Edward H. Koo

32.8k total citations · 11 hit papers
187 papers, 23.7k citations indexed

About

Edward H. Koo is a scholar working on Physiology, Molecular Biology and Pharmacology. According to data from OpenAlex, Edward H. Koo has authored 187 papers receiving a total of 23.7k indexed citations (citations by other indexed papers that have themselves been cited), including 149 papers in Physiology, 95 papers in Molecular Biology and 44 papers in Pharmacology. Recurrent topics in Edward H. Koo's work include Alzheimer's disease research and treatments (143 papers), Cholinesterase and Neurodegenerative Diseases (40 papers) and Prion Diseases and Protein Misfolding (35 papers). Edward H. Koo is often cited by papers focused on Alzheimer's disease research and treatments (143 papers), Cholinesterase and Neurodegenerative Diseases (40 papers) and Prion Diseases and Protein Misfolding (35 papers). Edward H. Koo collaborates with scholars based in United States, Singapore and Germany. Edward H. Koo's co-authors include Dennis J. Selkoe, Sharon L. Squazzo, Hui Zheng, Gopal Thinakaran, Christian Haass, Todd E. Golde, Sangram S. Sisodia, Albert Y. Hung, Donald L. Price and David B. Teplow and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Edward H. Koo

186 papers receiving 23.3k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 1.6k citations Edward H. Koo et al. profile →
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

2001 1.1k citations Sascha Weggen, Jason L. Eriksen et al. profile →
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

2012 911 citations Edward H. Koo et al. profile →
Amyloid Precursor Protein Trafficking, Processing, and Function

2008 872 citations Gopal Thinakaran, Edward H. Koo Journal of Biological Chemistry profile →
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

2009 837 citations Edward H. Koo et al. profile →
Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 834 citations Edward H. Koo, Sharon L. Squazzo Journal of Biological Chemistry profile →
Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 754 citations Edward H. Koo et al. profile →
Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 749 citations Edward H. Koo et al. profile →
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 591 citations Edward H. Koo et al. profile →
Amyloid diseases: Abnormal protein aggregation in neurodegeneration

1999 570 citations Edward H. Koo et al. profile →
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

2003 502 citations Jason L. Eriksen, Sarah A. Sagi et al. Journal of Clinical Investigation profile →

Peers

Countries citing papers authored by Edward H. Koo

Since Specialization

Citations

This map shows the geographic impact of Edward H. Koo's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edward H. Koo with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edward H. Koo more than expected).

Fields of papers citing papers by Edward H. Koo

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edward H. Koo. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edward H. Koo. The network helps show where Edward H. Koo may publish in the future.

Co-authorship network of co-authors of Edward H. Koo

This figure shows the co-authorship network connecting the top 25 collaborators of Edward H. Koo. A scholar is included among the top collaborators of Edward H. Koo based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Edward H. Koo. Edward H. Koo is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Incidence and Prevalence of Clinically Detected Smoldering Multiple Myeloma Among the General Population 2024 ·Blood ·(unknown), Irwindeep Sandhu, Michael P. Chu, Kathryn N. Rankin, Arleigh McCurdy, (unknown), (unknown), Edward H. Koo, (unknown), Sabrina Albert, (unknown), Christopher R. McCudden, Alissa Visram	0
2	Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits 2021 ·Acta Neuropathologica Communications ·Wan Yun Ho, Ira Agrawal, Sheue-Houy Tyan, (unknown), Wei‐Tang Chang, (unknown), (unknown), (unknown), Aung Aung Kywe Moe, (unknown), Peiyan Wong, Greg Tucker‐Kellogg, Edward H. Koo, Kai‐Hsiang Chuang, Shuo‐Chien Ling	24
3	Systemic toxicity of di (2-ethylhexyl) adipate (DEHA) in rats following 28-day intravenous exposure 2019 ·Regulatory Toxicology and Pharmacology ·Haiyan Xu, Barbara Musi, Zhimei Wang, (unknown), (unknown), (unknown), Tiantian Li, (unknown), (unknown), (unknown), Edward H. Koo	12
4	APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission 2017 ·Journal of Neuroscience ·(unknown), (unknown), Susann Ludewig, Jonathan Stephan, Marius Zimmermann, (unknown), (unknown), Martin Körte, Edward H. Koo, Ulrike Müller, Stefan Kins, Simone Eggert	56
5	Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway 2015 ·Nature Neuroscience ·Utpal Das, Lina Wang, Archan Ganguly, (unknown), Steven L. Wagner, Edward H. Koo, Subhojit Roy	146
6	Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity 2014 ·PLoS ONE ·Joo In Jung, (unknown), Pedro E. Cruz, Thomas B. Ladd, (unknown), Edward H. Koo, Kevin M. Felsenstein, Todd E. Golde, Yong Ran	27
7	Amyloid precursor protein (APP) regulates synaptic structure and function 2012 ·Molecular and Cellular Neuroscience ·Sheue-Houy Tyan, (unknown), Jessica J. Walsh, Hiroko Maruyama, Floyd Sarsoza, Lawrence Ku, Simone Eggert, Patrick R. Hof, Edward H. Koo, Dara L. Dickstein	137
8	Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift 2011 ·Neuron ·Todd E. Golde, Lon S. Schneider, Edward H. Koo	297
9	Novel Role of RanBP9 in BACE1 Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation 2009 ·Journal of Biological Chemistry ·Madepalli K. Lakshmana, Il‐Sang Yoon, Eunice Chen, (unknown), Edward H. Koo, David E. Kang	74
10	Formation of Pmel17 Amyloid Is Regulated by Juxtamembrane Metalloproteinase Cleavage, and the Resulting C-terminal Fragment Is a Substrate for γ-Secretase 2008 ·Journal of Biological Chemistry ·Markus P. Kummer, (unknown), (unknown), Sandra Baches, Sascha Weggen, Edward H. Koo	50
11	Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice 2007 ·BMC Neuroscience ·Thomas Kukar, (unknown), Jason L. Eriksen, V. Holloway, M. Paul Murphy, Edward H. Koo, Todd E. Golde, Michelle M. Nicolle	102
12	Low Density Lipoprotein Receptor-related Protein (LRP) Interacts with Presenilin 1 and Is a Competitive Substrate of the Amyloid Precursor Protein (APP) for γ-Secretase 2005 ·Journal of Biological Chemistry ·Alberto Lleó, Elaine Waldron, Christine A. F. Von Arnim, Lauren Herl, (unknown), Ithan D. Peltan, Dudley K. Strickland, Edward H. Koo, Bradley T. Hyman, Claus U. Pietrzik, Oksana Berezovska	59
13	Inhibitors of Rho‐kinase modulate amyloid‐β (Aβ) secretion but lack selectivity for Aβ42 2005 ·Journal of Neurochemistry ·Stefanie Leuchtenberger, Markus P. Kummer, Thomas Kukar, Eva Czirr, Nicole Teusch, Sarah A. Sagi, Rebecca Berdeaux, Claus U. Pietrzik, Thomas B. Ladd, Todd E. Golde, Edward H. Koo, Sascha Weggen	26
14	The endocytotic pathway is required for increased Aβ42 secretion during apoptosis 2004 ·Molecular Brain Research ·Chhinder P. Sodhi, (unknown), Ruth G. Perez, Edward H. Koo, Bruce Quinn, Numa R. Gottardi-Littell	12
15	NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo breakdown → 2003 ·Journal of Clinical Investigation ·Jason L. Eriksen, Sarah A. Sagi, (unknown), Sascha Weggen, Pritam Das, (unknown), Victor Ozols, (unknown), Kenton H. Zavitz, Edward H. Koo, Todd E. Golde	502
16	Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity 2003 ·Journal of Neurochemistry ·Daniel C. Lu, Salvador Soriano, Dale E. Bredesen, Edward H. Koo	87
17	Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein 2002 ·Cell ·Sung Hee Baek, Kenneth A. Ohgi, David W. Rose, Edward H. Koo, Christopher K. Glass, Michael G. Rosenfeld	469
18	The Nonconserved Hydrophilic Loop Domain of Presenilin (PS) Is Not Required for PS Endoproteolysis or Enhanced Aβ42 Production Mediated by Familial Early Onset Alzheimer's Disease-linked PS Variants 2000 ·Journal of Biological Chemistry ·Carlos A. Saura, Taisuke Tomita, Salvador Soriano, Masaaki Takahashi, (unknown), Toshiyuki Honda, Edward H. Koo, Takeshi Iwatsubo, Gopal Thinakaran	54
19	Expression of β-Amyloid Precursor Protein-CD3γ Chimeras to Demonstrate the Selective Generation of Amyloid β1–40and Amyloid β1–42 Peptides within Secretory and Endocytic Compartments 1999 ·Journal of Biological Chemistry ·Salvador Soriano, (unknown), Xiaohua Chen, Gorazd B. Stokin, Virginia M.‐Y. Lee, Edward H. Koo	76
20	Enhanced Release of Amyloid -Protein from Codon 670/671 Swedish Mutant -Amyloid Precursor Protein Occurs in Both Secretory and Endocytic Pathways 1996 ·Journal of Biological Chemistry ·Ruth G. Perez, Sharon L. Squazzo, Edward H. Koo	108

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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