Holger Wille

10.0k total citations · 2 hit papers
121 papers, 7.5k citations indexed

About

Holger Wille is a scholar working on Molecular Biology, Neurology and Nutrition and Dietetics. According to data from OpenAlex, Holger Wille has authored 121 papers receiving a total of 7.5k indexed citations (citations by other indexed papers that have themselves been cited), including 98 papers in Molecular Biology, 40 papers in Neurology and 35 papers in Nutrition and Dietetics. Recurrent topics in Holger Wille's work include Prion Diseases and Protein Misfolding (75 papers), Neurological diseases and metabolism (39 papers) and Trace Elements in Health (35 papers). Holger Wille is often cited by papers focused on Prion Diseases and Protein Misfolding (75 papers), Neurological diseases and metabolism (39 papers) and Trace Elements in Health (35 papers). Holger Wille collaborates with scholars based in United States, Canada and Germany. Holger Wille's co-authors include Stanley B. Prusiner, Fred E. Cohen, Jiri Safar, Eckhard Mandelkow�, Darlene Groth, Marilyn Torchia, Hana Serban, Stephen J. DeArmond, Vincenza Itri and Cédric Govaerts and has published in prestigious journals such as Cell, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

Holger Wille

119 papers receiving 7.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Eight prion strains have PrPSc molecules with different conformations

1998 1.0k citations Jiri Safar, Holger Wille et al. profile →
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

1996 445 citations Holger Wille, Stephen J. DeArmond et al. Proceedings of the National Academy of Sciences profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Holger Wille United States	42	6.4k	2.7k	2.3k	1.9k	582	121	7.5k
Giuseppe Legname Italy	50	7.8k 1.2×	3.7k 1.3×	2.8k 1.2×	1.9k 1.0×	288 0.5×	209	10.0k
Christina J. Sigurdson United States	42	4.4k 0.7×	1.6k 0.6×	1.1k 0.5×	1.6k 0.8×	182 0.3×	84	5.8k
Jiri Safar United States	40	6.0k 0.9×	3.0k 1.1×	2.3k 1.0×	1.3k 0.7×	146 0.3×	107	7.0k
Simone Hornemann Switzerland	34	5.3k 0.8×	2.7k 1.0×	2.3k 1.0×	855 0.5×	165 0.3×	70	6.0k
Jack Nguyen United States	27	3.8k 0.6×	1.1k 0.4×	1.0k 0.4×	1.3k 0.7×	236 0.4×	45	5.0k
Darlene Groth United States	49	12.9k 2.0×	7.0k 2.6×	5.8k 2.6×	1.3k 0.7×	270 0.5×	69	13.3k
Surachai Supattapone United States	39	6.3k 1.0×	1.8k 0.7×	1.7k 0.8×	848 0.5×	1.0k 1.8×	91	7.2k
Jörg Tatzelt Germany	37	3.9k 0.6×	1.4k 0.5×	838 0.4×	981 0.5×	756 1.3×	96	4.9k
Magdalini Polymenidou Switzerland	32	6.7k 1.1×	1.6k 0.6×	674 0.3×	1.2k 0.6×	494 0.8×	56	9.6k
Rubén Vidal United States	45	3.9k 0.6×	1.5k 0.6×	566 0.2×	3.9k 2.1×	574 1.0×	134	7.3k

Countries citing papers authored by Holger Wille

Since Specialization

Citations

This map shows the geographic impact of Holger Wille's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Holger Wille with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Holger Wille more than expected).

Fields of papers citing papers by Holger Wille

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Holger Wille. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Holger Wille. The network helps show where Holger Wille may publish in the future.

Co-authorship network of co-authors of Holger Wille

This figure shows the co-authorship network connecting the top 25 collaborators of Holger Wille. A scholar is included among the top collaborators of Holger Wille based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Holger Wille. Holger Wille is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Overduin, Michael, Mansoore Esmaili, Catharine A. Trieber, et al.. (2025). Design of zwitterionic fluorescent polymers for membrane protein solubilization into native nanodiscs. Biophysical Chemistry. 325. 107489–107489. 1 indexed citations

Cortez, Leonardo M., Emmanuel Planel, Jae‐Young Cho, et al.. (2025). Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions. International Journal of Nanomedicine. Volume 20. 1999–2019. 1 indexed citations

Zapf, Richard, et al.. (2024). Protein thermal sensing regulates physiological amyloid aggregation. Nature Communications. 15(1). 1222–1222. 4 indexed citations

Williams, Declan, Hansen Wang, Christine Sato, et al.. (2023). Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation. Scientific Reports. 13(1). 2337–2337. 4 indexed citations

Monleón, Eva, Jacques van der Merwe, Richard P. Fahlman, et al.. (2023). In Vitro and In Vivo Evidence towards Fibronectin’s Protective Effects against Prion Infection. International Journal of Molecular Sciences. 24(24). 17525–17525. 1 indexed citations

Daude, Nathalie, Agnes Lau, Ilaria Vanni, et al.. (2022). Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high–molecular weight complexes. Journal of Biological Chemistry. 298(4). 101770–101770. 6 indexed citations

Anand, Bibin G., Qi Wu, Maryam Nakhaei‐Nejad, et al.. (2022). Significance of native PLGA nanoparticles in the treatment of Alzheimer's disease pathology. Bioactive Materials. 17. 506–525. 38 indexed citations

Padilla‐Camberos, Eduardo, et al.. (2021). Biosynthesis of Silver Nanoparticles Using Stenocereus queretaroensis Fruit Peel Extract: Study of Antimicrobial Activity. Materials. 14(16). 4543–4543. 20 indexed citations

Wille, Holger, et al.. (2019). Combining molecular dynamics simulations and experimental analyses in protein misfolding. Advances in protein chemistry and structural biology. 118. 33–110. 15 indexed citations

10.

Daude, Nathalie, Charles E. Mays, Serene Wohlgemuth, et al.. (2018). A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles. PLoS Pathogens. 14(1). e1006826–e1006826. 17 indexed citations

11.

Requena, Jesús R. & Holger Wille. (2017). The Structure of the Infectious Prion Protein and Its Propagation. Progress in molecular biology and translational science. 150. 341–359. 16 indexed citations

12.

Godsave, Susan F., Holger Wille, Jason Pierson, Stanley B. Prusiner, & Peter J. Peters. (2013). Plasma membrane invaginations containing clusters of full-length PrPSc are an early form of prion-associated neuropathology in vivo. Neurobiology of Aging. 34(6). 1621–1631. 19 indexed citations

13.

Wan, William, Holger Wille, Jan Stöhr, et al.. (2012). Degradation of Fungal Prion HET-s(218-289) Induces Formation of a Generic Amyloid Fold. Biophysical Journal. 102(10). 2339–2344. 23 indexed citations

14.

Godsave, Susan F., Holger Wille, Pekka Kujala, et al.. (2008). Cryo-Immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site. Journal of Neuroscience. 28(47). 12489–12499. 69 indexed citations

15.

Malo, Jonathan, James C. Mitchell, Catherine Vénien‐Bryan, et al.. (2005). Engineering a 2D Protein–DNA Crystal. Angewandte Chemie International Edition. 44(20). 3057–3061. 153 indexed citations

16.

Govaerts, Cédric, et al.. (2004). 5 Structural Studies of Prion Proteins. Cold Spring Harbor Monograph Archive. 38. 191–228. 9 indexed citations

17.

Wille, Holger, Vincent Guénebaut, Surachai Supattapone, et al.. (2002). Structural studies of the scrapie prion protein by electron crystallography. Proceedings of the National Academy of Sciences. 99(6). 3563–3568. 324 indexed citations

18.

Kaneko, Kiyotoshi, Haydn L. Ball, Holger Wille, et al.. (2000). A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice. Journal of Molecular Biology. 295(4). 997–1007. 114 indexed citations

19.

Supattapone, Surachai, Patrick J. Bosque, Tamaki Muramoto, et al.. (1999). Prion Protein of 106 Residues Creates an Artificial Transmission Barrier for Prion Replication in Transgenic Mice. Cell. 96(6). 869–878. 173 indexed citations

20.

Wille, Holger, Eckhard Mandelkow�, Jane Dingus, Richard B. Vallee, & Lester I. Binder. (1992). Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2). Journal of Structural Biology. 108(1). 49–61. 40 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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