lester I. Binder

Since Specialization

Citations

This map shows the geographic impact of Lester I. Binder's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Lester I. Binder with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Lester I. Binder more than expected).

Fields of papers citing papers by Lester I. Binder

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Lester I. Binder. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Lester I. Binder. The network helps show where Lester I. Binder may publish in the future.

Co-authorship network of co-authors of Lester I. Binder

This figure shows the co-authorship network connecting the top 25 collaborators of Lester I. Binder. A scholar is included among the top collaborators of Lester I. Binder based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Lester I. Binder. Lester I. Binder is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease 2016 ·Neurobiology of Aging ·(unknown),Stephen D. Ginsberg,Angela Guillozet-Bongaarts,Sarah Ward,Bin He,Nicholas M. Kanaan,Elliott J. Mufson,Lester I. Binder,Scott Counts	28
2	Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody 2012 ·Molecular Neurodegeneration ·Katherine L. Youmans,Leon M. Tai,Takahisa Kanekiyo,W. Blaine Stine,(unknown),Evelyn Nwabuisi‐Heath,Arlene M. Manelli,Yifan Fu,Sean M. Riordan,William A. Eimer,Lester I. Binder,Guojun Bu,Chunjiang Yu,Dean M. Hartley,Mary Jo LaDu	143
3	Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer's Disease 2011 ·American Journal Of Pathology ·Juan F. Reyes,Yifan Fu,Laurel Vana,Nicholas M. Kanaan,Lester I. Binder	46
4	X-ray diffraction from intact tau aggregates in human brain tissue 2011 ·Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment ·Eric C. Landahl,Olga Antipova,(unknown),Raúl A. Barrea,R. Stephen Berry,Lester I. Binder,Thomas C. Irving,Joseph Orgel,Laurel Vana,(unknown)	8
5	Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport 2011 ·Neurobiology of Aging ·Nicholas M. Kanaan,Gerardo Morfini,Gustavo Pigino,Nichole E. LaPointe,Athena Andreadis,Yuyu Song,Ellen M. Leitman,Lester I. Binder,Scott T. Brady	116
6	Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease 2011 ·Journal of Biological Chemistry ·Kristina R. Patterson,Christine Remmers,Yifan Fu,Sarah M. Brooker,Nicholas M. Kanaan,Laurel Vana,Sarah Ward,Juan F. Reyes,Keith Philibert,Marc Glucksman,Lester I. Binder	279
7	Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases 2011 ·Journal of Neuroscience ·Nicholas M. Kanaan,Gerardo Morfini,Nichole E. LaPointe,Gustavo Pigino,Kristina R. Patterson,Yuyu Song,Athena Andreadis,Yifan Fu,Scott T. Brady,Lester I. Binder	214
8	Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease 2008 ·International Journal of Experimental Pathology ·Siddhartha Mondragón‐Rodríguez,Gustavo Basurto‐Islas,Ismael Santa‐María,Raúl Mena,Lester I. Binder,Jesús Ávila,Mark A. Smith,George Perry,Francisco García‐Sierra	109
9	Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy 2008 ·American Journal Of Pathology ·Chad A. Dickey,(unknown),Umesh K. Jinwal,John Koren,Amelia G. Johnson,Laura Anderson,Lori Lebson,Daniel C. Lee,Dennis W. Dickson,Rohan de Silva,Lester I. Binder,David Morgan,Jada Lewis	67
10	Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo 2006 ·Journal of Neurochemistry ·Angela Guillozet-Bongaarts,Michael E. Cahill,Vincent L. Cryns,Matthew R. Reynolds,Robert W. Berry,Lester I. Binder	127
11	Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease 2004 ·Journal of Neuroscience ·Peleg Horowitz,Kristina R. Patterson,Angela Guillozet-Bongaarts,Matthew R. Reynolds,Christopher A. Carroll,Susan T. Weintraub,David A. Bennett,Vincent L. Cryns,Robert W. Berry,Lester I. Binder	177
12	Tau epitope display in progressive supranuclear palsy and corticobasal degeneration 2004 ·Journal of Neurocytology ·Robert W. Berry,(unknown),(unknown),Sarita Lagalwar,Brittany Lapin,(unknown),(unknown),Angela Guillozet-Bongaarts,(unknown),Eileen H. Bigio,Lester I. Binder	37
13	Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease 2004 ·Neurobiology of Aging ·Angela Guillozet-Bongaarts,Francisco García‐Sierra,Matthew R. Reynolds,Peleg Horowitz,Yifan Fu,Tianyi Wang,Michael E. Cahill,Eileen H. Bigio,Robert W. Berry,Lester I. Binder	212
14	Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases 2000 ·Neurobiology of Aging ·Claudia Schwab,Anthony J. DeMaggio,Nupur Ghoshal,Lester I. Binder,Jeff Kuret,Patrick L. McGeer	130
15	Tau as a nucleolar protein in human nonneural cells in vitro and in vivo 1996 ·Chromosoma ·Virginia C. Thurston,Raymond Zinkowski,Lester I. Binder	80
16	Differential distribution of tau proteins in developing cat cerebellum 1994 ·Brain Research Bulletin ·Beat M. Riederer,Lester I. Binder	27
17	Actin‐binding protein is a component of bovine erythrocytes 1993 ·Cell Motility and the Cytoskeleton ·Kevin D. Brown,Raymond Zinkowski,(unknown),Lester I. Binder	1
18	Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2) 1992 ·Journal of Structural Biology ·Holger Wille,Eckhard Mandelkow�,Jane Dingus,Richard B. Vallee,Lester I. Binder	40
19	Epitopes that span the tau molecule are shared with paired helical filaments 1988 ·Neuron ·Kenneth S. Kosik,Lisa D. Orecchio,Lester I. Binder,John Q. Trojanowski,V.M.-Y. Lee,Gloria Lee	444
20	Phosphorylation determines two distinct species of tau in the central nervous system 1987 ·Cell Motility and the Cytoskeleton ·Sozos Ch. Papasozomenos,Lester I. Binder	372

About Lester I. Binder

Lester I. Binder is a scholar working on Physiology, Cell Biology and Cellular and Molecular Neuroscience, having authored 133 papers that have together received 19.9k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (84 papers), Microtubule and mitosis dynamics (29 papers) and Neuroscience and Neuropharmacology Research (29 papers). The work is most often cited by research in Physiology (13.1k citations), Neurology (3.0k citations) and Cellular and Molecular Neuroscience (5.9k citations). Lester I. Binder has collaborated with scholars based in United States, Mexico and Germany. Frequent co-authors include Robert W. Berry, Anthony Frankfurter, H. M. Wiśniewski, Y C Tung, Inge Grundke‐Iqbal, Khurshid Iqbal, L I Rebhun, Jeff Kuret, Sozos Ch. Papasozomenos and T. Chris Gamblin. Their work appears in journals such as Science, Cell and Proceedings of the National Academy of Sciences.

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